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Helicobacter pylori seropositivity in diabetic patients is associated with microalbuminuria

World Journal of gastroenterology 2013年第1期19卷 97-102页

作者： Goh eun Chung nam Ju Heo Min Jung Park Su Jin Chung Hae Yeon Kang Seung Joo Kang Department of Internal Medicine Healthcare Research InstituteSeoul National University Hospital Healthcare System Gangnam CenterSeoul 135-984South Korea

AIM:To investigate the relationship between Helicobacter pylori(***) seropositivity and the presence of ***:Between December 2003 and February 2010,asymptomatic individuals who visited the Seoul National University Healthcare System gangnam Center for a routine check-up and underwent tests for *** immunoglobulin G antibodies and urinary albumin to creatinine ratio(UACR) were *** study subjects completed a structured questionnaire,anthropometric measurements and laboratory *** immunoglobulin G was identified using an enzyme-linked immunosorbent assay kit.A random single-void urine sample,collected using a clean-catch technique,was obtained to determine the *** presence of microalbuminuria was defined as a UACR from 30 to 300 μg/*** presence of diabetes mellitus(DM) was defined as either a fasting serum glucose level greater than or equal to 126 mg/dL or taking anti-diabetic *** logistic regression analysis was performed to identify the risk *** dependent variable was microalbuminuria,and the independent variables were the other study ***:A total of 2716 subjects(male,71.8%;mean age,54.9 years) were *** them,224 subjects(8.2%) had microalbuminuria and 324 subjects(11.9%) had been diagnosed with *** with microalbuminuria had a significantly higher *** seropositivity rate than subjects without microalbuminuria(60.7% vs 52.8%,P = 0.024).Multivariate analysis after adjustment for age,body mass index(BMI),waist circumference,and glucose and triglyceride levels showed that *** seropositivity was significantly associated with microalbuminuria [odds ratio(OR),1.40,95% CI,1.05-1.89,P = 0.024].After the data were stratified into cohorts by glucose levels(≤ 100 mg/dL,100 mg/dL < glucose < 126 mg/dL,and ≥ 126 mg/dL or history of DM),*** seropositivity was found to be significantly associated with microalbuminuria in diabetic subjects after adjust

关键词： Helicobacter pylori Seropositivity Microalbuminuria Atherosclerosis Diabetes

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Advances in flexible sensors for intelligent perception system enhanced by artificial intelligence

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InfoMat 2023年第5期5卷 55-110页

作者： Hongsen Niu Feifei Yin eun-Seong Kim Wenxiao Wang Do-Young Yoon Cong Wang Junge Liang Yang Li nam-Young Kim RFIC Centre Kwangwoon UniversitySeoulRepublic of Korea Department of Electronics Engineering Kwangwoon UniversitySeoulRepublic of Korea NDAC Centre Kwangwoon UniversitySeoulRepublic of Korea Department of Chemical Engineering Kwangwoon UniversitySeoulRepublic of Korea School of Electronics and Information Engineering Harbin Institute of TechnologyHarbinthe People's Republic of China Department of Electronic Engineering Jiangnan UniversityWuxithe People's Republic of China School of Information Science and Engineering University of JinanJinanthe People's Republic of China

Intelligent perception means that with the assistance of artificial intelligence(AI)-motivated brain,flexible sensors achieve the ability of memory,learning,judgment,and reasoning about external information like the human *** to the superiority of machine learning(ML)algorithms in data processing and intelligent recognition,intelligent perception systems possess the ability to match or even surpass human perception ***,the built-in flexible sensors in these systems need to work on dynamic and irregular surfaces,inevitably affecting the precision and fidelity of the acquired *** recent years,the strategy of introducing the developed functional materials and innovative structures into flexible sensors has made some progress toward the above challenges,and with the blessing of ML algorithms,accurate perception and reasoning in various scenarios have been ***,the most representative functional materials and innovative structures for constructing flexible sensors are comprehensively reviewed,the research progress of intelligent perception systems based on flexible sensors and ML algorithms is further summarized,and the intersection of the two is expected to unlock new opportunities for next-stage AI development.

