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Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease

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Neural Regeneration Research 2021年第4期16卷 775-779页

作者： ga.riela.va.ínová Daniela Vejražkova Robert Rusina Iva Holmerová Hana vaňková Eva Jarolímová Josef Včelák Běla Bendlová Markéta vaňková Department of Molecular Endocrinology Institute of EndocrinologyPragueCzech Republic Department of Anthropology and Human Genetics Faculty of ScienceCharles UniversityPragueCzech Republic Department of Neurology Third Faculty of Medicine of Charles University and Thomayer Hospital PragueCzech Republic II.Internal Medicine Clinic Third Faculty of MedicineCharles UniversityPragueCzech Republic Faculty of Humanitites Charles University PragueCzech Republic

Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic *** upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid *** in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a *** aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of *** levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(MTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the *** RANTES levels were not correlated with cognitive *** AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory *** levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOMA-R)and pancreatic beta cell function(HOMA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD *** levels of RANTES appear to be an interesting

关键词： Alzheimer’s disease biomarker central nervous system cognitive impairment inflammation RANTES

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Analyzing Changes in Maize Leaves Orientation due to GxExM Using an Automatic Method from RGB Images

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Plant Phenomics 2023年第2期5卷 239-252页

作者： Mario Serouart Raul Lopez-Lozano gaëtan Daubige Maëva Baumont Brigitte Escale Benoit De Solan Frédéric Baret Arvalis Institut du végétal228route de l’aérodrome-CS 4050984914 Avignon Cedex 9France INRAE Avignon UniversitéUMR EMMAHUMT CAPTE228route de l’aérodrome-CS 4050984914 Avignon Cedex 9France Arvalis Ecophysiology21 Chemin de Pau64121 MontardonFrance

The sowing pattern has an important impact on light interception efficiency in maize by determining the spatial distribution of leaves within the *** orientation is an important architectural trait determining maize canopies light *** studies have indicated how maize genotypes may adapt leaves orientation to avoid mutual shading with neighboring plants as a plastic response to intraspecific *** goal of the present study is 2-fold:firstly,to propose and validate an automatic algorithm(Automatic Leaf Azimuth Estimation from Midrib detection[ALAEM])based on leaves midrib detection in vertical red green blue(RGB)images to describe leaves orientation at the canopy level;and secondly,to describe genotypic and environmental differences in leaves orientation in a panel of 5 maize hybrids sowing at 2 densities(6 and 12 plants.m^(−2))and 2 row spacing(0.4 and 0.8 m)over 2 different sites in southern *** ALAEM algorithm was validated against in situ annotations of leaves orientation,showing a satisfactory agreement(root mean square[RMSE]error=0.1,R^(2)=0.35)in the proportion of leaves oriented perpendicular to rows direction across sowing patterns,genotypes,and *** results from ALAEM permitted to identify significant differences in leaves orientation associated to leaves intraspecific *** both experiments,a progressive increase in the proportion of leaves oriented perpendicular to the row is observed when the rectangularity of the sowing pattern increases from 1(6 plants.m^(−2),0.4 m row spacing)towards 8(12 plants.m^(−2),0.8 m row spacing).Significant differences among the 5 cultivars were found,with 2 hybrids exhibiting,systematically,a more plastic behavior with a significantly higher proportion of leaves oriented perpendicularly to avoid overlapping with neighbor plants at high *** in leaves orientation were also found between experiments in a squared sowing pattern(6 plants.m^(−2),0.4 m

关键词： cultivar spacing pattern

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Brazilian adolescents’lifestyle in the COVID‑19 pandemic:a mixed‑methods study

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World Journal of Pediatrics 2022年第8期18卷 553-557页

作者： Caroline Lima Fonseca Carolina Ferreira Peterle Bruna Hinnah Borges Martins de Freitas Maria Aparecida Munhoz gaíva Paula Manuela Jorge Diogo Juliano Bortolini Federal University of Mato Grosso 2367 Fernando Corrêa da Costa AvBoa EsperançaCuiabáMT 78060-900Brazil Lisbon College of Nursing LisbonPortugal

The COVID-19 pandemic has forced the health authorities and governments worldwide to engage in a battle against the disease,adopting several mitigation strategies[1].Since then,the world population has been afected by various changes in its *** imposed by the COVID-19 pandemic are believed to have had an impact on adolescents'lifestyle(LS)[2].The LS is determined by discernible behavior patterns that can trigger efects on adolescents'health and is related to countless aspects that refect attitudes,values and life opportunities[3].Therefore,LS can be observed from the habits,behaviors and activities performed by people in their daily lives[4].

