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TWONEW　TRITERPENOID　SAPONINS，ASTERBATANOSIDE　H　AND　I，FROM　ASTER　BATANGENSIS

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Chinese Chemical Letters 1995年第2期6卷 105-108页

作者： Shao, Y Zhou, BN Lin, LZ Cordell, ga Acad Sinica Shanghai Inst Mat Med Shanghai 200031 Peoples R China Univ Illinois Coll Pharm Dept Med Chem & Pharmacognosy Programm Collaborat Res Pharmaceut Sci Chicago IL USA

Two new triterpenoid saponins named asterbatanoside H and I have been isolated from the roots of Aster batsngensis and their structures elucidated as 3-O-β-D-glucopyranosyl-(1→3) β-D-glucopyranosyl-bayogenin-28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosy-(1→6) and 3-O-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-23-O-acetyl-bayogenin-28-O-β-D-glucopyranosyl-(1→6) β-D-glucopyranoside, respectively, by means of spectral and chemical data.

关键词： ASTERBATANOSIDE TRITERPENOID TWONEW FROM SAPONINS AND BATANGENSIS

EXPERIMENTAL STUDY ON THE MECHANISM OF THE RICHTMYERMESHKOV INSTABILITY AT A gaS-LIQUID INTERFACE

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Journal of Hydrodynamics 2009年第3期21卷 423-428页

作者： SHI Hong-hui ZHANG ga DU Kai JIA Hui-xia College of Mechanical Engineering and Automation Zhejiang University of Science and Technology Hangzhou 310018 China

The mechanism of the Richtmyer-Meshkov instability was experimentally studied in a vertical rectangular shock tube. The velocity of the interface driven by the shock wave was measured by a self-designed measurement system, which consists of semiconductor lasers, signal amplification circuits, digital oscilloscope and computer. Tests were carded out at several shock wave Mach numbers. In addition, the movement of the interface and the variation of the mixed zone width with time were recorded by high-speed photography. The experimental results show that the interface velocity increases with the increase of the Mach number, and the distance of the interface＇s movement and the width of the mixed zone vary with time in a linear relationship.

关键词： Richtmyer-Meshkov instability shock wave shock tube laser interface

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MicroRNA与肿瘤铂类耐药的研究

中国药理学通报 2017年第5期33卷 593-597页

作者：魏小丽顾康生高梦如安徽医科大学第一附属医院肿瘤内科安徽合肥230032

化疗是目前临床上治疗恶性肿瘤主要手段之一,铂类药物是临床上最常用的周期非特异性抗肿瘤药物,在临床治疗实体肿瘤中显示了良好的疗效,然而铂类抗肿瘤药物结构上的相似性使得耐药性或交叉耐药性成为限制该类药物临床应用的主要障碍之一... 详细信息

化疗是目前临床上治疗恶性肿瘤主要手段之一,铂类药物是临床上最常用的周期非特异性抗肿瘤药物,在临床治疗实体肿瘤中显示了良好的疗效,然而铂类抗肿瘤药物结构上的相似性使得耐药性或交叉耐药性成为限制该类药物临床应用的主要障碍之一。microRNA是近年来的研究热点之一。miRNA在生物学中起着重要的作用,包括细胞增殖、分化、凋亡、应激耐受及生理新陈代谢。microRNA对靶基因的调控与肿瘤耐药关系密切。该文主要就microRNA在肿瘤铂类耐药中作用的研究进行了综述。

关键词： MicroRNA 抗肿瘤肿瘤耐药 MDR 靶点基因调控

Production of composites with high relative permittivity using the spouted bed technique

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Particuology 2019年第1期17卷 184-189页

作者： E. Eichner P.-K. Fischer S. Heinrich ga Schneider Institute of Solids Process Engineering and Particle Technology Denickestr1521073 HamburgGermany Institute of Advanced Ceramics Hamburg University of TechnologyDenickestr1521073 HamburgGermany

This contribution presents a new application of the spouted bed technique. The developed production process involves coating fine copper particles with a polymer in a spouted bed plant and then hot pressing the produced granules to form a compact consisting of a copper–polymer composite with a high filling degree. The fabricated composites possess high relative permittivity, which is advantageous for the production of effective capacitors. With increasing filling degree of copper, the relative permittivity of the composites increased, with a maximum relative permittivity of 214 obtained for the composite containing 78.1 vol% copper. Such a high filling degree can be achieved with conductive particles without obtaining a conductive composite by using the spouted bed technology in the production process. The high relative permittivity results from the high filling degree of particles isolated by a polymer coating.