关键词： flexible sensor intelligent perception artificial intelligence machine learning

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Correlations between endoscopic and clinical disease activity indices in intestinal Behcet's disease

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World Journal of gastroenterology 2012年第40期18卷 5771-5778页

作者： Hyun Jung Lee Youn nam Kim Hui Won Jang Han Ho Jeon eun Suk Jung Soo Jung Park Sung Pil Hong Tae Il Kim Won Ho Kim Chung Mo nam Jae Hee Cheon Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoul 120-752South Korea Department of Biostatistics Yonsei University College of MedicineSeoul 120-752South Korea Department of Preventive Medicine Yonsei University College of MedicineSeoul 120-752South Korea

AIM:To develop a novel endoscopic severity model of intestinal Behcet's disease(BD) and to evaluate its feasibility by comparing it with the actual disease activity index for intestinal Behcet's disease(DAIBD).METHODS:We reviewed the medical records of 167 intestinal BD patients between March 1986 and April *** also investigated the endoscopic parameters including ulcer locations,distribution,number,depth,shape,size and margin to identify independent factors associated with *** endoscopic severity model was developed using significant colonoscopic variables identified by multivariate regression analysis and its correlation with the DAIBD was *** determine factors related to the discrepancy between endoscopic severity and clinical activity,clinical characteristics and laboratory markers of the patients were ***:A multivariate regression analysis revealed that the number of intestinal ulcers(≥ 2,P = 0.031) and volcanoshaped ulcers(P = 0.001) were predictive factors for the *** endoscopic severity model(Y) was developed based on selected endoscopic variables as follows:Y = 47.44 + 9.04 × non-Ileocecal area + 11.85 ×≥ 2 of intestinal ulcers + 5.03 × shallow ulcers + 12.76 × deep ulcers + 4.47 × geographicshaped ulcers + 26.93 × volcano-shaped ulcers + 8.65 ×≥ 20 mm of intestinal ***,endoscopic parameters used in the multivariate analysis explained only 18.9% of the DAIBD *** with severe DAIBD scores but with moderately predicted disease activity by the endoscopic severity model had more symptoms of irritable bowel syndrome(21.4% vs 4.9%,P = 0.026) and a lower rate of corticosteroid use(50.0% vs 75.6%,P = 0.016) than those with severe DAIBD scores and accurately predicted disease by the ***:Our study showed that the number of intestinal ulcers and volcano-shaped ulcers were predictive factors for severe DAIBD ***,the correlation between endoscopic severity and DAIBD(r = 0.434) was weak.

关键词： Intestinal Behcet's disease Disease activityindex Colonoscopy Ulcer Endoscopic severity

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WNT5A drives interleukin-6-dependent epithelial-mesenchymal transition via the JAK/STAT pathway in keloid pathogenesis

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Burns & Trauma 2022年第1期10卷 200-215页

作者： Young In Lee Jung eun Shim Jihee Kim Won Jai Lee Jae Woo Kim Kee Hyun nam Ju Hee Lee Department of Dermatology Severance HospitalCutaneous Biology Research InstituteYonsei University College of MedicineSeoul 03722Korea Bioinformatics Collaboration Unit Yonsei University College of MedicineSeoul 03722Korea Department of Plastic and Reconstructive Surgery Severance HospitalYonsei University College of MedicineSeoul 03722Korea Scar Laser and Plastic Surgery Center Yonsei Cancer HospitalYonsei University College of MedicineSeoul 03722Korea Department of Biochemistry and Molecular Biology Chronic Intractable Disease for Systems Medicine Research CenterYonsei University College of MedicineSeoul 03722Korea Department of Surgery Severance HospitalYonsei University College of MedicineSeoulKorea

