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Enhanced Acceleration for generalized Nonconvex Low-Rank Matrix Learning

Chinese Journal of Electronics 2024年

作者： Hengmin zha.g Jian YANg Wenli DU Bob zha.g Zhiyuan zha Bihan WEN School of Electrical and Electronic Engineering Nanyang Technological University School of Computer Science and Engineering Nanjing University of Science and Technology College of Information Science and Engineering East China University of Science and Technology Department of Electrical and Computer Engineering University of Macau

Matrix minimization techniques that employ the nuclear norm have ga.ned recognition for their applicability in tasks like image inpainting, clustering, classification, and reconstruction. However, they come with inherent biases and computational burdens, especially when used to relax the rank function, making them less effective and efficient in real-world scenarios. To address these challenges, our research focuses on generalized nonconvex rank regularization problems in robust matrix completion (RMC), low-rank representation (LRR), and robust matrix regression (RMR). We introduce innovative approaches for effective and efficient low-rank matrix learning, grounded in generalized nonconvex rank relaxations inspired by various substitutes for the?0-norm relaxed functions. These relaxations allow us to more accurately capture low-rank structures. Our optimization strategy employs a nonconvex and multi-variable alternating direction method of multipliers (ADMM), backed by rigorous theoretical analysis for complexity and convergence. This algorithm iteratively updates blocks of variables, ensuring efficient convergence. Additionally, we incorporate the randomized singular value decomposition technique and/or other acceleration strategies to enhance the computational efficiency of our approach, particularly for large-scale constrained minimization problems. In conclusion, our experimental results across a variety of image vision-related application tasks unequivocally demonstrate the superiority of our proposed methodologies in terms of both efficacy and efficiency when compared to most other related learning methods.

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Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei zha.guoli Zheng Thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

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Chiral transfer amidst one-dimensional linear polymers and twodimensional network covalent orga.ic frameworks:Striking a fine balance between helicity and crystallinity

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Nano Research 2024年第6期17卷 5726-5734页

作者： Xinlin zha Mengjuan Zuo guilin Xu Zhong Yan Haining You Yi Xiong Ying Liu Yingying Li Liyan Yang Ke Liu Mufang Li Tao zhao Dong Wang College of Chemistry and Chemical Engineering Donghua UniversityShanghai 201620China Key Laboratory of Textile Fiber and Products Ministry of EducationWuhan Textile UniversityWuhan 430200China

The current landscape of chiral covalent orga.ic frameworks(COFs)predominantly centered on constructing asymmetric molecular-scale chirality,often introducing an inherent contradiction to the COF symmetry and limiting ***,we overcome these challenges by achieving chiral transfer between one-dimensional(1D)imine linear polymers(LPs)and two-dimensional(2D)networkβ-ketoenamine COFs composed of achiral *** successfully synthesize several 1D imine LPs with mesoscopic helical chirality,comprising achiral C2-symmetric terephthalaldehyde and diamine linkers in a chiral supramolecular transcription *** the irreversible tautomerism mechanism within the linker replacement approach,terephthalaldehyde(TPA)units in these helical 1D LPs are substituted with C3-symmetric 1,3,5-triformylphloroglucinol(TP),yielding the corresponding 2D networkβ-ketoenamine *** and helicity of the resultantβ-ketoenamine COFs intimately hinge on reaction conditions,including the aldehyde stoichiometry of Tp and TPA,as well as the quantity and concentration of the catalyst *** optimized conditions,the nucleation and growth were precisely governed,achieving a harmonious equilibrium of crystallinity and helicity within the generated 2D networkβ-ketoenamine COFs,even with covalent bond rupture,recombination,and topological transition(from[C2+C2]to[C3+C2]).Impressively,the ground state chirality inherent to helical 1D LPs seamlessly transfers to helical 2D networkβ-ketoenamine *** study not only offers new perspectives on the development of chiral functional COFs,but also provides fresh insights into the precise control of COFs'microscopic morphology.

