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Low-density lipoprotein receptor genetic polymorphism in chronic hepatitis C virus Egyptian patients affects treatment response

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World Journal of gastroenterology 2015年第39期21卷 11141-11151页

作者： Mazen Naga Mona Amin Dina algendy Ahmed Elbadry May Fawzi Ayman Foda Serag esmat Dina Sabry Laila Rashed Samia ga.al Manal Kamal Division of gastro-enterology Department of Internal Medicine Faculty of Medicine Cairo University Department of Biochemistry Faculty of Medicine Cairo University Department of Pathology Faculty of Medicine Cairo University Department of Clinical and Chemical pathology Faculty of Medicine Cairo University

AIM: To correlate a genetic polymorphism of the low-density lipoprotein(LDL) receptor with antiviral responses in Egyptian chronic hepatitis C virus(HCV) ***: Our study included 657 HCV-infected patients with genotype 4 who received interferonbased combination therapy. Patients were divided into two groups based on their response to therapy: 356 were responders, and 301 were non-responders. Patients were compared to 160 healthy controls. all patients and controls underwent a thorough physical examination, measurement of body mass index(BMI) and the following laboratory tests: serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, albumin, total bilirubin, direct bilirubin, prothrombin time, prothrombin concentration, INR, complete blood count, serum creatinine, fasting blood sugar, HCV antibody, and hepatitis B surface antigen. all HCV patients were further subjected to the following laboratory tests: HCV-RNA using quantitative polymerase chain reaction(PCR), antinuclear antibodies, thyroid-stimulating hormone, an LDL receptor(LDLR) genotype study of LDLR exon8 c.1171G>A and exon-10 c.1413G>A using real-time PCR-based assays, abdominal ultrasonography, ultrasonographic-guided liver biopsy, and histopathological examination of liver biopsies. Correlations of LDL receptor polymorphisms with HAI, METAVIR score, presence of steatosis, and BMI were performed in all ***: There were no statistically significant differences in response rates between the different types of interferon used or LDLR exon10 c.1413G>A. However, there was a significant difference in the frequency of the LDL receptor exon8 c.1171G>A genotype between cases(AA: 25.9%, ga: 22.2%, GG: 51.9%) and controls(AA: 3.8%, ga: 53.1% and GG: 43.1%)(P ally significant difference in the frequency of the LDLR exon 8C:1171 G>A polymorphism between responders(AA: 3.6%, ga: 15.2%, GG: 81.2%) and nonresponders(AA: 52.2%, ga: 30.6%, GG: 17.

关键词： Hepatitis C virus Genetic polymorphisms Low-densit

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Interplay between micro RNA-17-5p, insulin-like growth factor-Ⅱ through binding protein-3 in hepatocellular carcinoma

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World Journal of Hepatology 2016年第23期8卷 976-984页

作者： Danira Ashraf Habashy Hend Mohamed El Tayebi Injie Omar Fawzy Karim Adel Hosny ga.al esmat Ahmed Ihab Abdelaziz Department of Pharmacology and Toxicology German University in Cairo Main Entrance Al Tagamoa Al Khames Department of General Surgery Faculty of Medicine Cairo University Department of Endemic Medicine and Hepatology Cairo University Department of Biology American University in Cairo

