检索结果-南通市图书馆

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping yu Emily Choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit Glun3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of Bi addition on dynamic recrystallization and precipitation behaviors during hot extrusion of pure Mg

引用

Journal of Materials Science & Technology 2020年第9期44卷 62-75页

作者： Jongbin Go Jong un Lee hui yu Sung hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu41566Republic of Korea School of Materials Science and Engineering Hebei University of TechnologyTianjin300130China

Low material cost and high extrudability for ensuring price competitiveness with Al alloys,as well as excellent mechanical properties,are essential for expanding the application range of Mg *** is a promising alloying element for developing extruded Mg alloys that satisfy such *** is inexpensive,exhibits a high solubility limit,and forms a thermally stable Mg3Bi2 phase,which improves the commercial viability and enables the high-speed extrusion of Mg–Bi *** this study,the effects of Bi addition on the dynamic recrystallization(DRX)and dynamic precipitation behaviors during hot extrusion of a pure Mg and the resultant microstructure and mechanical properties of the extruded materials were *** addition of 6 wt%and 9 wt%Bi to a pure Mg yielded numerous fine Mg3Bi2 precipitates during the early stage of hot ***,the area fraction of dynamic recrystallized(DRXed)grains decreased because of DRX-behavior suppression by the Zener pinning ***,the DRXed grain size was substantially reduced through the grain-boundary pinning *** size and number of undissolved Mg3Bi2 particles in the homogenized billets increased when the Bi content was increased,which resulted in increased DRX fractions owing to the enhanced levels of particle stimulated *** addition yielded considerable strength improvement of the extruded pure ***,the extruded Mg–Bi binary materials were less ductile than the extruded pure Mg *** lower ductility resulted from the cracking at twins formed in the coarse unDRXed grains of the Mg-6Bi material and the cracking at large undissolved Mg3Bi2 particles in the Mg-9Bi material.

关键词： Magnesium Bi addition Extrusion Recrystallization Precipitation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of Sn addition on the microstructure and mechanical properties of extruded Mg-Bi binary alloy

引用

Journal of Magnesium and Alloys 2022年第3期10卷 920-931页

作者： Sang-Cheol Jin Jong un Lee Jongbin Go hui yu Sung hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566South Korea Department of Materials Science and Engineering Kyoto UniversityYoshida-honmachiSakyo-kuKyoto606-8501Japan School of Materials Science and Engineering Hebei University of TechnologyTianjin 300130China

We investigated the effects of Sn addition on the microstructural characteristics and mechanical properties of an extruded Mg-Bi binary alloy by comparing Mg-5 Bi(B5)and Mg-5 Bi-4 Sn(BT54).Both the extruded alloys exhibit a partially recrystallized grain structure with a strong extrusion fiber texture and numerous Mg3Bi2 ***,the addition of Sn significantly decreases the average grain size of the extruded alloy from 123.9 to 75.2μ*** Sn solute atoms inhibit the activity of dislocation slip,which reduces the internal strain energy accumulated in the dynamically recrystallized(DRXed)grains during ***,this reduced strain energy leads to the decrease in the DRXed grain size owing to weakened grain growth during natural *** extruded BT54 alloy exhibits higher tensile strength and ductility than the extruded B5 *** improvement in the strength by the Sn addition is attributed to the combined effects of grain refinement,Sn solute atoms,and increased dislocation *** formation of{10-11}and{10-11}-{10-12}twins during tension is suppressed by the grain refinement,thereby improving the tensile elongation considerably.

关键词： Mg±Bi alloy Extrusion Dynamic recrystallization Microstructure Mechanical properties.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tribological properties of polyimide composites reinforced with fibers rubbing against Al_(2)O_(3)

引用

Friction 2021年第2期9卷 301-314页

作者： huimin QI ga ZhANG Zhiqin ZhENG Jiaxin yu Chao hU Key Laboratory of Testing Technology for Manufacturing Process in Ministry of Education State Key Laboratory of Environment-friendly Energy MaterialsSouthwest University of Science and TechnologyMianyang 621010China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Qingdao Center of Resource Chemistry&New Materials Qingdao 266071China Fundamental Science on Nuclear Wastes and Environmental Safety Laboratory Southwest University of Science and TechnologyMianyang 621010China

