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The role of SARS-COV-2 infection in promoting abnormal immune response and sepsis:A comparison between SARS-COV-2-related sepsis and sepsis from other causes

Infectious Medicine

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Infectious Medicine 2023年第3期2卷 202-211页

作者： Andrea Piccioni Laura Franza Federico Rosa Marcello Candelli Marcello Covino Michela Ferrara GianpietroVolonnino Giuseppe Bertozzi Maria Vittoria Zamponi Aniello Maiese gabriele savioli Francesco Franceschi Raffaele La Russa Department of Emergency Medicine Fondazione Policlinico Universitario A.Gemelli IRCCS1-00168 RomeItaly UniversitàCattolica del Sacro Cuore 1-00168 RomeItaly Department of Anatomical HistologicalForensic and Orthopedic SciencesSapienza University of Rome00186 RomeItaly Department of Clinical and Experimental Medicine Institute of Legal MedicineUniversity of Foggia71100 FoggiaItaly Department of Surgical Medicaland Molecular Pathology and Critical Care MedicineUniversity of Pisavia Roma 5556126 PisaItaly Emergency Department IRCCS Policlinico San Matteo27100 PaviaItaly Department of Clinical-Surgical Diagnostic and Pediatric SciencesUniversity of Pavia27100 PaviaItaly

Background:COVID-19 caused by SARS-CoV-2 virus is characterized by respiratory compromise and immune system involvement,even leading to serious disorders,such as cytokine ***:We then conducted a literature review on the topic of sepsis and covid-19,and in parallel conducted an experimental study on the histological finding of patients who died from SARS-Covid 19 infection and a control ***:Sepsis associated with covid-19 infection has some similarities and differences from that from other ***:In this paper the complex interplay between the 2 disorders was discussed,focusing on the similarities and on the effect that one could have on the other.A preliminary experimental section that demonstrates the multisystemic involvement in subjects who die from SARS-CoV-2 is also proposed.

关键词： SARS-COV-2 Cytokine storm SARS-CoV-2 Septic shock Sepsis

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The role of acetazolamide in critical care and emergency medicine

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Journal of Geriatric Cardiology 2024年第11期21卷 1085-1095页

作者： Jacopo Davide Giamello gabriele savioli Yaroslava Longhitano Fiorenza Ferrari Salvatore D’Agnano Ciro Esposito Manfredi Tesauro Christian Zanza Department of Emergency Medicine Azienda Ospedaliera S.Croce e CarleCuneoItaly Emergency Medicine and Surgery IRCCS Fondazione Policlinico San MatteoPaviaItaly Department of Anesthesiology and Perioperative Medicine University of PittsburghPittsburghPA 15260USA Department of Emergency Medicine-Emergency Medicine Residency Program Humanitas University-Research Hospital20089 RozzanoItaly International Renal Research Institute of Vicenza(IRRIV) Department of NephrologyDialysis and TransplantationSan Bortolo HospitalAzienda ULSS Berica VicenzaItaly Department of Anaesthesia Critical Care and EmergencyFoundation IRCCS Ca'Granda Ospedale Maggiore PoliclinicoMilanItaly Unit of Nephrology and Dialysis ICS MaugeriUniversity of PaviaPaviaItaly Department of Systems Medicine University of Rome"Tor Vergata"RomeItaly Geriatric Medicine Residency Program University of Rome"Tor Vergata"RomeItaly

Acetazolamide is the commonly prescribed oral and intravenous carbonic anhydrase inhibitor;over the years,its use in clinical practice has decreased in favor of more recent ***,it is a rather handy drug,which can be useful in several clinical settings when managing critically ill *** objective of this review is the evaluation of the most recent evidence on the use of acetazolamide in emergency medicine and critical care ***,the safety profile of this drug has been *** is a narrative review on the use of acetazolamide in the main contexts in which this drug can be useful in emergency situations for patients with potential critical *** the timeline 1999–2024,a search was conducted on the main scientific platforms;resources of greatest relevance for the use of acetazolamide in critical care and emergency medicine were *** most common emergency situations in which a critically ill patient could benefit from acetazolamide therapy are acute heart failure,acute mountain sickness,post hypercapnic metabolic alkalosis,idiopathic intracranial hypertension and acute angle-closure *** a few cases,however,randomized controlled clinical trials have been *** are also other less solid indications based mostly on experience or retrospective *** seems to be an overall safe drug;serious side effects are rare and can be avoided by carefully selecting the patients to be *** represents a precious resource for emergency physicians and intensivists;critical patients with different conditions can in fact benefit from it;furthermore,acetazolamide is a safe drug if administered to correctly selected patients.

关键词： critical prescribed furthermore

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