AIM: To investigate the effect of microR NA on insulinlike growth factor binding protein-3(IGFBP-3) and hence on insulin-like growth factor-Ⅱ(IGF-Ⅱ) bioavailability in hepatocellular carcinoma(HCC).METHODS: Bioinformatic analysis was performed using ***, DIANA lab and Segal lab softwares. Total RNA was extracted from 23 HCC and 10 healthy liver tissues using mir Vana mi RNA Isolation Kit. microR NA-17-5p(miR-17-5p) expression was mimicked and antagonized in Hu H-7 cell lines using Hi Per Fect Transfection Reagent, then total RNA was extracted using Biozol reagent then reverse transcribed into cD NA followed by quantification of mi R-17-5p and IGFBP-3 expression using Taq Man real-time quantitative PCR. Luciferase reporter assay was performed to validate the binding of miR-17-5p to the 3'UTR of IGFBP-3. Free IGF-Ⅱ protein was measured in transfected Hu H-7 cells using IGF-Ⅱ ELISA kit. RESULTS: Bioinformatic analysis revealed IGFBP-3 as a potential target for miR-17-5p. Screening of miR-17-5p and IGFBP-3 revealed a moderate negative correlation in HCC patients, where mi R-17-5p was extensively underexpressed in HCC tissues(P = 0.0012), while IGFBP-3 showed significant upregulation in the same set of patients(P = 0.0041) compared to healthy donors. Forcing mi R-17-5p expression in Hu H-7 cell lines showed a significant downregulation of IGFBP-3 mR NA expression(P = 0.0267) and a significant increase in free IGF-Ⅱ protein(P = 0.0339) compared to mock untransfected cells using unpaired t-test. Luciferase assay validated IGFBP-3 as a direct target of mi R-17-5p; luciferase activity was inhibited by 27.5% in cells co-transfected with miR-17-5p mimics and the construct harboring the wild-type binding region 2 of IGFBP-3 compared to cells transfected with this construct alone(P = 0.0474).CONCLUSION: These data suggest that regulating IGF-Ⅱ bioavailability and hence HCC progression can be achieved through targeting IGFBP-3 via manipulating the expression of miR NAs.

关键词： Insulin-like growth factor binding protein-3 Insulin-like growth factor signaling pathway MicroR NA Insulin-like growth factor-Ⅱ Hepatocellular carcinoma

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A 2.4 GHz Switched Beam Antenna for Indoor Applications Using Angle of Arrival Estimation

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Open Journal of Antennas and Propagation 2016年第3期4卷 109-118页

作者： Reham Elsamnty Ahmed Mohamed Attiya esmat Abdel Fattah Abdallah Abdel Hadi Ammar Electrical Engineering Department Al-Azhar University Cairo Egypt Microwave Engineering Department Electronics Research Institute Giza Egypt Microstrip Department Electronics Research Institute Giza Egypt

This study introduces a new design of planar antenna array for ISM band applications at 2.4 GHz. This prototype is switched beam antenna, namely planar antenna with four meandered slotted triangular elements (PAFMSTE), which is proposed for wireless indoor applications. The Base Station (BS) equipped with this planar antenna is preferred to be at the center position on the room ceiling to cover all sectors of the room. It is designed to use four directional triangular elements arranged to form a square planar antenna array. The PAFMSTE is used to obtain optimal directivity in four directions in azimuth plane with 3 dB beamwidth of 90°at a specific orientation of 30°in elevation plane. Switched parasitic technique is used to enable PAFMSTE to steer a directional beam through four locations by using four PIN diodes switches. The High Frequency Structure Simulator (HFSS) is used as an efficient simulation tool to optimize the performance of the PAFMSTE antenna. The fabrication and measurements of the PAFMSTE antenna are introduced. The proposed antenna enable radio positioning via Angle of Arrival (AOA) information collected from nearby devices. Then, the Cramér-Rao Bound (CRB) is presented for AOA estimation using identically and equally spaced antenna elements. The CRB depends on the directivity, where the maximum values of CRB are 1.35 × 10-3 and 8 × 10-3 at HPBW of 60° and 90°, respectively.

