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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès Sylvain gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Endoscopic techniques for the diagnosis of pancreatic cystic lesions

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World Journal of Gastroenterology 2025年第1期31卷 1-7页

作者： Sahib Singh Saurabh Chandan Rakesh Vinayek Jahnvi Dhar Jayanta Samanta gabriele Capurso Ivo Boskoski Cristiano Spada Jorge D Machicado Stefano Francesco Crinò Antonio Facciorusso Department of Internal Medicine Sinai HospitalBaltimoreMD 21215United States Division of Gastroenterology and Hepatology Creighton University School of MedicineOmahaNE 68131United States Department of Gastroenterology Sinai Hospital of BaltimoreBaltimoreMD 21215United States Department of Gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Division of Pancreato-Biliary Endoscopy and Endosonography Pancreas Translational and Clinical Research CenterIRCCS San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilano 20132Italy Digestive Endoscopy Unit Fondazione Policlinico Universitario Agostino Gemelli IRCSSUniversitàCattolica del Sacro Cuore di RomaCenter for Endoscopic Research Therapeutics and TrainingRoma 00168Italy Department of Gastroenterology and Endoscopy Catholic UniversityRoma 00168Italy Department of Gastroenterology University of Michigan HealthAnn ArborMI 48107United States Department of Endoscopy University of VeronaVerona 37121VenetoItaly Gastroenterology Unit Department of Medical and Surgical SciencesUniversity of FoggiaFoggia 71122Italy

Pancreatic cysts are mostly incidental findings on computed tomography or magnetic resonance imaging scans,with few patients presenting with abdominal pain or other *** accurate diagnosis of cysts is important as management depends on the type(neoplastic or non-neoplastic).Cross-sectional imaging is fast being replaced with endoscopic ultrasound(EUS)and various techniques based on that such as EUS-guided fine needle aspiration,EUS-guided needle confocal laser endomicroscopy,EUS-through-the-needle biopsy,and contrast-enhanced *** studies have reported varying diagnostic and adverse event rates with these *** addition,American,European,and Kyoto guidelines for the diagnosis and management of pancreatic cysts have provided different *** this editorial,we elaborate on the clinical guidelines,recent studies,and comparison of different endoscopic methods for the diagnosis of pancreatic cysts.

关键词： Endoscopic ultrasound Fine needle aspiration Needle confocal laser endomicroscopy Through-the-needle biopsy Contrast-enhanced endoscopic ultrasound

Pre-breakdown to stable phase and origin of multiple current pulses in argon dielectric barrier discharge

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Plasma Science and Technology 2021年第12期23卷 83-94页

作者： Saurav GAUTAM gabriele MORRA Department of Mechanical Engineering University of California MercedMercedCalifornia 95343United States of America Department of Physics University of Louisiana at LafayetteLafayetteLouisiana 70503United States of America

We report on the results of numerical models of the(i)initial growth and(ii)steady state phases of atmospheric-pressure homogeneous dielectric barrier discharge in *** employ our new inhouse code called Py DBD,which solves continuity equations for both particles and energy,shows exceptional stability,is accelerated by adaptive time stepping and is openly available to the scientific *** argon plasma is numerically challenging due to the lower speeds of more inertial ions compared to more commonly modeled neon and helium,but its common use for plasma jets in medicine makes its modeling *** DBD is here applied to modeling two setups:(i)the exponential growth from natural electron-ion seeds(onset phase)until saturation is reached and(ii)the multiple current pulses that naturally appear during the steady state *** find that the time required for the onset phase,when the plasma density grows from 10^(9)m^(-3)to 10^(17)m^(-3),varies from 80μs at 4.5 k V down to a fewμs above 6.5 k V,for voltage frequency f=80 k Hz and gap width d_(g)=0.9 *** the steady state,our model reproduces two previously observed features of the current in dielectric barrier discharge reactors:(1)an oscillatory behavior associated to the capacitative character of the circuit and(2)several(N_(p))current pulses occurring every half sinusoidal *** show that the oscillations are present during the exponential growth,while current pulses appear approaching the steady *** each micro-discharge,the gas voltage decreases abruptly and charged particles rapidly accumulate at the dielectric boundaries,causing avalanches of charged particles near the reactor ***,we run a parametric study finding that N_(p)increases linearly with voltage amplitude V_(amp),is inversely proportional to dielectric gap d_(g)and decreases when voltage frequency f *** code developed for this publication is freely available at the address https://***/gabers