关键词： has routine COV

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Toward development of ecosystem asset accounts at the national level

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Ecosystem Health and Sustainability 2019年第1期5卷 36-46,I0022页

作者： Dava vačkářů Ioanna Grammatikopoulou Department of Human Dimensions of Global Change Global Change Research Institute of the Czech Academy of SciencesBrnoCzech Republic

Ecosystem accounting has become one of the key components in the revision of international statistical *** of the System of Environmental-Economic Accounting for ecosystem services follows the rapid progress of science in this area as well as expanding applications to sustainability *** this contribution,we discuss approaches to accounting of ecosystem assets as a natural capital basis that is critical for ecosystem service *** on examples from the Czech Republic,a Central European country,we illustrate the construction of ecosystem extent accounts based on the methodology of Land and Ecosystem *** analysis is complemented by monetary ecosystem asset accounting through quantification of the present value of future ecosystem service *** condition is represented by the Mean Species Abundance indicator,which gauges the direction of ecosystem *** on the demonstration of approaches to ecosystem asset accounting,we discuss selected aspects of ecosystem condition measurements,valuation,and policy implications of ecosystem asset accounting at the national level.

关键词： Ecosystem accounting ecosystem services land cover change Mean Species Abundance value transfer Czech Republic

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Parallel Cloth Simulation Using OpenGL Shading Language

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Computer Systems Science & Engineering 2022年第5期41卷 427-443页

作者： Hongly va Min-Hyung Choi Min Hong Department of Software Convergence Soonchunhyang UniversityAsan31538Korea Department of Computer Science and Engineering University of Colorado DenverDenverCO 80217USA Department of Computer Software Engineering Soonchunhyang UniversityAsan31538Korea

The primary goal of cloth simulation is to express object behavior in a realistic manner and achieve real-time performance by following the fundamental concept of *** general,the mass–spring system is applied to real-time cloth simulation with three types of ***,hard spring cloth simulation using the mass–spring system requires a small integration time-step in order to use a large stiffness ***,to obtain stable behavior,constraint enforcement is used instead of maintenance of the force of each *** force computation involves a large sparse linear solving *** to the large computation,we implement a cloth simulation using adaptive constraint activation and deactivation techniques that involve the mass-spring system and constraint enforcement method to prevent excessive elongation of *** the same time,when the length of the spring is stretched or compressed over a defined threshold,adaptive constraint activation and deactivation method deactivates the spring and generate the implicit *** method that uses a serial process of the Central Processing Unit(CPU)to solve the system in every frame cannot handle the complex structure of cloth model in *** simulation utilizes the Graphic Processing Unit(GPU)parallel processing with compute shader in OpenGL Shading Language(GLSL)to solve the system *** this paper,we design and implement parallel method for cloth simulation,and experiment on the performance and behavior comparison of the mass-spring system,constraint enforcement,and adaptive constraint activation and deactivation techniques the using GPU-based parallel method.

关键词： Adaptive constraint cloth simulation constraint enforcement GLSL compute shader mass–spring system parallel GPU

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Real-time Volume Preserving Constraints for Volumetric Model on GPU

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Computers, Materials & Continua 2022年第10期73卷 831-848页

作者： Hongly va Min-Hyung Choi Min Hong Department of Software Convergence Soonchunhyang UniversityAsan31538Korea Department of Computer Science and Engineering University of Colorado DenverDenver80217COUSA Department of Computer Software Engineering Soonchunhyang UniversityAsan31538Korea

This paper presents a parallel method for simulating real-time 3D deformable objects using the volume preservation mass-spring system method on tetrahedron *** general,the conventional mass-spring system is manipulated as a force-driven method because it is fast,simple to implement,and the parameters can be ***,the springs in traditional mass-spring system can be excessively elongated which cause severe stability and robustness issues that lead to shape restoring,simulation blow-up,and huge volume loss of the deformable *** addition,traditional method that uses a serial process of the central processing unit(CPU)to solve the system in every frame cannot handle the complex structure of deformable object in ***,the first order implicit constraint enforcement for a mass-spring model is utilized to achieve accurate visual realism of deformable objects with tough constraint *** this paper,we applied the distance constraint and volume conservation constraints for each tetrahedron element to improve the stability of deformable object simulation using the mass-spring system and behave the same as its real-world *** reduce the computational complexity while ensuring stable simulation,we applied a method that utilizes OpenGL compute shader,a part of OpenGL Shading Language(GLSL)that executes on the graphic processing unit(GPU)to solve the numerical problems *** applied the proposed methods to experimental volumetric models,and volume percentages of all objects are *** average volume percentages of all models during the simulation using the mass-spring system,distance constraint,and the volume constraint method were 68.21%,89.64%,and 98.70%,*** proposed approaches are successfully applied to improve the stability of mass-spring system and the performance comparison from our experimental tests also shows that the GPU-based method is faster than CPU-based implementation for all cases.

关键词： Deformable object simulation mass-spring system implicit constraint enforcement volume conservation constraint GPU parallel computing

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Transit timing variations and linear ephemerides of confirmed Kepler transiting exoplanets

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Research in Astronomy and Astrophysics 2019年第3期19卷 79-84页

作者： Pavol gajdo? Martin vaňko ?tefan Parimucha Institute of Physics Faculty of Science Pavol Jozef šafárik University Astronomical Institute Slovak Academy of Sciences

We determine new linear ephemerides of transiting exoplanets using long-cadence de-trended data from quarters Q1 to Q17 of the Kepler mission. We analysed transit-timing variation(TTV) diagrams of 2098 extrasolar planets. The TTVs of 121 objects were excluded(because of insufficient datapoints, influence of stellar activity, etc.). Finally, new linear ephemerides of 1977 exoplanets from the Kepler archive are presented. A significant linear trend was observed on TTV diagrams of approximately 35% of the exoplanets studied. Knowing the correct linear ephemeris is key for successful follow-up observations of transits. Residual TTV diagrams of 64 analysed exoplanets show periodic variation, and 43 of these TTV planets were not previously reported.

