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Petroleum Research 2024年第3期9卷 418-431页

作者： Nelson Choueri Jr Marcelo Anunciacao Jaculli Amanda gabriela Aparecida Silva Leite JoséRicardo Pelaquim Mendes University of Campinas Brazil

Two independent barrier envelopes are the usual requirement used in most well operations to avoid catastrophic *** are classified as primary-concerning preventing the occurrence of a kick,and secondary-concerning controlling the kick to avoid a *** envelopes consist of barrier elements,thus verifying the quality of these elements is *** elements may be either redundant or mandatory,and these relationships are what constitute the barrier *** this work,we present a methodology to evaluate well safety by identifying existing barrier elements and barrier envelopes and mapping their relationships through the usage of graphs *** technique explicitly states the relationship between barriers and between them and *** enables a simpler visualization for well designers and allows the development of computer programs to control the safety and integrity of wells,both in the design phase and during drilling.12 graphs are provided for a 4-phase well(conductor,surface,production,and drill-in),considering both the primary and secondary *** for constructing each graph is thoroughly *** these graphs are used,reliability values can then be assigned to each barrier element,which results in the reliability of entire barrier *** can be further extended to analyze the safety of each operation by applying the system to operational sequences and even comparing well designs.

关键词： Barrier elements Barrier envelopes Well design Well safety Graphs technique

Coronavirus disease-2019 and the intestinal tract:An overview

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World Journal of Gastroenterology 2021年第13期27卷 1255-1266页

作者： gabriela Gama Freire Alberca Rosa Liliana Solis-Castro Maria Edith Solis-Castro Ricardo Wesley Alberca Department of Microbiology Institute of Biomedical Sciences-University of São PauloSão Paulo 05508-000Brazil Departamento Académico de Biología Bioquímica Facultad de Ciencias de la SaludUniversidad Nacional de TumbesPampa Grande 24000TumbesPeru Departamento Académico de Medicina Humana Facultad de Ciencias de la SaludUniversidad Nacional de TumbesPampa Grande 24000TumbesPeru Laboratorio de Dermatologia e Imunodeficiencias(LIM-56) Departamento de DermatologiaFaculdade de Medicina FMUSPUniversidade de São PauloSão Paulo 01246-903Brazil

Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) infection can progress to a severe respiratory and systemic disease named coronavirus disease–2019(COVID-19). The most common symptoms are fever and respiratory discomfort. Nevertheless, gastrointestinal infections have been reported, with symptoms such as diarrhea, nausea, vomiting, abdominal pain, and lack of appetite. Importantly, SARS-CoV-2 can remain positive in fecal samples after nasopharyngeal clearance. After gastrointestinal SARS-CoV-2 infection and other viral gastrointestinal infections, some patients may develop alterations in the gastrointestinal microbiota. In addition, some COVID-19 patients may receive antibiotics, which may also disturb gastrointestinal homeostasis. In summary, the gastrointestinal system, gut microbiome, and gut-lung axis may represent an important role in the development, severity, and treatment of COVID-19. Therefore, in this review, we explore the current pieces of evidence of COVID-19 gastrointestinal manifestations, possible implications, and interventions.

关键词： COVID-19 SARS-CoV-2 Gastrointestinal Microbiota Antibiotics

THz plasmonics and electronics in germanene nanostrips

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Journal of Semiconductors 2023年第10期44卷 37-49页

作者： Talia Tene Marco Guevara gabriela Tubon-Usca Oswaldo Villacrés Cáceres Gabriel Moreano Cristian Vacacela Gomez Stefano Bellucci Department of Chemistry Universidad Técnica Particular de Loja110160 LojaEcuador UNICARIBE Research Center University of CalabriaI-87036 RendeCSItaly Grupo de Investigación en Materiales Avanzados(GIMA) Facultad de CienciasEscuela Superior Politécnica de Chimborazo(ESPOCH)RiobambaEcuador Facultad de Ciencias Escuela Superior Politécnica de Chimborazo(ESPOCH)RiobambaEcuador Faculty of Mechanical Engineering Escuela Superior Politécnica de Chimborazo(ESPOCH)Riobamba 060155Ecuador INFN-Laboratori Nazionali di Frascati Via E.Fermi 54I-00044 FrascatiItaly

Germanene nanostrips(GeNSs)have garnered significant attention in modern semiconductor technology due to their exceptional physical characteristics,positioning them as promising candidates for a wide range of *** exhibit a two-dimensional(buckled)honeycomb-like lattice,which is similar to germanene but with controllable *** modeling of GeNSs is essential for developing appropriate synthesis methods as it enables understanding and controlling the growth process of these ***,one can adjust the strip width,which in turn can tune the bandgap and plasmonic response of the material to meet specific device *** this study,the objective is to investigate the electronic behav-ior and THz plasmon features of GeNSs(≥100 nm wide).A semi-analytical model based on the charge-carrier velocity of free-standing germanene is utilized for this *** charge-carrier velocity of freestanding germanene is determined through the GW approximation(V_(F)=0.702×10^(6)m·s^(−1)).Within the width range of 100 to 500 nm,GeNSs exhibit narrow bandgaps,typi-cally measuring only a few ***,upon analysis,it was found that the bandgaps of the investigated GeNSs ranged between 29 and 6 *** well,these nanostrips exhibit√q-like plasmon dispersions,with their connected plasmonic fre-quency(≤30 THz)capable of being manipulated by varying parameters such as strip width,excitation plasmon angle,and sam-ple *** manipulations can lead to frequency variations,either increasing or decreasing,as well as shifts towards larger momentum *** outcomes of our study serve as a foundational motivation for future experiments,and further con-firmation is needed to validate the reported results.

