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Transjugular portosystemic shunt for early-onset refractory ascites after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 90-93页

作者： Giuseppe Bianco Marco Maria Pascale Francesco Frongillo Erida Nure Salvatore Agnes gabriele Spoletini General Surgery and Liver Transplant Unit Fondazione IRCCS-Policlinico Universitario“A.Gemelli”Rome 00168Italy

Liver transplantation(LT)is the most effective treatment for end-stage liver disease and complications of portal hypertension(PHT).However,PHT can relapse as a consequence of viral,alcoholic or metabolic chronic liver disease(CLD)recurrence,rejection,vascular abnormalities,small-for-size syndrome and technical complications(e.g.,portal or hepatic veins stenosis and/or thrombosis)[1].LT recipients with PHT may suffer from com plications similarly to non-transplanted cirrhotic patients(e.g.,refractory ascites,variceal hemorrhages and hydrothorax)although with higher morbidity and mortality due to their postoperative status and concomitant immunosuppressive therapy[2].

关键词： ascites liver mortality

Liver resection in liver transplant recipients

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Hepatobiliary & Pancreatic Diseases International 2008年第6期7卷 590-594页

作者： gabriele Marangoni Walid Faraj Harsheet Sethi Mohamed Rela Paolo Muiesan Nigel Heaton King's College London School of Medicine at King's College Hospital Institute of Liver StudiesDenmark Hill SE5 9RS University Hospital Birmingham EdgbastonB15 2TH

BACKGROUND:Liver resection after liver transplantation is a relatively uncommon *** for liver resection include hepatic artery thrombosis(HAT),non- anastomotic biliary stricture(ischemic biliary lesions), liver abscess,liver trauma and recurrence of hepatocellular carcinoma(HCC).Organ shortage and lower survival after re-transplantation have encouraged us to make attempts at graft salvage. METHODS:Eleven resections at a mean of 59 months after liver transplantation were made over 18 *** for liver resection included HCC recurrence in 4 patients, ischemic cholangiopathy,segmental HAT,sepsis and infected hematoma in 2 each,and ischemic segmentⅣafter split liver transplantation in 1. RESULTS:There was no perioperative *** included one re-laparotomy for small bowel perforation, one bile leak treated conservatively,one right subphrenic collection,one wound infection and 5 episodes of Gram- negative *** patient underwent re-transplantation 4 months after resection for chronic *** were 3 deaths,two from HCC recurrence and one from post- transplant lymphoproliferative *** overall mean follow-up after resection was 48 months. CONCLUSIONS:Liver resection in liver transplant recipients is safe,and has good outcome in selected patients and avoids re-transplantation in the majority of patients. Recipients with recurrent HCC in graft may benefit from resection,but cure is uncommon.

关键词： liver transplantation liver resection hepatocellular carcinoma recurrence

The Tip60/Ep400 chromatin remodeling complex impacts basic cellular functions in cranial neural crest-derived tissue during early orofacial development

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International Journal of Oral Science 2023年第2期15卷 241-254页

作者： Sebastian Gehlen-Breitbach Theresa Schmid Franziska Frob gabriele Rodrian Matthias Weider Michael Wegner Lina Gölz Institut für Biochemie Friedrich-Alexander-Universit?t Erlangen-NürnbergErlangenGermanyand Zahnklinik 3-Kieferorthopodie Universitotsklinikum Erlangen und Friedrich-Alexander-Universitot Erlangen-NürnbergErlangenGermany

The cranial neural crest plays a fundamental role in orofacial development and ***,mutations with impact on the cranial neural crest and its development lead to orofacial malformations such as cleft lip and *** a pluripotent and dynamic cell population,the cranial neural crest undergoes vast transcriptional and epigenomic alterations throughout the formation of facial structures pointing to an essential role of factors regulating chromatin state or transcription levels.

关键词： neural functions alterations

Practical insights into chronic management of hepatic Wilson’s disease

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World Journal of Clinical Cases 2022年第14期10卷 4334-4347页

作者： Erica Nicola Lynch Claudia Campani Tommaso Innocenti gabriele Dragoni Paolo Forte Andrea Galli Gastroenterology Research Unit Department of Experimental and Clinical Biomedical Sciences“Mario Serio”University of FlorenceFlorence 50134Italy Department of Experimental and Clinical Medicine University of FlorenceFlorence 50134Italy Department of Medical Biotechnologies University of SienaSiena 53100Italy Division of Gastroenterology University Hospital“Careggi”Florence 50134Italy

