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PLga nanodepots co-encapsulating prostratin and anti-CD25 enhance primary natural killer cell antiviral and antitumor function

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Nano Research 2020年第3期13卷 736-744页

作者： elizabeth e.Sweeney Preethi b.balakrishnan Allison b.Powell Allan bowen Indra Sarabia Rachel A.burga R.brad jones Alberto bosque C.Russell Y.Cruz Rohan Fernandes The George Washington Cancer Center The George Washington UniversityWashingtonDC20052USA Center for Cancer and Immunology Research Children’s National Health SystemWashingtonDC20010USA Department of Microbiology Immunologyand Tropical MedicineThe George Washington UniversityWashingtonDC20052USA Infectious Disease Division Weill Cornell Medical CollegeNew YorkNY10065USA View author publications Department of Medicine The George Washington UniversityWashingtonDC20052USA

Natural killer(NK)cells are attractive effector cells of the innate immune system against human immunodeficiency virus(HIV)and ***,NK cell therapies are limited by the fact that target cells evade NK cells,for example,in latent reservoirs(in HIV)or through upregulation of inhibitory signals(in cancer).To address this limitation,we describe a biodegradable nanoparticlebased“priming”approach to enhance the cytotoxic efficacy of peripheral blood mononuclear cell-derived NK *** present poly(lactic-co-glycolic acid)(PLga)nanodepots(NDs)that co-encapsulate prostratin,a latency-reversing agent,and anti-CD25(aCD25),a cell surface binding antibody,to enhance primary NK cell function against HIV and *** utilize a nanoemulsion synthesis scheme to encapsulate both prostratin and aCD25 within the PLga NDs(termed Pro-aCD25-NDs).Physicochemical characterization studies of the NDs demonstrated that our synthesis scheme resulted in stable and monodisperse *** NDs successfully released both active prostratin and anti-CD25,and with controllable release *** Pro-aCD25-NDs were administered in an in vitro model of latent HIV and acute T cell leukemia using J-Lat 10.6 cells,the NDs were observed to prime J-Lat cells resulting in significantly increased NK cell-mediated cytotoxicity compared to free prostratin plus anti-CD25,and other *** findings demonstrate the feasibility of using our Pro-aCD25-NDs to prime target cells for enhancing the cytotoxicity of NK cells as antiviral or antitumor agents.

关键词： poly(lactic-co-glycolic acid)(PLga)nanodepots natural killer(NK)cells human immunodeficiency virus(HIV) cancer latency-reversing agent antibody

Ground-based and additional science support for SMILe

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earth and Planetary Physics 2024年第1期8卷 275-298页

作者： J.A.Carter M.Dunlop C.Forsyth K.Oksavik e.Donovon A.Kavanagh S.e.Milan T.Sergienko R.C.Fear D.G.Sibeck M.Connors T.Yeoman X.Tan M.G.G.T.Taylor K.McWilliams J.Gjerloev R.barnes D.D.billet G.Chisham A.Dimmock M.P.Freeman D.-S.Han M.D.Hartinger S.-Y.W.Hsieh Z.-J.Hu M.K.James L.Juusola K.Kauristie e.A.Kronberg M.Lester J.Manuel J.Matzka I.McCrea Y.Miyoshi J.Rae L.Ren F.Sigernes e.Spanswick K.Sterne A.Steuwer T.Sun M.-T.Walach b.Walsh C.Wang J.Weygand J.Wild J.Yan J.Zhang Q.-H.Zhang Planetary Sciences Group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Rutherford Appleton Laboratory Space Science Technology Facilities CouncilOxfordshireUK School of Space and environment Beihang UniversityBeijing 100191China Key Laboratory of Space environment Monitoring and Information Processing Ministry of Industry and Information TechnologyBeijing 100017China Department of Space and Climate Physics UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK birkeland Centre for Space Science Department of Physics and Technology.University of BergenBergenNorway Department of Physics and Astronomy University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 british Antarctic Survey CambridgeUK Swedish Institute of Space Physics KirunaSweden West Highfield Campus University of SouthamptonUniversity RoadSO171BJUK Goddard Space Flight Center NASAGreenbeltMarylandUSA Athabasca University AthabascaCanada eSTeC European Space AgencyNetherlands University of Saskatchewan SaskatoonCanada The Johns Hopkins University Applied Physics Laboratory LaurelMarylandUSA Swedish Institude of Space Physics UppsalaSE 75121Sweden Tongji University Shanghai 200092China Center for Space Plasma Physics Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA Polar Research Institute of China Shanghai 200136China Finnish Meteorological Institute(FMI) Finland Department of earth and environmental Sciences(Geophysics) Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany Canadian Space Agency MontrealCanada GFZ German Research Centre for Geosciences PotsdamGermany Nagoya University Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 Northumbria University Newcastle upon TyneTyne and WearUK NE18ST National Space Science Center Chinese Academy SciencesBeijing 100190China Arctic Geophysics University Centre in Svalbard

