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Inhibitory effects of methanolic Olea europaea and acetonic Acacia laeta on growth of Babesia and Theileria

Asian Pacific Journal of Tropical Medicine 2019年第9期12卷 425-434页

作者： Amany Magdy Beshbishy gaber el-saber batiha Oluyomi Stephen Adeyemi Naoaki Yokoyama Ikuo Igarashi Natonal Research Certer for Protocron Diseases Obihiro Uninersity of Agricnuture and Veterinary MedicineNishi 2-13Inada-choObihiroHolkkaido 080-8555Japan Department of Pharmacology and Therapeutics Faculy of Velerinary MedicineDamanhour UniersitDamonhour 22511Al BeheiraEgpt Medicinal Biochemistry Infectious DiseasesNanomedicine and Toricology LaboratoryDepurtment of BiochenmistryLandmarks UniversityOmu Aran 251101Kiuarc StateNigeria

Objective:To evaluate the antipiroplasmic activities of methanolic extract of Olea europaea(MOE)and acetonic extract of Acacia laeta(AAL)against Babesia and Theileria parasites in vitro and evaluate the chemotherapeutic effects of these extracts against Babesia(B.)microti in ***:Fluorescence assay using SYBR Green 1 nucleic acid stain was used to detect inhibitory effects of the two extracts as well as the combination effects of the two extracts with diminazene aceturate and atovaquone on four Babesia species and Theileria equi in vitro while for in vivo experiments,8-weekold female BALB/c mice were injected intraperitoneally with 1× 107 ***-iRBCs and treated orally at a dose of 150 mg/kg of both ***:The half maximal inhibitory concentration(IC50)values of AAL against ***,***,***,***,and Theileria equi were lower than those of MOE *** assay on Madin-Darby bovine kidney,mouse embryonic fibroblast(NIH/3T3),and human foreskin fibroblast cell lines showed that MOE and AAL affected only the viability of Madin-Darby bovine kidney cell line with half maximal effective concentrations(EC50)of(794.7±41.9)and(873.9±17.5)μg/mL,*** oral treatments of MOE and AAL at 150 mg/kg inhibited the growth of *** in mice by 80.4% and 64.4%,*** MOE and diminazene aceturate combination showed a higher chemotherapeutic effect than that of ***:MOE and AAL have the potential to be an alternative remedy for treating ***,the combination therapy of MOE + DA was more potent against *** infection in mice than their monotherapies.

关键词： Olea europaea Acacia laeta Babesia Theileria In vitro In vivo Inhibition

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