关键词： nanostrips carrier velocity germanene plasmonics electronics

COX-2 as a potential biomarker and therapeutic target in melanoma

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Cancer Biology & Medicine 2020年第1期17卷 20-31页

作者： Diana Valentina Tudor Ioana Baldea Mihai Lupu Teodor Kacso Eniko Kutasi Andreea Hopartean Roland Stretea Adriana gabriela Filip Department of Physiology University of Medicine and Pharmacy"Iuliu Ha(t)ieganu"Cluj-Napoca 400000Romania

With a constantly increasing incidence,cutaneous melanoma has raised the need for a better understanding of its complex microenvironment that may further guide therapeutic *** is a model tumor in *** represents an important hallmark of cancer capable of inducing and sustaining tumor *** inflammatory process also orchestrates the adaptative immunosuppression of tumor cells that helps them to evade immune *** its role in proliferation,angiogenesis,and apoptosis,cyclooxygenase-2(COX-2)is a well-known promoter of immune suppression in ***-2 inhibitors are closely involved in this *** review attempts to answer two controversial questions:is COX-2 a valuable prognostic factor?Among all COX-2 inhibitors,is celecoxib a suitable adjuvant in melanoma therapy?

关键词： Melanoma inflammation,COX-2 COX-2 inhibitors celecoxib

Aggressive surgical approach in patients with adrenal-only metastases from hepatocellular carcinoma enables higher survival rates than standard systemic therapy

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Hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 28-33页

作者： Sorin T Alexandrescu Adina E Croitoru Razvan T Grigorie Dana R Tomescu gabriela Droc Mugur C Grasu Irinel Popescu Dan Setlacec Centre of General Surgery and Liver Transplantation Fundeni Clinical InstituteBucharest 022328Romania Carol Davila University of Medicine and Pharmacy Bucharest 020021Romania Department of Oncology Fundeni Clinical InstituteBucharest 022328Romania Faculty of Medicine Titu Maiorescu UniversityBucharest 031593Romania Dan Tulbure Centre of Anesteziology and Intensive Care Fundeni Clinical InstituteBucharest 022328Romania Department of Radiology Fundeni Clinical InstituteBucharest 022328Romania

Background:Although guidelines recommend systemic therapy even in patients with limited extrahepatic metastases from hepatocellular carcinoma(HCC),a few recent studies suggested a potential benefit for resection of extrahepatic ***,the benefit of adrenal resection(AR)for adrenal-only metastases(AOM)from HCC was not proved *** is the first study to compare long-term outcomes of AR to those of sorafenib in patients with AOM from ***:The patients with adrenal metastases(AM)from HCC were identified from the electronic records of the institution between January 2002 and December *** who presented AM and other sites of extrahepatic disease were ***,the patients with AOM who received other therapies than AR or sorafenib were ***:A total of 34 patients with AM from HCC were *** of these,22 patients had AOM,6 receiving other treatment than AR or ***,8 patients with AOM underwent AR(AR group),while 8 patients were treated with sorafenib(SOR group).The baseline characteristics of the two groups were not significantly different in terms of age,sex,number and size of the primary tumor,timing of AM diagnosis,Child-Pugh and ECOG *** a median follow-up of 15.5 months,in the AR group,the 1-,3-,and 5-year overall survival rates(85.7%,42.9%,and 0%,respectively)were significantly higher than those achieved in the SOR group(62.5%,0%and 0%at 1-,3-and 5-year,respectively)(P=0.009).The median progression-free survival after AR(14 months)was significantly longer than that after sorafenib therapy(6 months,P=0.002).Conclusions:In patients with AOM from HCC,AR was associated with significantly higher overall and progression-free survival rates than systemic therapy with *** results could represent a starting-point for future phase II/III clinical trials.

关键词： Adrenal metastases Hepatocellular carcinoma Adrenal resection Sorafenib Survival

The Development of New Intelligence in Education: Promoting the New Type of Leader

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Management Studies 2020年第4期8卷 284-289页

作者： Ionela gabriela Solomon Bucharest University of Economic Studies BucharestRomania

Starting from the Romanian education system,where competencies acquired during formal education—for example,in case of faculty specializations—are presented within diploma supplement,the article presents the need for harmonization of the competences at European level through the EQF and also globally,by harmonizing national qualifications frameworks with those of non-EU countries such as New Zealand or *** article aims to show that behind these existing skills described in diploma supplement,are intelligences that need to be developed in the education system,as intellectual-rational intelligence,emotional intelligence and especially quantum or spiritual intelligence—as it is known in the United *** article presents a SWOT analysis of the need and urgency of immediate application of skills and competencies in Romania,EU,and non-EU countries.

