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Antisalmonellal and antioxidant potential of hydroethanolic extract of Canarium schweinfurthii Engl.(Burseraceae) in Salmonella enterica serovar Typhimurium-infected chicks

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Asian Pacific Journal of Tropical Biomedicine 2019年第11期9卷 474-483页

作者： Jean Baptiste Sokoudjou Siméon Pierre Chegaing Fodouop Flavie Gaelle Djoueudam Norbert Kodjio JeanRaphael Kana Alain Bertrand Fowa gabriel tchuente kamsu Donatien Gatsing Microbiology and Antimicrobial Substances Research Unit Faculty of ScienceUniversity of DschangCameroon Department of Biomedical Sciences University of NgaoundéréCameroon Animal Production and Nutrition Research Unit Faculty of Agronomy and Agricultural SciencesUniversity of DschangCameroon

Objective:To evaluate the anti-infectious and antioxidant activities of hydroethanolic extract of Canarium schweinfurthii on broiler chickens infected by Salmonella enterica serovar Typhimurium,known to be threatening public ***:Animals were divided into six groups of eight animals per group:the normal control group,negative control group,positive control group and three test groups receiving the plant extract at 5,19 and 75 mg/kg bw,*** evolution of the disease as well as the effectiveness of the treatment were monitored by stool culture from the second day post infection until the end of the *** addition,the effects of treatment on growth performances and feed conversion efficiency of broilers were *** the assessment of antioxidant status,enzymatic and non-enzymatic biomarkers such as catalase,glutathione peroxidase,malondialdehyde and nitric oxide were evaluated in the serum and tissues of ***:The infected chickens treated with oxytetracycline recovered on day 7 after treatment,while animals treated with 19 and 75 mg/kg of Canarium schweinfurthii extract recovered on day 9 and those with 5 mg/kg of the extract on day *** infection caused a decrease on catalase and glutathione peroxidase activities;the administration of various doses of Canarium schweinfurthii extract increased these enzymatic *** receiving the extract at 5 mg/kg showed a significant increase in catalase activity in serum,heart and lungs while all concentrations of the extract significantly increased glutathione peroxidase activity in the serum,liver and *** non-enzymatic biomarkers,Salmonella infection caused a significant increase of nitric oxide and malondialdehyde concentration in the liver and *** with 75 mg/kg of the extract significantly reduced nitric oxide concentration in the heart and lungs while each dose of the extract reduced and normalized the malondialdehyde level in the serum.A

关键词： Avian salmonellosis Antisalmonellal efficacy Canarium schweinfurthii Salmonella Typhimurium Antioxidant activity

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Synthesis, Structural Characterization and Antimicrobial Activity of a Novel Cobalt(II) Complex Based on 3-Methyl-1-Phenyl-4-(2-Thienoyl)-Pyrazol-5-One

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Journal of Modern Physics 2023年第8期14卷 109-126页

作者： Emeline Sorelle Mefouegang Claudelle Sybilline Anensong Djadock Golngar Djimassingar gabriel tchuente kamsu Donald Raoul Tchuifon Tchuifon Alain Charly Tagne Kuate Dirk Bockfeld Jean Ngoune Research Unit of Noxious Chemistry and Environmental Engineering Department of Chemistry Faculty of Science University of Dschang Dschang Cameroon Department of Fundamental Sciences Mongo Polytechnique University Institute (IUPM) Mongo Chad Research Unit of Microbiology and Antimicrobial Substances Department of Biochemistry Faculty of Science University of Dschang Dschang Cameroon Department of Process Engineering Laboratory of Energy Materials Modeling and Method National Higher Polytechnic School of Douala University of Douala Douala Cameroon Institute of Inorganic and Analytical Chemistry Technical University of Braunschweig Braunschweig Germany

New cobalt(II) complex, [Co(O2C15H11N2S)2(OH2)2]∙2H2O (1∙2H2O), has been synthesized upon reaction of cobalt chloride hexahydrate (Co(Cl)2∙6H2O) with 3-methyl-1-Phenyl-4-(2-thienoyl)-pyrazol-5-one (referred as HL) in ethanol at room temperature. Single crystal X-ray diffraction (XRD), spectroscopic methods, and microelemental analyses were used to characterize 1∙2H2O. Compound 1∙2H2O crystallizes in the orthorhombic crystal system with a Pbca space group and with the cobalt atom being pseudo-octahedral coordinated. The broth microdilution technique was used to screen the free ligand (HL) and the complex (1∙2H2O) for antimicrobial activities. HL has a low activity (MIC > 100 μg/mL) on all microorganisms, whereas compound 1∙2H2O displayed moderate activity (10 ∙2H2O exhibited bactericidal and fungicidal activity respectively on all the bacteria and yeasts tested. These findings reveal that the antimicrobial activity of HL was enhanced upon coordination to Co(II) ion against all microorganisms (bacteria and fungus).