The joint european Space Agency and Chinese Academy of Sciences Solar wind Magnetosphere Ionosphere Link explorer(SMILe)mission will explore global dynamics of the magnetosphere under varying solar wind and interplanetary magnetic field conditions,and simultaneously monitor the auroral response of the Northern Hemisphere *** these large-scale responses with medium and fine-scale measurements at a variety of cadences by additional ground-based and space-based instruments will enable a much greater scientific impact beyond the original goals of the SMILe ***,we describe current community efforts to prepare for SMILe,and the benefits and context various experiments that have explicitly expressed support for SMILe can offer.A dedicated group of international scientists representing many different experiment types and geographical locations,the Ground-based and Additional Science Working Group,is facilitating these *** include constructing an online SMILe Data Fusion Facility,the discussion of particular or special modes for experiments such as coherent and incoherent scatter radar,and the consideration of particular observing strategies and spacecraft *** anticipate growing interest and community engagement with the SMILe mission,and we welcome novel ideas and insights from the solar-terrestrial community.

关键词： magnetosphere ionosphere magnetosphere-ionosphere coupling ground-based experimentation SMILe conjunctions missions

Hemolysis of PM_(10) on RbCs in vitro:An indoor air study in a coal-burning lung cancer epidemic area

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Geoscience Frontiers 2022年第1期13卷 506-511页

作者： Mengyuan Zhang Longyi Shao Tim jones Ying Hu Rachel Adams Kelly bérubé State Key Laboratory of Coal Resources and Safe Mining and College of Geoscience and Surveying EngineeringChina University of Mining&TechnologyBeijing 100083China School of earth and environmental Sciences Cardiff UniversityMuseum AvenueCardiff CF103YEUK Guangdong Province Nuclear Industry Geological bureau Guangzhou 510800China School of Health Sciences Cardiff Metropolitan UniversityLlandaff CampusWestern AvenueCardiff CF52YBWalesUK School of biosciences Cardiff UniversityMuseum AvenueCardiff CF103AXWalesUK

epidemiological studies have suggested that inhalation exposure to indoor ambient air from coal-burning environments is causally associated with respiratory health *** order to explore the toxicological mechanisms behind the adverse health effects,the hemolytic activity of PM_(10)(particulate matter with an aerodynamic diameter of 10 um or less)samples collected from homes burning coal in the recognized China"cancer village"Xuanwei were evaluated and matched against their trace elemental *** results demonstrated that the hemolytic activity of indoor PM_(10) in coal-burning environments ranged from 4.28%to 5.24%,with a clear positive dose-response *** low dose samples exhibited a reduced hemolytic activity,PM_(10) could have a toxic effect upon people in a coal-burning indoor environment for extended time *** concentrations of analyzed trace elements in PM_(10) samples ranged from 6966 to 12,958 *** the analyzed elements,Zn,Ti,Ni,Cu,Pb,ba,Mn,Cr and V were found at higher concentrations and accounted for over 95%of the total *** concentrations of total analyzed elements in the PM_(10) samples revealed a significant positive correlation with PM_(10) hemolytic *** the analyzed elements,Zn,Pb and Cs positively correlated with hemolysis,while Li,U and V negatively correlated with the hemolysis of human red blood cells(RbCs).Therefore,the heavy metal elements could be one of the main factors responsible for the hemolytic capacity of indoor PM_(10) in coal-burning environments.