关键词： Indoor Communications Switched Beam Antenna Directional Microstrip Antenna Slotted Patch Antenna Radio-Positioning AOA Estimation CRB

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Effect of corn pre-puffing on the efficiency of MgO-engineered biochar for phosphorus recovery from livestock wastewater:mechanistic investigations and cost benefit analyses

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Biochar 2023年第1期5卷 462-478页

作者： Yaru Peng Yuan Luo Yimeng Li Muhammad Azeem Ronghua Li Chuchu Feng Guangzhou Qu esmat F.ali Mohamed A.Hamouda Peter S.Hooda Jörg Rinklebe Ken Smith Zengqiang Zhang Sabry M.Shaheen College of Natural Resources and Environment Northwest A&F UniversityYangling 712100Shaanxi ProvinceChina Key Laboratory of Urban Environment and Health Ningbo Observation and Research StationInstitute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Institute of Soil and Environmental Sciences Pir Mehr Ali Shah Arid Agriculture University RawalpindiRawalpindi 46300PunjabPakistan Department of Biology College of ScienceTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Department of Civil and Environmental Engineering Faculty of EngineeringUnited Arab Emirates UniversityAl AinAbu DhabiUnited Arab Emirates School of Engineering and the Environments Kingston University LondonKingston University LondonKingston Upon Thames KT12EELondonUK University of Wuppertal School of Architecture and Civil EngineeringLaboratory of Soil and Groundwater ManagementInstitute of Foundation EngineeringWater-and Waste-ManagementPauluskirchstraße 742285 WuppertalGermany The Department of Environmental Science The University of ArizonaShantz Building Rm 4291177 E 4Th St.TucsonTucsonArizona 85721USA Department of Arid Land Agriculture Faculty of MeteorologyEnvironmentand Arid Land AgricultureKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Soil and Water Sciences Faculty of AgricultureUniversity of KafrelsheikhKafr El-Sheikh 33516Egypt

To improve the phosphorus(P)recovery efficiency from livestock wastewater,a novel MgO doped mildewed corn biochar with thermal pre-puffing treatment(Mg-PBC)and without pre-puffing(Mg-BC)was synthesized and *** thermal-puffing pretreatment improved the effectiveness of metal soaking and MgO dispersion.P recovery time with Mg-PBC(7 h)was significantly shorter than that with Mg-BC(12 h).Moreover,Mg-PBC showed significantly higher P recovery capacity(241 mg g^(−1))than Mg-BC(96.6 mg g^(−1)).P recovery capacity of the Mg-PBC fitted to the Thomas model was 90.7 mg g^(−1),which was 4 times higher than that of Mg-BC(22.9 mg g^(−1))under column test *** mechanisms involved in P recovery included precipitation,surface complexation,and electrostatic *** adsorption,both Mg-BC and Mg-PBC showed relatively low regeneration *** P loaded Mg-BC(Mg-BC-P)and Mg-PBC(Mg-PBC-P),the later particularly,obviously increased the available P content and promoted plant *** release of P increased with time in the Mg-PBC-P treated soil,while it decreased with time in the P fertilizer treated soil.A cost-benefit analysis revealed that thermal-puffing pretreatment greatly increased the profit of MgO doped biochar from−0.66 to 5.90 US$kg^(−1).These findings highlight that biomass pre-puffing is a feasible treatment to produce MgO modified biochar and to recover P from livestock wastewater,and that the Mg-PBC-P can be used as a slow-release P fertilizer.

关键词： Engineered biochar Biomass pre-puffing Nutrient recovery Wastewater engineering Cost-benefit analysis

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Bio-assembled MgO-coated tea waste biochar efficiently decontaminates phosphate from water and kitchen waste fermentation liquid