关键词： Cobalt Acylpyrazolone X-Ray Diffraction Antimicrobial Activity 3-Methyl-1-Phenyl-4-(2-Thienoyl)-Pyrazol-5-One

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<i>Fusarium lini</i>Potential for the Biotransformation of Norandrostenedione and Evaluation of Urease and Chymotrypsin Properties of the Transformed Products

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Advances in Biological Chemistry 2021年第2期11卷 65-77页

作者： Simeon Pierre Chegaing Fodouop Alex Doris Kengni Mboussaah Didiane Yemele Mefokou Alain Bertrand Fowa Mahwish Siddiqui gabriel T. kamsu Donatien Gatsing Muhammad Iqbal Choudhary Research Unit of Metabolic and Infectious Diseases Department of Biomedical Sciences Faculty of Science University of Ngaoundéré Ngaoundéré Cameroon H.E.J. Research Institute of Chemistry International Center for Chemical and Biological Sciences University of Karachi Karachi Pakistan Research Unit of Applied Chemistry Department of Chemistry Faculty of Science University of Dschang Dschang Cameroon Research Unit of Microbiology and Antimicrobial Substances Department of Biochemistry Faculty of Science University of Dschang Dschang Cameroon International Center for Chemical and Biological Sciences University of Karachi Karachi Pakistan

Several androgenic steroids have been biotransformed by fungi into metabolites with numerous biological properties. Incubation of norandrostenedione (1) with Fusarium lini NRRL 2204 was carried out for the first time, yielding two new metabolites, 3,7β-dihydroxy-19-norandrost-1,3,5-trien-17-one (3) and 6α,10β,17β-trihydroxy-19-nor-4-androsten-3-one (4), along with three known compounds, 3-hydroxy-19-norandrost-1,3,5-trien-17-one (2), 10β,

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Antibacterial Effects of Ethanolic Extract of Zehneria scabra on Quails Artificially Infected with Salmonella Enteritidis

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Journal of Pharmacy and Pharmacology 2021年第11期9卷 387-396页

作者： Herman M.F Biekop Marc K Kouam Vivian Yengeh gabriel T kamsu Bridget Katte Alexis Teguia Biekop Herman Department of Animal Science Faculty of Agronomy and Agricultural SciencesPO BOX 188DschangCameroon Center for Research on Filariases and other Tropical Diseases(CRFilMT) P.O.Box 5797YaoundéCameroon Microbiology and Antimicrobial Substances Research Unit Faculty of ScienceUniversity of DschangCameroon 不详

Antimicrobial use in livestock is faced with various challenges including emergence of antimicrobial resistance and presence of drug residues in meat products,hence the need for *** aim of this work was to assess the effect a plant(Zehneria scabra)extract on Salmonella infected quails,as an alternative to antibiotic *** were randomly assigned into six groups each containing twelve *** neutral control(T0)group was not infected and received tap water whereas other groups were *** negative control(T-)received tap *** positive control(T+)received a single dose of oxytetracycline(20 mg/kg).T1,T2 andT3 orally received the plant extract at the following respective doses:9,18 and 37 mg/*** were infected by oral administration of a single dose of Salmonella Enteritidis(10^(5)CFU).Haematological and biochemical parameters were *** day 2 to day 9 to day 16,the bacterial load of all treatment groups(T+,T1,T2,T3)*** infection resulted in a significant(p<0.05)increase in serum levels of alanine aminotransferase,triglycerides,total cholesterol and white blood cells,and a significant decrease in the liver and kidney protein *** treatment resulted in the correction of the aforementioned *** plant extract(18 mg/kg)is as effective as oxytetracycline,and can be safely used in phytomedicine for the treatment of Salmonella Enteritidis infection without kidney and liver damage.

关键词： Zehneria scabra Salmonella Enteritidis antisalmonellal activity quails

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