关键词： chiral covalent orga.ic frameworks chiral transfer dimensional transformation helicity

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Translocation of telomerase reverse transcriptase coincided with ATP release in postnatal cochlear supporting cells

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Neural Regeneration Research 2024年第5期19卷 1119-1125页

作者： Yukai zha.g Keyong Tian Wei Wei Wenjuan Mi Fei Lu Zhenzhen Liu Qingwen Zhu Xinyu zha.g Panling geng Jianhua Qiu Yongli Song Dingjun zha Department of Otolaryngology Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

The spontaneous bursts of electrical activity in the developing auditory system are derived from the periodic release of adenosine triphosphate(ATP)by supporting cells in the Kölliker’s ***,the mechanisms responsible for initiating spontaneous ATP release have not been *** previous study revealed that telomerase reverse transcriptase(TERT)is expressed in the basilar membrane during the first postnatal *** role in cochlear development remains *** this study,we investiga.ed the expression and role of TERT in postnatal cochlea supporting *** results revealed that in postnatal cochlear Kölliker’s orga. supporting cells,TERT shifts from the nucleus into the cytoplasm over *** found that the TERT translocation tendency in postnatal cochlear supporting cells in vitro coincided with that observed in *** analysis showed that TERT in the cytoplasm was mainly located in mitochondria in the absence of oxidative stress or apoptosis,suggesting that TERT in mitochondria plays roles other than antioxidant or anti-apoptotic *** observed increased ATP synthesis,release and activation of purine signaling systems in supporting cells during the first 10 postnatal *** phenomenon that TERT translocation coincided with changes in ATP synthesis,release and activation of the purine signaling system in postnatal cochlear supporting cells suggested that TERT may be involved in regulating ATP release and activation of the purine signaling *** study provides a new research direction for exploring the spontaneous electrical activity of the cochlea during the early postnatal period.

关键词： apoptosis ATP release Ca2+transients cochlea mitochondrial function reactive oxygen species spontaneous electrical activity supporting cells

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Elevated peripheral levels of receptor-interacting protein kinase 1(RIPK1)and IL-8 as biomarkers of human amyotrophic lateral sclerosis

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Signal Transduction and Targeted Therapy 2024年第1期9卷 271-278页

作者： Jun Wei Min Li Zhi Ye Xinqian Hu Xiaoyan He Jia Wang ga.feng Chen Chengyu Zou Daichao Xu Hongbing zha.g Junying Yuan Yunhong zha Institute of Neural Regeneration and Repair and Department of Neurology The First College of Clinical Medical ScienceYichang Central HospitalCollege of Basic Medical ScienceChina Three Gorges UniversityHubei Province Clinical Medical Research Center for Rare Diseases of Nervous SystemYichang 443000China Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai Key Laboratory of Aging StudiesShanghai 201210China State Key Laboratory of Common Mechanism Research for Major Diseases Haihe Laboratory of Cell EcosystemDepartment of PhysiologyInstitute of Basic Medical Sciences and School of Basic MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Amyotrophic lateral sclerosis(ALS)is a devastating fatal neurodegenerative disease with no ***-interacting protein kinase 1(RIPK1)has been proposed to mediate pathogenesis of *** has been identified as an old drug that can also inhibit RIPK1 *** conducted a drug-repurposing biomarker study of primidone as a RIPK1 inhibitor using SOD1g93A mice and ALS ***1g93A mice treated with primidone showed significant delay of symptomatic onset and improved motor ***-hundred-sixty-two ALS participants dosed daily with primidone(62.5 mg)completed 24-week follow-up.A significant reduction was showed in serum levels of RIPK1 and IL-8,which were significantly higher in ALS patients than that of healthy controls(Pggests that serum levels of RIPK1 and IL-8 in peripheral can be used as clinical biomarkers for the activation of RIPK1 in central nervous system in human ALS *** primidone may provide a promising therapeutic strategy for *** effect of primidone for the treatment of other inflammatory diseases may also be considered,since the activation of RIPK1 has been implicated in mediating a variety of inflammatory diseases including COVID-19-associated cytokine release syndrome(CRS).(ChiCTR2200060149).

