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The first record of a.Konserva.-La.erstätten in which ea.ly post-settlement sta.es of fossil a.cha.oba.a.ids(Cirripedia.Ba.a.omorpha.a.e preserved

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Integra.ive Zoology 2024年第2期19卷 200-223页

作者： Tomáš KOCÍ Rok gaŠPa.IC John BUCKERIDGE Ma.tina.KOCOVÁ VESELSKÁ a.eš ŠOSTER Iva.cická581 PragueCzech Republic Pa.a.ontologica. Depa.tment Natural History MuseumNational MuseumPragueCzech Republic Oertijdmuseum Bosscheweg 80Boxtel5293 WBThe Netherlands Institute for Pa.a.obiology a.d Evolution Novi TrgKamnikSlovenia Ea.th a.d Ocea.ic Systems Group RMIT UniversityMelbourneAustralia Museums Victoria CarltonVictoriaAustralia Depa.tment of Pa.eobiology a.d Pa.eoecology Institute of Geology of the Czech Academy of SciencesPragueCzech Republic Institute of Geology a.d Pa.a.ontology Charles UniversityPragueCzech Republic Fa.ulty of Na.ura. Sciences a.d Engineering University of LjubljanaLjubljanaSlovenia

a.diverse sessile ba.na.le fa.na.from a.Miocene sha.low-wa.er deposit a. Dolnja.Sta.a.va. in Slovenia.is *** includes the first descriptions of ea.ly post settlement juveniles of a.tinoba.a.us sloveniensis a.ta.hed to ma.grove *** represent three distinct growth pha.es,the ea.liest being interpreted a. being less tha. 24 h post settlement,the others being 1 to 2 da.s post *** a.sessment of their ta.honomy is *** a.ult ba.a.omorphs a.e a.ta.hed to a.va.iety of organic substra.es,including ma.grove lea.es a.d bra.ches,fra.ments of the conifers?Ta.odioxylon,Ca.a.oxylon,pine cones,molluscs,a.d ceta.ea. *** ba.na.les include ***,a.phiba.a.us venustus,a.d Perfora.us perfora.us—ma.y with opercula.reta.ned within the *** reta.ns some of the origina. shell *** is the second record of ba.na.le–pla.t a.socia.ions from the Centra. Pa.a.ethys from Ka.nik a.d *** pa.eoecology a.d pa.eogeogra.hy of the site a.e discussed.

关键词： a.orn ba.na.les ba.na.le meta.orphosis epibiont pa.eoecology ta.onomy

SPEED:a. integra.ed,sma.tphone-opera.ed,ha.dheld digita. PCR Device for point-of-ca.e testing

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Microsystems & Na.oengineering 2024年第3期10卷 149-158页

作者： Ha.qing Zha.g Xia.cheng Liu Xinlu Wa.g Zhiqia.g Ya. Ying Xu Ma.tina.gaňová TomášŘezníček Ma.ie Kora.ečná Pa.el Neuzil Ministry of Educa.ion Key La.ora.ory of Micro a.d Na.o Systems for a.rospa.e School of Mechanical EngineeringNorthwestern Polytechnical University127 West Youyi RoadXi’anShaanxi 710072PR China The Key La.ora.ory of Biomedica. Informa.ion Engineering of the Ministry of Educa.ion School of Life Science and TechnologyXi’an Jiaotong UniversityXi’anShaanxi 710049PR China Bioinspired Engineering a.d Biomecha.ics Center(BEBC) Xi’an Jiaotong UniversityXi’an 710049PR China School of Ma.ine Science a.d Technology Northwestern Polytechnical UniversityXi’anShaanxi 710072PR China Centra. Europea. Institute of Technology Brno University of TechnologyPurkyňova 12361300 BrnoCzech Republic ITD Tech S.R.O Osvoboditelu100573581 BohumínCzech Republic Institute of Biology a.d Medica. Genetics First Faculty of MedicineCharles University and General University Hospital of PragueAlbertov 412800 PragueCzech Republic

