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A Novel Approach to Breast Tumor Detection: Enhanced Speckle Reduction and Hybrid Classification in Ultrasound Imaging

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Computers, Materials & Continua 2024年第5期79卷 1875-1901页

作者： K.Umapathi S.Shobana Anand Nayyar Judith Justin R.Vanithamani miguel Villagómez galindo Mushtaq Ahmad Ansari Hitesh Panchal Department of Biomedical Engineering KIT-Kalaignarkarunanidhi Institute of TechnologyCoimbatore641402India Graduate School Faculty of Information TechnologyDuy Tan UniversityDa Nang550000Viet Nam Department of Biomedical and Instrumentation Engineering Avinashilingam Institute for Home Science and Higher Education forWomenCoimbatore641043India UniversidadMichoacana de sanNicolás de hidalgoAvenida Francisco J.Múgica S/N Ciudad Universitaria MoreliaCP58030Mexico Department of Pharmacology and Toxicology College of PharmacyKing Saud UniversityRiyadh11451Saudi Arabia Department of Mechanical Engineering Gujarat Technological UniveristyNigam NagarChandkhedaAhmedabadGujarat382424India

Breast cancer detection heavily relies on medical imaging, particularly ultrasound, for early diagnosis and effectivetreatment. This research addresses the challenges associated with computer-aided diagnosis (CAD) of breastcancer fromultrasound images. The primary challenge is accurately distinguishing between malignant and benigntumors, complicated by factors such as speckle noise, variable image quality, and the need for precise segmentationand classification. The main objective of the research paper is to develop an advanced methodology for breastultrasound image classification, focusing on speckle noise reduction, precise segmentation, feature extraction, andmachine learning-based classification. A unique approach is introduced that combines Enhanced Speckle ReducedAnisotropic Diffusion (SRAD) filters for speckle noise reduction, U-NET-based segmentation, Genetic Algorithm(ga)-based feature selection, and Random Forest and bagging Tree classifiers, resulting in a novel and efficientmodel. To test and validate the hybrid model, rigorous experimentations were performed and results state thatthe proposed hybrid model achieved accuracy rate of 99.9%, outperforming other existing techniques, and alsosignificantly reducing computational time. This enhanced accuracy, along with improved sensitivity and specificity,makes the proposed hybrid model a valuable addition to CAD systems in breast cancer diagnosis, ultimatelyenhancing diagnostic accuracy in clinical applications.

关键词： Ultrasound images breast cancer tumor classification segmentation deep learning lesion detection

从世界到中国:未来素养何以有必要成为未来教育研究的新视点——于金申与未来学家瑞尔·米勒的对话

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华东师范大学学报（教育科学版） 2024年第3期42卷 115-126页

作者：于金申 [法]瑞尔·米勒华东师范大学教育学系上海200062 巴黎高科路桥学校商学院巴黎75012

近些年未来教育已经成为了国际热点话题。但未来尚未发生,谁也无法预测未来教育将会走向何方,因此,我们需要通过新视点来研究未来教育。为此,联合国教科文组织未来素养研究中心前主任瑞尔·米勒研究员提出了未来素养概念,这是一种旨在... 详细信息

近些年未来教育已经成为了国际热点话题。但未来尚未发生,谁也无法预测未来教育将会走向何方,因此,我们需要通过新视点来研究未来教育。为此,联合国教科文组织未来素养研究中心前主任瑞尔·米勒研究员提出了未来素养概念,这是一种旨在帮助人们知道未来是什么以及如何使用未来的能力。近十年,在联合国教科文组织的推动下,未来素养研究已经在全球44个国家和地区开展了100多场未来素养创新实验室活动,探讨了未来素养对于未来教育和社会发展的意义,且正形成全球化发展之势。鉴于此,本对话主要围绕未来素养的学理背景,未来教育研究的可能路径,中国未来教育探索以及对中国未来教育镜鉴价值四个方面展开,以昭示未来素养视点下未来教育研究的方向与路径。

关键词：未来教育未来素养未来素养创新实验室中国未来教育

Highly sensitive ratiometric fluorescent fiber matrices for oxygen sensing with micrometer spatial resolution

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Bio-Design and Manufacturing 2024年第3期7卷 292-306页

作者： Giuliana Grasso Valentina Onesto Stefania Forciniti Eliana D’Amone Francesco Colella Lara Pierantoni Valeria Famà Giuseppe Gigli Rui L.Reis J.miguel Oliveira Loretta L.del Mercato nstitute of Nanotechnology National Research Council(CNR-NANOTEC)c/o Campus Ecoteknevia Monteroni73100 LecceItaly Department of Mathematics and Physics“Ennio De Giorgi” University of Salentoc/o Campus Ecoteknevia Monteroni73100 LecceItaly 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT government Associate Laboratory 4806-909 Braga/GuimarãesPortugal Department of Experimental Medicine University of Salentoc/o Campus Ecoteknevia Monteroni73100 LecceItaly