关键词： stars planetary systems-eclipses-techniques photometric

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*-Regular Leavitt Path Algebras of Arbitrary Graphs

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Acta Mathematica Sinica,English Series 2012年第5期28卷 957-968页

作者： Gonzalo ARANDA PINO Kulumani RANgaSWAMY Lia va Departamento de lgebra Geometría y Topología Universidad de Mlaga Department of Mathematics University of Colorado Department of Mathematics Physics and Statistics University of the Sciences in Philadelphia

If K is a field with involution and E an arbitrary graph, the involution from K naturally induces an involution of the Leavitt path algebra LK（E）. We show that the involution on LK（E） is proper if the involution on K is positive-definite, even in the case when the graph E is not necessarily finite or row-finite. It has been shown that the Leavitt path algebra LK（E） is regular if and only if E is acyclic. We give necessary and sufficient conditions for LK（E） to be ＊-regular （i.e., regular with proper involution）. This characterization of ＊-regularity of a Leavitt path algebra is given in terms of an algebraic property of K, not just a graph-theoretic property of E. This differs from the known characterizations of various other algebraic properties of a Leavitt path algebra in terms of graph- theoretic properties of E alone. As a corollary, we show that Handelman＇s conjecture （stating that every ,-regular ring is unit-regular） holds for Leavitt path algebras. Moreover, its generalized version for rings with local units also continues to hold for Leavitt path algebras over arbitrary graphs.

关键词： Leavitt path algebra *-regular involution arbitrary graph

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Who will carry out the tests that would be necessary for proper safety evaluation of food emulsifiers?

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Food Science and Human Wellness 2019年第2期8卷 126-135页

作者： Katalin FCsáki∗ Éva Sebestyén National Food Chain Safety Office Directorate for Food Safety Risk AssessmentPO BOX 407H-1537 BudapestHungary

Surfactant food emulsifiers are among the most extensively used food *** all authorized food additives,emulsifiers have been evaluated by risk assessors,who consider them as ***,there are growing concerns among scientists about their possible harmful effects on intestinal barriers and *** is also suggested that emulsifier consumption might be one of the main causes of the rising incidence of a number of diseases,such as allergic diseases,celiac disease,type I diabetes and Crohn’s ***,it has recently been suggested that emulsifier consumption might contribute to the development of metabolic syndrome and can promote colitis-associated colorectal cancer *** paper provides an overview of the current scientific knowledge on possible effects of surfactant emulsifiers on intestinal barriers and also of regulatory risk assessment *** main objective is to reveal the reasons for the discrepancies between the opinions of risk assessors and the scientific *** would like to draw the attention of the academic world to the need of specific in vivo and/or clinical studies for each emulsifier in order to help risk assessors make adequate evaluations and rule out with certainty that authorized food emulsifiers pose a safety concern to consumers’health.

关键词： Food emulsifiers Surfactants Intestinal barriers Crohn’s diseases Microbiota Risk assessment EFSA

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Matrilin-2, an extracellular adaptor protein, is needed for the regeneration of muscle, nerve and other tissues

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Neural Regeneration Research 2015年第6期10卷 866-869页

作者： éva Korpos Ferenc Deák Ibolya Kiss Institute of Physiological Chemistry and Pathobiochemistry University of Muenster Cells-in-Motion Cluster of Excellence University of Muenster Institute of Biochemistry Biological Research CentreHungarian Academy of Sciences Avidin Ltd.

The extracellular matrix （ECM） performs essential functions in the differentiation, maintenance and remodeling of tissues during development and regeneration, and it undergoes dynamic changes during remodeling concomitant to alterations in the cell-ECM interactions. Here we discuss recent data addressing the critical role of the widely expressed ECM protein, matrilin-2 （Matn2） in the timely onset of differentiation and regeneration processes in myogenic, neural and other tissues and in tumorigenesis. As a multiadhesion adaptor protein, it interacts with other ECM proteins and integrins. Matn2 promotes neurite outgrowth, Schwann cell migration, neuromuscular junction formation, skeletal muscle and liver regeneration and skin wound healing. Matn2 deposition by myoblasts is crucial for the timely induction of the global switch toward terminal myogenic differentiation during muscle regeneration by affecting transforming growth factor beta/bone morphogenetic protein 7/Smad and other signal transduction pathways. Depending on the type of tissue and the pathomechanism, Math2 can also promote or suppress tumor growth.

关键词： Schwann cells neurite outgrowth neuromuscular junction (NM]) multiple sclerosis TGF-β/BMP-7/Smad signaling myogenic differentiation Trf3 tumor suppression

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