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Influence of olive oil and its components on mesenchymal stem cell biology

World Journal of Stem Cells 2019年第12期11卷 1045-1064页

作者： Antonio Casado-Díaz gabriel dorado Jose Manuel Quesada-Gómez CIBER de Fragilidad y Envejecimiento Saludable(CIBERFES) Instituto Maimónides de Investigación Biomédica de Córdoba(IMIBIC)Hospital Universitario Reina SofíaCórdoba 14004Spain Departement Bioquímica y Biología Molecular Campus Rabanales C6-1-E17Campus de Excelencia Internacional Agroalimentario(ceiA3)Universidad de CórdobaCIBERFESCórdoba 14071Spain Unidad de Gestión Clínica de Endocrinología y Nutrición CIBER de Fragilidad y Envejecimiento Saludable(CIBERFES)Instituto Maimónides de Investigación Biomédica de Córdoba(IMIBIC)Hospital Universitario Reina SofíaCórdoba 14004Spain

Extra virgin olive oil is characterized by its high content of unsaturated fatty acid residues in triglycerides,mainly oleic acid,and the presence of bioactive and antioxidant *** consumption is associated with lower risk of suffering chronic diseases and unwanted processes linked to aging,due to the antioxidant capacity and capability of its components to modulate cellular signaling *** of olive oil can alter the physiology of mesenchymal stem cells(MSCs).This may explain part of the healthy effects of olive oil consumption,such as prevention of unwanted aging *** date,there are no specific studies on the action of olive oil on MSCs,but effects of many components of such food on cell viability and differentiation have been *** objective of this article is to review existing literature on how different compounds of extra virgin olive oil,including residues of fatty acids,vitamins,squalene,triterpenes,pigments and phenols,affect MSC maintenance and differentiation,in order to provide a better understanding of the healthy effects of this ***,most studies have shown a positive effect of these compounds on *** collective findings support the hypothesis that at least part of the beneficial effects of extra virgin olive oil consumption on health may be mediated by its effects on MSCs.

关键词： Olive oil Mesenchymal stem cells Cellular differentiation Aging Cellular niche Mediterranean diet

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Role of hypoxia preconditioning in therapeutic potential of mesenchymal stem-cell-derived extracellular vesicles

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World Journal of Stem Cells 2022年第7期14卷 453-472页

作者： Victoria Pulido-Escribano Bárbara Torrecillas-Baena Marta Camacho-Cardenosa gabriel dorado MaríaÁngeles Gálvez-Moreno Antonio Casado-Díaz Unidad de Gestión Clínica de Endocrinología y Nutrición-GC17 Instituto Maimónides de Investigación Biomédica de CórdobaHospital Universitario Reina SofíaCórdoba 14004Spain Dep.Bioquímica y Biología Molecular Campus Rabanales C6-1-E17Campus de Excelencia Internacional Agroalimentario(ceiA3)Universidad de CórdobaCIBERFESCórdoba 14071Spain

The use of mesenchymal stem-cells(MSC)in cell therapy has received considerable attention because of their *** properties include high expansion and differentiation in vitro,low immunogenicity,and modulation of biological processes,such as inflammation,angiogenesis and ***,the regenerative effect of MSC is partly due to their paracrine *** has prompted numerous studies,to investigate the therapeutic potential of their secretome in general,and specifically their extracellular vesicles(EV).The latter contain proteins,lipids,nucleic acids,and other metabolites,which can cause physiological changes when released into recipient ***,contents of EV can be modulated by preconditioning MSC under different culture *** them,exposure to hypoxia stands out;these cells respond by activating hypoxia-inducible factor(HIF)at low O_(2) *** has direct and indirect pleiotropic effects,modulating expression of hundreds of genes involved in processes such as inflammation,migration,proliferation,differentiation,angiogenesis,metabolism,and cell *** of these genes is reflected in the contents of secreted ***,numerous studies show that MSC-derived EV conditioned under hypoxia have a higher regenerative capacity than those obtained under *** this review,we show the implications of hypoxia responses in relation to tissue *** addition,hypoxia preconditioning of MSC is being evaluated as a very attractive strategy for isolation of EV,with a high potential for clinical use in regenerative medicine that can be applied to different pathologies.