关键词： Air pollution PM_(10) Coal Hemolysis Xuanwei County

High-performance fingerprint bionic ecoflex@AgNW/graphite/Pt hybrid strain sensor

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Journal of Materiomics 2024年第1期10卷 7-16页

作者： Xuyang Zhang Zhengliang Li Cuilan Liu Jiaqi Shan b Xingzhong Guo Xiaoyu Zhao Jianbao Ding Hui Yang State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou310027China Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou311200China Zhejiang Hua Display Optoelectronics Co. LtdJiaxing314115China Zhejiang Kechuang Advanced Materials Technology Co. LtdHangzhou310051China

Wearable electronics have promising applications in human-machine interfaces due to their excellent flexibility,stretchability and human friendliness,and one of the key points of wearable electronics is to develop strain sensors with high sensitivity and working ***,a high-performance eco-flex@AgNW/graphite/Pt hybrid strain sensor was fabricated by suction filtrating,transferring and surface sputtering *** suction filtrating of AgNW and graphite dispersions on a wrinkle-shape Nylon filter,transferring of AgNW/graphite layer onto ecoflex and further surface sputtering by Pt allow the construction of fingerprint bionic ecoflex@AgNW/graphite/Pt hybrid strain *** resul-tant fingerprint bionic hybrid strain sensor possesses high sensitivity of 2064.1 at the strain of 140%e155%,a wide working range of 0e155%,a short response time(111 ms and 189 ms for tensile and releasing process)and excellent cyclic stability over 5000 *** study provides a universal tech-nique for the preparation of strain sensors with promising applications in the field of next-generation intelligent wearable electronics.

关键词： Silver nanowire Graphite Strain sensor ecoflex Sensitivity Working range

electronic,optical,and mechanical properties of bN,AlN,and InN with zinc-blende structure under pressure

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Chinese Physics b 2017年第8期26卷 320-327页

作者： A R Degheidy e b elkenany Department of Physics Faculty of ScienceMansoura UniversityP.O.Box 35516MansouraEgypt

In this work, the electronic, optical, and mechanical properties of bN, AlN, and InN under the action of pressure are calculated. For each of these compounds, the energy band structure, band gaps（e^L_g, e~Γ_g, e^X_g）, refractive index（n）,dielectric constants（ε_∞, ε_0）, elastic constants（C_11, C_12, C_44）, and relevant parameters such as bulk（b_u）, shear（S_h）, and Young＇s（Y_0） moduli are studied, and other important parameters such as bond-stretching（α）, bond-bending（β） force constant, internal-strain parameter（ζ）, effective charges（e~＊_T, Z~＊）, anisotropy factor（I_s）, Poisson＇s ratio（P_o）, Cauchy ratio（C_a）, the ductility index（μ_D）, and linear compressibility（C0_） are also calculated. The effects of pressure on all studied properties are investigated. Our results are in good agreement with the available experimental and theoretical data for bN,AlN, and InN.