关键词： Spouted bed High relative permittivity Fine particles Coating Metal-polymer composite

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血液病患者感染甲型H1N1流感的预后分析

中华血液学杂志 2012年第2期33卷 113-116页

作者：高峥何雪峰张日苏州大学附属第一医院 215006 江苏省血液研究所卫生部血栓与止血重点实验室

目的探讨血液病患者与非血液病患者感染甲型H1N1流感病毒的临床特征和预后转归。方法收集2009年11月至2010年3月确诊的76例甲型H1N1流感患者临床资料，分析其中血液病患者与非血液病患者感染后的临床特征并采用回顾性多因素分析方法探... 详细信息

目的探讨血液病患者与非血液病患者感染甲型H1N1流感病毒的临床特征和预后转归。方法收集2009年11月至2010年3月确诊的76例甲型H1N1流感患者临床资料，分析其中血液病患者与非血液病患者感染后的临床特征并采用回顾性多因素分析方法探讨临床特征和治疗转归的关系。结果76例患者中，重症46例，危重23例。所有患者均接受奥司他韦治疗。76例患者中血液病患者6例（重症2例、危重4例），4例（66．67％）死亡；非血液系统基础疾病患者70例，5例（7．14％）死亡。Logistic多因素分析表明，血液病基础、发病年龄均与死亡显著相关（P值分别为0．0008和0．0380），其中，血液病基础这一因素OR值为75．368（95％凹为5．980-949．853），而慢性肺部基础疾病、抗病毒药物介入时间、淋巴细胞计数与死亡无明显相关性（P〉0．05）。结论血液病患者感染甲型H1N1流感预后较差，病程进展快，病死率高。

关键词：流感病毒A型血液病预后限定因素分析

Recent progress on lanthanide complexes/clay minerals hybrid luminescent materials

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Journal of Rare Earths 2022年第9期40卷 1360-1370,I0001页

作者： ga Zhang Lefu Mei Junjie Ding Ke Su Qingfeng Guo Guocheng Lv Libing Liao Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes National Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of GeosciencesBeijing 100083China School of Gemmology China University of GeosciencesBeijing 100083China

The unique luminescent performance of lanthanide complexes/clay minerals hybrid materials has been fascinating many researchers for recent *** not only retains the excellent luminescent characteristics of lanthanide complexes but also improves the poor stability of the *** this article,we introduce the luminescence mechanism of lanthanide complexes and point out the necessity of their combination with clay *** the analysis of the structure and interlayer environment differences of 1:1-type and 2:1-type clay minerals,the intercalation methods(covalent grafting and ion exchange)appropriate for different clay minerals are summarized with *** on the luminescence characteristics of the hybrid materials,the applications of these materials as luminescent probes in recognition of specific metal cations and molecules,detection of pH value,and temperature are ***,the current problems in the preparation of lanthanide complexes/clay minerals hybrid luminescent materials and shortcomings that need improvement in their performance are analyzed,and the application prospect is forecast.

关键词： Luminescence Hybrid materials Lanthanide complexes Clay minerals Luminescent probes Rare earths

SYMPLECTIC SCHEMES FOR QUASILINEAR WAVE EQUATIONS OF KLEIN-GORDON AND SINE-GORDON TYPE

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Journal of Computational Mathematics 2001年第5期19卷 475-488页

作者： Xiao-wu Lu (Department of Mathematics and Computer Science, Emory University, Atlanta, ga 30322, USA) Emory University 美国 30322

Presents a class of finite difference methods of first and second order accuracy for the computation of solutions to the quasilinear wave equations. Overview of general symplectic schemes and generating functional; Nu... 详细信息

关键词： Symplectic integration Sine-Gordon equations Finite difference method.

Dynamic Response of Sea-Crossing Rail-cum-Road Cable-Stayed Bridge Influenced by Random Wind–Wave–Undercurrent Coupling

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China Ocean Engineering 2023年第1期37卷 85-100页

作者： BIAN Chen-jie DU Li-ming WANG ga-ping LI Xin LI Wei-ran School of Civil Engineering Dalian Jiaotong UniversityDalian 116028China School of Locomotive and Rolling stock Engineering Dalian Jiaotong UniversityDalian 116028China School of Civil Engineering Beijing Jiaotong UniversityBeijing 100044China

