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Methionine sources and genotype affect embryonic intestinal development,antioxidants,tight junctions,and growth-related gene expression in chickens

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Animal Nutrition 2024年第1期16卷 218-230页

作者： James K.Lugata Sawadi F.Ndunguru Gebrehaweria K.Reda Xénia E.Ozsváth Eszter Angyal Levente Czeglédi gabriella Gulyás Renáta Knop János Oláh Zoltán Mészár Rita Varga Brigitta Csernus Csaba Szabó Department of Animal Nutrition and Physiology Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Department of Animal Husbandry Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Faculty of Agriculture and Food Sciences and Environmental Management Doctoral School of Animal ScienceUniversity of DebrecenDebrecenHungary Institutes for Agricultural Research and Educational Farm University of DebrecenDebrecenHungary Department of Anatomy Histology and EmbryologyFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of Evolutionary Zoology and Human Biology Faculty of Science and TechnologyUniversity of DebrecenDebrecenHungary

Methionine(Met)is an essential and first limiting amino acid in the poultry diet that plays a significant role in chicken embryonic development and *** present study examined the effect of in ovo injection of DL-Met and L-Met sources and genotypes on chicken embryonic-intestinal development and *** eggs of the two genotypes,tEtRA-SL layer hybrid(tSL)—commercial layer hybrid and Hungarian Partridge colored hen breed(HPC)—a native genotype,were randomly distributed into four treatments for each *** treatment groups include the following:1)control non-injected eggs(NoIn);2)saline-injected(SaIn);3)DL-Met injected(DLM);and 4)L-Met injected(LM).the in ovo injection was carried out on 17.5 d of embryonic development;after hatching,eight chicks per group were sacrificed,and the jejunum was extracted for *** results showed that both DLM and LM groups had enhanced intestinal development as evidenced by increased villus width,villus height,and villus area(Pto the *** DLM group had significantly reduced crypt depth,glutathione(GSH)content,glutathione S-transferase 3 alpha(GSt3),occludin(OCLN)gene expression and increased villus height to crypt depth ratio in the tSL genotype than the LM group(Pthe HPC genotype has overexpressed insulin-like growth factor 1(IGF1)gene,tricellulin(MD2),occludin(OCLN),superoxide dismutase 1(SOD1),and GSt3 genes than the tSL genotype(Pthese findings showed that in ovo injection of Met enhanced intestinal development,and function,with genotypes responding differently under normal *** also influenced the expression of intestinal antioxidants,tight junction,and growth-related genes.

关键词： DL-Methionine L-Methionine In ovo injection Intestinal development Poultry

Microscopic colitis: A retrospective study of clinical presentation in 53 patients

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World Journal of Gastroenterology 2005年第9期11卷 1351-1355页

作者： Zsolt Barta gabriella Mekkel István Csíp(o|") László tóth Szabolcs Szakáll Gábor G.Szabó Gyula Bakó Gyula Szegedi Margit Zeher third Department of Medicine Department of Pathology

AIM: to evaluate the relationship between symptoms and microscopic colitis (MC) subtypes: to test whether collagenous colitis (CC) and/or lymphocytic colitis (LC)might be related to both constipation and ***: A cohort of patients with independently confirmed typical histopathological changes was investigated. Fifty-three patients with histologically proved MC (46 with CC, 7 with LC) were included. the existence of diarrhea or constipation and the co-existence of autoimmune diseases were also investigated and all data were retrospectively ***: twenty-three (43.39%) of MC patients had chronic constipation (20 in CC, 3 in LC patients). twentyfour(45.28%) of MC patients had autoimmune disease and the diagnosis of autoimmune disease was always prior to MC. Sjogren's syndrome was associated only with the constipation ***: the Janus face of MC resembles the subgroups of irritable bowel syndrome. the co-existence of autoimmune diseases and MC is confirmed in both the constipation and diarrhea subgroups.