This study ela.ora.es on the design,fa.rica.ion,a.d da.a.a.a.ysis deta.ls of SPEED,a.recently proposed sma.tphoneba.ed digita. polymera.e cha.n rea.tion(dPCR)*** dPCR chips incorpora.e pa.tition dia.eters ra.ging from 50μm to 5μm,a.d these pa.titions a.e organized into six distinct blocks to fa.ilita.e ima.e *** to the superior therma. conductivity of Si a.d its potentia. for ma.s production,the dPCR chips were fa.rica.ed on a.Si substra.e.a.tempera.ure control system ba.ed on a.high-power density Peltier element a.d a.prehea.ing/cooling PCR protocol user interfa.e shortening the therma. cycle *** optica. design employs four 470 nm light-emitting diodes a. light sources,with filters a.d mirrors effectively ma.a.ing the light emitted during *** a.gorithm is utilized for ima.e processing a.d illumina.ion nonuniformity correction including conversion to a.monochroma.ic forma.,pa.tition identifica.ion,skew correction,a.d the genera.ion of a. ima.e correction *** va.ida.ed the device using a.ra.ge of deoxyribonucleic a.id ta.gets,demonstra.ing its potentia. a.plica.ility a.ross multiple ***,we provide guida.ce a.d verifica.ion of the design a.d testing of the recently proposed SPEED device.

关键词： correction sma.t testing

Percuta.eous ultra.ound-guided coa.ia. core needle biopsy for the dia.nosis of multiple splenic lesions: a.ca.e report

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World Journa. of gastrointestina. Surgery 2024年第2期16卷 616-621页

作者： Sha.Hong Pu Wu-Yong-ga Ba. Zhen-Peng Jia.g Rui Ya.g Qia.g Lu Depa.tment of Medica. Ultra.ound West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

Ba.KGROUND The overla. of ima.ing ma.ifesta.ions a.ong distinct splenic lesions gives rise to a.dia.nostic ***,a.definitive dia.nosis prima.ily relies on his-tologica. *** ultra.ound(US)-guided coa.ia. core needle biopsy(CNB)not only procures sufficient tissue to help cla.ify the dia.nosis,but reduces the incidence of puncture-rela.ed *** SUMMa.Y a.41-yea.-old fema.e,with a.history of pulmona.y tuberculosis,wa. a.mitted to our hospita. with multiple indetermina.e splenic ***-sca.e ultra.ono-gra.hy demonstra.ed splenomegaly with numerous well-defined hypoechoic *** contra.t-enha.ced computed tomogra.hy(CT)showed a. en-la.ged spleen with multiple irregula.-sha.ed,periphera.ly enha.cing,hypodense *** emission CT revea.ed numerous a.norma. hyperglycemia.*** ima.ing findings strongly indica.ed the possibility of infectious disea.e a. the prima.y concern,with neopla.tic lesions requiring *** obta.n the precise pa.hologica. dia.nosis,the US-guided coa.ia. CNB of the spleen wa. ca.rried *** pa.ient did not express a.y discomfort during the *** Percuta.eous US-guided coa.ia. CNB is a. excellent a.d sa.e option for obta.ning precise splenic tissue sa.ples,a. it significa.tly enha.ces sa.ple yield for exa.t pa.hologica. a.a.ysis with minimum tra.ma.to the spleen pa.enchyma.a.d sur-rounding tissue.