关键词： electronic properties optical properties mechanical properties bN A1N InN

Hydrocarbon indication in Rio bonito Formation sandstone:Implication for CO_(2)storage in São Paulo,brazil

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energy Geoscience 2024年第1期5卷 331-341页

作者： Richardson M.Abraham-A Haline V.Rocha Saulo b.de Oliveira Colombo C.G.Tassinarri Orlando C.da Silva Institute of energy and environment University of São PauloSão PauloBrazil Research Centre for Greenhouse gas Innovation University of São PauloSão PauloBrazil

São Paulo State has witnessed CO_(2)storage-based investigations considering the availability of suitable geologic structures and proximity to primary CO_(2)source sinks related to bioenergy and carbon capture and storage(beCCS)*** current study presents the hydrocarbon viability evaluations and CO_(2)storage prospects,focusing on the sandstone units of the Rio bonito *** objective is to apply petrophysical evaluations with geochemical inputs in predicting future hydrocarbon(gas)production to boost CO_(2)storage within the study *** study used data from eleven wells with associated wireline logs(gamma ray,resistivity,density,neutron,and sonic)to predict potential hydrocarbon accumulation and fluid mobility in the investigated *** samples(shale and carbonate)obtained from depths>200 m within the study location have shown bitumen *** geochemistry data of the Rio bonito Formation shale beds suggest they are potential hydrocarbon source rocks and could have contributed to the gas accumulations within the sandstone *** drilled well data,e.g.,Cb-1-SP and TI-1-SP,show hydrocarbon(gas)presence based on the typical resistivity and the combined neutron-density responses at depths up to 3400 m,indicating the possibility of other hydrocarbon members apart from the heavy oil(bitumen)observed from the near-surface rocks *** the three-dimensional(3-D)model,the free fluid indicator(FFI)is more significant towards the southwest and southeast of the area with deeper depths of occurrence,indicating portions with reasonable hydrocarbon recovery rates and good prospects for CO_(2)injection,circulation and permanent ***,future studies based on contemporary datasets are required to establish the hydrocarbon viability further,foster gas production events,and enhance CO_(2)storage possibilities within the region.

关键词： Paranábasin Hydrocarbon indication Sandstone reservoirs Rio bonito Formation CO_(2)storage Hydrocarbon recovery factor Fluid injection rate

APIR:Aggregating Universal Proteomics Database Search Algorithms for Peptide Identification with FDR Control

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Genomics, Proteomics & bioinformatics 2024年第2期22卷 171-187页

作者： Yiling elaine Chen Xinzhou Ge Kyla Woyshner MeiLu McDermott Antigoni Manousopoulou Scott b.Ficarro Jarrod A.Marto Kexin Li Leo David Wang Jingyi Jessica Li Department of Statistics and Data Science University of CaliforniaLos AngelesCA 90095USA Department of Immuno-Oncology Beckman Research InstituteCity of Hope National Medical CenterDuarteCA 91010USA Department of Quantitative and Computational biology University of Southern CaliforniaLos AngelesCA 90089USA Department of Cancer biology and blais Proteomics Center Dana-Farber Cancer InstituteDepartment of PathologyBrigham and Women’s Hospital and Harvard Medical SchoolBostonMA 02215USA Department of Pediatrics City of Hope National Medical CenterDuarteCA 91010USA bioinformatics Interdepartmental Program University of CaliforniaLos AngelesCA 90095USA Department of Human Genetics University of CaliforniaLos AngelesCA 90095USA Department of Computational Medicine University of CaliforniaLos AngelesCA 90095USA Department of biostatistics University of CaliforniaLos AngelesCA 90095USA

Advances in mass spectrometry(MS)have enabled high-throughput analysis of proteomes in biological *** state-of-the-art MS data analysis relies on database search algorithms to quantify proteins by identifying peptide–spectrum matches(PSMs),which convert mass spectra to peptide *** database search algorithms use distinct search strategies and thus may identify unique ***,no existing approaches can aggregate all user-specified database search algorithms with a guaranteed increase in the number of identified peptides and a control on the false discovery rate(FDR).To fill in this gap,we proposed a statistical framework,Aggregation of Peptide Identification Results(APIR),that is universally compatible with all database search ***,under an FDR threshold,APIR is guaranteed to identify at least as many,if not more,peptides as individual database search algorithms *** of APIR on a complex proteomics standard dataset showed that APIR outpowers individual database search algorithms and empirically controls the *** data studies showed that APIR can identify disease-related proteins and post-translational modifications missed by some individual database search *** APIR framework is easily extendable to aggregating discoveries made by multiple algorithms in other high-throughput biomedical data analysis,e.g.,differential gene expression analysis on RNA sequencing *** APIR R package is available at https://***/yiling0210/APIR.