Wilson’s disease(WD)is a rare inherited disorder of human copper metabolism,with an estimated prevalence of 1:30000-1:50000 and a broad spectrum of hepatic and neuropsychiatric *** healthy individuals,the bile is the main route of elimination of *** WD patients,copper accumulates in the liver,it is released into the bloodstream,and is excreted in *** can also be accumulated in the brain,kidneys,heart,and osseous matter and causes damage due to direct toxicity or oxidative *** WD is commonly but not exclusively diagnosed in childhood or young ***,non-cirrhotic WD patients seem to have a normal life ***,chronic management of patients with Wilson’s disease is challenging,as available biochemical tests have many limitations and do not allow a clear identification of non-compliance,overtreatment,or treatment *** provide optimal care,clinicians should have a complete understanding of these limitations and counterbalance them with a thorough clinical *** aim of this review is to provide clinicians with practical tools and suggestions which may answer doubts that can arise during chronic management of patients with hepatic *** particular,it summarises current knowledge on Wilson’s disease clinical and biochemical monitoring and *** also analyses available evidence on pregnancy and the role of low-copper diet in *** research should focus on trying to provide new copper metabolism tests which could help to guide treatment adjustments.

关键词： Wilson’s disease Urinary copper excretion Non-ceruloplasmin-bound copper D-penicillamine Trientine Zinc salts

Transcomplementation, but not Physical Association of the CC-NB-ARC and LRR Domains of Tomato R Protein Mi-1.2 is Altered by Mutations in the ARC2 Subdomain

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Molecular Plant 2008年第3期1卷 401-410页

作者： Gerben van Ooijen gabriele Mayr Mario Albrecht Ben J. C. Cornelissen Frank L.W. Takken Plant Pathology Swammerdam Institute for Life Sciences University of Amsterdam PO Box 94062 1090 GB Amsterdam the Netherlands Max Planck Institute for Informatics Stuhlsatzenhausweg 85 66123 Saarbrücken Germany

Race-specific disease resistance in plants is mediated by Resistance （R） proteins that recognize pathogen at- tack and initiate defence responses. Most R proteins contain a central NB-ARC domain and a C-terminal leucine-rich repeat （LRR） domain. We analyzed the intramolecular interaction of the LRR domain of tomato R protein Mi-1.2 with its N- terminus. We expressed the CC-NB-ARC and LRR parts in trans and analyzed functional transcomplementation and physical interactions. We show that these domains functionally transcomplement when expressed in trans. Known autoactivating LRR domain swaps were found to induce a hypersensitive response （HR） upon co-expression. Likewise, autoactivating mutants in the NB subdomain transcomplemented to induce HR. Point mutations in the ARC2 subdomain that induce strong autoactivation in the full-length Mi-1.2 protein, however, fail to induce HR in the transcomplementation assay, These data indicate distinct functions for the NB-ARC subdomains in induction of HR signalling. Furthermore, dissociation of the LRR is not required to release its negative regulation, as in all combinations of CC-NB-ARC and LRR domains tested, a physical interaction was observed.

关键词： RESISTANCE PROTEIN DISEASE RESISTANCE NUCLEOTIDE-BINDING CELL-DEATH HYPERSENSITIVE RESPONSE

Tulip bundle technique and fibrin glue injection:Unusual treatment of colonic perforation

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World Journal of Gastroenterology 2011年第8期17卷 1088-1090页

作者： Filippo Mocciaro gabriele Curcio Ilaria Tarantino Luca Barresi Marco Spada Sergio Li Petri Mario Traina Department of Gastroenterology IsMeTT UPMC Surgery Unit IsMeTT UPMC

We report a case of a 63-year-old male who experienced an iatrogenic sigmoid perforation repaired combining three endoscopic *** lesion was large and irregular with three discrete perforations,therefore,we decided to close it by placing one clip per perforation,and then connecting all the clips with two *** we chose to use a fibrin glue injection to obtain a complete *** days after the colonoscopy the patient underwent a laparoscopic right hemicolectomy due to evidence of a large polyp of the caecum with high grade dysplasia and focal carcinoma in *** of the sigma showed complete repair of the *** report underlines how a conservative approach,together with a combination of various endoscopic techniques,can resolve complicated iatrogenic perforations of the colon.