Reinforcing fillers are of great importance in tribological performance and tribofilm formation of polymeric *** this study,the tribological properties of aramid particle(AP)and short carbon fiber(SCF)reinforced polyimide(PI)composites were added to hexagonal boron nitride(h-BN),and silica(SiO_(2))nanoparticles sliding against alumina were comprehensively *** sliding occurred with AP-reinforced PI composites,the tribological properties were not closely depended on the pressure×velocity(p×v)factors and the *** interactions between AP and its counterpart could not induce tribo-sintering of the transferred wear *** such,the tribofilm seemed to be in a viscous state,leading to higher friction and ***,the inclusion of hard SCF into the PI matrix changed the interfacial interactions with alumina.A robust tribofilm consisting of a high fraction of silica was generated when the SCF-reinforced PI was added to the SiO_(2) *** exhibited a high load-carrying capability and was easily *** caused a significant decrease in the friction and wear of the PI composite at 8 MPa·1m/***,due to their high melting point,few h-BN nanoparticles were observed in the tribofilm of the SCF-reinforced PI when hexagonal boron nitride was added.

关键词： reinforcing filler polyimide composite tribofilm Al_(2)O_(3)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Development of low-carbon technologies in China's integrated hydrogen supply and power system

引用

Advances in Climate Change Research 2024年第5期15卷 936-947页

作者： Dai-Wei LI un-Ling hUANG Dan yu Da ZhANG Xi-Liang ZhANG Tsinghua university-China Three Gorges Corporation Joint Research Center for Climate Governance Mechanism and Green Low-carbon Transformation Strategy Beijing 100084China Institutes of Energy Environment and EconomyTsinghua UniversityBeijing 100084China International Clean Energy Research Office China Three Gorges CorporationBeijing 100038China National Center for Climate Change Strategy and International Cooperation Bejing 100035China

hydrogen and electricity are crucial and interdependent energy carriers in China's pursuit of carbon neutrality,suggesting the necessity of utilizing cost-effective low-carbon technologies that facilitate their integrated *** cost-optimal,provincial level,deployment of low-carbon technologies under this long-term goal remains to be *** study employs the REPO model to identify the cost-optimal,low-carbon hydrogen production mixes and the evolution of the integrated power system of China from 2020 to *** integrated planning and operation of hydrogen supply and power systems are explored at the provincial *** role of high-temperature gas-cooled reactors in this integrated energy system is also *** results reveal that electrolytic hydrogen would dominate China's hydrogen supply after 2040,with alkaline,proton exchange membrane,and solid oxide electrolyzers produce over 1 Mt of hydrogen in the short term,by 2035,and in *** the low-carbon heat production of high-temperature gas-cooled reactors in addition to its electricity generation to meet the thermal requirements of solid oxide electrolyzers could boost the output to 4.2 Mt in 2050 and reducing the total system CO_(2) emissions and costs by 2.28%and 0.05%,*** 2050,the integration of hydrogen supply and power systems also generates up to 2194 TW h of flexible electricity demand by electrolyzers,which raised the renewable energy penetration by 4 percentage points while decreasing the need of flexible natural gas power generations and energy *** study is valuable for proposing the analytical framework and performing the provincial-level study of decarbonization of China's integrated hydrogen supply and power system.

关键词： hydrogen energy Power system Energy system modelling Scenario analysis Carbon neutrality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

日本加入联合国始末

引用

史学集刊 2025年第1期 133-144页

作者：刘子玉温州大学人文学院浙江温州325035

1952年6月日本正式提交入联申请时,联合国受美苏冷战等因素影响,难以通过规范的单独审议程序吸纳新成员。苏联提出共产主义阵营与西方阵营的申请国可以同时入联的“一揽子方案”,但遭到美国的强烈反对。1953年,联合国大会认为应以普适... 详细信息