Background:Keloid scarring is a fibroproliferative disease caused by aberrant genetic activation with an unclear underlying *** predisposition,aberrant cellular responses to environmental factors,increased inflammatory cytokines and epithelial-mesenchymal transition(EMT)phenomena are known as major *** this study,we aimed to identify the molecular drivers that initiate keloid ***:Bulk tissue RNA sequencing analyses of keloid and normal tissues along with ex vivo and in vitro tests were performed to identify the contributing genes to keloid *** animal model of inflammatory keloid scarring was reproduced by replication of a skin fibrosis model with intradermal bleomycin injection in C57BL/6 ***:Gene set enrichment analysis revealed upregulation of Wnt family member 5A(WNT5A)expression and genes associated with EMT in keloid ***,human keloid tissues and the bleomycin-induced skin fibrosis animal model showed significantly increased expression ofWNT5A and EMT *** activation of the interleukin(IL)-6/Janus kinase(JAK)/signal transducer and activator of transcription(STAT)pathway and subsequent elevation of EMT markerswas also observed in keratinocytes co-cultured withWNT5A-activated fibroblasts or keloid ***,WNT5A silencing and the blockage of IL-6 secretion via neutralizing IL-6 antibody reversed hyperactivation of the STAT pathway and EMT markers in ***,STAT3 silencing significantly reduced the EMT-like phenotypes in both keratinocytes and IL-6-stimulated ***:Intercellular communication via the WNT5A and STAT pathways possibly underlies a partial mechanism of EMT-like phenomena in keloid ***-6 secreted from WNT5A-activated fibroblasts or keloid fibroblasts activates the JAK/STAT signaling pathway in adjacent keratinocytes which in turn express EMT markers.A better understanding of keloid development and the

关键词： Keloid Wnt family member 5A Interleukin-6 JAK/STAT pathway Epithelial-mesenchymal transition Scar Epithelial mesenchymal transition

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SERKs serve as co-receptors for SYR1 to trigger systemin-mediated defense responses in tomato

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Journal of Integrative Plant Biology 2024年第10期66卷 2273-2287页

作者： Hyewon Cho Dain Seo Minsoo Kim Bo eun nam Soyoun Ahn Minju Kang Geul Bang Choon-Tak Kwon Youngsung Joo eunkyoo Oh Department of Life Sciences Korea UniversitySeoul 02841Korea Research Institute of Basic SciencesSeoul National UniversitySeoul 08826Korea School of Biological Sciences Seoul National UniversitySeoul 08826Korea Digital Omics Research Center Ochang Institute of Biological and Environmental ScienceKorea Basic Science InstituteCheongju 28119Korea Department of Smart Farm Science Kyung Hee UniversityYongin 17104Korea

Systemin, the first peptide hormone identified in plants, was initially isolated from tomato(Solanum lycopersicum) leaves. Systemin mediates local and systemic wound-induced defense responses in plants, conferring resistance to necrotrophic fungi and herbivorous insects. Systemin is recognized by the leucine-rich-repeat receptor-like kinase(LRRRLK) receptor SYSTEMIN RECEPTOR1(SYR1), but how the systemin recognition signal is transduced to intracellular signaling pathways to trigger defense responses is poorly understood. Here, we demonstrate that SERK family LRR-RLKs function as coreceptors for SYR1 to mediate systemin signal transduction in tomato. By using chemical genetic approaches coupled with engineered receptors, we revealed that the association of the cytoplasmic kinase domains of SYR1 with SERKs leads to their mutual trans-phosphorylation and the activation of SYR1, which in turn induces a wide range of defense responses. Systemin stimulates the association between SYR1 and all tomato SERKs(SlSERK1,SlSERK3A, and SlSERK3B). The resulting SYR1-SlSERK heteromeric complexes trigger the phosphorylation of TOMATO PROTEIN KINASE 1B(TPK1b), a receptor-like cytoplasmic kinase that positively regulates systemin responses. Additionally,upon association with SYR1, SlSERKs are cleaved by the Pseudomonas syringae effector HopB1, further supporting the finding that SlSERKs are activated by systemin-bound SYR1. Finally, genetic analysis using Slserk mutants showed that SlSERKs are essential for systemin-mediated defense responses. Collectively, these findings demonstrate that the systeminmediated association of SYR1 and SlSERKs activates defense responses against herbivorous insects.

