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M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3169-3183页

作者： ha Eun Shin Jun-Hyeok han Seungyong Shin ga.Hyun Bae Boram Son Tae-Hyung Kim Hee Ho Park Chun Gwon Park Wooram Park Department of Integrative Biotechnology Sungkyunkwan University(SKKU)SuwonGyeonggi 16419Republic of Korea Deparment of Inteligent Precision Healthcare Convergence SKKUSuwonGyeonggi 16419Republic of Korea Department of MetaBioHealth SKKU Institute for ConvergenceSKKUSuwonGyeonggi 16419Republic of Korea Department of Bioengineering Hanyang UniversitySeoul 04763Republic of Korea Department of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biomedical Engineering SKKUSuwonGyeonggi 16419Republic of Korea Korea Institute of Science and Technology(KIST) Seoul 02792Republic of Korea

Optimum genetic delivery for modulating target genes to diseased tissue is a major obstacle for profitable gene *** nanoparticles(LNPs),considered a prospective vehicle for nucleic acid delivery,have demonstrated efficacy in human use during the COVID-19 *** study introduces a novel biomaterial-based platform,M1-polarized macrophage-derived cellular nanovesicle-coated LNPs(M1-C-LNPs),specifically engineered for a combined gene-immunotherapy approach aga.nst solid *** dual-function system of M1-C-LNPs encapsulates Bcl2-targeting sirNA within LNPs and immune-modulating cytokines within M1 macrophage-derived cellular nanovesicles(M1-NVs),effectively facilitating apoptosis in cancer cells without impacting T and NK cells,which activate the intratumoral immune response to promote granule-mediating killing for solid tumor *** retention within tumor was observed upon intratumoral administration of M1-C-LNPs,owing to the presence of adhesion molecules on M1-NVs,thereby contributing to superior tumor growth *** findings represent a promising strategy for the development of targeted and effective nanoparticle-based cancer genetic-immunotherapy,with significant implications for advancing biomaterial use in cancer therapeutics.

关键词： Genetic-immunotherapy M1 macrophage-derived cellular nanovesicles Lipid nanoparticles(LNPs) Gene therapy sirNA Cancer immunotherapy Solid tumor Tumor microenvironment(TME)

Estimation of hydraulic parameters from pumping tests in a multiaquifer system

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Underground Space 2020年第3期5卷 210-222页

作者： Da ha ga.g Zheng haizuo Zhou Chaofeng Zeng Huihui Zhang School of Civil Engineering Tianjin UniversityTianjin 300072China Key Laboratory of Coast Civil Structure Safety of Ministry of Education Tianjin UniversityTianjin 300072China Hunan Provincial Key Laboratory of Geotechnical Engineering for Stability Control and Health Monitoring School of Civil EngineeringHunan University of Science and TechnologyXiangtanHunan 411201China School of resources and Environmental Sciences Wuhan UniversityWuhan 430079China

The hydrogeologic conditions in Tianjin,China,are characterized by a system of multiple alternating aquifers and aquitards and a high groundwater ***,the groundwater system to a depth of 70 m includes one phreatic aquifer and three semiconfined aquifers(AqI–AqIII).The distribution of aquifers varies *** estimates of aquifer parameters from pumping tests are essential in geotechnical engineering *** this study,the applicability of different models for estimating hydraulic parameters in a multiaquifer system is *** avoid errors in the graphic-analytical process and to enhance the efficiency and accuracy,a hybrid algorithm,called ga.MA(a genetic algorithm(ga.combined with the Levenberg–Marquardt(LM)algorithm),is used with the Neuman and Witherspoon model and ratio *** estimated values in the second and third semiconfined aquifers(AqII and AqIII)from various solutions are compared with the measured *** validations based on the prediction of the drawdown values are performed via a three dimensional numerical simulation.

