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Telomerase and neurons:an unusual relationship

Neural Regeneration Research 2022年第11期17卷 2364-2367页

作者： gabriele saretzki Biomedical Sciences Campus for Ageing and VitalityNewcastle UniversityNewcastle Upon TyneUK

Most people associate the enzyme telomerase with its role in maintaining telomeres,which is its best-known canonical *** this important function,two main components are required:the protein telomerase reve rse transcriptase(TERT)and the telomerase RNA *** addition,over the last decades,an ever-growing number of othe r,non-telomeric,non-canonical functions for the telomerase protein TERT has been *** reach from tumor promotion to decreasing oxidative stress and apoptosis as well as activating *** functions are more and more recognized as being important in many tissues and physiological as well as pathological *** role of telomerase in brain development and neuronal cells has been investigated for more than 20 ***,the non-telomeric role in non-dividing neurons of the brain for telomerase and the TERT-protein has only recently been highlighted by extensive ***,these developments promoted the suggestion of a beneficial and protective role of TERT against neurodegenerative diseases such as Alzheimer's disease and Parkinson's *** review summarizes the most important findings in the field of telomerase in neuro ns and gives an outlook onto possible therapeutic applications of boosting telomerase/TERT levels with telomerase activators to prevent or ameliorate various neurodegene rative diseases.

关键词： autophagy brain neurons neurodegeneration telomerase TERT protein

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Telomerase and mTOR in the brain:the mitochondria connection

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Neural Regeneration Research 2017年第3期12卷 358-361页

作者： Satomi Miwa gabriele saretzki Ageing Biology Centre and Institute for Cell and Molecular Biosciences Campus for Ageing and VitalityNewcastle UniversityNewcastle upon TyneUK

Telomerase is an enzyme that maintains telomeres in dividing cells using a template on its inherent RNA ***,the protein part TERT（Telomerase Reverse Transcriptase） has various non-canonical *** example,it can localize to mitochondria under increased stress and protect cells in vitro from oxidative stress,DNA damage and *** it has been demonstrated that TERT protein persists in adult neurons in the brain and data emerge suggesting that it might have a protective function in these post-mitotic cells as *** have recently published that TERT protein accumulated in mitochondria from brain tissue of mice that have undergone short-term dietary restriction（DR） and rapamycin *** localization correlated to lower levels of oxidative stress in these brain *** rapamycin treatment decreases mTOR signaling which is also thought to play an important role for the beneficial effects of DR,we conclude that the mTOR pathway might be involved in the TERT localization and its effects in brain mitochondria in *** data are in line with previous findings from our group about increased mitochondrial localization of TERT in Alzheimer＇s disease（AD） brains and a protective function of TERT protein in neurons in vitro against pathological tau.

关键词： telomerase brain neuron mitochondria roTOR ROS dietary restriction rapamycin

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