关键词： LRR-RLK peptide SERK SYR1 systemin

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M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3169-3183页

作者： Ha eun Shin Jun-Hyeok Han Seungyong Shin ga-Hyun Bae Boram Son Tae-Hyung Kim Hee Ho Park Chun Gwon Park Wooram Park Department of Integrative Biotechnology Sungkyunkwan University(SKKU)SuwonGyeonggi 16419Republic of Korea Deparment of Inteligent Precision Healthcare Convergence SKKUSuwonGyeonggi 16419Republic of Korea Department of MetaBioHealth SKKU Institute for ConvergenceSKKUSuwonGyeonggi 16419Republic of Korea Department of Bioengineering Hanyang UniversitySeoul 04763Republic of Korea Department of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biomedical Engineering SKKUSuwonGyeonggi 16419Republic of Korea Korea Institute of Science and Technology(KIST) Seoul 02792Republic of Korea

Optimum genetic delivery for modulating target genes to diseased tissue is a major obstacle for profitable gene *** nanoparticles(LNPs),considered a prospective vehicle for nucleic acid delivery,have demonstrated efficacy in human use during the COVID-19 *** study introduces a novel biomaterial-based platform,M1-polarized macrophage-derived cellular nanovesicle-coated LNPs(M1-C-LNPs),specifically engineered for a combined gene-immunotherapy approach against solid *** dual-function system of M1-C-LNPs encapsulates Bcl2-targeting siRNA within LNPs and immune-modulating cytokines within M1 macrophage-derived cellular nanovesicles(M1-NVs),effectively facilitating apoptosis in cancer cells without impacting T and NK cells,which activate the intratumoral immune response to promote granule-mediating killing for solid tumor *** retention within tumor was observed upon intratumoral administration of M1-C-LNPs,owing to the presence of adhesion molecules on M1-NVs,thereby contributing to superior tumor growth *** findings represent a promising strategy for the development of targeted and effective nanoparticle-based cancer genetic-immunotherapy,with significant implications for advancing biomaterial use in cancer therapeutics.

关键词： Genetic-immunotherapy M1 macrophage-derived cellular nanovesicles Lipid nanoparticles(LNPs) Gene therapy siRNA Cancer immunotherapy Solid tumor Tumor microenvironment(TME)

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Genome-wide SNP discovery and core marker sets for assessment of genetic variations in cultivated pumpkin(Cucurbita spp.)

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Horticulture Research 2020年第1期7卷 1139-1148页

作者： nam Ngoc Nguyen Minkyung Kim Jin-Kee Jung eun-Jo Shim Sang-Min Chung Younghoon Park Gung Pyo Lee Sung-Chur Sim Department of Bioresources Engineering Sejong UniversitySeoul 05006South Korea Seed Testing and Research Center Korea Seed&Variety ServiceGimcheon 39660South Korea Department of Life Sciences Dongguk UniversitySeoul 04620South Korea Department of Horticultural Bioscience Pusan National UniversityMiryang 50463South Korea Department of Plant Science and Technology Chung-Ang UniversityAnsung 17546South Korea Plant Engineering Research Institute Sejong UniversitySeoul 05006South Korea