关键词： Hydraulic parameter Leaky aquifer Pumping test Optimal approach

Numerical Identification of Nonlocal Potentials in Aggrega.ion

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Communications in Computational Physics 2022年第8期32卷 638-670页

作者： Yuchen He Sung ha Kang Wenjing Liao hao Liu Yingjie Liu Institute of Natural Sciences Shanghai Jiao Tong UniversityShanghaiChina School of Mathematics Georgia Institute of TechnologyAtlantaGeorgiaGA 30332-0160USA Department of Mathematics Hong Kong Baptist UniversityHong Kong SAR

Aggrega.ion equations are broadly used tomodel population dynamicswith nonlocal interactions,characterized by a potential in the *** paper considers the inverse problem of identifying the potential from a single noisy spatialtemporal *** identification is challenging in the presence of noise due to the instability of numerical *** propose a robust model-based technique to identify the potential by minimizing a regularized data fidelity term,and regularization is taken as the total variation and the squared Laplacian.A split Bregman method is used to solve the regularized optimization *** method is robust to noise by utilizing a Successively Denoised Differentiation *** consider additional constraints such as compact support and symmetry constraints to enhance the performance *** also apply thismethod to identify time-varying potentials and identify the interaction kernel in an agent-based *** numerical examples in one and two dimensions are included to verify the effectiveness and robustness of the proposed method.

关键词： Aggrega.ion equation nonlocal potential PDE identification Bregman iteration operator splitting

An Efficient Plant regeneration System of Hydrangea bretschneideri Dipp via Stem Segments as Explants

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Phyton-International Journal of Experimental Botany 2021年第2期90卷 595-604页

作者： Si ran Wang Jia Yan Bu er.ha.Yu’e Bai Institute of Forest Tree Genetic Breeding Forestry CollegeInner Mongolia Agricultural UniversityHohhot010000China

Hydrangea bretschneideri Dipp is a highly popular ornamental plant for ga.den *** engineering technology has been successfully used in many plant species,but it is limited in *** we established an efficient regeneration system by using stem segments as explants for the first *** our study,the plant growth regulators(PGrs)were evaluated at the different regeneration processes,including axillary shoots regeneration and root *** found that the optimal concentration for axillary buds’induction was 2.0 mgL^(-1)6-BA and 0.5 mgL^(-1)1 IAA,its highest induction rate was 70%.Moreover,the highest axillary shoots proliferation coefficient was 10.7 on the Murashige and Skoog(MS)medium with 2.0 mgL^(-1)6-benzyladenine(BA),0.2 mgL^(-1)indole-3-butyric acid(IBA),and 1.0 mgL^(-1)gibberellin A3(ga.).The highest frequency of root induction was 80.0±0.06%by culturing the elonga.ed shoots in 1/2 MS medium containing 0.1 mgL^(-1)*** summary,our study will provide an effective technology for large-scale propaga.ion and important pathway for promoting the popularization and application of Hydrangea bretschneideri Dipp.

关键词： Hydrangea bretschneideri Dipp stem segments regeneration

比色法测定蒙药铜灰体系中产生的·OH自由基

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光谱实验室 2001年第2期18卷 210-212页

作者：贺锋嘎哈森其木格斯琴内蒙古民族大学理工学院化学系内蒙古通辽市028043 包头医学院附属医院内蒙古包头市014700

根据细胞色素 C的氧化特性 ,采用比色法测定蒙药铜灰体系中产生的·OH自由基。实验证明 ,以盐酸羟胺为还原剂 ,在磷酸二氢钾缓冲溶液中测定 ,效果较好。该体系不受 β-胡萝卜素的抑制 ,仅受硫脲的抑制 ,说明蒙药铜灰可作为筛选抗· OH... 详细信息

根据细胞色素 C的氧化特性 ,采用比色法测定蒙药铜灰体系中产生的·OH自由基。实验证明 ,以盐酸羟胺为还原剂 ,在磷酸二氢钾缓冲溶液中测定 ,效果较好。该体系不受 β-胡萝卜素的抑制 ,仅受硫脲的抑制 ,说明蒙药铜灰可作为筛选抗· OH自由基的消除剂 ,并具有“燥脓、清肺、肝之热”等功能。

关键词：蒙药铜灰盐酸羟胺药物分析烃基自由基比色法

Efficient TE-Selective P-I-i-I-N ga.s/Al_( 0.35)ga.(0.65)As Waveguide Phase Modulator at λ=1.55μm

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光学学报 2003年第S1期23卷 341-342页

作者： Sun-Pil Kim Sang-Sun Lee Seok Lee Deok-ha Woo Sun-Ho Kim Photonics research Laboratory Division of Electrical and Computer Engineering Hanyang University 17 Hangdang-Dong Seongdong-Ku Seoul 133-791 Korea Photonics research Center KIST P.O.Box 131 Cheongryang Seoul 130-650 Korea

We fabricated a phase modulator with significant phase shift for TE mode but negligible for TM mode. The measured phase shift efficiency was 7.9°/*** for TE mode. No modulation was observed for TM mode.