关键词： Cell priming Extracellular vesicles Hypoxia Hypoxia-inducible factor Mesenchymal stemcells Regenerative medicine

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Modelling fuel loads of understorey vegetation and forest floor components in pine stands in NW Spain

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Forest Ecosystems 2022年第6期9卷 775-789页

作者： Jose A.Vega Stefano Arellano-Perez Juan gabriel Alvarez-Gonzalez Cristina Fernandez Enrique Jimenez Pedro Cuinas Jose María Fernandez-Alonso Daniel J.Vega-Nieva Fernando Castedo-dorado Cecilia Alonso-Rego Teresa Fontúrbel Ana Daría Ruiz-Gonzalez Centro de Investigacion Forestal de Lourizan PO Box 12736080PontevedraSpain Unidad de Gestion Ambiental y Forestal Sostenible(UXAFORES) Departamento de Ingeniería AgroforestalEscuela Politecnica Superior de IngenieríaUniversidad de Santiago de CompostelaCampus Universitario s/n27002LugoSpain Facultad de Ciencias Forestales Universidad Juarez del Estado de DurangoRío Papaloapan y Blvd.Durango s/nCol.Valle del Sur34120DurangoMexico Departamento de Ingeniería y Ciencias Agrarias Universidad de LeonCampus de Ponferrada24401PonferradaSpain

In this study,310 destructively sampled plots were used to develop two equation systems for the three main pine species in NW Spain(***;*** and ***):one for estimating loads of understorey fuel components by size and condition(live and dead)and another one for forest floor *** systems of equations were simultaneously fitted for estimating fuel loads using overstorey,understorey and forest floor variables as *** systems of equations included both the effect of pine species and the effect of understorey compositions dominated by ferns-brambles or by woody species,due to their obvious structural and physiological *** general,the goodness-of-fit statistics indicated that the estimates were reasonably robust and accurate for all of the fuel *** best results were obtained for total understorey vegetation,total forest floor and raw humus fuel loads,with more than 76%of the observed variability explained,whereas the poorest results were obtained for coarse fuel loads of understory vegetation with a 53%of observed variability *** reduce the overall costs associated with the field inventories necessary for operational use of the models,the additive systems were fitted again using only overstorey variables as potential *** relationships for fine(<6 mm)and total understorey vegetation and total forest floor fuel loads were obtained,indicating the complexity of the forest overstorey-understorey and overstorey-forest floor ***,these models explained around 52%of the observed ***,equations estimating the total understorey vegetation and the total forest floor fuel loads based only on canopy cover were *** models explained only 26%-32%of the observed variability;however,their main advantage is that although understorey vegetation in forested landscapes is largely invisible to remote sensing,canopy cover can be estimated with moderate accuracy,allowin

关键词： Area-based approach Additive equation systems Live and dead fine fuel Pinus pinaster Pinus radiata Pinus sylvestris

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Robust Soil Quality Index for Tropical Soils Influenced by Agricultural Activities

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Journal of Agricultural Chemistry and Environment 2017年第4期6卷 199-221页

作者： Jesus gabriel Rangel-Peraza Edith Padilla-Gasca Rosalía López-Corrales Jaime Rochín Medina Yaneth Bustos-Terrones Leonel Ernesto Amabilis-Sosa Abraham Efraim Rodríguez-Mata Tomás Osuna-Enciso Instituto Tecnológico de Culiacán Departamento de Ing Ambiental Juan de Dios Batiz 310 Col. Guadalupe Culiacán Mexico CONACYT-Instituto Tecnológico de Culiacán Juan de Dios Bátiz 310. Col. Guadalupe P.C. 80220 Culiacán Sinaloa México Centro de Investigación en Alimentación y Desarrollo A. C. Carretera Culiacán-El Dorado Km. 5.5 C.P. 80129 Culiacán México

The knowledge of the soil quality plays a vital role in the agricultural sector. Despite its importance, there is scarce scientific information concerning this regard. The objective of this research is to develop a methodology to identify and select the most appropriate indicators of Soil Quality Index (SQI) in a region with high agricultural activity. For its conformation, a descriptive statistical analysis and a Pearson correlation matrix were performed and the indicators that showed greater variation were identified using a Principal Components Analysis (PCA). A sensitivity analysis was carried out and the most sensible soil indicators of?SQI?were identified. This statistical procedure was also used to specify the weights of the indicators in?SQI. The variables resulting from the multiparametric statistical analysis were pH, organic matter, sodium, calcium, iron, zinc, cation exchange capacity and electrical conductivity. The robustness of the?SQI?obtained in this study was demonstrated through simulations carried out by the numerical optimization through simplex method. The Soil Quality Index range obtained (0.54 - 0.75) locates Culiacan Valley soils as moderate/high quality.

关键词： Principal Components Analysis Soil Quality Index Pearson Correlation Soil Quality Indicators Sensitivity Analysis

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