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A case of bowel schitosomiasis not adhering to endoscopic findings

World Journal of Gastroenterology 2005年第44期11卷 7044-7047页

作者： Manfredi Rizzo Pasquale Mansueto Daniela Cabibi Elisetta Barresi Kaspar Berneis Mario Affronti gabriele di lorenzo Sergio Vigneri Giovam Battista Rini Department of Clinical Medicine and Emerging diseases Institute of Pathological Anatomy Medical University Clinic

Schistosomiasis is a chronic worm infection caused by a species of trematodes, the Schistosomes. We may distinguish a urinary form from Schistosomes haematobium and an intestinal-hepatosplenic form mainly from Schistosomes mansonicharacterized by nausea, meteorism, abdominal pain, bloody diarrhea,rectal tenesmus, and hepatosplenomegaly. These infections represent a major health issue in Africa,Asia, and South America, but recently S mansoni has increased its prevalence in other countries, such as Europe countries and USA, due to international travelers and immigrants, with several diagnostic and prevention problems. We report a case of a 24-yearold patient without HIV infection, originated from Ghana, admitted for an afebrile dysenteric *** microbiologic studies were negative and colonoscopy revealed macroscopic lesions suggestive of a bowel inflammatory chronic disease. Since symptoms became worse, a therapy with mesalazine (2 g/d) was started,depending on the results of a bowel biopsy, but without any resolution. The therapy was stopped after 2 wk when the following result was available: a diagnosis of"intestinal schistosomiasis" was done (two Schistosoma eggs were detected in the colonic mucosa) and this was confirmed by the detection of Schistosoma eggs in the feces. Therapy was therefore changed to praziquantel(40 mg/kg, single dose), a specific anti-parasitic agent,with complete recovery. Schistosomiasis shows some peculiar difficulties in terms of differential diagnosis from the bowel inflammatory chronic disease, as the two disorders may show similar colonoscopic *** this infection has recently increased its prevalence worldwide, it was considered in the differential diagnosis of our patient with gastrointestinal symptoms.

关键词： Schistosomiasis Chronic inflammatory bowel disease Ulcerative colitis Granuloma

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Food allergy in gastroenterologic diseases:Review of literature

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World Journal of Gastroenterology 2006年第48期12卷 7744-7752页

作者： Pasquale Mansueto Giuseppe Montalto Maria Luisa Pacor Maria Esposito-Pellitteri Vito ditta Claudia Lo Bianco Stefania Maria Leto-Barone gabriele di lorenzo dipartimento di Medicina Clinica e delle Patologie Emergenti Università degli Studi di Palermo Italy dipartimento di Medicina Clinica e Medicina Sperimentale Università degli Studi di Verona Italy

Food allergy is a common and increasing problem worldwide. The newly-found knowledge might provide novel experimental strategies, especially for laboratory diagnosis. Approximately 20% of the population alters their diet for a perceived adverse reaction to food, but the application of double-blind placebo-controlled oral food challenge, the ＂gold standard＂ for diagnosis of food allergy, shows that questionnaire-based studies overestimate the prevalence of food allergies. The clinical disorders determined by adverse reactions to food can be dassified on the basis of immunologic or nonimmunologic mechanisms and the organ system or systems affected. diagnosis of food allergy is based on clinical history, skin prick tests, and laboratory tests to detect serum-food specific IgE, elimination diets and challenges. The primary therapy for food allergy is to avoid the responsible food. Antihistamines might partially relieve oral allergy syndrome and IgE-mediated skin symptoms, but they do not block systemic reactions. Systemic corticosteroids are generally effective in treating chronic IgE-mediated disorders. Epinephrine is the mainstay of treatment for anaphylaxis. Experimental therapies for IgE-mediated food allergy have been evaluated, such as humanized IgG anti-IgE antibodies and allergen specific immunotherapy.