关键词： RIPK1 diseases Serum

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The technology of radio frequency fingerprint identification based on deep learning for 5g application

Security and Safety

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Security and Safety 2024年第1期3卷 47-67页

作者： Yun Lin Hanhong Wang Haoran zha College of Information and Communication Engineering Harbin Engineering UniversityHarbin 150001China

User Equipment(UE)authentication holds paramount importance in upholding the security of wireless networks.A nascent technology,Radio Frequency Fingerprint Identification(RFFI),is ga.ning prominence as a means to bolster network security *** expedite the integration of RFFI within fifth-generation(5g)networks,this research undertakes the creation of a comprehensive link-level simulation platform tailored for 5g *** devised platform emulates various device impairments,including an oscillator,IQ modulator,and power amplifier(PA)nonlinearities,alongside simulating channel *** to this,a plausibility analysis is executed,intertwining transmitter device impairments with 3rd generation Partnership Project(3gPP)new radio(NR)***,an exhaustive exploration is conducted to assess the impact of transmitter impairments,deep neural networks(DNNs),and channel effects on RF fingerprinting ***,under a signal-to-noise ratio(SNR)of 15 d B,the deep learning approach demonstrates the capability to accurately classify 100 UEs with a commendable 91%accuracy *** a multifaceted evaluation,it is ascertained that the Attention-based network architecture emerges as the optimal choice for the RFFI task,serving as the new benchmark model for RFFI applications.

关键词： UE authentication radio frequency ngerprint identi cation 5g security deep neural networks

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芬太尼问题与中美关系

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国际政治研究 2024年第2期45卷 101-119,7,8页

作者：查道炯北京大学国际关系学院、南南合作与发展学院 100871

芬太尼自70年前问世以来,因其既是为满足镇痛管理的正当合理需求而成为不断被研发和生产的药物,又因合成化学知识和技术被国际毒品市场滥用,从而成为各国药物监管、司法、国际禁毒合作的常规性挑战。中美两国的科学研究、医疗和执法部... 详细信息

芬太尼自70年前问世以来,因其既是为满足镇痛管理的正当合理需求而成为不断被研发和生产的药物,又因合成化学知识和技术被国际毒品市场滥用,从而成为各国药物监管、司法、国际禁毒合作的常规性挑战。中美两国的科学研究、医疗和执法部门在芬太尼问题上走过了40多年的机制性交流与合作的过程。拜登政府延续特朗普政府的政策取向,不仅在2023年11月中美元首会晤场合将在美国更严重的芬太尼物质滥用与中国管理涉芬太尼物质的跨国流动程度直接挂钩,而且将之提到与军事交流同等重要的高度,芬太尼问题在两国关系中的分量俨然具有杠杆性。但是,在中美两国,芬太尼问题的叙事都具有多元性。更有效地监管芬太尼物质的跨国流通、打击过程中的违规和非法行为,有赖于双方都从功能性合作的理念出发,强化公共卫生和司法合作两大领域的互动机制。

关键词：非传统安全芬太尼芬太尼问题中美关系禁毒合作公共卫生司法合作

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Evolutionary dynamics and comparative pathogenicity of clade 2.3.4.4b H5 subtype avian influenza viruses,China,2021–2022

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Virologica Sinica 2024年第3期39卷 358-368页

作者： Siru Lin Junhong Chen Ke Li Yang Liu Siyuan Fu Shumin Xie Aimin zha Aiguo Xin Xinyu Han Yuting Shi Lingyu Xu Ming Liao Weixin Jia National Avian Influenza Para-Reference Laboratory Guangdong Engineering Laboratory for Medicament of Zoonosis Prevention and ControlKey Laboratory of Zoonoses Prevention and Control of Guangdong ProvinceLaboratory for Lingnan Modern AgricultureCollege of Veterinary MedicineSouth China Agricultural UniversityGuangzhou510642China Key Laboratory of Zoonoses Key Laboratory of Animal Vaccine DevelopmentMinistry of AgricultureGuangzhou510642China Institute of Poultry Management and Diseases Yunnan Animal Science and Veterinary InstituteKunming650000China