关键词： plasma onset micro-discharge multiple current pulse(MCP) discharge asymmetry seed electrons

Multilevel Techniques for the Solution of HJB Minimum-Time Control Problems

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Journal of Systems Science & Complexity 2021年第6期34卷 2069-2091页

作者： CIARAMELLA gabriele FABRINI Giulia Department of Mathematics and Statistics University of KonstanzKonstanz 78464Germany

The solution of minimum-time feedback optimal control problems is generally achieved using the dynamic programming approach,in which the value function must be computed on numerical grids with a very large number of *** numerical strategies,such as value iteration(VI)or policy iteration(PI)methods,become very inefficient if the number of grid points is *** is a strong limitation to their use in real-world *** address this problem,the authors present a novel multilevel framework,where classical VI and PI are embedded in a full-approximation storage(FAS)*** fact,the authors will show that VI and PI have excellent smoothing properties,a fact that makes them very suitable for use in multilevel ***,a new smoother is developed by accelerating VI using Anderson’s extrapolation *** effectiveness of our new scheme is demonstrated by several numerical experiments.

关键词： Anderson acceleration FAS Hamilton-Jacobi equation minimum-time problem multi-level acceleration methods policy iteration value iteration

Controlled location of S vacancies in MoS_(2) nanosheets for high-performance hydrogenation of CO_(2) to methanol

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Journal of Energy Chemistry 2022年第1期31卷 113-115,I0004页

作者： gabriele Centi Dept.ChiBioFarAm University of MessinaItaly and ERIC Aisbl.BrusselsBelgium

Introduction In a joint contribution among many Chinese research Institutes,a recent paper published on Nature Catalysis reported the use of sulfur vacancy-rich MoS_(2)as a novel catalyst for the hydrogenation of CO_(2)to methanol[1].A commentary on this paper was also published on the same journal[2]reporting as a summary:"Highly active,selective and stable catalysts for the hydrogenation ofC0_(2)to methanol are immensely sought ***,using a broad range of spectroscopic methods,in-plane double sulfur vacancies of MoS_(2)sheets have been suggested to catalyse this reaction using an unusual mechanism".

关键词： CO_(2) Methanol MOS_(2)nanosheet In-plane S vacancies

Telomerase and neurons:an unusual relationship

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Neural Regeneration Research 2022年第11期17卷 2364-2367页

作者： gabriele Saretzki Biomedical Sciences Campus for Ageing and VitalityNewcastle UniversityNewcastle Upon TyneUK

Most people associate the enzyme telomerase with its role in maintaining telomeres,which is its best-known canonical *** this important function,two main components are required:the protein telomerase reve rse transcriptase(TERT)and the telomerase RNA *** addition,over the last decades,an ever-growing number of othe r,non-telomeric,non-canonical functions for the telomerase protein TERT has been *** reach from tumor promotion to decreasing oxidative stress and apoptosis as well as activating *** functions are more and more recognized as being important in many tissues and physiological as well as pathological *** role of telomerase in brain development and neuronal cells has been investigated for more than 20 ***,the non-telomeric role in non-dividing neurons of the brain for telomerase and the TERT-protein has only recently been highlighted by extensive ***,these developments promoted the suggestion of a beneficial and protective role of TERT against neurodegenerative diseases such as Alzheimer's disease and Parkinson's *** review summarizes the most important findings in the field of telomerase in neuro ns and gives an outlook onto possible therapeutic applications of boosting telomerase/TERT levels with telomerase activators to prevent or ameliorate various neurodegene rative diseases.

关键词： autophagy brain neurons neurodegeneration telomerase TERT protein

CO_(2) conversion to solar fuels and chemicals:Opening the new paths

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Journal of Energy Chemistry 2024年第4期91卷 680-683页

作者： gabriele Centi Claudio Ampelli Department of Chemical BiologicalPharmaceutical and Environmental Sciences(ChiBioFarAm)University of MessinaERIC aisbl and CASPE/INSTMV.le F.Stagno d'Alcontres 3198166 MessinaItaly