关键词： Colonic perforation Endoscopic treatment Fibrin glue injection Tulip bundle technique

Palladium Iodide-Catalyzed Selective Carbonylative Double Cyclization of 4-(2-Aminophenyl)-3-yn-1-ols to Dihydrofuroquinolinone Derivatives

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Chinese Journal of Chemistry 2023年第21期41卷 2801-2809页

作者： Raffaella Mancuso Alex De Salvo Patrizio Russo Aurelia Falcicchio Nicola Della Ca’ Leonardo Pantoja Munoz Bartolo gabriele Laboratory of Industrial and Synthetic Organic Chemistry(LISOC) Department of Chemistry and Chemical TechnologiesUniversity of CalabriaVia Pietro Bucci 12/C87036 Acavacata di Rende(CS)Italy Institute of Crystallography National Research CouncilVia Amendola122/O70126 BariItaly Department of Chemistry Life Sciences and Environmental Sustainability(SCVSA)University of ParmaParco Area delle Scienze17/A43124 ParmaItaly Department of Natural Sciences Faculty of Science and TechnologyMiddlesex UniversityThe BurroughsNW44BT LondonUK

The PdI_(2)/KI-catalyzed oxidative carbonylation of 4-(2-aminophenyl)-3-yn-1-ols,bearing two potential nucleophilic groups in suitable position selectively leads to dihydrofuroquinolinone derivatives in fair to high yields(60%—89%)and excellent turnover numbers(180—267 mol of product per mol of Pd)over 19 examples,through a mechanistic pathway involving initial O-cyclization followed by *** such process,the selective catalytic construction of two rings and three new bonds is achieved in one synthetic step to afford high value added fused heterocyclic structures starting from readily available materials.

关键词： Carbonylation Cyclization Heterocycles Palladium Polycyclic heterocycles

Extemal Quality Control and its Impacts on Quality in Auditing Companies With Focus on Small and Medium-sized Audit Companies

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Economics World 2014年第3期2卷 169-179页

作者： gabriele Hahne HAHNE Revisions- und TreuhandgeseUschaft mbH Dulmen Germany

After numerous spectacular balance scandals in the United States and Europe, an international discussion about the quality of audits as well as the necessity to raise the quality of financial audits arose. The United States of America responded to this discussion with the ＂Sarbanes-Oxley Act＂, while the European Union decreed the directive 2006/43/EC. The mentioned directive updated the statutory provisions for the professional guild of auditors to increase the quality of audits. In detail, it demanded an external quality-control-system combined with public supervision for the profession of auditors to ensure a better quality. Due to this fact, the audit companies now have to fulfill a large range of requirements to provide evidence of their consistent auditing-quality and furthermore of the quality standards within their company. Since many small and medium-sized companies are not able to fulfill these new requirements, the number of small and medium-sized audit companies decreases noticeably. This paper discusses the research results on the effects of external quality control^given by law---on the auditor market in Germany focusing on small and medium-sized audit companies. Additionally the research examines that, if the external quality control, which was one of the justifications of the conversions of the EU-directive 2006/43/EC is able to increase the quality in audit companies at all. Therefore it needs to be tested whether there is a uniform and fits all approach of quality in audits. The research questions and the tests were analyzed scientifically and confirmed in several expert interviews with four different expert groups in Germany.

关键词： auditor market stronger regulations quality in audits small and medium-sized audit companies

Completely obstructed colorectal anastomosis: A new non-electrosurgical endoscopic approach before balloon dilatation

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World Journal of Gastroenterology 2010年第37期16卷 4751-4754页

作者： gabriele Curcio Marco Spada Fabrizio di Francesco Ilaria Tarantino Luca Barresi Gaetano Burgio Mario Traina Department of Gastroenterology IsMeTT UPMC

Benign stricture is a relatively common complication of colorectal anastomosis after low anterior resection. On occasion, the anastomosis may close completely. A variety of endoscopic techniques have been described, but there is a lack of data from controlled prospective trials as to the optimal approach. Through-the-scope balloon dilatation is well known and easy to perform. Some case reports describe different endoscopic approaches, including endoscopic electrocision with a papillotomy knife or hook knife. We report a case of a colorectal anastomosis web occlusion, treated without electrocision. Gastrografin enema and sigmoidoscopy showed complete obstruction at the anastomotic site due to the presence of an anastomotic occlusive web. In order to avoid thermal injuries, we decided to use a suprapapillary biliary puncture catheter. The Artifon catheter was inserted into the center of the circular staple line at the level of the anastomosis, and fluoroscopic identification of the proximal bowel was obtained with dye injection. A 0.025-inch guidewire was then passed through the catheter into the colon and progressive pneumatic dilatation was performed. The successful destruction of the occlusive web facilitated passage of the colonoscope, allowing evaluation of the entire colon and stoma closure after three months of follow-up. The patient tolerated the procedure well, with no complications. This report highlights an alternative non-electrosurgical approach that uses a new device that proved to be safe and useful.

关键词： Anastomosis Dilation Balloon Obstructed Artifon