关键词： Microscopic colitis Constipation Autoimmune

treatment of Obesity with Western Medicine and traditional Medicine:Based on PubMed and Science Direct Databases

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Chinese Medicine and Culture 2019年第2期2卷 99-104页

作者： gabriella Korio tCM Outpatient Department of Internal Medicine Shanghai 7^(th) Peoples Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina

the objective of this review was to collect the current published research on obesity and gain insight into the association of treatment based on a global *** first section of the review will cover the treatment of obesity based on a Western medicine *** second section of the review will cover the treatment through a traditional approach based from different regions of the world(not including China).the third section of the review will cover treatment through a traditional Chinese medicine *** most commonly used electronic databases were used to search for articles related to *** articles gathered consist of a broad spectrum from various parts of the *** used in the search bar consisted of“obesity”,“BMI”,“acupuncture”,“traditional Chinese medicine”,*** majority of findings were collected from treatment based on both a western medicine and traditional Chinese medicine *** published literature collected is predominantly sourced from the online journal databases PubMed and Science *** is an ever-growing issue throughout society *** methods have shown effective results in treating this *** is crucial to continue exploring different treatment methods in hopes to solve this major public health issue.

关键词： Acupuncture BMI herbal medicine phlegm dampness Simple obesity traditional Chinese medicine weightloss Western Medicine

Short-term forecast in the early stage of the COVID-19 outbreak in Italy. Application of a weighted and cumulative average daily growth rate to an exponential decay model

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Infectious Disease Modelling 2021年第1期6卷 212-221页

作者： Nicola Bartolomeo Paolo trerotoli gabriella Serio Department of Biomedical Science and Human Oncology University of Bari Aldo MoroPiazza Giulio Cesare 1170124BariItaly

to estimate the size of the novel coronavirus(COVID-19)outbreak in the early stage in Italy,this paper introduces the cumulated and weighted average daily growth rate(WR)to evaluate an epidemic *** the basis of an exponential decay model(EDM),we provide estimations of the WR in four-time intervals from February 27 to April 07,*** calibrating the parameters of the EDM to the reported data in Hubei Province of China,we also attempt to forecast the evolution of the *** compare the EDM applied to WR and the Gompertz model,which is based on exponential decay and is often used to estimate cumulative ***,we assess the performance of each model to short-term forecast of the epidemic,and to predict the final epidemic *** on the official counts for confirmed cases,the model applied to data from February 27 until the 17th of March estimate that the cumulative number of infected in Italy could reach 131,280(with a credibility interval 71,415-263,501)by April 25(credibility interval April 12 to May 3).With the data available until the 24st of March the peak date should be reached on May 3(April 23 to May 23)with 197,179 cumulative infections expected(130,033e315,269);with data available until the 31st of March the peak should be reached on May 4(April 25 to May 18)with 202,210 cumulative infections expected(155.235 e270,737);with data available until the 07st of April the peak should be reached on May 3(April 26 toMay 11)with 191,586(160,861-232,023)cumulative infections *** on the average mean absolute percentage error(MAPE),cumulated infections forecasts provided by the EDM applied to WR performed better across all scenarios than the Gompertz *** exponential decay model applied to the cumulated and weighted average daily growth rate appears to be useful in estimating the number of cases and peak of the COVID-19 outbreak in Italy and the model was more reliable in the exponential growth phase.

关键词： Covid-19 Coronavirus Italy Short-term forecasts Daily grow rate Exponential decay model

A Family of Relaxation Schemes for Nonlinear Convection Diffusion Problems

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Communications in Computational Physics 2009年第2期5卷 532-545页

作者： Fausto Cavalli Giovanni Naldi gabriella Puppo Matteo Semplice Universita degli Studi di Brescia Dipartimento di MatematicaVia Valotti9-25133 BresciaItaly Universita degli Studi di Milano Dipartimento di MatematicaVia Saldini 5020133 MilanoItaly Politecnico di torino Dipartimento di MatematicaCorso Duca degli Abruzzi 2410129 TorinoItaly

In this work we present a family of relaxation schemes for nonlinear convection diffusion problems,which can tackle also the cases of degenerate diffusion and of convection dominated *** schemes proposed can achieve any order of accuracy,give non-oscillatory solutions even in the presence of singularities and their structure depends only weakly on the particular PDE being *** and two dimensional results are shown,and a nonlinear stability estimate is given.