Sea-crossing bridges are affected by random wind–wave–undercurrent coupling loads, due to the complex marine environment. The dynamic response of long-span Rail-cum-Road cable-stayed bridges is particularly severe under their influence, potentially leading to safety problems. In this paper, a fluid–structure separation solution method is implemented using Ansys–Midas co-simulation, in order to solve the above issues effectively while using less computational resources. The feasibility of the method is verified by comparing the tower top displacement response with relevant experimental data. From time and frequency domain perspectives, the displacement and acceleration responses of the sea-crossing Rail-cum-Road cable-stayed bridge influenced by wave-only, wind–wave, and wind–wave–undercurrent coupling are comparatively studied. The results indicate that the displacement and acceleration of the front bearing platform top are more significant than those of the rear bearing platform. The dominant frequency under wind–wave–undercurrent coupling is close to the natural vibration frequencies of several bridge modes,such that wind–wave–undercurrent coupling is more likely to cause a resonance effect in the bridge. Compared with the wave-only and wind–wave coupling, wind–wave–undercurrent coupling can excite bridges to produce larger displacement and acceleration responses: at the middle of the main girder span, compared with the wave-only case, the maximum displacement in the transverse bridge direction increases by 23.58% and 46.95% in the wind–wave and wind–wave–undercurrent coupling cases, respectively;at the tower top, the variation in the amplitude of the displacement and acceleration responses of wind–wave and wind–wave–undercurrent coupling are larger than those in the wave-only case, where the acceleration change amplitude of the tower top is from-0.93 to 0.86 m/s^(2) in the waveonly case, from-2.2 to 2.1 m/s^(2) under wind–wave coupling effect, and from-2.6 to 2.6

关键词： random wind wave undercurrent coupling effect Rail-cum-Road cable-stayed bridge dynamic response

Traditional Healer’s Medicinal Practice Survey and Clinical Evidence Assessment of “YIKI”: An Antimalarial Phytomedicine Recipe from Bobo-Dioulasso, Burkina Faso

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Pharmacology & Pharmacy 2024年第7期15卷 248-267页

作者： Zachari Kabre Rakiswende Serge Yerbanga Aminata Fofana Roland Nâg-Tiero Meda Anyirekun Fabrice Some Alassane Haro Natacha A. J. A. Boro Fazhira B. Ye Benjamin Kouliga Koama Sami Eric Kam Eliasse Zongo Hadidjatou Belèm Windmi Kagambèga Florence Fournet Georges A. Ouedraogo Jean-Bosco Ouedraogo Institut de Recherche en Sciences de la Sant Direction Rgionale de lOuest Bobo-Dioulasso Burkina Faso Laboratoire de Recherche et dEnseignement en Sant et Biotechnologies Animales Universit Nazi BONI Bobo-Dioulasso Burkina Faso Institut des Sciences et Techniques Bobo-Dioulasso Burkina Faso Laboratoire de Recherche en Bactriologie INSP/Centre MURAZ Bobo-Dioulasso Burkina Faso Maladies Infectueuses et Vecteurs: Ecologie Gntique Evolution et Contrle (MIVEGEC) Institut de Recherche pour le Dveloppement Universit de Monpellier Montpellier France

YIKI is an antimalarial phytomedicine used by a traditional healer to treat malaria in Bobo-Dioulasso. However, there is no scientific evidence to support its use by local populations. The aim of this study was to identify the medicinal practices of the healer holder of YIKI and assess the clinical evidence of its phytomedicine in the uncomplicated malaria treatment. Ethnomedical survey based on a semi-structured and open questionnaire was conducted from October to December 2019 with the healer. Malaria knowledge and diagnosis methods, patient treatment and monitoring, and recipe formulation steps were surveyed. Moreover, thick and thin blood smears were taken, haemoglobin levels and temperature of consenting patients were measured before treatment, mid-treatment and at the end of treatment. The survey revealed that the healer has a good knowledge of malaria symptoms and his diagnosis is based on observation and physical examination of patients. The healer’s malaria diagnosis was rudimentary and had accuracy problems, with only 62.79% of malaria cases confirmed by microscopy. The formulation of YIKI and its use to treat malaria follow a standard process for plant harvesting, powder quantities and posology, but do not use any reproducible parameters for dose adjustment. Forty-three patients diagnosed and treated by the healer participated in the study. Laboratory results revealed 27 Plasmodium falciparum infection cases, including 2 with parasitaemia ≥ 200,000 p/µl blood. 25 patients were selected for therapeutic evidence assessment. There was a 48% elimination of parasites, a 28% parasitaemia decrease without complete cure, with gametocytogenesis in some patients, and a 24% parasitaemia increase. Haemoglobin and temperature results suggested that YIKI was not cytotoxic and reduced fever. Encouraging preliminary results have been obtained, but in view of the low number of patients, further YIKI efficacy and toxicity studies will be necessary for patient safety.

关键词： Antimalarial-Phytomedicine Efficacy Traditional Practices Bobo-Dioulasso