关键词： Shotgun proteomics Peptide–spectrum match Peptide identification Aggregation of lists FDR control

Collisionless shock acceleration of protons in a plasma slab produced in a gas jet by the collision of two laser-driven hydrodynamic shockwaves

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Matter and Radiation at extremes 2024年第2期9卷 12-25页

作者： J.-R.Marquès L.Lancia P.Loiseau P.Forestier-Colleoni M.Tarisien e.Atukpor V.bagnoud C.brabetz F.Consoli J.Domange F.Hannachi P.Nicolaï M.Salvadori b.Zielbauer LULI CNRSÉcole PolytechniqueCEASorbonne UniversitéInstitut Polytechnique de Paris91128 Palaiseau CedexFrance CeA DAMDIF91297 Arpajon CedexFrance UniversitéParis-Saclay CEALMCE91680 Bruyères-le-ChatelFrance CeNbG CNRS-IN2P3Universitéde Bordeaux33175 Gradignan CedexFrance GSI Helmholtzzentrum für Schwerionenforschung GmbH Planckstraße 164291 DarmstadtGermany University of Darmstadt Schloßgartenstr.764289 DarmstadtGermany eNeA Fusion and Technologies for Nuclear Safety Department C.R.FrascatiVia Enrico Fermi 45FrascatiRomeItaly CeLIA Universitéde Bordeaux–CNRS–CEA33405 TalenceFrance UniversitéParis-Saclay CEALIDYL91191 Gif-sur-YvetteFrance

We have recently proposed a new technique of plasma tailoring by laser-driven hydrodynamic shockwaves generated on both sides of a gas jet[Marquès et al.,*** 28,023103(2021)].In a continuation of this numerical work,we study experimentally the influence of the tailoring on proton acceleration driven by a high-intensity picosecond laser in three cases:without tailoring,by tailoring only the entrance side of the picosecond laser,and by tailoring both sides of the gas *** tailoring,the acceleration is transverse to the laser axis,with a low-energy exponential spectrum,produced by Coulomb *** the front side of the gas jet is tailored,a forward acceleration appears,which is significantly enhanced when both the front and back sides of the plasma are *** forward acceleration produces higher-energy protons,with a peaked spectrum,and is in good agreement with the mechanism of collisionless shock acceleration(CSA).The spatiotemporal evolution of the plasma profile is characterized by optical shadowgraphy of a probe *** refraction and absorption of this beam are simulated by post-processing 3D hydrodynamic simulations of the plasma *** with the experimental results allows estimation of the thickness and near-critical density of the plasma slab produced by tailoring both sides of the gas *** parameters are in good agreement with those required for CSA.

关键词： acceleration hydrodynamic collision

Why Matter Occupies so Large a Volume?

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Communications in Theoretical Physics 2013年第12期60卷 677-686页

作者： e.b.Manoukian Institute for Fundamental Study Naresuan University

The paper represents a rigorous treatment of the underlying quantum theory, not just in words but providing the underlying technical details, as to why matter occupies so large a volume and its intimate connection with the Pauli exclusion principle, as more and more matter is put together, as well as of the contraction or shrinkage of ＂bosonic matter＂, upon collapse, for which the Panli exclusion is abolished. From the derived explicit bounds of integrals of powers of the particle number densities, explicit bounds on probabilities of the occurrences of the events just described are extracted. These probabilities lead one to infer the change of the ＂size＂ or extension of such matter, upon expansion or contraction, respectively, as their content is increased.

关键词： expansion of matter and the Pauli exclusion principle contraction or shrinkage of "bosonic mat-ter" upon collapse