Three pumpkin species Cucurbita maxima,***,and *** are commonly cultivated *** identify genome-wide SNPs in these cultivated pumpkin species,we collected 48 F1 cultivars consisting of 40 intraspecific hybrids(15 ***,18 ***,and 7 ***)and 8 interspecific hybrids(*** x ***).Genotyping by sequencing identified a total of 37,869 confident SNPs in this *** SNPs were filtered to generate a subset of 400 SNPs based on polymorphism and genome *** the 400 SNPs,288 were used to genotype an additional 188 accessions(94 F1 cultivars,50 breeding lines,and 44 landraces)with a SNP array-based *** polymorphisms were observed in 224 SNPs(78.0%)and were used to assess genetic variations between and within the four predefined populations in 223 cultivated pumpkin *** principal component analysis and UPGMA clustering found four major clusters representing three pumpkin species and interspecific *** genetic differentiation was supported by pairwise Fst and Nei’s genetic *** interspecific hybrids showed a higher level of genetic diversity relative to the other three *** the 224 SNPs,five subsets of 192,96,48,24,and 12 markers were evaluated for variety *** 192,96,and 48 marker sets identified 204(91.5%),190(85.2%),and 141(63.2%)of the 223 accessions,respectively,while other subsets showed<25%of variety identification *** SNP markers provide a molecular tool with many applications for genetics and breeding in cultivated pumpkin.

关键词： breeding cultivar Cucurbita

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Inhibitory effect of Jeju endemic seaweeds on the production of pro-inflammatory mediators in mouse macrophage cell line RAW 264.7

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第5期11卷 315-322页

作者： eun-Jin YANG Ji-Young MOON Min-Jin KIM Dong Sam KIM Chan-Shick KIM Wook Jae LEE nam Ho LEE Chang-Gu HYUN Jeju Biodiversity Research Institute(JBRI) Jeju High-Tech Development Institute(HiDI) Jeju 699-943Korea Jeju Seaweed Industry Development Agency Cheju National UniversityJeju 690-756Korea Faculty of Biotechnology Cheju National UniversityJeju 690-756Korea Department of Chemistry Cheju National UniversityJeju 690-756Korea

Seaweed has been used in traditional cosmetics and as a herbal medicine in treatments for cough,boils,goiters,stomach ailments,and urinary diseases,and for reducing the incidence of tumors,ulcers,and *** the fact that seaweeds are frequently used in the practice of human health,little is known about the role of seaweed in the context of *** study aimed to investigate the influence of Jeju endemic seaweed on a mouse macrophage cell line(RAW 264.7) under the stimulation of lipopolysaccharide(LPS).Ethyl acetate extracts obtained from 14 different kinds of Jeju seaweeds were screened for inhibitory effects on pro-inflammatory *** results revealed that extracts from five seaweeds,Laurencia okamurae,Grateloupia elliptica,Sargassum thun-bergii,Gloiopeltis furcata,and Hizikia fusiformis,were potent inhibitors of the production of pro-inflammatory mediators such as nitric oxide(NO),prostaglandin E2(PGE2),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α).Based on these results,the anti-inflammatory effects and low cell toxicity of these seaweed extracts suggest potential thera-peutic applications in the regulation of the inflammatory response.

关键词： Nitric oxide Interleukin-(IL-) Prostaglandin E(PGE) Tumor necrosis factor-α(TNF-α) Seaweeds Pro-inflammatory mediators

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The association of stromal antigen 3(STAG3) sequence variations with spermatogenic impairment in the male Korean population

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Asian Journal of Andrology 2020年第1期22卷 106-111页

作者： Yeojung nam Kyung Min Kang Se Ra Sung Ji eun Park Yun-Jeong Shin Seung Hun Song Ju Tae Seo Tae Ki Yoon Sung Han Shim Department of Biomedical Science College of Life ScienceCHA UniversitySeongnam 13488Korea Genetics Laboratory Fertility Center of CHA Gangnam Medical CenterCHA UniversitySeoul 06135Korea Department of Urology CHA Gangnam Medical CenterCHA UniversitySeoul 06135Korea Department of Urology Cheil General HospitalSeoul 04619Korea Department of Obstetrics and Gynecology CHA Gangnam Medical CenterSeoul 04637Korea