This future article discusses the new prospects and directions of CO_(2)conversion via the photo-electrocatalytic(PEC)*** second(2nd)generation solar fuels and chemicals(SFs)are generated directly in PEC systems via electrons/protons reactions without forming molecular H_(2)as an intermediate,overcoming the thermodynamics limitations and practical issues encountered for electro-fuels produced by multistep thermocatalytic processes(***_(2)conversion with H_(2)coming from water electrolysis).A distributed and decentralized production of SFs requires very compact,highly integrated,and intensified *** the existing reactors of advanced design(based on artificial leaves or photosynthesis),the integrated photovoltaic plus electrocatalytic(PV-EC)device is the only system(demonstrated at large scale)to produce SFs with high solar-to-fuel(STF)***,while the literature indicates STF efficiency as the main(and only)measure of process performance,we remark here the need to refer to productivity(in terms of current density)and make tests with reliable flow PEC systems(with electrodes of at least 5–10 cm^(2))to accelerate the scaling-up *** approaches that minimize downstream separation costs is also *** limitations exist in PEC systems,but most can be overcome by proper electrode and cell engineering,thus going beyond the properties of the *** examples of current developments,we present the progress of(i)artificial leaf/tree devices for green H_(2)distributed production and(ii)a PEC device producing the same chemicals at both cathode and anode parts without downstream operations for green solvent distributed *** on these developments,future directions,such as producing fertilizers and food components from the air,are *** aim is to provide new ideas and research directions from a personal perspective.

关键词： Solar fuels Artificial leaf PEC devices PV-EC devices Cell engineering green H_(2) Chemicals from theair

Could JC virus provoke metastasis in colon cancer?

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World Journal of Gastroenterology 2014年第42期20卷 15745-15749页

作者： Emanuele Sinagra Dario Raimondo Elena Gallo Mario Stella Mario Cottone Ambrogio orlando Francesca Rossi Emanuele orlando Marco Messina Giovanni Tomasello Attilio Ignazio Lo Monte Ennio La Rocca Aroldo gabriele Rizzo Gastroenterology and Endoscopy Unit Fondazione Istituto San Raffaele-G Giglio Contrada Pietra Pollastra Pisciotto course in Surgical Biotechnology and Regenerative Medicine University of Palermo Euro-Mediterranean Institute of Science and Technology (IEMEST) Unit of Pathology Ospedali Riuniti Villa Sofia - Cervello University of Palermo DIBIMIS Unit of Internal Medicine Ospedali Riuniti Villa Sofia - Cervello University of Palermo Oncology Unit Fondazione Istituto San Raffaele-G Giglio Contrada Pietra Pollastra Pisciotto Department of Surgical and Oncological Disciplines School of Medicine University of Palermo Unità Operativa di Medicina interna e trapiantologia Ospedale San Raffaele

AIM: To evaluate the prevalence of John Cunningham virus(JC virus) in a small cohort of patients with colon cancer and to assess its presence in hepatic ***: Nineteen consecutive patients with histologically diagnosed colon cancer were included in our study, together with ten subjects affected by histologically and serologically diagnosed hepatitis C virus infection. In the patients included in the colon cancer group, JC virus was searched for in the surgical specimen; in the control group, JC virus was searched for in the hepatic biopsy. The difference in the prevalence of JC virus in the hepatic biopsy between the two groups was assessed through the χ2 ***: Four out of 19 patients with colon cancer had a positive polymerase chain reaction(PCR) test for JC virus, and four had liver metastasis. Among the patients with liver metastasis, three out of four had a positive PCR test for JC virus in the surgical specimen and in the liver biopsy; the only patient with liver metastasis with a negative test for JC virus also presented a negative test for JC virus in the surgical specimen. In the control group of patients with hepatitis C infection, none of the ten patients presented JC virus infection in the hepatic biopsy. The difference between the two groups regarding JC virus infection was statistically significant(χ2 = 9.55, P = 0.002).CONCLUSION: JC virus may play a broader role than previously thought, and may be mechanistically involved in the late stages of these tumors.

关键词： John Cunningham virus Colon cancer Me-tastasis

View on microRNAs as a potential tool to fight blindness: focus on Müller glia and gliosis

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Neural Regeneration Research 2022年第7期17卷 1501-1502页

作者： Stefanie gabriele Wohl The State University of New York College of OptometryDepartment of Biological and Vision SciencesNew YorkNYUSA

The neural retina is a part of the central nervous *** it lacks regenerative capacity,in an event of injury or disease,neuronal loss leads to visual impairment and often to ***,Müller glia(MG),the predominant glia in the retina,undergo a variety of molecular and cellular changes and discontinue to carry out their important regular functions in the tissue(e.g.,maintaining tissue homeostasis and nurturing neurons).

关键词： homeostasis predominant carry