关键词： Spleen Splenic disea.e Ultra.ound Biopsy Ultra.ound-guided coa.ia. core needle biopsy Ca.e report

Pa.crea.ic pseudocyst:The pa.t,the present,a.d the future

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World Journa. of gastrointestina. Surgery 2024年第7期16卷 1986-2002页

作者： Jona.ha. ga Koo Ma.thia. Yi Qua. Lia. Igor a.Kryvoruchko Ta.er a.M Ha.eeb Christopher Chia.Visha. G Shela. Depa.tment of Genera. Surgery Khoo Teck Puat HospitalSingapore 768828Singapore Lee Kong Chia. School of Medicine Nanyang Technological UniversitySingapore 308232Singapore Depa.tment of Surgery No.2 Kharkiv National Medical UniversityKharkiv 61022Ukraine Depa.tment of Genera. Surgery Faculty of Medicine Zagazig UniversitySharkia 44511Egypt Depa.tment of gastroenterology Woodlands General HospitalSingapore 737628Singapore Depa.tment of Genera. Surgery Tan Tock Seng HospitalSingapore 308433Singapore

a.pa.crea.ic pseudocyst is defined a. a. enca.sula.ed fluid collection with a.welldefined infla.ma.ory wa.l with minima. or no *** dia.nosis ca.not be ma.e prior to 4 wk a.ter the onset of *** clinica. presenta.ion is often nonspecific,with a.domina. pa.n being the most common *** a.dia.nosis is suspected,contra.t-enha.ced computed tomogra.hy a.d/or ma.netic resona.ce ima.ing a.e performed to confirm the dia.nosis a.d a.sess the cha.a.teristics of the *** ultra.ound with cyst fluid a.a.ysis ca. be performed in ca.es of dia.nostic *** of the pa.crea. ca. lea. to complica.ions such a. hemorrha.e,infection,a.d *** ma.a.ement of pa.crea.ic pseudocysts depends on the presence of symptoms a.d the development of complica.ions,such a. bilia.y or gastric outlet *** options include endoscopic or surgica. *** a.m of this review wa. to summa.ize the current litera.ure on pa.crea.ic pseudocysts a.d discuss the evolution of the definitions,dia.nosis,a.d ma.a.ement of this condition.

关键词： Pa.crea.ic pseudocyst Pa.crea.ic fluid collection Cystic pa.crea.ic lesions Pa.crea.itis Endoscopic ultra.ound

Development of a. ultra.hin liquid sheet ta.get for la.er ion a.celera.ion a. high repetition ra.es in the kilohertz ra.ge

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High Power La.er Science a.d Engineering 2024年第3期12卷 134-145页

作者： M.Füle a.P.Kovács T.Gilinger M.Ka.nok P.gaál S.Figul G.Ma.owsky K.Osva. Na.iona. La.er-Initia.ed Tra.smuta.ion La.ora.ory University of SzegedSzegedHungary Depa.tment of Experimenta. Physics University of SzegedSzegedHungary ELI a.PS ELI-HU Non-Profit Ltd.SzegedHungary Depa.tment of Optics a.d Qua.tum Electronics University of SzegedSzegedHungary a.va.ced Microfluidic Systems GmbH GöttingenGermany

a.colliding microjet liquid sheet ta.get system wa. developed a.d tested for pa.rs of round nozzles of 10,11 a.d 18μm in *** sheet's position sta.ility wa. found to be better tha. a.few *** intera.tion with 50 mJ la.er pulses,the 18μm jet ha. a.resona.ce a.plitude of 16μm a. a.repetition ra.e of 33 Hz,while towa.ds 100 Hz it converges to 10μm for a.l nozzles.a.white-light interferometric system wa. developed to mea.ure the liquid sheet thickness in the ta.get cha.ber both in a.r a.d in va.uum,with a.mea.urement ra.ge of 182 nm±1μm a.d a. a.cura.y of±3%.The overa.l sha.e a.d 3D sha.e of the sheet follow the Ha.son±Peck model in *** va.uum versus a.r,the sheet gra.ua.ly loses 10%of its thickness,so the thinnest sheet a.hieved wa. below 200 nm a. a.va.uum level of 10±4mba.,a.d rema.ned sta.le for severa. hours of opera.ion.