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Biochar 2023年第1期5卷 391-408页

作者： Chuchu Feng Lan Zhang Xiu Zhang Jingyu Li Yimeng Li Yaru Peng Yuan Luo Ronghua Li Bin gao Mohamed A.Hamouda Ken Smith esmat F.ali Sang Soo Lee Zengqiang Zhang Jörg Rinklebe Sabry M.Shaheen College of Natural Resources and Environment Northwest A&F UniversityYangling 712100ShaanxiChina Ningxia Key Laboratory for the Development and Application of Microbial Resources in Extreme Environments North Minzu UniversityYinchuan 750021Ningxia Hui Autonomous RegionChina Department of Agricultural and Biological Engineering University of FloridaGainesvilleFL 32611USA Department of Civil and Environmental Engineering Faculty of EngineeringUnited Arab Emirates UniversityAl AinAbu DhabiUnited Arab Emirates The Department of Environmental Science The University of ArizonaShantz Building Rm 4291177 E 4th St.TucsonAZ 85721USA Department of Biology College of ScienceTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Department of Environmental and Energy Engineering Yonsei UniversityWonju 26493Republic of Korea School of Architecture and Civil Engineering Laboratory of Soil and Groundwater ManagementInstitute of Foundation EngineeringWater-and Waste-ManagementUniversity of WuppertalPauluskirchstraße 742285 WuppertalGermany Department of Arid Land Agriculture Faculty of MeteorologyEnvironmentand Arid Land AgricultureKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Soil and Water Sciences Faculty of AgricultureUniversity of KafrelsheikhKafr El-Sheikh 33516Egypt

Crystal morphology of metal oxides in engineered metal-biochar composites governs the removal of phosphorus(P)from aqueous *** to our best knowledge,preparation of bio-assembled MgO-coated biochar and its application for the removal of P from solutions and kitchen waste fermentation liquids have not yet been ***,in this study,a needle-like MgO particle coated tea waste biochar composite(MTC)was prepared through a novel biological assembly and template elimination *** produced MTC was used as an adsorbent for removing P from a synthetic solution and real kitchen waste fermentation *** maximum P sorption capacities of the MTC,deduced from the Langmuir model,were 58.80 mg g^(−1) from the solution at pH 7 and 192.8 mg g^(−1) from the fermentation liquid at pH *** increase of ionic strength(0-0.1 mol L^(−1) NaNO_(3))reduced P removal efficiency from 98.53%to 93.01%in the synthetic solution but had no significant impact on P removal from the fermentation *** of MgHPO4 and Mg(H_(2)PO_(4))_(2)(76.5%),ligand exchange(18.0%),and electrostatic attraction(5.5%)were the potential mechanisms for P sorption from the synthetic solution,while struvite formation(57.6%)and ligand exchange(42.2%)governed the sorption of P from the kitchen waste fermentation *** to previously reported MgO-biochar composites,MTC had a lower P sorption capacity in phosphate solution but a higher P sorption capacity in fermentation ***,the studied MTC could be used as an effective candidate for the removal of P from aqueous environments,and especially from the fermentation *** the future,it will be necessary to systematically compare the performance of metal-biochar composites with different metal oxide crystal morphology for P removal from different types of wastewater.

关键词： MgO carbon composite Biowaste-derived biochar Phosphorus sorption Fermentation liquid Dephosphorization

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玻璃熔体电阻率测定的不确定度评估

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玻璃 2022年第10期49卷 8-12页

作者：柏晓强邢文忠章林伊瑟马特哈莫扎维巨石集团有限公司桐乡314500 埃及国家研究中心开罗

玻璃熔体电阻率测定有_(2)种计算分析方法,第1种方法包含玻璃测试样截面积的测定与计算,第2种方法包含玻璃测试样熔体密度的测定与计算。通过对_(2)种测定与计算方法作不确定度评估可知,测试过程中玻璃熔体液面的波动与张力会增加电阻... 详细信息

玻璃熔体电阻率测定有_(2)种计算分析方法,第1种方法包含玻璃测试样截面积的测定与计算,第2种方法包含玻璃测试样熔体密度的测定与计算。通过对_(2)种测定与计算方法作不确定度评估可知,测试过程中玻璃熔体液面的波动与张力会增加电阻率测试的不确定度,_(2)种方法中玻璃截面积与熔体密度的测试偏差也会分别增加不确定度。对于CaO-B_(2)O_(3)-SiO_(2)-al_(2)O_(3)无碱玻璃配方,前者测试1500℃下玻璃熔体电阻率的不确定度为±5.0 W·cm,后者为±1.0 W·cm。结果表明:熔体密度法计算电阻率时,不确定度更小。

关键词：玻璃熔体电阻率测试方法不确定度评估

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