关键词： Food intolerance Food allergy Skin pricktest Serum food-specific IgE Oral food challenges

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Patient-derived organoids for therapy personalization in inflammatory bowel diseases

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World Journal of Gastroenterology 2022年第24期28卷 2636-2653页

作者： Marianna Lucafò Antonella Muzzo Martina Marcuzzi lorenzo Giorio Giuliana Decorti gabriele Stocco Advanced Translational diagnostics Laboratory Institute for Maternal and Child Health-IRCCS“Burlo Garofolo”Trieste 34137Italy Department of Medicine Surgery and Health SciencesUniversity of TriesteTrieste 34127Italy Department of Life Sciences University of TriesteTrieste 34127Italy

Inflammatory bowel diseases(IBDs)are chronic inflammatory disorders of the intestinal tract that have emerged as a growing problem in industrialized *** of IBD pathogenesis is still incomplete,and the most widely-accepted interpretation considers genetic factors,environmental stimuli,uncontrolled immune responses and altered intestinal microbiota composition as determinants of IBD,leading to dysfunction of the intestinal epithelial *** vitro models commonly used to study the intestinal barrier do not fully reflect the proper intestinal *** important innovation is represented by organoids,3D in vitro cell structures derived from stem cells that can self-organize into functional organ-specific *** may be generated from induced pluripotent stem cells or adult intestinal stem cells of IBD patients and therefore retain their genetic and transcriptomic *** models are powerful pharmacological tools to better understand IBD pathogenesis,to study the mechanisms of action on the epithelial barrier of drugs already used in the treatment of IBD,and to evaluate novel target-directed molecules which could improve therapeutic *** aim of this review is to illustrate the potential use of organoids for therapy personalization by focusing on the most significant advances in IBD research achieved through the use of adult stem cells-derived intestinal organoids.

关键词： Inflammatory bowel disease Organoids Intestinal epithelium 3D cell cultures Personalized medicine

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In vitro laboratory infection research in orthopaedics:Why,when,and how

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World Journal of Orthopedics 2023年第8期14卷 598-603页

作者： Konstantinos Tsikopoulos lorenzo Drago gabriele Meroni dimitrios Kitridis Byron Chalidis Fotios Papageorgiou Paraskevi Papaioannidou 1^(st)Department of Pharmacology School of MedicineFaculty of Health SciencesAristotle University of ThessalonikiThessaloniki 54124Greece Department of Biomedical Sciences for Health School of MedicineUniversity of MilanMilan 20133Italy Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilan 20133Italy 1^(st)Department of Orthopaedic School of MedicineFaculty of Health SciencesAristotle University of ThessalonikiThessaloniki 57010Greece Department of Orthopaedic Surgery 404 General Army HospitalLarisa 41222Greece 1^(st)Department of Pharmacology Aristotle University of ThessalonikiThessaloniki 54124Greece

The musculoskeletal system involves multiple tissues which are constantly exposed to being exposed to various biological and mechanical *** such,isolating and studying a particular system from a complex human clinical environment is not always a realistic *** top of that,recruitment limitations,in addition to the nature of orthopaedic interventions and their associated cost,sometimes preclude consideration of human trials to answer a clinical ***,in this mini review,we sought to rationalize the rapid evolution of biomedical research at a basic scientific level and explain why the perception of orthopaedic conditions has fundamentally changed over the last *** more detail,we highlight that the number of orthopaedic in vitro publications has soared since *** but not least,we elaborated on the minimum requirements for conducting a scientifically sound infection-related laboratory experiment to offer valuable information to clinical *** also explained the rationale behind implementing molecular biology techniques,ex vivo experiments,and artificial intelligence in this type of laboratory research.