1952年6月日本正式提交入联申请时,联合国受美苏冷战等因素影响,难以通过规范的单独审议程序吸纳新成员。苏联提出共产主义阵营与西方阵营的申请国可以同时入联的“一揽子方案”,但遭到美国的强烈反对。1953年,联合国大会认为应以普适性原则为基础,通过政治妥协打破入联僵局,尽早吸纳日本等国加入联合国。1955年,加拿大提出日本与蒙古等18个国家同时入联的方案,因中国台湾当局反对蒙古入联而失败。苏联随机应变,提出排除日蒙两国的“16国入联方案”,并顺利通过安理会与联合国大会审议,日本入联再度受挫。1956年10月,日苏恢复邦交,苏联承诺支持日本入联。1956年12月,日本正式加入联合国。1952—1956年间,日本入联进程深受美苏冷战及联合国职能与内部权力关系变化的影响,日本政府的外交努力难以发挥有效作用。

关键词：日本入联美苏冷战联合国大会

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anisotropic Dzyaloshinskii-Moriya interaction protected by D_(2d) crystal symmetry in two-dimensional ternary compounds

引用

npj Computational Materials 2022年第1期8卷 1209-1215页

作者： Yonglong ga Qirui Cui Yingmei Zhu Dongxing yu Liming Wang Jinghua Liang hongxin Yang Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo315201China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China

Magnetic skyrmions,topologically protected chiral spin swirling quasiparticles,have attracted great attention in fundamental physics and ***,the discovery of two-dimensional(2D)van der Waals(vdW)magnets have aroused great interest due to their appealing physical ***,both experimental and theoretical works have revealed that isotropic Dzyaloshinskii–Moriya interaction(DMI)can be achieved in 2D magnets or ferromagnet-based ***,2D magnets with anisotropic DMI haven’t been reported ***,via using first-principles calculations,we unveil that anisotropic DMI protected by D_(2d)crystal symmetry can exist in 2D ternary compounds MCuX_(2)(M:3d transition metal(TM),X:group VIA).Interestingly,by using micromagnetic simulations,we demonstrate that ferromagnetic(FM)antiskyrmions,FM bimerons,antiferromagnetic(AFM)antiskyrmions,and AFM bimerons can be realized in the MCuX_(2)*** discovery opens up an avenue to creating antiskyrmions and bimerons with anisotropic DMI protected by D_(2d)crystal symmetry in 2D magnets.

关键词： DMI symmetry magnets

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Giant Goos–hnchen shifts of waveguide coupled long-range surface plasmon resonance mode

引用

Chinese Physics B 2018年第8期27卷 30-34页

作者： Qi You jia-Qi Zhu ]un Guo Lei-Ming Wu Xiao-yu Dai yuan-Jiang Xiang SZU-NUS Collaborative Innovation Center for Optoelectronic Science ＆ Technology Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China

A hybrid structure based on a planar waveguide （PWG） mode coupling a long-range surface plasmon resonance （LRSPR） mode is proposed to enhance the Gh shift. Both the PWG mode and LRSPR mode can be in strong resonance, and these two modes can be coupled together due to the normal-mode splitting. The largest Gh shift of PWG-coupled LRSPR structure is 4156 times that of the incident beam, which is 23 times and 3.6 times that of the surface plasmon resonance （SPR） structure and the LRSPR structure, respectively. As a Gh shift sensor, the highest sensitivity of 4.68 x 107 λ is realized in the coupled structure. Compared with the sensitivity of the traditional SPR structure, the sensitivity of our structure is increased by more than 2 orders, which theoretically indicates that the proposed configuration can be applied to the field of high-sensitivity sensors in the future.

关键词： Goos-hfinchen (Gh) shift planar waveguide (PWG) long-range surface plasmon polartons (LR-SPPs)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of antibacterial compounds produced by Saccharomyces cerevisiae in Koumiss on pathogenic Escherichia coli O8 and its cell surface characteristics

引用

Journal of Integrative Agriculture 2017年第3期16卷 742-748页

作者： ChEN yu-jie WANG Chun-jie hOU Wen-qian WANG Xiao-shuo gaLI Bing-ga hUASAI Si-mu-jide YANG Si-qin WU A-qi-ma ZhAO yu-fei WU Ying-ga ChEN Ao-ri-ge-le Vocational and Technical College Inner Mongolia Agricultural University Baotou 014109 P.R. China College of Animal Science Inner Mongolia Agricultural university Hohhot 010018 P.R. China College of Veterinary Medicine Inner Mongolia Agricultural University Hohhot 010018 P.R. China

