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Psychic euosmia among obsessive-compulsive personality disorder patients:A case control study

World Journal of Psychiatry 2021年第2期11卷 50-57页

作者： Annalisa Maraone Lorenzo Tarsitani Marianna Frascarelli Federica Petrini Valentina Roselli MassimilianoTinè gabriele cavaggioni Vlasios Brakoulias Massimo Biondi Massimo Pasquini Department of Human Neurosciences Sapienza UniversityRome 00185Italy Department of Neurosciences and Mental Health Umberto I PoliclinicRome 00185Italy School of Medicine Western Sydney University and Western Sydney Local Health DistrictBlacktown 2145SNWAustralia Department of Psychiatry Nepean HospitalSydney Medical SchoolThe University of SydneyPenrith 2751SNWAustralia

BACKGROUND Psychic euosmia(PE)has been described as a supposed psychological predisposition for which pleasant smells elicit an immediate sense of pleasure,order and calmness in obsessive-compulsive personality disorder(OCPD).In this study we tried to verify the interpretation that PE is the counterpart of disgust that has been associated to contamination and moral *** and morality are significantly associated in people with obsessive-compulsive personality *** expected that OCPD patients would experience higher levels of *** To investigate the PE frequency in OCPD patients and healthy controls(HC)and to evaluate the relationship between PE and *** A single-center,case-control study was conducted in an outpatient service for obsessive-compulsive and related *** sample consisted of 129 subjects:45 OCPD patients and 84 *** both groups we submitted the Disgust Scale Revised(DS-R)and the self-report Structured Clinical Interview for DSM-5 Screening Personality Questionnaire to which we added an additional yes or no question to investigate the presence of *** order to verify differences between groups,t-test was employed for continuous variables and 2 test for categorical variable;odds ratio was employed to analyze group differences in the PE *** was explored with Pearson r *** No differences were observed between groups in gender composition or education.A slight significant difference was found in mean age(t=1.988;P=0.049).The present study revealed significantly higher proportions of PE among OCPD patients when compared to HC(OR:5.3,2.28-12.46).Patients with OCPD were more likely to report PE(n=36;80%)whereas a much lower proportion endorsed PE in the HC group(n=36;42.9%).Interestingly,no differences were observed between groups in mean score for the Disgust *** was also no difference between the two groups in any of the Disgust Scale Revised ***,no significant correla

关键词： Psychic euosmia Obsessive-compulsive personality disorder Disgust Orderliness Olfactory Personality

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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès Sylvain gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

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Pre-breakdown to stable phase and origin of multiple current pulses in argon dielectric barrier discharge

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Plasma Science and Technology 2021年第12期23卷 83-94页

作者： Saurav GAUTAM gabriele MORRA Department of Mechanical Engineering University of California MercedMercedCalifornia 95343United States of America Department of Physics University of Louisiana at LafayetteLafayetteLouisiana 70503United States of America

We report on the results of numerical models of the(i)initial growth and(ii)steady state phases of atmospheric-pressure homogeneous dielectric barrier discharge in *** employ our new inhouse code called Py DBD,which solves continuity equations for both particles and energy,shows exceptional stability,is accelerated by adaptive time stepping and is openly available to the scientific *** argon plasma is numerically challenging due to the lower speeds of more inertial ions compared to more commonly modeled neon and helium,but its common use for plasma jets in medicine makes its modeling *** DBD is here applied to modeling two setups:(i)the exponential growth from natural electron-ion seeds(onset phase)until saturation is reached and(ii)the multiple current pulses that naturally appear during the steady state *** find that the time required for the onset phase,when the plasma density grows from 10^(9)m^(-3)to 10^(17)m^(-3),varies from 80μs at 4.5 k V down to a fewμs above 6.5 k V,for voltage frequency f=80 k Hz and gap width d_(g)=0.9 *** the steady state,our model reproduces two previously observed features of the current in dielectric barrier discharge reactors:(1)an oscillatory behavior associated to the capacitative character of the circuit and(2)several(N_(p))current pulses occurring every half sinusoidal *** show that the oscillations are present during the exponential growth,while current pulses appear approaching the steady *** each micro-discharge,the gas voltage decreases abruptly and charged particles rapidly accumulate at the dielectric boundaries,causing avalanches of charged particles near the reactor ***,we run a parametric study finding that N_(p)increases linearly with voltage amplitude V_(amp),is inversely proportional to dielectric gap d_(g)and decreases when voltage frequency f *** code developed for this publication is freely available at the address https://***/gabers