关键词： Biofilm In vitro Laboratory research Methodology

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非晶碳纳米球的低温石墨化(英文)

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催化学报 2014年第6期35卷 869-876页

作者： Katia Barbera Leone Frusteri Giuseppe Italiano lorenzo Spadaro Francesco Frusteri Siglinda Perathoner gabriele Centi University of Messina and INSTM/CASPE (Lab.of Catalysis for Sustainable Production and Energy) Department of Electronic Engineering Industrial Chemistry and Engineering-Contrada di Dio I-98166 Messina Italy Eco-Rigen S.r.l.R&D – Contrada Piana del Signore c/o Raffineria di Gela I-93012 Gela (CL) Italy Institute of Advanced Technologies for Energy "Nicola Giordano" (ITAE) Department of Energy and Transport (DET) National Council of Research (CNR) - Salita S.Lucia sopra Contesse 5 I-98126 Messina Italy

The investigation by SEM/TEM, porosity, and X-ray diffraction measurements of the graphitization process starting from amorphous carbon nanospheres, prepared by glucose carbonization, is reported. Aspects studied are the annealing temperature in the 750–1000 °C range, the type of inert carrier gas, and time of treatment in the 2–6 h range. It is investigated how these parameters influence the structural and morphological characteristics of the carbon materials obtained as well as their nanostructure. It is shown that it is possible to maintain after graphitization the round-shaped macro morphology, a high surface area and porosity, and especially a large structural disorder in the graphitic layers stacking, with the presence of rather small ordered domains. These are characteristics interesting for various catalytic applications. The key in obtaining these characteristics is the thermal treatment in a flow of N2. It was demonstrated that the use of He rather than N2 does not allow obtaining the same results. The effect is attributed to the presence of traces of oxygen, enough to create the presence of oxygen functional groups on the surface temperatures higher than 750 °C, when graphitization occurs. These oxygen functional groups favor the graphitization process.

关键词：石墨化过程无定形碳纳米球含氧官能团 X射线衍射测量低温纳米结构形态特征

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Intimate partner violence:A loop of abuse,depression and victimization

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World Journal of Psychiatry 2021年第6期11卷 215-221页

作者： Marianna Mazza Giuseppe Marano Angela Gonsalez del Castillo Daniela Chieffo Laura Monti Delfina Janiri lorenzo Moccia gabriele Sani Department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Service of Clinical Psychology Fondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy

Intimate partner violence has been recognized as a serious public health *** to violence contributes to the genesis of,and exacerbates,mental health conditions,and existing mental health problems increase vulnerability to partner violence,a loop that imprisons victims and perpetuates the abuse.A recently described phenomenon is when male violence against females occurs within intimate relationships during youth,and it is termed adolescent or teen dating *** this narrative review,factors associated with intimate partner violence and consequences of exposure of children to parental domestic violence are discussed,along with possible intensification of violence against women with the spread of coronavirus disease 2019 pandemic and subsequent *** programs with a multicomponent approach involving many health care settings and research have a pivotal role in developing additional strategies for addressing violence and to provide tailored interventions to *** policy with a particular attention on healthy child and adolescent development is mandatory in the struggle against all forms of violence.

关键词： Intimate partner violence Women Depression Abuse COVID-19 Personalized medicine

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Psychic euosmia among obsessive-compulsive personality disorder patients:A case control study

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World Journal of Psychiatry 2021年第2期11卷 50-57页

作者： Annalisa Maraone lorenzo Tarsitani Marianna Frascarelli Federica Petrini Valentina Roselli MassimilianoTinè gabriele Cavaggioni Vlasios Brakoulias Massimo Biondi Massimo Pasquini Department of Human Neurosciences Sapienza UniversityRome 00185Italy Department of Neurosciences and Mental Health Umberto I PoliclinicRome 00185Italy School of Medicine Western Sydney University and Western Sydney Local Health DistrictBlacktown 2145SNWAustralia Department of Psychiatry Nepean HospitalSydney Medical SchoolThe University of SydneyPenrith 2751SNWAustralia