The effects of antibacterial compounds produced by Saccharomyces cerevisiae in Koumiss on pathogenic Escherichia coli O8 and its cell surface characteristics were *** isolated from Koumiss produced antibacterial compounds which were active against pathogenic *** O8 as determined by the Oxford cup *** aqueous phases from *** at p h=2.0（S2）and ph=8.0（S8）were extracted and tested,*** organic acids of S2 and S8 were determined by high performance liquid chromatography（hPLC）,and the concentrations of killer toxins were determined by enhanced bicinchoninic acid（BCA）Protein Assay *** minimum inhibition concentration（MIC）and the minimum bactericidal concentration（MBC）of S2 and S8 on *** O8 were determined by the broth microdilution *** effects of S2 and S8 on the growth curve of *** O8 were determined by turbidimetry,and the hydrophobicities of *** O8 cell surface were determined using the microbial adhesion to solvents method,the permeation of *** O8 cell membrane were determined by the o-nitrophenyl-β-D-galactoside（ONPG）*** phases at ph 2.0 and 8.0had larger inhibition zones and then S2 and S8 were obtained by *** main component in S2 was citric acid and it was propanoic acid in *** organic acids and killer toxins were also *** the MICs of S2 and S8 on *** O8 were 0.025 g m L^-1,the MBCs were 0.100 and 0.200 g m L^-1,*** normal growth curve of *** O8was S-shaped,however,it changed after addition of S2 and *** O8 was the basic character,and had a relatively hydrophilic *** hydrophobicity of *** O8 cell surface and the permeation of *** O8 cell membrane were increased after adding S2 and *** present study showed that S2 and S8 inhibit the growth of pathogenic *** O8and influence its cell surface characteristics.

关键词： antibacterial compound Saccharomyces cerevisiae Escherichia coil hydrophobicity permeation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A possible relationship between serum sex hormones and benign prostatic hyperplasia/Iower urinary tract symptoms in men who underwent transurethral prostate resection

引用

Asian Journal of Andrology 2017年第2期19卷 230-233页

作者： yu Wu hong Pan Wei-Ming Wang Ding Xu Liang Zhang Zheng-Qin Gu Qiang Bai un Qi e-Feng huang Department of Urology Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200092 China Department of Gynecology Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200092 China Department of Assisted Reproduction Medicine International Peace Maternity and Child Health Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200030 China

In this study, we examined the relationship between sex hormone levels and lower urinary tract symptoms （LUTS） in men with benign prostatic hyperplasia （BPh） who underwent transurethral surgery. The study was conducted in 158 patients who came to our hospital for surgery. Clinical conditions were assessed by body mass index （BMI）, digital rectal examination, International Prostate Symptom Score （IPSS） and transrectal ultrasound （TRUS）. The levels of sex hormones （including total testosterone （TT）, estradiol （E2）, progesterone （P）, luteinizing hormone （Lh）, follicle-stimulating hormone （FSh） and prolactin （PRL）） and prostate-specific antigen （PSA） were reviewed. Correlations were determined through statistical analysis. The mean age was 72.06 _＋ 8.68 years. The total IPSS was significantly associated with the TT level （r = -0.21, P = 0.01）. Other sex hormone levels were not correlated with total IPSS. however, some ratios such as E2/TT （r = 0.23, P = 0o00） and FSh/Lh （r = -0.17, P = 0.04） were associated with total IPSS. Further analysis showed that the nocturia was associated with age （r = 0.16, P = 0.04）, BMI （r = 0.21, P = 0.01）, and TT （r = -0.19, P = 0.02）. Moreover, we divided the patients into two subgroups based on IPSS severity （〈20 or 〉20）. The mean TT level was in the normal range, but it was significantly related to the presence of severe LUTS. In summary, our study has shown that the severity of LUTS is associated with TT, EJTT and FSh/Lh in men who underwent prostate surgery. Increasing nocturia was observed in lower testosterone patients. Additional larger studies are needed to elucidate the potential mechanisms.

关键词： aging benign prostatic hyperplasia lower urinary tract symptoms sex hormones testosterone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：