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Computer Modeling in Engineering & Sciences 2025年第1期142卷 501-530页

作者： Khuram Ali Khan Saba Mubeen Ishfaq Atiqe Ur Rahman Salwa el-Morsy Department of Mathematics University of SargodhaSargodha40100Pakistan Department of Mathematics University of Management and TechnologyLahore54000Pakistan Department of Mathematics College of ScienceQassim UniversityBuraydah51452Saudi Arabia

Due to the numerous variables to take into account as well as the inherent ambiguity and uncertainty,evaluating educational institutions can be *** concept of a possibility Pythagorean fuzzy hypersoft set(pPyFHSS)is more flexible in this regard than other theoretical fuzzy set-like models,even though some attempts have been made in the literature to address such *** study investigates the elementary notions of pPyFHSS including its set-theoretic operations union,intersection,complement,OR-and *** results related to these operations are also modified for ***,the similarity measures between pPyFHSSs are formulated with the assistance of numerical examples and ***,an intelligent decision-assisted mechanism is developed with the proposal of a robust algorithm based on similarity measures for solving multi-attribute decision-making(MADM)problems.A case study that helps the decision-makers assess the best educational institution is discussed to validate the suggested *** algorithmic results are compared with the most pertinent model to evaluate the adaptability of pPyFHSS,as it generalizes the classical possibility fuzzy set-like theoretical ***,while considering significant evaluating factors,the flexibility of pPyFHSS is observed through structural comparison.

关键词： Hypersoft set Pythagorean fuzzy hypersoft set computational complexity multi-attribute decision-making optimization similarity measures uncertainty

Solid Waste Management:A MADM Approach Using Fuzzy Parameterized Possibility Single-Valued Neutrosophic Hypersoft Expert Settings

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 531-553页

作者： Tmader Alballa Muhammad Ihsan Atiqe Ur Rahman Noorah Ayed Alsorayea Hamiden Abd el-Wahed Khalifa Department of Mathematics College of SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia 2 Department of Mathematics University of Management and TechnologyLahore54000Pakistan Department of Mathematics College of ScienceQassim UniversityBuraydah51452Saudi Arabia

The dramatic rise in the number of people living in cities has made many environmental and social problems *** search for a productive method for disposing of solid waste is the most notable of these *** scholars have referred to it as a fuzzy multi-attribute or multi-criteria decision-making problem using various fuzzy set-like approaches because of the inclusion of criteria and anticipated *** goal of the current study is to use an innovative methodology to address the expected uncertainties in the problem of solid waste site *** characteristics(or sub-attributes)that decision-makers select and the degree of approximation they accept for various options can both be indicators of these *** tackle these problems,a novel mathematical structure known as the fuzzy parameterized possibility single valued neutrosophic hypersoft expert set(ρˆ-set),which is initially described,is integrated with a modified version of Sanchez’s *** this,an intelligent algorithm is *** steps of the suggested algorithm are explained with an example that explains *** compatibility of solid waste management sites and systems is discussed,and rankings are established along with detailed justifications for their *** study’s strengths lie in its application of fuzzy parameterization and possibility grading to effectively handle the uncertainties embodied in the parameters’nature and alternative approximations,*** uses specific mathematical formulations to compute the fuzzy parameterized degrees and possibility grades that are missing from the prior *** is simpler for the decisionmakers to look at each option separately because the decision is *** the computed results,it is discovered that they are consistent and dependable because of their preferred properties.

关键词： Hypersoft expert set Sanchez’s method decision making optimization solid waste management possibility grade fuzzy parameterization

Synthesis, in vitro antitumor activity and molecular modeling studies of a new series of benzothiazole Schiff bases

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Chinese Chemical Letters 2016年第3期27卷 380-386页

作者： Moustafa T.gabr Nadia S.el-Gohary Eman R.el-Bendary Mohamed M.el-Kerdawy Nanting Ni Department of Medicinal Chemistry Faculty of Pharmacy Mansoura University Mansoura 35516 Egypt Department of Chemistry Ceorgia State University Atlanta CA 30303 USA

A new series of benzothiazole Schiff bases 3–29 was synthesized and screened for antitumor activity against cervical cancer（Hela） and kidney fibroblast cancer（COS-7） cell lines. Results indicated that compounds 3, 14, 19, 27 and 28 have promising activity against Hela cell line with IC50 values of 2.41,3.06, 6.46, 2.22 and 6.25 mmol/L, respectively, in comparison to doxorubicin as a reference antitumor agent（IC50 2.05 mmol/L）. In addition, compound 3 displayed excellent activity against COS-7 cell line with IC50 value of 4.31 mmol/L in comparison to doxorubicin（IC50 3.04 mmol/L）. In the present work,structure based pharmacophore mapping, molecular docking, protein-ligand interaction, fingerprints and binding energy calculations were employed in a virtual screening strategy to identify the interaction between the compounds and the active site of the putative target, EGFR tyrosine kinase. Molecular properties, toxicity, drug-likeness, and drug score profiles of compounds 3, 14, 19, 27, 28 and 29 were also assessed.