BACKGROUND Psychic euosmia(PE)has been described as a supposed psychological predisposition for which pleasant smells elicit an immediate sense of pleasure,order and calmness in obsessive-compulsive personality disorder(OCPD).In this study we tried to verify the interpretation that PE is the counterpart of disgust that has been associated to contamination and moral *** and morality are significantly associated in people with obsessive-compulsive personality *** expected that OCPD patients would experience higher levels of *** To investigate the PE frequency in OCPD patients and healthy controls(HC)and to evaluate the relationship between PE and *** A single-center,case-control study was conducted in an outpatient service for obsessive-compulsive and related *** sample consisted of 129 subjects:45 OCPD patients and 84 *** both groups we submitted the disgust Scale Revised(DS-R)and the self-report Structured Clinical Interview for DSM-5 Screening Personality Questionnaire to which we added an additional yes or no question to investigate the presence of *** order to verify differences between groups,t-test was employed for continuous variables and 2 test for categorical variable;odds ratio was employed to analyze group differences in the PE *** was explored with Pearson r *** No differences were observed between groups in gender composition or education.A slight significant difference was found in mean age(t=1.988;P=0.049).The present study revealed significantly higher proportions of PE among OCPD patients when compared to HC(OR:5.3,2.28-12.46).Patients with OCPD were more likely to report PE(n=36;80%)whereas a much lower proportion endorsed PE in the HC group(n=36;42.9%).Interestingly,no differences were observed between groups in mean score for the disgust *** was also no difference between the two groups in any of the disgust Scale Revised ***,no significant correla

关键词： Psychic euosmia Obsessive-compulsive personality disorder disgust Orderliness Olfactory Personality

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Main factors influencing long-term outcomes of liver transplantation in 2022

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World Journal of Hepatology 2023年第3期15卷 321-352页

作者： Elisa Fuochi lorenzo Anastasio Erica Nicola Lynch Claudia Campani gabriele Dragoni Stefano Milani Andrea Galli Tommaso Innocenti Gastroenterology Research Unit Department of Experimental and Clinical Biomedical Sciences“Mario Serio”University of FlorenceFlorence 50134Italy Department of Experimental and Clinical Medicine University of FlorenceFlorence 50134Italy Department of Medical Biotechnologies University of SienaSiena 53100Italy

Liver transplant(LT)outcomes have markedly improved in the recent decades,even if long-term morbidity and mortality are still *** of late deaths are independent from graft function and different comorbidities,including complications of metabolic syndrome and de novo neoplasms,seem to play a key role in determining long-term outcomes in LT *** review discusses the main factors associated with late mortality and suggests possible strategies to improve long-term management and follow-up after liver *** particular,the reduction of drug toxicity,the use of tools to identify high-risk patients,and setting up a multidisciplinary team also for long-term management of LT recipients may further improve survival after liver transplantation.

关键词： Alcohol Liver transplantation Long term survival Metabolic syndrome Renal dysfunction Therapy adherence

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Viral infections in orthopedics: A systematic review and classification proposal

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World Journal of Orthopedics 2022年第11期13卷 1015-1028页

作者： Konstantinos Sidiropoulos Savvas Ilias Christofilos Konstantinos Tsikopoulos dimitrios Kitridis lorenzo Drago gabriele Meroni Carlo Luca Romanò Venu Kavarthapu General Hospital of Serres Serres 62100Greece Department of Genetics Evolution and EnvironmentUniversity College LondonLondon WC1E 6BTUnited Kingdom Department of Orthopaedics 404 Army General HospitalLarissa 41222Greece the First Department of Orthopaedics Aristotle University of ThessalonikiThessaloniki 54124Greece Department of Biomedical Sciences for Health and Microbiome University of MilanMilan 20133Italy Department of Biomedical Surgicaland Dental SciencesOne Health UnitUniversity of MilanMilan 20133Italy Gruppo di Studio SIOT Infezioni-Clinica San Gaudenzio-Novara-Gruppo Policlinico di Monza University of MilanMilan 20100Italy Trauma and OrthopaedicsKings College Hospital LondonDenmark HillLondon SE59RSUnited Kingdom