Oxygen(O_(2))-sensing matrices are promising tools for the live monitoring of extracellular O_(2) consumption levels in long-term cell *** this study,ratiometric O_(2)-sensing membranes were prepared by electrospinning,an easy,low-cost,scalable,and robust method for fabricating ***(ε-caprolactone)and poly(dimethyl)siloxane polymers were blended with tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II)dichloride,which was used as the O_(2)-sensing probe,and rhodamine B isothiocyanate,which was used as the reference *** functionalized scaffolds were morphologically characterized by scanning electron microscopy,and their physicochemical profiles were obtained by Fourier transform infrared spectroscopy,thermogravimetric analysis,and water contact angle *** sensing capabilities were investigated by confocal laser scanning microscopy,performing photobleaching,reversibility,and calibration curve studies toward different dissolved O_(2)(DO)*** sensing nanofibers showed a high response to changes in DO concentrations in the physiological-pathological range from 0.5%to 20%and good stability under ratiometric *** addition,the sensing systems were highly biocompatible for cell growth promoting adhesiveness and growth of three cancer cell lines,namely metastatic melanoma cell line SK-MEL2,breast cancer cell line MCF-7,and pancreatic ductal adenocarcinoma cell line Panc-1,thus recreating a suitable biological environment in *** O_(2)-sensing biomaterials can potentially measure alterations in cell metabolism caused by changes in ambient O_(2)content during drug testing/validation and tissue regeneration processes.

关键词： Electrospinning Ruthenium(II)dichloride Oxygen sensors Ratiometric imaging Fluorescence

基于数据挖掘的藏医泻治方配伍规律及用药特点分析

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中南民族大学学报（自然科学版） 2024年第2期43卷 194-200页

作者：扎西卓玛才旦拉毛嘎登尼玛贡保东知嘎务西藏藏医药大学拉萨850000 青海民族大学西宁810000 西藏自治区藏医院拉萨850004 甘肃中医药大学兰州730000

为藏医泻治方临床合理用药及新药研发提供理论依据,搜集《藏医经典文献集成》中关于历代藏医泻治方的古籍文献;共收集到92本有关藏医泻治方的古籍文献及356首藏医泻治方,应用SPPS Modeler 18软件分析法等方法,对其进行整理及分析,结果发... 详细信息

为藏医泻治方临床合理用药及新药研发提供理论依据,搜集《藏医经典文献集成》中关于历代藏医泻治方的古籍文献;共收集到92本有关藏医泻治方的古籍文献及356首藏医泻治方,应用SPPS Modeler 18软件分析法等方法,对其进行整理及分析,结果发现356首藏医泻治方中使用频次最高的前10的药物依次为白狼毒、长蝝诃子、巴豆、大果大戟、硇砂、大黄、漆树脂、荜拔、斑蝥、甘青大戟.其次,应用Apriori算法的关联规则分析法,将支持度设置为5%,置信度15%条件下发现94条藏医泻治方常用药对;其中白狼毒-长蝝诃子、白狼毒-巴豆、长蝝诃子-巴豆、白狼毒-大果大戟等是藏医泻治方2399条药对中最为常用的药物组合.356首藏医泻治方剂中使用频次最高的药物及组方关联最强的核心药对都以白狼毒、长蝝诃子、巴豆、大果大戟、硇砂等毒性较强的药物为主,而藏医临床上针对这些毒性药物具有非常严格的入药条件,必须经过专业的藏医炮制工艺技术,才能入药服用;同时,提高自身临床经验,确保泻治药物质量,搞清泻治药物炮制原理,掌握泻治疗法的具体操作方法是藏医泻治疗法临床合理应用的前提和所需条件.

关键词：藏医藏药泻治方数据挖掘配伍规律

Epidemiological and Clinical Aspects of Chronic Renal Failure in the Medical Department at the Hospital of Sikasso

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Open Journal of Nephrology 2023年第1期13卷 57-66页

作者： Djénéba Maïga Drissa goïta Magara samaké Aboudou Messoum Dolo Yohanna Koné Aboubacar Sidiki Fofana Seydou Sy Moctar Coulibaly Atabième Kodio sahdit baba Coulibaly saharé Fongoro Nephrology Unit of Sikasso Hospital Sikasso Mali National Center for Scientific and Technological Research (CNRST) Bamako Mali Service de Médecine CHU Mère-Enfant le Luxembourg Bamako Mali Nephrology Unit of the Fousseyni DAOU Hospital Kayes Mali Nephrology and Hemodialysis Service CHU du Point-G Bamako Mali Faculty of Medicine of bamako Bamako Mali Nephrology Unit of Mali gaVARDO Hospital of Sebenicoro Bamako Mali