关键词： Benzothiazole Schiff bases Antitumor activity Molecular modeling In silico studies

Synthesis,antimicrobial, antiquorum-sensing and cytotoxic activities of new series of benzothiazole derivatives

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Chinese Chemical Letters 2015年第12期26卷 1522-1528页

作者： Moustafa T.gabr Nadia S.el-Gohary Eman R.el-Bendary Mohamed M.el-Kerdawy Nanting Ni Mona I.Shaaban Department of Medicinal Chemistry Faculty of Pharmacy Mansoura University Department of Chemistry Georgia State University Department of Microbiology Faculty of Pharmacy Mansoura University Department of Microbiology College of Pharmacy Taibah University

New series of benzothiazole derivatives were designed and synthesized. The newly synthesized compounds were screened for their antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus cereus. Compounds 6j and 6o showed the highest activity against E. coli and S. aureus. The antifungal activity of these compounds was also tested against Candida albicans and Aspergillus fumigatus293. Compounds 4c, 4g and 6j exhibited the highest activity against C. albicans. In addition, compounds4 a and 6j displayed promising activity against A. fumigatus 293. The same compounds were examined for their antiquorum-sensing activity against Chromobacterium violaceum ATCC 12472, whereas compounds4 a, 6j and 6p showed moderate activity. The in vitro cytotoxicity testing of the synthesized compounds was performed against cervical cancer（Hela） and kidney fibroblast cancer（COS-7） cell lines. Results indicated that all tested compounds have IC50 values 〉50 mmol/L against both cell lines. Molecular properties, toxicities, drug-likeness, and drug score profiles of compounds 4a–c, 5a, 6g,h, 6j, 6l, 6o and7 c,d were also assessed.

关键词： antibacterial moiety antifungal antimicrobial cytotoxic screened moderate substituent Candida albicans

Predicting resilient modulus of recycled concrete and clay masonry blends for pavement applications using soft computing techniques

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Frontiers of Structural and Civil Engineering 2019年第6期13卷 1379-1392页

作者： Mosbeh R.KALOOP Alaa R.gabr Sherif M.el-BADAWY Ali ARISHA Sayed SHWALLY Jong Wan HU Department of Civil and Environmental Engineering Incheon National UniversityIncheon 22012South Korea Incheon Disaster Prevention Research Center Incheon National UniversityIncheon 22012South Korea Department of Public Works and Civil Engineering Mansoura UniversityMansoura 35516Egypt

To date,very few researchers employed the Least Square Support Vector Machine(LSSVM)in predicting the resilient modulus(Mr)of Unbound Granular Materials(UGMs).This paper focused on the development of a LSSVM model to predict the MT of recycled materials for pavement applications and comparison with other different models such as Regression,and Artificial Neural Network(ANN).Blends of Recycled Concrete Aggregate(RCA)with Recycled Clay Masonry(RCM)with proportions of 100/0,90/10,80/20,70/30,55/45,40/60,20/80,and 0/100 by the total aggregate mass were evaluated for use as ***/RCM materials were collected from dumps on the sides of roads around Mansoura city,*** investigated blends were evaluated experimentally by routine and advanced tests and the Mr values were detennined by Repeated Load Triaxial Test(RLTT).Regression,ANN,and LSSVM models were utilized and compared in predicting the Mr of the investigated blends optimizing the best design *** showed that the Mx values of the investigated RCA/RCM blends were generally increased with the decrease in RCM *** analyses were utilized for evaluating the performance of the developed models and the inputs sensitivity ***,the results approved that the LSSVM model can be used as a novel tool to estimate the Mx of the investigated RCA/RCM blends.