BACKGROUND Although the impact of microbial infections on orthopedic clinical outcomes is well recognized,the influence of viral infections on the musculoskeletal system might have been *** To systematically review the available evidence on risk factors and musculoskeletal manifestations following viral infections and to propose a pertinent classification *** We searched MEDLINE,Cochrane Central Register of Controlled Trials(CENTRAL),the Reference Citation Analysis(RCA),and Scopus for completed studies published before January 30,2021,to evaluate risk factors and bone and joint manifestations of viral infection in animal models and patient *** assessment was performed using SYRCLE's risk of bias tool for animal studies,Moga score for case series,Wylde score for registry studies,and Newcastle-Ottawa Scale for case-control *** Six human and four animal studies were eligible for inclusion in the qualitative *** C virus was implicated in several peri-and post-operative complications in patients without cirrhosis after major orthopedic *** virus may affect the integrity of lumbar discs,whereas Ross River and Chikungunya viruses provoke viral arthritis and bone *** Evidence of moderate strength suggested that viruses can cause moderate to severe arthritis and *** factors such as pre-existing rheumatologic disease contributed to higher disease severity and duration of ***,based on our literature search,the proposed clinical and pathogenetic classification scheme is as follows:(1)Viral infections of bone or joint;(2)Active bone and joint inflammatory diseases secondary to viral infections in other organs or tissues;and(3)Viral infection as a risk factor for post-surgical bacterial infection.

关键词： Viral infection Musculoskeletal system Bone and joint manifestations Chikungunya Zika Hepatitis C virus Herpesviridae Ross River virus Cross-reactivity Classification

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Proficiency score as a predictor of early trifecta achievement during the learning curve of robot-assisted radical prostatectomy for high-risk prostate cancer:Results of a multicentric series

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Current Urology 2024年第2期18卷 110-114页

作者： Umberto Anceschi Rocco Simone Flammia Antonio Tufano Michele Morelli Antonio Galfano lorenzo Giuseppe Luciani Leonardo Misuraca Paolo Dell’Oglio gabriele Tuderti Aldo Brassetti Maria Consiglia Ferriero Alfredo Maria Bove Riccardo Mastroianni Francesco Prata Isabella Sperduti Giovanni Petralia SilviaSecco Ettore di Trapani DanieleMattevi Tommaso Cai Aldo Massimo Bocciardi Giuseppe Simone Department of Urology IRCCS“Regina Elena”National Cancer InstituteRomeItaly Urologic Clinic Department of Maternal-Child and Urologic SciencesSapienza University of RomeItaly Ospedale Niguarda Ca’Granda Department of UrologyMilanItaly Department of Urology APSS Santa Chiara Regional HospitalTrentoItaly Department of Biostatistical Unit IRCCS Regina Elena National Cancer InstituteRomeItaly

Background:Recently,an innovative tool called“proficiency score”was introduced to assess the learning curve for robot-assisted radical prostatectomy(RARP).However,the initial study only focused on patients with low-risk prostate cancer forwhompelvic lymph node dissection(PLND)was not *** address this issue,we aimed to validate proficiency scores of a contemporarymulticenter cohort of patients with high-risk prostate cancer treated with RARP plus extended PLND by trainee *** andmethods:Between 2010 and 2020,4 Italian institutional prostate-cancer datasets weremerged and queried for“RARP”and“high-risk prostate cancer.”High-risk prostate cancer was defined according to the most recent European Association of Urology guidelines as follows:prostate-specific antigen>20 ng/mL,International Society ofUrological Pathology≥4,and/or clinical stage(cT)≥2c on preoperative *** selected cohort(n=144)included clinical cases performed by trainee surgeons(n=4)after completing their RARP learning curve(50 procedures for low-risk prostate cancer).The outcome of interest,the proficiency score,was defined as the coexistence of all the following criteria:a comparable operation time to the interquartile range of the mentor surgeon at each center,absence of any significant perioperative complications Clavien-dindo Grade 3–5,no perioperative blood transfusions,and negative surgical margins.A logistic binary regression model was built to identify the predictors of 1-year trifecta achievement in the trainee *** all statistical analyses,a 2-sided pdicted 1-year trifecta achievement(odds ratio,9.58;95%confidence i

关键词： Trifecta Learning curve Robot-assisted radical prostatectomy High-risk prostate cancer

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