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Effects of a multimodal exercise protocol on functional outcomes,epigenetic modulation and brain-derived neurotrophic factor levels in institutionalized older adults:a quasi-experimental pilot study

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Neural Regeneration Research 2021年第12期16卷 2479-2485页

作者： Iasmin Fraga camila Weber Wériton Baldo Galiano Lucio Iraci Mariana Wohlgemuth gabriela morales.camila cercato Juliana Rodriguez Daniela Pochmann Caroline Dani Pérsia Menz Adriane Dal Bosco Viviane Rostirola Elsner Programa de Pós-Graduação em Ciências Biológicas:Fisiologia Universidade Federal do Rio Grande do SulPorto AlegreRSBrasil Curso de Fisioterapia do Centro Universitário Metodista-IPA Porto AlegreRSBrasil Programa de Pós-Graduação em Biociências e Reabilitação Centro Universitário Metodista-IPAPorto AlegreRSBrasil Physiotherapist working in Long-Term InstitutionsPorto AlegreRSBrasil

Epigenetic changes have been shown to be associated with both aging process and aging-related *** is evidence regarding the benefits of physical activity on the functionality,cognition,and quality of life of institutionalized older adults,however,the molecular mechanisms involved are not *** purpose of this pilot study was to investigate the effects of a multimodal exercise intervention on functional outcomes,cognitive performance,quality of life(QOL),epigenetic markers and brain-derived neurotrophic factor(BDNF)levels among institutionalized older adult ***(n=8)without dementia who were aged 73.38±11.28 years and predominantly female(87.5%)were included in this quasi-experimental pilot study.A multimodal exercise protocol(cardiovascular capacity,strength,balance/agility andﬂexibility,perception and cognition)consisted of twice weekly sessions(60 minutes each)over 8 ***(Berg Scale),mobility(Timed Up and Go test),functional capacity(Six-Minute Walk test),cognitive function(Mini-Mental State Examination)and QOL(the World Health Organization Quality of Life-BREF Scale questionnaire)were evaluated before and after the *** sample(15 mL)was also collected before and after intervention for analysis of biomarkers global histone H3 acetylation and brain-derived neurotrophic factor *** improvements were observed in cognitive function,balance,mobility,functional capacity and QOL after the *** addition,a tendency toward an increase in global histone H3 acetylation levels was observed,while brain-derived neurotrophic factor level remained *** study provided evidence that an 8-week multimodal exercise protocol has a significant effect on ameliorating functional outcomes and QOL in institutionalized older adult *** addition,it was also able to promote cognitive improvement,which seems to be partially related to histone hyperacetylation *** Ethics Research Com

关键词： aging balance brain-derived neurotrophic factor cognition epigenetics physical exercise quality of life risk of falling

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