关键词： phase shift

Towards understanding structure–property relations in materials with interpretable deep learning

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npj Computational Materials 2023年第1期9卷 157-168页

作者： Tien-Sinh Vu Minh-Quyet ha Duong-Nguyen Nguyen Viet-Cuong Nguyen Yukihiro Abe Truyen Tran Huan Tran Hiori Kino Takashi Miyake Koji Tsuda Hieu-Chi Dam Japan Advanced Institute of Science and Technology NomiIshikawaJapan HPC SYSTEMS Inc. MinatoTokyoJapan Applied Artificial Intelligence Institute Deakin UniversityGeelongVICAustralia School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGAUSA research and Services Division of Materials Data and Integrated System National Institute for Materials ScienceTsukubaIbarakiJapan research Center for Computational Design of Advanced Functional Materials National Institute of Advanced Industrial Science and TechnologyTsukubaIbarakiJapan Department of Computational Biology and Medical Sciences Graduate School of Frontier SciencesUniversity of TokyoKashiwa-shiChiba-kenJapan International Center for Synchrotron radiation Innovation Smart(SrIS) Tohoku UniversityAoba-kuSendaiJapan

Deep learning(DL)models currently employed in materials research exhibit certain limitations in delivering meaningful information for interpreting predictions and comprehending the relationships between structure and material *** address these limitations,we propose an interpretable DL architecture that incorporates the attention mechanism to predict material properties and ga.n insights into their structure–property *** proposed architecture is evaluated using two well-known datasets(the QM9 and the Materials Project datasets),and three in-house-developed computational materials ***–test–split validations confirm that the models derived using the proposed DL architecture exhibit strong predictive capabilities,which are comparable to those of current state-of-the-art ***,comparative validations,based on first-principles calculations,indicate that the degree of attention of the atoms’local structures to the representation of the material structure is critical when interpreting structure–property relationships with respect to physical *** properties encompass molecular orbital energies and the formation energies of *** proposed architecture shows great potential in accelerating material design by predicting material properties and explicitly identifying crucial features within the corresponding structures.

关键词： properties property structure

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光度法测定三种卷柏中总黄酮

理化检验（化学分册） 2007年第2期43卷 156-156,163页

作者：贺锋嘎哈森其木格肖田梅内蒙古民族大学化学学院通辽028043

选用旱生卷柏、卷柏和垫状卷柏,Maxim等三种卷柏的全草进行试验。卷柏为多年生草本,民间药用全草,具有活血散瘀、凉血的功效、有活血通经之功能,用于经闭痛经,症痛痞块,跌扑损伤;经炒炭而成卷柏炭,化瘀止血,用于吐血崩漏,便血,脱肛。[... 详细信息

选用旱生卷柏、卷柏和垫状卷柏,Maxim等三种卷柏的全草进行试验。卷柏为多年生草本,民间药用全草,具有活血散瘀、凉血的功效、有活血通经之功能,用于经闭痛经,症痛痞块,跌扑损伤;经炒炭而成卷柏炭,化瘀止血,用于吐血崩漏,便血,脱肛。[第一段]

关键词：光度法测定卷柏总黄酮 Maxim 多年生草本活血炭

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山苦荬化学成分及药理研究进展

天然产物研究与开发 2020年第7期32卷 1259-1267页

作者：希古日干哈力嘎白淑珍拉喜那木吉拉内蒙古民族大学蒙医药学院内蒙古民族大学化学化工学院通辽028000

本次研究通过国内外文献报道及详细的进行总结归纳为蒙药材山苦荬的化学成分及药理研究进展提供有力依据。通过文献检索,对蒙药材山苦荬的化学成分及药理研究分类归纳研究现状及进行综述。蒙药材山苦荬含有多种化学成分,主要有萜类、三... 详细信息

本次研究通过国内外文献报道及详细的进行总结归纳为蒙药材山苦荬的化学成分及药理研究进展提供有力依据。通过文献检索,对蒙药材山苦荬的化学成分及药理研究分类归纳研究现状及进行综述。蒙药材山苦荬含有多种化学成分,主要有萜类、三萜类、甾体化合物、黄酮类及其苷类,还少量含有挥发油、酚类等。而且具有保肝、降血脂、抗氧化、抗肿瘤、止咳祛痰及保健作用。为蒙药材山苦荬的进一步研究、开发提供了有益的参考。

关键词：山苦荬化学成分苦荬菜属药理研究