Introduction: Chronic renal failure is a real public health problem because of its prevalence, the cost of its management and the high morbidity and mortality rate associated with it. The objective of this study was to determine the frequency, causes and main aggravating factors of chronic renal failure in the medical department of the hospital of Sikasso. Materials and Methods: This was a cross-sectional, retrospective, descriptive study conducted in the medical department of the Sikasso hospital from January 1, 2021 to November 30, 2022. It covered all the records of patients with chronic renal failure hospitalized in the department during this period. The MDRD formula was used to estimate the glomerular filtration rate. The KDIgo 2012 classification was used to stage CKD. Results: Of 820 patient records reviewed, we retained 197 records. The mean age of our patients was 42.25 ± 10 years. The male sex represented 114 (57.9%). The socio-economic level was considered low and precarious in 79.8% of cases. The frequency of chronic renal failure was 24%. The reason for hospitalization was mostly hyper creatinine > 185 μmol/l (92.4%). Herbal medicine was reported in 103 cases (52.3%). Medical history was hypertension 101 cases (51.3%), undocumented gastro duodenal ulcer (UGD) 14 cases (7.6%), hypertension and diabetes 11 cases (5.1%), diabetes 8 cases (4%), lower limb edema 9 cases (4.6%). Hypocalcemia was 147 cases (75.6%) with hyper phosphoremia was 153 cases (77.7%). Hemoglobin level was: <6 g/dl, 44 cases (22.3%);between 6 - 8 g/dl, 77 cases (39.1%), from 8 - 10 g/dl, 54 cases (27.4%). The etiologies of CKD were vascular nephropathy 106 cases (53.8%), interstitial nephropathy, 44 cases (22.3%), glomerular nephropathy, 33 cases (16.8%), diabetic nephropathy, 12 cases (6.1%) and polycystic kidney disease 2 (1%). CKD was classified as stage 5, 171 cases (86.8%), stage 4, 11 cases (5.6%), stage 3, 13 cases (6.6%) and stage 2, 2 cases (1%.) Dialysis was performed in 1095

关键词： Epidemiology Clinical Chronic Renal Failure Sikasso Mali

Event-based hydrology and sedimentation in paired watersheds under commercial eucalyptus and grasslands in the Brazilian Pampa biome

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International Soil and Water Conservation Research 2021年第2期9卷 180-194页

作者： Ederson Diniz Ebling Jose miguel Reichert Jhon Jairo Zuluaga Pelaez Miriam Fernanda Rodrigues Mirian Lago Valente Rosane barbosa Lopes Cavalcante Paolo Reggiani Raghavan Srinivasan Soils Department Universidade Federal de Santa MariaAvenida Roraima1000 Bairro CamobiSanta MariaRS97105-900Brazil Corporacion Colombiana de Investigacion Agropecuaria(AGROsaVIA) Centro de Investigacion NataimaEspinalColombia CMPC Celulose Riograndense Rua Sao Geraldo1680GuaibaRS92500-000Brazil Department of Civil Engineering University of SiegenPaul Bonatz Strasse 9-11Siegen D57068Germany Department of Ecology and Conservation Biology Texas A&M University(TAMU)534 John Kimbrough Blvd.Room 305College StationTX77843-2120USA Current address:Instituto Tecnologico Vale.Rua Boaventura da Silva 955UmarizalBelemPABrazil.

Ecological and hydrological impacts are expected when watersheds are under commercial *** this study we evaluated event-based hydrology and sedimentation in paired watersheds under commercial eucalyptus and grasslands ***,suspended sediment concentration,and sediment production were measured and simulated with the Limburg Soil Erosion Model(LISEM)in paired hydrographic watersheds located in southern Brazil;one occupied with 7-years old Eucalyptus saligna plantation(forest watershed-FW;0.83 km^(2))and another Pampa biome with native and exotic grasses used for beef cattle production(grassland watershed-GW;1.10 km^(2)).The effect of rainfall on hydrological and sedimentological variables was more evident in GW compared with *** shape of the hydrograph was steepest in GW,with rapid,marked increase and decrease in flow during *** parameters changed for model calibration in FW and GW were soil saturated hydraulic conductivity,initial soil moisture,and Manning roughness coefficient,whereby the statistical performance was classified as good(NSE>0.75).Fourteen events different from those used in the calibration process were validated for FW and GW,with NSE index classified as“good”and“very good”for *** study shows limitations of LISEM in calibrating and validating the sediment yield for individual events due to the spatial variability of factors controlling soil *** validated modeling results of this study may be applied in simulating soil and crop scenarios in watersheds cultivated with commercial forest and grassland for grazing.