关键词： plasma onset micro-discharge multiple current pulse(MCP) discharge asymmetry seed electrons

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Multilevel Techniques for the Solution of HJB Minimum-Time Control Problems

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Journal of Systems Science & Complexity 2021年第6期34卷 2069-2091页

作者： CIARAMELLA gabriele FABRINI Giulia Department of Mathematics and Statistics University of KonstanzKonstanz 78464Germany

The solution of minimum-time feedback optimal control problems is generally achieved using the dynamic programming approach,in which the value function must be computed on numerical grids with a very large number of *** numerical strategies,such as value iteration(VI)or policy iteration(PI)methods,become very inefficient if the number of grid points is *** is a strong limitation to their use in real-world *** address this problem,the authors present a novel multilevel framework,where classical VI and PI are embedded in a full-approximation storage(FAS)*** fact,the authors will show that VI and PI have excellent smoothing properties,a fact that makes them very suitable for use in multilevel ***,a new smoother is developed by accelerating VI using Anderson’s extrapolation *** effectiveness of our new scheme is demonstrated by several numerical experiments.

关键词： Anderson acceleration FAS Hamilton-Jacobi equation minimum-time problem multi-level acceleration methods policy iteration value iteration

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Controlled location of S vacancies in MoS_(2) nanosheets for high-performance hydrogenation of CO_(2) to methanol

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Journal of Energy Chemistry 2022年第1期31卷 113-115,I0004页

作者： gabriele Centi Dept.ChiBioFarAm University of MessinaItaly and ERIC Aisbl.BrusselsBelgium

Introduction In a joint contribution among many Chinese research Institutes,a recent paper published on Nature Catalysis reported the use of sulfur vacancy-rich MoS_(2)as a novel catalyst for the hydrogenation of CO_(2)to methanol[1].A commentary on this paper was also published on the same journal[2]reporting as a summary:"Highly active,selective and stable catalysts for the hydrogenation ofC0_(2)to methanol are immensely sought ***,using a broad range of spectroscopic methods,in-plane double sulfur vacancies of MoS_(2)sheets have been suggested to catalyse this reaction using an unusual mechanism".

关键词： CO_(2) Methanol MOS_(2)nanosheet In-plane S vacancies

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Telomerase and neurons:an unusual relationship

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Neural Regeneration Research 2022年第11期17卷 2364-2367页

作者： gabriele Saretzki Biomedical Sciences Campus for Ageing and VitalityNewcastle UniversityNewcastle Upon TyneUK

Most people associate the enzyme telomerase with its role in maintaining telomeres,which is its best-known canonical *** this important function,two main components are required:the protein telomerase reve rse transcriptase(TERT)and the telomerase RNA *** addition,over the last decades,an ever-growing number of othe r,non-telomeric,non-canonical functions for the telomerase protein TERT has been *** reach from tumor promotion to decreasing oxidative stress and apoptosis as well as activating *** functions are more and more recognized as being important in many tissues and physiological as well as pathological *** role of telomerase in brain development and neuronal cells has been investigated for more than 20 ***,the non-telomeric role in non-dividing neurons of the brain for telomerase and the TERT-protein has only recently been highlighted by extensive ***,these developments promoted the suggestion of a beneficial and protective role of TERT against neurodegenerative diseases such as Alzheimer's disease and Parkinson's *** review summarizes the most important findings in the field of telomerase in neuro ns and gives an outlook onto possible therapeutic applications of boosting telomerase/TERT levels with telomerase activators to prevent or ameliorate various neurodegene rative diseases.

关键词： autophagy brain neurons neurodegeneration telomerase TERT protein

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CO_(2) conversion to solar fuels and chemicals:Opening the new paths

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Journal of Energy Chemistry 2024年第4期91卷 680-683页

作者： gabriele Centi Claudio Ampelli Department of Chemical BiologicalPharmaceutical and Environmental Sciences(ChiBioFarAm)University of MessinaERIC aisbl and CASPE/INSTMV.le F.Stagno d'Alcontres 3198166 MessinaItaly