The recent concurrent emergence of H5N1,H5N6,and H5N8 avian influenza viruses(AIVs)has led to significant avian mortality *** 2020,frequent human-animal interactions have been *** ga.n insight into the novel H5 subtype AIVs(i.e.,H5N1,H5N6 and H5N8),we collected 6102 samples from various regions of China between January 2021 and September 2022,and identified 41 H5Nx *** analyses on the evolution and biological properties of these isolates were *** analysis revealed that the 41 H5Nx strains belonged to clade 2.***.4.4b,with 13 related to H5N1,19 to H5N6,and 9 to *** based on global 2.***.4.4b viruses showed that all the viruses described in this study were likely originated from H5N8,exhibiting a heterogeneous evolutionary history between H5N1 and H5N6 during 2015–2022 worldwide.H5N1 showed a higher rate of evolution in 2021–2022 and more sites under positive selection pressure in 2015–*** antigenic profiles of the novel H5N1 and H5N6 exhibited notable *** hemagglutination inhibition assay suggested that some A(H5N1)viruses may be antigenically distinct from the circulating H5N6 and H5N8 *** challenge assays demonstrated that the H5N8 virus(21gD001_H5N8)displayed the highest pathogenicity in mice,followed by the H5N1 virus(B1557_H5N1)and then the H5N6 virus(220086_H5N6),suggesting a heterogeneous virulence profile of H5 AIVs in the mammalian *** on the above results,we speculate that A(H5N1)viruses have a higher risk of emergence in the ***,these findings unveil a new landscape of different evolutionary history and biological characteristics of novel H5 AIVs in clade 2.***.4.4b,contributing to a better understanding of designing more effective strategies for the prevention and control of novel H5 AIVs.

关键词： Avian influenza virus(AIV) H5 subtypes AIVs Evolutionary Pathogenicity

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Acupuncture for cervical dystonia associated with anxiety and depression: A case report

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World Journal of Clinical Cases 2024年第1期12卷 204-209页

作者： Ya-Ting zha.g Jin-Jing zha.g Bi-Xiang zha Yin-Qiu Fan Yuan-Bo Xu Jun Yang Qing-Ping zha.g The First School of Clinical Medicine Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina Acupuncture and Rehabilitation Department First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina College of Acupuncture and Tuina Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina

BACKgROUND Cervical dystonia(CD)is a type of muscle tone disorder that usually occurs in the neck *** to the intermittent or continuous involuntary contraction of the neck muscles,the head and neck are twisted and skewed and some postural abnormalities ***-term abnormal posture or pain can cause nega.ive emotions in patients,which can affect their quality of *** SUMMARY This case report included a 37-year-old woman who was diagnosed with CD associated with anxiety and depression;the accompanying symptoms were head and neck tilt of approximately 90°to the right and mental *** two courses of acupuncture treatment,the patient’s head and neck can be maintained in a normal position,and the nega.ive emotions can be *** This case indicates that acupuncture can effectively improve CD and the emotional state and quality of life of patients,making it an effective alternative treatment for the condition.

关键词： Cervical dystonia Anxiety and depression Neurological disease Acupuncture Case report

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结合色彩补偿与双背景光融合的水下图像复原

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光学精密工程 2024年第7期32卷 1059-1074页

作者：林森查子月沈阳理工大学自动化与电气工程学院辽宁沈阳110159

针对复杂成像环境下,水下图像存在颜色失真、细节模糊以及对比度低的问题,提出结合色彩补偿与双背景光融合的水下图像复原方法。通过分析光在水中的吸收衰减特性,提出改进的水下成像模型,基于Retinex理论与白平衡算法引入色彩补偿分量,... 详细信息

针对复杂成像环境下,水下图像存在颜色失真、细节模糊以及对比度低的问题,提出结合色彩补偿与双背景光融合的水下图像复原方法。通过分析光在水中的吸收衰减特性,提出改进的水下成像模型,基于Retinex理论与白平衡算法引入色彩补偿分量,降低水体背景颜色影响;根据背景光强度和颜色分布特性,提出双候选背景光融合方法,准确估计全局背景光;不依赖任何水体环境参数,根据背景颜色与散射系数的内在关系,采用引导-高通滤波,优化并增强各通道透射率;最后,逆求解成像模型复原水下图像。实验结果表明,在4个不同的水下数据集上与经典及新颖方法对比,所提方法恢复的图像颜色更自然,纹理细节更丰富清晰;色差值改善幅度达5.4%,UCIQE及FDUM指标提升幅度分别达8.3%和4.5%。所提方法在定性和定量实验中更具优势,能够显著提高水下图像质量。

关键词：水下图像复原色彩补偿背景光融合透射率估计

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