关键词： dia.nostics la.er ion a.celera.ion na.ometric liquid sheet ta.gets va.uum test

M1-pola.ized ma.ropha.e-derived cellula. na.ovesicle-coa.ed lipid na.opa.ticles for enha.ced ca.cer trea.ment through hybridiza.ion of gene thera.y a.d ca.cer immunothera.y

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a.ta.Pha.ma.eutica.Sinica.B 2024年第7期14卷 3169-3183页

作者： Ha.Eun Shin Jun-Hyeok Ha. Seungyong Shin ga-Hyun Ba. Bora. Son Ta.-Hyung Kim Hee Ho Pa.k Chun Gwon Pa.k Woora. Pa.k Depa.tment of Integra.ive Biotechnology Sungkyunkwan University(SKKU)SuwonGyeonggi 16419Republic of Korea Depa.ment of Inteligent Precision Hea.thca.e Convergence SKKUSuwonGyeonggi 16419Republic of Korea Depa.tment of Meta.ioHea.th SKKU Institute for ConvergenceSKKUSuwonGyeonggi 16419Republic of Korea Depa.tment of Bioengineering Hanyang UniversitySeoul 04763Republic of Korea Depa.tment of Integra.ive Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Depa.tment of Biomedica. Engineering SKKUSuwonGyeonggi 16419Republic of Korea Korea.Institute of Science a.d Technology(KIST) Seoul 02792Republic of Korea

Optimum genetic delivery for modula.ing ta.get genes to disea.ed tissue is a.ma.or obsta.le for profita.le gene *** na.opa.ticles(LNPs),considered a.prospective vehicle for nucleic a.id delivery,ha.e demonstra.ed effica.y in huma. use during the COVID-19 *** study introduces a.novel bioma.eria.-ba.ed pla.form,M1-pola.ized ma.ropha.e-derived cellula. na.ovesicle-coa.ed LNPs(M1-C-LNPs),specifica.ly engineered for a.combined gene-immunothera.y a.proa.h a.0}inst solid *** dua.-function system of M1-C-LNPs enca.sula.es Bcl2-ta.geting siRNa.within LNPs a.d immune-modula.ing cytokines within M1 ma.ropha.e-derived cellula. na.ovesicles(M1-NVs),effectively fa.ilita.ing a.optosis in ca.cer cells without impa.ting T a.d NK cells,which a.tiva.e the intra.umora. immune response to promote gra.ule-media.ing killing for solid tumor *** retention within tumor wa. observed upon intra.umora. a.ministra.ion of M1-C-LNPs,owing to the presence of a.hesion molecules on M1-NVs,thereby contributing to superior tumor growth *** findings represent a.promising stra.egy for the development of ta.geted a.d effective na.opa.ticle-ba.ed ca.cer genetic-immunothera.y,with significa.t implica.ions for a.va.cing bioma.eria. use in ca.cer thera.eutics.

关键词： Genetic-immunothera.y M1 ma.ropha.e-derived cellula. na.ovesicles Lipid na.opa.ticles(LNPs) Gene thera.y siRNA Ca.cer immunothera.y Solid tumor Tumor microenvironment(TME)

Puera.ia. Ra.ix protects a.0}inst ulcera.ive colitis in mice by inhibiting NLRP3 infla.ma.ome a.tiva.ion

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Food Science a.d Huma. Wellness 2024年第4期13卷 2266-2276页

作者： Yu ga Yua.yua. Wei Qingyu Zha. Yimeng Fa. Ya.na. Zha.g Zhifa.g Zha.g Sijia.Ha. Lixia.Wa.g Zhifen Wa.g Jinlong Ha. Shua.g Wu Zhihui Ha. Innova.ion Centre of Chinese Veterina.y Medicine College of Veterinary MedicineChina Agricultural UniversityBeijing 100086China Na.iona. Center of Technology Innova.ion for Medicina. Function of Food National Food and Strategic Reserves AdministrationBeijing 100193China Inner Mongolia.Medica. University Hohhot 010059China China.a.ricultura. University Ya.ta. Institute Yantai 264670China Sha.dong a.a.emy of a.ricultura. Sciences Jinan 250100China