The stromal antigen 3(STAG3)gene,encoding a meiosis-specific cohesin component,is a strong candidate for causing male infertility,but little is known about this gene so *** identified STAG3 in patients with nonobstructive azoospermia(NOA)and normozoospermia in the Korean *** coding regions and their intron boundaries of STAG3 were identified in 120 Korean men with spermatogenic impairments and 245 normal controls by using direct sequencing and haplotype analysis.A total of 30 sequence variations were identified in this *** the total,seven were exonic variants,18 were intronic variants,one was in the 5’-UTR,and four were in the 3'-*** variations that directly caused NOA were not ***,two variants,c.3669+35C>G(rs1727130)and+198A>T(rs1052482),showed significant differences in the frequency between the patient and control groups(P=0.021,odds ratio[OR]:1.79,95%confidence interval[Cl]:1.098-2.918)and were tightly linked in the linkage disequilibrium(LD)*** pmir-rs1052482A was cotransfected with miR-3162-5p,there was a substantial decrease in luciferase activity,compared with *** result suggests that rsl052482 was located within a binding site of miR-3162-5p in the STAG33'-UTR,and the minor allele,the rs1052482T polymorphism,might offset inhibition by *** are the first to identify a total of 30 single-nucleotide variations(SNVs)of STAG3 gene in the Korean *** found that two SNVs(rs1727130 and rsl052482)located in the 3'-UTR region may be associated with the NOA *** findings contribute to understanding male infertility with spermatogenic impairment.

关键词： linkage disequilibrium meiotic-specific gene single-nucleotide variations spermatogenic impairment stromal antigen 3 gene

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Rapid delivery of Cas9 gene into the tomato cv.‘Heinz 1706’through an optimized Agrobacterium-mediated transformation procedure

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BIOCELL 2021年第1期45卷 199-215页

作者： BEEMNET MENGESHA KASSAHUN BEUM-CHANG KANG SU-JI BAE YE JIN nam GRETEL FONSECA MUNDO ga-HUI KANG KYOUNGOOK KIM JeunG-SUL HAN Department of Horticulture Kyungpook National UniversityDaegu41566Korea Center for Genome Engineering Institute for Basic ScienceDaejeon34047Korea School of Water Energyand EnvironmentCranfield UniversityCranfieldMK430ALUK Institute of Agricultural Science and Technology Kyungpook National UniversityDaegu41566Korea

Solanum lycopersicum‘Heinz 1706’is a pioneer model cultivar for tomato research,whose whole genome sequence valuable for genomics studies is ***,a genetic transformation procedure for this cultivar has not yet been ***,various genome editing technologies such as transfection of clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated(Cas)ribonucleoprotein complexes into cells are in the *** the Cas9-expressing genotype possessing a reference genome can simplify the verification of an off-target effect,resolve the economic cost of Cas9 endonuclease preparation,and avoid the complex assembly process together with single-guide RNA(sgRNA)in the transfection ***,this study was designed to generate Cas9-expressing‘Heinz 1706’lines by establishing an Agrobacterium tumefaciens-mediated transformation(ATMT)***,we report a rapid and reproducible transformation procedure for‘Heinz 1706’by finetuning various factors:*** strain,pre-culture and co-culture durations,a proper combination of phytohormones at each step,supplementation of acetosyringone,and shooting/rooting ***,through eluding subculture and simultaneously inducing shoot elongation and rooting from leaf cluster,we achieved a short duration of three months for recovering the transgenic plants expressing *** presence of the Cas9 gene and its stable expression were confirmed by PCR and qRT-PCR analyses,and the Cas9 gene integrated into the T_(0) plant genome was stably transmitted to T_(1) ***,we anticipate that our procedure appears to ease the conventional ATMT in‘Heinz 1706’,and the created Cas9-expressing‘Heinz 1706’lines are ultimately useful in gene editing via unilateral transfection of sgRNA into the protoplasts.

关键词： Transgenic plant Phytohormone Acetosyringone Gene editing

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