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Prevalence of congenital cytomegalovirus infection in preterm,small for gestational age and low birth weight newborns:characteristics and cytokines profile

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World Journal of Pediatrics 2022年第7期18卷 498-504页

作者： Janaina Fortes Lino Llian Martins Oliveira Diniz debora Marques de Miranda Daniela Valadao freitas Rosa Nathalia Gualberto Souza e Silva Eduardo de Souza Nicolau Larissa Goncalves Rezende Lais Silva Carvalho Marianna Fischer de Paula Lopes Luisa Petri Correa gabriela Mafra de Oliveira Flavia Miranda da Silva Alves Lorena Batista Pascoal Erika Lima Dolabella Teixeira da Costal Leni Marcia Anchieta Roberta Maia de Castro Romaneli Odete Valadares Maternity Hospital Belo HorizonteBrazil Pediatrics department.Faculy of Medice of Federal University of Minas Gerais Belo Horizonte.Brazil Molecular Laboratory of the INCT-MM.Faculy of Medicine.Federal University of Minas Gerais-UFMG.Belo Horizonte Brazil Faculty of Medicine.Federal University of Minas Gerais-UFMG Belo Horizonte.Brazil Risoleta Tolentino.Neves University Hospital's Maternity Belo HorizonteBrazil Sofia Feldman Maternity Hospital Belo HorizonteBrazil Hospital das Clinicas Maternity-Federal University of Minas Gerais.Belo Horizonte Brazil Pediatrics department of Federal University of Minas Gerais School Medicine.Minas Gerais.Av Professor Alfredo Balena 190.Belo Horizonte 30130-100Brazil

Cytomegalovirus is the most frequent agent of congenital viral infections,affecting approximately 0.2%-2.4%of live births in different countries[1-7].Universal screening for congenital cytomegalovirus infection in newborns is not a standard practice considering cost-benefit issues and viabil-ity of diagnostic ***,most newborns are asympto-matic and there is no effective treatment for this population[2-5].

关键词： weight birth characteristics

In Silico Pharmacokinetics Studies for Quinazolines Proposed as EGFR Inhibitors

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Open Journal of Medicinal Chemistry 2015年第4期5卷 106-115页

作者： gabriela Souza Fernandes Michelle Bueno de Moura Pereira Ana Cláudia Barbosa Marinho Brisa Machado Ana Carla Moreira Matheus Puggina de freitas Karen Luise Lang Joao Eustáquio Antunes department of Medicine Federal University of Juiz de Fora Governador Valadares Brazil department of Pharmacy Federal University of Juiz de Fora Governador Valadares Brazil department of Chemistry Federal University of Lavras Lavras Brazil

In silico pharmacokinetics studies can aid the search for molecules with potential ability to be drug candidates. In this paper, a number of quinazoline candidates for epidermal growth factor receptor inhibitors—EGFR, important targets for the treatment of cancer, are computationally analyzed. The literature described that 69 quinazoline molecules were synthesized and the respective half maximum inhibitory concentrations (IC50) were obtained. A bilinear parabolic model was built to investigate the druglikeness by correlating the corresponding lipophilicities, which can be represented by the ideal Log P , with the optimal biological activity in terms of pIC50 values. Structural characteristics leading to improved pharmacokinetics parameters were then analyzed. Compound 56 exhibited the lowest IC50 and, therefore, it had the highest ability to inhibit the EGFR. In the present work, the most potent inhibitor 56 is not calculated to be the most promising drug candidate, since it’s out of the parabolic model obtained due to a Log P above 5, which is not within the expected optimum range. Finally, this work is an example of computational prediction that an experimentally, highly active EGFR inhibitor can be unsuccessful as drug candidate because of pitfalls in pharmacokinetics parameters.

关键词： Cancer Treatment Quinazoline Inhibitors Rational Drug design Pharmacokinetics

Growth and Visual Symptoms of Nutrients deficiency in Mangosteens(Garcinia mangostana L.)

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American Journal of Plant Sciences 2018年第5期9卷 1014-1028页

作者： Ismael de Jesus Matos Viégas Ricardo Augusto Martins Cordeiro gabriela Mourao de Almeida Diocléa Almeida Seabra Silva Bianca Cavalcante da Silva Ricardo Shigueru Okumura Mário Lopes da Silva Júnior Sávia Poliana da Silva Joze Melisa Nunes de freitas Universidade Federal Rural da Amazonia Capanema CampusCapanemaBrazil Institute Federal do Pará Castanhal CampusCastanhalBrazil Universidade Federal Rural da Amazonia Capitao Poco CampusCapitao PocoBrazil Universidade Federal Rural da Amazonia Belém CampusBelémBrazil