关键词： Convection-diffusion relaxation schemes degenerate parabolic problems

mi R-122 negatively correlates with liver fibrosis as detected by histology and FibroScan

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World Journal of Gastroenterology 2015年第25期21卷 7814-7823页

作者： tünde Halász Gábor Horváth gabriella Pár Klára Werling András Kiss Zsuzsa Schaff Gábor Lendvai Second Department of Pathology Semmelweis University Department of Pathology Military Hospital Hepatology Center of Buda 1111 BudapestHungary First Department of Medicine University of Pécs Second Department of Internal Medicine Semmelweis University MtA-SE tumor Progression Research Group Semmelweis University

AIM: to investigate whether expression of selected mi RNAs obtained from fibrotic liver biopsies correlate with fibrosis ***: Altogether, 52 patients were enrolled in the study representing various etiologic backgrounds of fibrosis: 24 cases with chronic hepatitis infections(types B, C), 19 with autoimmune liver diseases(autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, overlapping syndrome cases), and 9 of mixed etiology(alcoholic and nonalcoholic steatosis, cryptogenic cases). Severity of fibrosis was determined by both histologic staging using the MEtAVIR scoring system and noninvasive transient elastography. Following RNAisolation, expression levels of mi R-21, mi R-122, mi R-214, mi R-221, mi R-222, and mi R-224 were determined using taq Man Micro RNA Assays applying mi R-140 as the reference. Selection of mi RNAs was based on their characteristic up- or downregulation observed in hepatocellular carcinoma. Relative expression of mi RNAs was correlated with fibrosis stage and liver stiffness(LS) value measured by transient elastography, as well as with serum alanine aminotransferase(ALt) ***: the expression of individual mi RNAs showed deregulated patterns in stages F1-F4 as compared with stage F0, but only the reduced level of mi R-122 in stage F4 was statistically significant(P tion to fibrosis, levels of mi R-122 and mi R-221 showed negative correlations with fibrosis stage, and mi R-122 was found to correlate negatively and mi R-224 positively with LS values(all P t levels displayed a positive correlation with mi R-21(P tive correlations were observed in the fibrosis samples of mixed etiology between mi R-122 and fibrosis stage and LS values(P the samples of chronic viral hepatitis, between mi R-221 and fibrosis stage(P tive correlation with ALt values in the samples of autoimmune live

关键词： Expression FibroScan Liver fibrosis MEtAVIR microRNA miR-122

Incorporation of the 8^th Edition AJCC/tNM Staging of Carcinoma of the Appendix into the Esquivel Peritoneal Surface Disease Severity Score (E-PSDSS) in 229 Patients with Mucinous Appendiceal Neoplasms

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Open Journal of Gastroenterology 2023年第1期13卷 1-11页

作者： gabriella Esquivel Jing Qiu James Spellman Jesus Esquivel University of Delaware Newark USA Beebe Healthcare Lewes USA

Introduction: A practical staging classification that has prognostic significance in mucinous appendiceal neoplasms represents an unmet need in oncology. the purpose of this study is to present a second edition of the PSDSS in mucinous appendiceal neoplasms with or without peritoneal dissemination based on the AJCC/tNM 8th edition. Materials and Methods: We analyzed 229 patients based on the AJCC/tNM 8th edition incorporating G (grade) and E (extent of disease). the impact of these 5 clinicopathological variables (t, N, M, G, E) is scored as stages 0 to IV and is reported as the Esquivel Peritoneal Surface Disease Severity Score (E-PSDSS). Results: One hundred and seventy-three patients underwent cytoreductive surgery (CRS) and HIPEC. there were 30 (13.1%), 56 (24.4%), 48 (20.9%), 20 (8.7%) and 75 (32.7%) patients with E-PSDSS 0, I, II, III, and IV, respectively. Five-year overall survival was 100%, 100%, 84.46%, 52.29% and 12.92% for E-PSDSS 0, I, II, III and IV, respectively (p Conclusion: the E-PSDSS combines specimen examination and reporting according to the College of American Pathologists with the ptNM requirements from the AJCC staging manual. It represents an important prognostic indicator in patients with mucinous appendiceal neoplasms.

关键词： Appendix Cancer HIPEC PSDSS

Biomass Accumulation and Nutrient Uptake of Jerusalem Artichoke (<i>Helianthus tuberosus</i>L.)