关键词： Southern grasslands Paired watersheds Runoff Erosion LISEM

Scintillation and optical properties of Ce-doped YAGG transparent ceramics

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Journal of Rare Earths 2016年第8期34卷 763-768页

作者： Masaki Mori Jian Xu go Okada Takayuki Yanagida Jumpei Ueda Setsuhisa Tanabe Graduate School of Materials' Science Nara Institute of Science and Technology (NAIST) 8916-5 Takayama-cho Ikoma-shi Nara 630-0192 Japan Graduate School of Human and Environmental Studies Kyoto University Yoshida-nihonmatsu-eho Sakyo-ku Kyoto 606-8501 Japan

We investigated photoluminescence （PL） and scintillation properties of Ce3＋-doped Y3A12ga3OI2 （Ce：YAGG） trans- parent ceramics synthesized by vacuum sintering with different Ce3＋ concentrations （mol.%） from 0.3% to 1% （0.3%Ce：YAGG, 0.5%Ce：YAGG, 0.8%Ce：YAGG and I%Ce：YAGG）. The samples were synthesized by the vacuum sintering technique. The obtained samples showed a very strong and broad PL emission by the 5dl-4f transition of Ce3＋ in the wavelength range from 470 to 600 nm. The PL decay profiles were approximated by a single exponential decay function with the time constants of around 33-39 ns, Fur- thermore, the scintillation spectra induced by X-rays showed similar features with those observed in PL. The scintillation decay time profiles followed a second-order exponential decay function. The fast component group （ranged 3542 ns） were dominantly contrib- uted by the 5d1-4f transition of Ce3＋. The pulse height spectra utilizing the latter emissions showed a clear photoabsorption peak. Among those samples tested, 0.5%Ce：YAGG sample showed the highest scintillation light yield of 21,400 ph/MeV under 13VCs y-ray irradiation.

关键词： YAGG cerium transparent ceramic scintillation photoluminescence rare earths

Hybrid magnetorheological elastomers enable versatile soft actuators

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npj Computational Materials 2022年第1期8卷 1546-1559页

作者： miguel Angel Moreno-Mateos Mokarram Hossain Paul Steinmann Daniel garcia-gonzalez Department of Continuum Mechanics and Structural Analysis Universidad Carlos III de MadridAvda.de la Universidad 3028911LeganésMadridSpain Zienkiewicz Centre for Computational Engineering Faculty of Science and EngineeringSwansea UniversitySA18ENSwanseaUK Institute of Applied Mechanics University of Erlangen-NurembergEgerland Str.5ErlangenGermany Glasgow Computational Engineering Centre School of EngineeringUniversity of GlasgowG128QQGlasgowUK

Recent advances in magnetorheological elastomers(MREs)have posed the question on whether the combination of both soft-and hard-magnetic particles may open new routes to design versatile multifunctional ***,we conceptualise ultra-soft hybrid MREs(≈1–10 kPa stiffness)combining experimental and computational ***,a comprehensive experimental characterisation is *** results unravel that the magneto-mechanical performance of hybrid MREs can be optimised by selecting an adequate mixing ratio between ***,a multi-physics computational framework provides insights into the synergistic magneto-mechanical interactions at the *** particles amplify the magnetisation and hard particles contribute to torsional *** numerical results suggest that the effective response of hybrid MREs emerges from these intricate ***,we uncover exciting possibilities to push the frontiers of MRE *** are demonstrated by simulating a bimorph beam that provides actuation flexibility either enhancing mechanical bending or material stiffening,depending on the magnetic stimulation.

关键词： versatile magneto enable

The elphbolt ab initio solver for the coupled electron-phonon Boltzmann transport equations

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npj Computational Materials 2022年第1期8卷 236-244页

作者： Nakib H.Protik Chunhua Li miguel Pruneda David Broido Pablo Ordejón Catalan Institute of Nanoscience and Nanotechnology(ICN2) CSIC and BISTCampus Bellaterra8193BarcelonaSpain Department of Physics Boston CollegeChestnut HillBostonMA02467USA

elphbolt is a modern Fortran (2018 standard) code for efficiently solving the coupled electron–phonon Boltzmann transport equations from first *** results from density functional and density functional perturbation theory as inputs,it can calculate the effect of the non-equilibrium phonons on the electronic transport (phonon drag) and non-equilibrium electrons on the phononic transport (electron drag) in a fully self-consistent manner and obeying the constraints mandated by *** can calculate the lattice,charge,and thermoelectric transport coefficients for the temperature gradient and electric fields,and the effect of the mutual electron–phonon drag on these transport *** code fully exploits the symmetries of the crystal and the transport-active window to allow the sampling of extremely fine electron and phonon wave vector meshes required for accurately capturing the drag *** coarray feature of modern Fortran,which offers native and convenient support for parallelization,is *** code is compact,readable,well-documented,and extensible by design.

关键词： properties phonon equations