The aims of study were to evaluate growth and characterize the visual symptoms of macronutrient and micronutrient deficiencies in mangosteens. The seedlings were cultivated in nutritive solution containing all required macronutrient and micronutrients and in solutions with omission of N, P, K, Ca, Mg, S, B, Cu, Fe, Mn, and Zn, using the missing element technique. The experimental design was completely randomized with five replicates and twelve treatments. Symptoms of nutrient deficiency were accompanied by photographic records and described from beginning until complete definition, in which the plants were collected. Growth was evaluated through of dry mass production and nutrient contents. Nutrients omissions resulted in morphological alterations, characteristic symptoms of nutritional deficiency, promoted the reduction in dry mass production in plant, in which the Fe was most limiting, followed by N, and S. Macronutrients and micronutrients contents, without deficiencies (complete treatment) and deficient in mangosteen leaves were respectively: N (16.4 and 12.5 g kg-1);P (1.1 and 0.2 g kg-1);K (10.2 and 8.1 g kg-1);Ca (6.7 and 1.9 g kg-1);Mg (1.1 and 0.1 g kg-1);S (3.0 and 2.2 g kg-1);B (20 and 16 mg kg-1);Cu (7 and 3 mg kg-1);Fe (266 and 86 mg kg-1);Mn (58 and 17 mg kg-1). The decreasing order in appearance of visual symptoms of deficiency was N > S > K > B > Ca > P > Mg > Mn > Cu > Zn.

关键词： Mineral Nutrition Tropical Fruit Nutritional deficiency Missing Element

Superoxide Anion Release by Human Blood Phagocytes Can Increase the Microbicidal Activity Induced by a New Microemulsioned System Containing Cotton Oil

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Advances in Biological Chemistry 2022年第6期12卷 207-227页

作者： Luana Cristina da Silva Ramos André Henrique Furtado Torres Letícia Damas Leão Dalcin Katleyn Polizeli Galvão Silva Luana gabriela Silva de freitas Mahmi Fujimori Danny Laura Gomes Fagundes Eduardo Luzia França Adenilda Cristina Honorio França Universidade Federal de Mato Grosso. Barra do Garç as Brazil

The study aimed to develop and characterize a microemulsified system based on cotton oil and verify its effect on superoxide release anion and microbicidal activity by human peripheral blood cells. Microemulsions were formulated using distilled water, degummed cotton oil, Span 80 (SP), Tween 80 (TW), and 1-butanol (BT). The pseudo-ternary diagram delimited ME regions, and the points were pre-selected. The physical-chemical and rheological characterization of the microemulsions was carried out. The ME activity on the interactions between leukocytes and bacteria was analyzed by superoxide release, phagocytosis, and microbicidal activity. The developed formulation was classified as Oil/Water, with an average pH of 5.76, and the viscosity showed resistance to temperature changes. The rheological model of the Power Law classified the microemulsion as a non-Newtonian fluid with pseudoplastic characteristics. The cell viability of cotton oil microemulsion was greater than 90%. There was an increase in the superoxide release by MN phagocytes when treated with cotton oil microemulsion. The cotton oil microemulsion increased phagocytosis and microbicidal activity. The present study suggests that cotton oil is an alternative biomaterial for therapeutic applications, especially in treating infections.

关键词： Cotton Oil Microemulsion Phagocytosis Infection Human Phagocytes

Resistance of the Eucalyptus Wood in Natura and Torrefied Exposed to the Attack of Cryptotermes brevis

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Journal of Agricultural Science and Technology(B) 2018年第8期8卷 512-516页

作者： Vinícius Resende de Castro Matheus Perdigao de Castro freitas Pereira Paula gabriela Surdi Matheus da Silva Berger José Cola Zanuncio Angélica de Cássia Carneiro departament of Forest Engineer Universidade Federal de Vicosa (UFV) Vicosa 36570000 Brazil departament of Entomology Universidade Federal de Vicosa (UFV) Vicosa 36570000 Brazil

The reduced natural durability and low energy density of eucalyptus wood hampers its use to generate energy. Torrefaction or pre-carbonization, treatment in low oxygenation with temperatures between 200 ℃ and 300℃, accumulates carbon and lignin, decreases hygroscopicity, increases energy efficiency and reduces the wood attractiveness to xylophagous organisms, such as termites. Therefore, this work had as its main aim to study the influence of the roasting temperature on the endurance of the Eucalyptus urophylla wood in natura as well as roasted, both exposed to the attack of dry-wood termites. To the execution of this study, in natura wood chips and torrefied chips (torrefied for 20 min at the following temperatures: 180, 220 and 260 ℃) were submitted to the dry-wood termite resistance test. In this experiment, termites of the Cryptotermes brevis species were used. After 45 d of exposure, it was possible to observe that the torrefied treatment presented a greater resistance that consequently increased the endurance when exposed to the termite’s attack, observing that the control sample, loss five times more than mass than the chips torrefied at 260℃. Besides, in the treatment with in natura chips, was observed less mortality of the termites and greater visual damage, confirming the lower durability of such material compared to torrefied chips.

关键词： Biomass heat treatment termites.