关键词： competences types of intelligence formal education EQF SWOT analysis

Particular evolution in a 72-year-old diabetic patient with acute coronary syndrome

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Journal of Geriatric Cardiology 2018年第7期15卷 523-526页

作者： gabriela S Gheorghe Ana Clobanu Ioan T Nanea Andreea S Serban Mihaela R Mititelu Department of Internal Medicine and Cardiology "Theodor Burghele" Clinical Hospital "Carol Davila " University of Medicine and Pharmacy Bucharest Romania Nuclear Medicine Department "Dr. Carol Davila " Central Emergency Military Clinical Hospital Bucharest Romania

Diabetes mellitus is an important risk factor for coronary atherosclerosis and many patients present extensive coronary stenosis at coronarography. However, in patients with diabetes, endothelial and microvascular dysfunction also participate in chronic and acute myocardial ischemia. Although the majority of diabetic patients with myocardial infarction have angiographic evidence of significant coronary artery disease.

关键词： Diabetes Elderly Myocardial infarction

Efficient visual learning by bumble bees in virtual-reality conditions:Size does not matter

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Insect Science 2023年第6期30卷 1734-1748页

作者： Gregory Lafon Marco Paoli Benjamin HPaffhausen gabriela de Brito Sanchez Mathieu Lihoreau Aurore Avarguès-Weber Martin Giurfa Centre de Recherches sur la Cognition Animale Centre de Biologie Intégrative(CBI)University of ToulouseCNRSUPSToulouseFrance French Academy of Sciences for University Professors Institut Universitaire de France(IUF)ParisFrance

Recent developments allowed establishing virtual-reality (VR) setups to study multiple aspects of visual learning in honey bees under controlled experimental conditions. Here, we adopted a VR environment to investigate the visual learning in the buff-tailed bumble bee Bombus terrestris. Based on responses to appetitive and aversive reinforcements used for conditioning, we show that bumble bees had the proper appetitive motivation to engage in the VR experiments and that they learned efficiently elemental color discriminations. In doing so, they reduced the latency to make a choice, increased the proportion of direct paths toward the virtual stimuli and walked faster toward them. Performance in a short-term retention test showed that bumble bees chose and fixated longer on the correct stimulus in the absence of reinforcement. Body size and weight, although variable across individuals, did not affect cognitive performances and had a mild impact on motor performances. Overall, we show that bumble bees are suitable experimental subjects for experiments on visual learning under VR conditions, which opens important perspectives for invasive studies on the neural and molecular bases of such learning given the robustness of these insects and the accessibility of their brain.

关键词： Bombus terrestris bumble bees interindividual size/weight differences reinforcement responses visual learning virtual reality

The Study of the Influence of the Froude Criterion and of the Thermal Regime upon the Quality of the Granular Frozen Products by the Process of Fluidization

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Journal of Mechanics Engineering and Automation 2020年第4期10卷 120-127页

作者： Mihaela-gabriela Chirilă Technological High School“Simion Mehedinți” The Department of Food Science and EngineeringUniversity“Dunarea de Jos”GalaţiGalați 800344Romania

In the first part of the research,it was shown that the main factors that are responsible for the quality of the granular food products frozen using the fluidization method,are the size and the shape of the product that is exposed to the freezing by fluidization process,the heat transfer coefficients,the temperature,and the speed of the fluidization *** these factors are responsible for the size and the distribution of the ice crystals that are formed during the freezing *** qualitative characteristic that is modified after the freezing by fluidization process is the structural-textural stiffness.

关键词： Quality granular products fluidization thermal regime

Interaction between Spermatozoa and the Different Epithelia along the Female Reproductive Tract of Mustelus schmitti

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Journal of Life Sciences 2015年第3期9卷 111-119页

作者： Femanda gabriela Elias Departamento de Biologia Bioquimica y Farmacia Universidad Nacional del Sur Bahia Blanca San Juan 670-8000 Argentina

The presence of sperm was observed in different organs of the reproductive tract of M. schmitti. These were the club, baffle and terminal zone of the oviducal gland, posterior portion of the uterus and in the cervix. This fact allowed for consideration not only its storage but its interaction with the female reproductive tract epithelia as well. SEM （microscopic observation studies） detected loose and sole spermatozoa in the club and baffle zones in a pregnant female. On the other hand, histochemical techniques showed sperm storage tubules of the terminal zone, which contain bundles of sperm, do not stain AB （alcian blue） or PAS （periodic acid schiff）. Disintegration of some of the male gametes was observed in the posterior part of the uterus with TEM （transmission electron microscopy） studies which would indicate a first uterine sperm selection. The uterine epithelial cells involved in this process showed an important level of secretion vacuoles suggesting an interaction with sperm cells. Sperm in the cervix was found without the matrix that constitutes the spermatozeugmata formed in the male tract. Some heads of the sperm were uncurled while they were interacting with the cervical cells.

关键词： Sperm uterine epithelium oviducal gland chondrichthyes.