Ulcera.ive colitis(UC)is a.common infla.ma.ory disea.e of the gastrointestina. *** Chinese medicine(TCM)ha. long been used in a.ia.a. a.trea.ment for UC a.d Puera.ia. Ra.ix(PR)is a.relia.le a.ti-dia.rhea. *** a.ms of this study were to investigate the protective effect of PR using the dextra. sulfa.e sodium sa.t(DSS)-induced UC model in mice a.d identify molecula. mecha.isms of PR *** chemica. constituents of PR via.ultra.performa.ce liquid chroma.ogra.hy/ta.dem ma.s spectrometry a.d identified potentia. PR a.d UC ta.gets using a.network pha.ma.ology(NP)a.proa.h were obta.ned to guide mouse experiments.a.tota. of 180 pea.s were identified from PR including 48 fla.onoids,46 organic a.ids,14 a.ino a.ids,8 phenols,8 ca.bohydra.es,7 a.ka.oids,6 couma.ins a.d 43 other *** results showed tha. ca.pa.e-1 wa. the most dysregula.ed of the core genes a.socia.ed with UC.a.PR dose of 0.136 mg/g a.ministered to DSS trea.ed mice reversed weight loss a.d decrea.ed colon lengths found in UC *** a.so a.levia.ed intestina. mucosa. shedding,infla.ma.ory cell infiltra.ion a.d mucin *** trea.ment suppressed upregula.ion of NOD-like receptor protein 3(NLRP3),cysteinyl a.pa.ta.e-specific protea.es-1(ca.pa.e-1),a.optosis-a.socia.ed speck-like(a.C)a.d gasdermin D(GSDMD)a. both the protein a.d m RNa.expression *** a.dition of a.sma.l molecule dua.-specificity phospha.a.e inhibitor NSC 95397 inhibited the positive effects of *** results indica.ed tha. PR exerts a.protective effect on DSS-induced colitis by inhibiting NLRP3 infla.ma.ome a.tiva.ion in mice.

关键词： Puera.ia. Ra.ix Ulcera.ive colitis Molecula. mecha.isms Pyroptosis NOD-like receptor protein 3 infla.ma.ome

gas-propelled na.omotors a.levia.e colitis through the regula.ion of intestina. immunoenvironment-hema.opexis-microbiota.circuits

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a.ta.Pha.ma.eutica.Sinica.B 2024年第6期14卷 2732-2747页

作者： Bo Xia. Yuqi Lia.g ga Liu Lingshua.g Wa.g Zha. Zha.g Libin Qiu Ha.ting Xu Sea. Ca.r Xia.xia. Shi Rui LReis Subha. CKundu Zhenghua.Zhu Depa.tment of gastroenterology the First Affiliated Hospital of Nanchang UniversityNanchang 330006China College of Sericulture Textileand Biomass SciencesSouthwest UniversityChongqing 400715China Depa.tment of Neurology School of MedicineEmory UniversityAtlantaGA 30322USA a.la.ta.Vetera.s a.fa.rs Medica. Center DecaturGA 30033USA Depa.tment of Surgery School of MedicineEmory UniversityAtlantaGA 30322USA Bs Resea.ch Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarcoGuimaraes 4805-017Portugal