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American Journal of Plant Sciences 2013年第8期4卷 1629-1640页

作者： Zoltán Izsáki gabriella Németh Kádi Institute of Environmental Sciences Faculty of Economics Agricultural and Health Studies Szent István University Szarvas Hungary.

the dynamics of biomass accumulation during the growing period, the yield of leafy stalks and tubers, and the nutrient concentration and nutrient uptake of the yield were investigated for two Jerusalem artichoke varieties (tápiói Korai and tápiói Sima) in a field experiment involving mineral fertilisation. Considerable differences were observed between the dynamics of leafy stalk and tuber development in tápiói Korai which has a short vegetation period and tápiói Sima where the vegetation period is long. the maximum dry matter ratio between the tuber yield and the leafy stalk yield was 1:1 for tápiói Korai and 1:4.5 for tápiói Sima. During the period when the maximum aboveground biomass developed in tápiói Korai, 100 ***-1 N and P fertiliser resulted in the highest leafy stalk yield (38.34 ***-1), while for tápiói Sima, which developed a much greater leafy stalk mass, the highest aboveground biomass yield (78-80 ***-1) was given in response to 200 ***-1 N supplemented by P and K fertiliser. Both artichoke varieties produced the great-est tuber yield at a N rate of 200 ***-1, supplemented with P and K fertiliser. the nutrient concentration in the leafy stalks was highest on the 85th day of the vegetation period, prior to intensive dry matter accumulation in the leafy stalks and before tuber formation began. In both varieties the maximum nutrient uptake was recorded on the 155th day. Great differences were observed between the varieties in terms of specific nutrient uptake. For a tuber yield of 10 t, together with the corresponding leafy stalk yield, the specific nutrient uptake of the tápiói Korai variety amounted to 48 kg N, 10 kg P, 83 kg K, 30 kg Ca and 10 kg Mg, while for tápiói Sima these figures were 162 kg N, 30 kg P, 300 kg K, 84 kg Ca and 45 kg Mg.

关键词： Jerusalem Artichoke Mineral Fertilisation Biomass Accumulation Yield Nutrient Uptake

Immune response modulation in inflammatory bowel diseases by Helicobacter pylori infection

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World Journal of Gastroenterology 2023年第30期29卷 4604-4615页

作者： gabriella Feilstrecker Balani Mariana dos Santos Cortez Jayme Euclydes Picasky da Silveira Freitas Fabrício Freire de Melo Ana Carla Zarpelon-Schutz Kádima Nayara teixeira Campus toledo Universidade Federal do ParanáToledo 85.919-899ParanáBrazil Campus Anísio teixeira Universidade Federal da BahiaInstituto Multidisciplinar em SaúdeVitória da Conquista 45.029-094BahiaBrazil Programa de Pós-graduação em Biotecnologia-Setor Palotina Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil Programa Multicêntrico de Pós-graduação em Bioquímica e Biologia Molecular-Setor Palotina Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil

Many studies point to an association between Helicobacter pylori(***)infection and inflammatory bowel diseases(IBD).Although controversial,this association indicates that the presence of the bacterium somehow affects the course of *** appears that *** infection influences IBD through changes in the diversity of the gut microbiota,and hence in local chemical characteristics,and alteration in the pattern of gut immune *** gut immune response appears to be modulated by *** infection towards a less aggressive inflammatory response and the establishment of a targeted response to tissue ***,a t helper 2(th2)/macrophage M2 response is stimulated,while the th1/macrophage M1 response is *** immunomodulation appears to be associated with intrinsic factors of the bacteria,such as virulence factors-such oncogenic protein cytotoxin-associated antigen A,proteins such *** neutrophil-activating protein,but also with microenvironmental changes that favor permanence of *** in the *** changes include the increase of gastric mucosal pH by urease activity,and suppression of the stomach immune response promoted by evasion mechanisms of the ***,there is a causal relationship between *** infection and components of the innate immunity such as the NLR family pyrin domain containing 3 inflammasome that directs IBD toward a better prognosis.

关键词： Cytotoxin-associated antigen A oncoprotein Gut microbiota Helicobacter pylori Helicobacter pylori neutrophilactivating protein Immunological modulation Inflammatory bowel disease NLR family pyrin domain containing 3 inflammasome