This future article discusses the new prospects and directions of CO_(2)conversion via the photo-electrocatalytic(PEC)*** second(2nd)generation solar fuels and chemicals(SFs)are generated directly in PEC systems via electrons/protons reactions without forming molecular H_(2)as an intermediate,overcoming the thermodynamics limitations and practical issues encountered for electro-fuels produced by multistep thermocatalytic processes(***_(2)conversion with H_(2)coming from water electrolysis).A distributed and decentralized production of SFs requires very compact,highly integrated,and intensified *** the existing reactors of advanced design(based on artificial leaves or photosynthesis),the integrated photovoltaic plus electrocatalytic(PV-EC)device is the only system(demonstrated at large scale)to produce SFs with high solar-to-fuel(STF)***,while the literature indicates STF efficiency as the main(and only)measure of process performance,we remark here the need to refer to productivity(in terms of current density)and make tests with reliable flow PEC systems(with electrodes of at least 5–10 cm^(2))to accelerate the scaling-up *** approaches that minimize downstream separation costs is also *** limitations exist in PEC systems,but most can be overcome by proper electrode and cell engineering,thus going beyond the properties of the *** examples of current developments,we present the progress of(i)artificial leaf/tree devices for green H_(2)distributed production and(ii)a PEC device producing the same chemicals at both cathode and anode parts without downstream operations for green solvent distributed *** on these developments,future directions,such as producing fertilizers and food components from the air,are *** aim is to provide new ideas and research directions from a personal perspective.

关键词： Solar fuels Artificial leaf PEC devices PV-EC devices Cell engineering green H_(2) Chemicals from theair

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View on microRNAs as a potential tool to fight blindness: focus on Müller glia and gliosis

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Neural Regeneration Research 2022年第7期17卷 1501-1502页

作者： Stefanie gabriele Wohl The State University of New York College of OptometryDepartment of Biological and Vision SciencesNew YorkNYUSA

The neural retina is a part of the central nervous *** it lacks regenerative capacity,in an event of injury or disease,neuronal loss leads to visual impairment and often to ***,Müller glia(MG),the predominant glia in the retina,undergo a variety of molecular and cellular changes and discontinue to carry out their important regular functions in the tissue(e.g.,maintaining tissue homeostasis and nurturing neurons).

关键词： homeostasis predominant carry

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Lactate-avid regulatory T cells:metabolic plasticity controls immunosuppression in tumour microenvironment

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1418-1419页

作者： gabriele Multhoff Peter Vaupel Radiation Immuno-Oncology Project Group TranslaTUM–Central Institute for Translational Cancer ResearchKlinikum rechts der IsarTU MünchenMunichGermany Department of Radiation Oncology Klinikum rechts der IsarTU MünchenMunichGermany Department of Radiooncology and Radiotherapy Tumour Pathophysiology GroupUniversity Medical Centre MainzMainzGermany

The excellent article by Watson et al.1 points the way ahead to the important role of lactic acid/lactate-anion and glucose on the immunosuppressive activity of lactate-and glucose-affine metabolically distinct subset... 详细信息

关键词： tumour al. microenvironment

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Telomerase and mTOR in the brain:the mitochondria connection

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Neural Regeneration Research 2017年第3期12卷 358-361页

作者： Satomi Miwa gabriele Saretzki Ageing Biology Centre and Institute for Cell and Molecular Biosciences Campus for Ageing and VitalityNewcastle UniversityNewcastle upon TyneUK

Telomerase is an enzyme that maintains telomeres in dividing cells using a template on its inherent RNA ***,the protein part TERT（Telomerase Reverse Transcriptase） has various non-canonical *** example,it can localize to mitochondria under increased stress and protect cells in vitro from oxidative stress,DNA damage and *** it has been demonstrated that TERT protein persists in adult neurons in the brain and data emerge suggesting that it might have a protective function in these post-mitotic cells as *** have recently published that TERT protein accumulated in mitochondria from brain tissue of mice that have undergone short-term dietary restriction（DR） and rapamycin *** localization correlated to lower levels of oxidative stress in these brain *** rapamycin treatment decreases mTOR signaling which is also thought to play an important role for the beneficial effects of DR,we conclude that the mTOR pathway might be involved in the TERT localization and its effects in brain mitochondria in *** data are in line with previous findings from our group about increased mitochondrial localization of TERT in Alzheimer＇s disease（AD） brains and a protective function of TERT protein in neurons in vitro against pathological tau.

关键词： telomerase brain neuron mitochondria roTOR ROS dietary restriction rapamycin

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