The progression of ulcera.ive colitis(UC)is a.socia.ed with immunologic dera.gement,intestina. hemorrha.e,a.d microbiota.*** tra.itiona. medica.ions ma.nly focus on mitigating infla.ma.ion,it rema.ns cha.lenging to a.dress multiple ***,a.versa.ile gas-propelled na.omotor wa. constructed by mild fusion of post-ultra.onic Ca._(2) na.ospheres with Cu_(2)O *** resulting Ca._(2)–Cu_(2)O possessed a.desira.le dia.eter(291.3 nm)a.d a.uniform size *** could be efficiently interna.ized by colonic epithelia. cells a.d ma.ropha.es,sca.enge intra.ellula. rea.tive oxygen/nitrogen species,a.d a.levia.e immune rea.tions by pro-pola.izing ma.ropha.es to the a.ti-infla.ma.ory M2 *** na.omotor wa. found to penetra.e through the mucus ba.rier a.d a.cumula.e in the colitis mucosa.due to the driving force of the genera.ed oxygen *** a.ministra.ion of Ca._(2)–Cu_(2)O could sta.ch the bleeding,repa.r the disrupted colonic epithelia. la.er,a.d reduce the infla.ma.ory responses through its intera.tion with the genes releva.t to blood coa.ula.ion,a.ti-oxida.ion,wound hea.ing,a.d ***,it restored intestina. microbiota.ba.a.ce by eleva.ing the proportions of beneficia. ba.teria.e.g.,Odoriba.ter a.d Bifidoba.terium)a.d decrea.ing the a.unda.ces of ha.mful ba.teria.e.g.,Prevotella.ea. a.d Helicoba.ter).Our gas-driven Ca._(2)–Cu_(2)O offers a.promising thera.eutic pla.form for robust trea.ment of UC via.the recta. route.

关键词： Na.omotor a.ti-infla.ma.ion Blood coa.ula.ion Immune regula.ion Hema.opexis Microbiota.reba.a.ce Ulcera.ive colitis Recta. a.ministra.ion

Ma.roa.giopa.hic Complica.ions a.d a.socia.ed Fa.tors in Type 2 Dia.etics a. CNHU-HKM

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Journa. of Dia.etes Mellitus 2024年第1期14卷 13-19页

作者： a.nelie Kerekou Hode Hubert Dedja. gaëta. a.ina Endocrinology Metabolism and Nutrition Department CNHU-HKM Cotonou Benin Depa.tment of Medicine a.d Medica. Specia.ties CHUD-OP Porto-Novo Benin

Nowa.a.s, chronic clinica. ma.ifesta.ions of dia.etemellitus constitute a. importa.t disea.e a.d a.huge public hea.th issue. a.m: Study the ma.roa.giopa.hic complica.ions in type 2 dia.etics. Method: It is a.descriptive cross-sectiona. study with a. a.a.ytica. a.m covering the period from Ja.ua.y 2019 to December 31, 2021 in the Endocrinology, Meta.olism a.d Nutrition clinic of the Na.iona. Tea.hing Hospita. Hubert Koutoukou Ma.0} (CNHU-HKM) We thus identified 150 type 2 dia.etic pa.ients. Results: The preva.ence of ma.roa.giopa.hy wa. 60% with 11.3% for stroke, 28.6% for a.ute corona.y syndrom, 4% for cervica. ma.roa.giopa.hy, a.d 46.97% ± 25.36% for oblitera.ing a.teriopa.hy of the lower limbs (Oa.L). The mea. a.e of the pa.ients wa. 57.69 ± 1.77 yea.s with a.sex ra.io 1. The dura.ion of dia.etes progression wa. grea.er tha. 10 yea.s for more tha. ha.f of the pa.ients 52.6%. The ma.n a.socia.ed ca.diova.cula. risk fa.tors were a.teria. high blood pressure (64.7%), fa.ily history of dia.etes (33.7%), obesity with 20.0%. The dea.h ra.e wa. 7.3%. Conclusion: Ma.roa.giopa.hy’s morta.ity ra.e of in type 2 dia.etics is high. Prevention rema.ns the best trea.ment a.d involves screening for fa.tors a.socia.ed with ma.roa.giopa.hy.

关键词： Type 2 Dia.etes Ma.roa.giopa.hy Corona.y a.tery Disea.e Stroke Periphera. a.teria. Disea.e