关键词： Least Square Support Vector Machine Artificial Neural Network resilient modulus Recycled Concrete Aggregate Recycled Clay Masonry

Efficacy of two chemical coagulants and three different filtration media on removal of Aspergillus flavus from surface water

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Journal of Environmental Sciences 2014年第2期26卷 274-280页

作者： Hamid Mohammad Al-gabr Tianling Zheng Xin Yu Key Laboratory of Urban Environment and Health Institute of Urban Environment Chinese Academy of Sciences State Key Laboratory of Marine Environmental Science and Key Laboratory of MOE for Coast and Wetland Ecosystems School of Life SciencesXiamen University

Aquatic fungi are common in various aqueous environments and play potentially crucial roles in nutrient and carbon cycling as well as interacting with other organisms. Species of Aspergillus are the most common fungi that occur in water. The present study was undertaken to elucidate the efficacy of two coagulants, aluminum sulfate and ferric chloride, used at different concentrations to treat drinking water, in removing Aspergillusflavus, as well as testing three different filtration media： sand, activated carbon, and ceramic granules, for their removal of fungi from water. The results revealed that both coagulants were effective in removing fungi and decreasing the turbidity of drinking water, and turbidity decreased with increasing coagulant concentration. Also, at the highest concentration of the coagulants, A. flavus was decreased by 99.6% in the treated water. Among ceramic granules, activated carbon, and sand used as media for water filtration, the sand and activated carbon filters were more effective in removing *** than ceramic granules while simultaneously decreasing the turbidity levels in the test water samples. Post-treatment total organic carbon （TOC） and total nitrogen （TN） concentrations in the experimental water did not decrease; on the contrary, TN concentrations increased with the increasing dosage of coagulants. The filtration process had no effect in reducing TOC and TN in tested water.

关键词： Aspergillus flavus coagulation filtration drinking water

Emerging small-molecule therapeutic approaches for Alzheimer's disease and Parkinson's disease based on targeting microRNAs

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Neural Regeneration Research 2022年第2期17卷 336-337页

作者： Somaya A.Abdelrahman Moustafa T.gabr Department of Medicinal Chemistry Faculty of PharmacyMansoura UniversityMansouraEgypt Department of Radiology Stanford University School of MedicineStanfordCAUSA

The role of micro RNAs in the progression of neurodegenerative diseases: Micro RNAs(mi RNAs) are endogenous, non-coding and short RNA nucleotides that regulate gene expression through base pairing with the targeted me... 详细信息

关键词： endogenous Alzheimer diseases

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar el Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Multitarget therapeutic strategies for Alzheimer's disease

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Neural Regeneration Research 2019年第3期14卷 437-440页

作者： Mostafa M.Ibrahim Moustafa T.gabr Department of Pharmacognosy Faculty of Pharmacy Mansoura University Department of Basic Pharmaceutical and Toxicological Sciences College of Pharmacy University of Louisiana at Monroe Department of Medicinal Chemistry Faculty of Pharmacy Mansoura University Department of Chemistry University of Iowa

Neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's diseases have multifaceted nature because of the different factors contributing to their progression. The complex nature of neurodegenerative diseases has developed a pressing need to design multitarget-directed ligands to address the complementary pathways involved in these diseases. The major enzyme targets for development of therapeutics for Alzheimer's disease are cholinesterase and β-secretase enzymes. In this review, we discuss recent advances in profiling single target inhibitors based on these enzymes to multitarget-directed ligands as potential therapeutics for this devastating disease. In addition, therapeutics based on iron chelation strategy are discussed as well.

关键词： multitarget-directed ligands acetylcholinesterase β-secretase Alzheimer's disease hybridization neurodegenerative diseases tacrine brain permeability

Valorization of sustainable vegetable oil deodorizer distillate as a novel fatliquor

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Collagen and Leather 2023年第3期5卷 60-72页

作者： el-Shahat H.A.Nashy Adel gabr Abdel-Razek Minar Mahmoud M.Hassanein Ghada A.Abo-elwafa Hamed elsayed Chemical Industries Research Institute National Research CentreDokkiCairo 12622Egypt Department of Fats and Oils National Research CentreDokkiCairo 12622Egypt

The deodorizer distillate(DD)is a byproduct of vegetable oil processing industry and is rich in functional bioactive *** study aimed to employ phosphorylation modification for DD to produce a new sustainable *** bioactive ingredients in DD,namely fatty acids,sterols,and tocopherols,were determined by using HPLC and *** results revealed that the DD sample contained a high percentage of unsaturated fatty acids(72.3%)and high levels ofγandδ-tocopherols(54.8%and 31.60%,respectively).Mechanical parameters(tensile strength,elongation at break,and tear strength)of leather were improved after being treated with the prepared fatliquor ***,SEM showed that the texture of the fatliquored leather had been remarkably ***,the fatliquored leather possessed effective antibacterial effect against the specified+ve,-ve bacteria,and Candida albicans *** strength,fullness,soft handle,and elasticity of leather were all improved,and the grain of leather was protected from becoming loose after drying.

关键词： Vegetable oil Deodorizer distillate Bioactive components Fatliquor Phosphorylation Chrome tanned leather