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Hepatitis B virus infection, diabetes mellitus, and their synergism for cholangiocarcinoma development: A casecontrol study in Korea

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World Journal of gastroenterology 2015年第2期21卷 502-510页

作者： Ban Seok Lee eun-Cheol Park Seung Woo Park Chung Mo nam Jaehoon Roh Department of Medicine Graduate SchoolYonsei University College of MedicineSeoul 120-752South Korea Digestive Disease Center and Department of Internal Medicine Cheju Halla General HospitalJeju 690-766South Korea Department of Preventive Medicine Yonsei University College of MedicineSeoul 120-752South Korea Institute of Health Services Research Yonsei University College of MedicineSeoul 120-752South Korea Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoul 120-752South Korea

AIM: To identify possible risk factors and their synergism for cholangiocarcinoma ***: A hospital-based, case-control study in which we included 276 cholangiocarcinoma patients [193 extrahepatic cholangiocarcinoma(ECC) and 83 intrahepatic cholangiocarcinoma(ICC)], diagnosed at a training hospital in Korea between 2007 and 2013, and 552 healthy controls matched 2:1 for age, sex, and date of diagnosis. Risk factors for cholangiocarcinoma and possible synergism between those factors were evaluated using conditional logistic regression and synergism index, ***:There was an association between cholangiocarcinoma and hepatitis B virus(HBV) infection, diabetes mellitus(DM), cholecystolithiasis, choledocholithiasis, and hepatolithiasis, with the adjusted odds ratios(AORs) of 4.1, 2.6, 1.7, 12.4, and 39.9, respectively. Synergistic interaction on the additive model was investigated between HBV infection and DM(AOR = 12.2; 95%CI: 1.9-80.1). In the subgroup analyses, cholecystolithiasis, choledocholithiasis, hepatolithiasis, and DM were significant risk factors for ECC(AOR = 2.0, 18.1, 14.9, and 2.0, respectively), whereas choledocholithiasis, hepatolithiasis, HBV infection, and DM were risk factors for ICC(AOR = 8.6, 157.4, 5.3 and 4.9, respectively). Synergistic interaction was also observed between HBV infection and DM(OR = 22.7; 95%CI: 2.4-214.1). However, there was no synergistic interaction between other significant risk factors for ***: In this Korean study, HBV infection and DM were found to exert independent and synergistic effects on the risk for cholangiocarcinoma, including ICC. Exploring the underlying mechanismsfor such synergy may lead to the development of cholangiocarcinoma prevention strategies in high-risk individuals.

关键词： Cholangiocarcinoma Risk factor Hepatitis Synergism

Advances in advanced solution-synthesis-based structural materials for tactile sensors and their intelligent applications

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InfoMat 2024年第1期6卷 31-64页

作者： Hongsen Niu Ning Li eun-Seoung Kim Young Kee Shin nam-Young Kim Guozhen Shen Yang Li School of Information Science and Engineering University of JinanJinanthe People's Republic of China RFIC Centre Department of Electronics EngineeringKwangwoon UniversitySeoulRepublic of Korea Department of Molecular Medicine and Biopharmaceutical Sciences Seoul National UniversitySeoulRepublic of Korea School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijingthe People's Republic of China School of Microelectronics Shandong UniversityJinanthe People's Republic of China

Intelligent applications,with tactile sensors at their core,represent significant advancement in the field of artificial ***,achieving perception abilities in tactile sensors that match or exceed human skin remains a formidable ***,the design and implementation of hierarchical structural materials are considered the optimal solution to this *** contrast to conventional methods,such as complicated lithography and three-dimensional printing,the cost-effective and scalable nature of advanced solution-synthesis methods makes them ideal for preparing diverse tactile sensors with hierarchical structural ***,the process and applicability of advanced solution synthesis methods have yet to form a seamless ***,the development and intellectualization of tactile sensors based on advanced solution synthesis methods are still in their early stages,and require a comprehensive and systematic review to usher in *** study delves into the advantages and disadvantages of various advanced solution synthesis methods,providing detailed ***,the positive effects of hierarchical structural materials constructed using these methods in tactile sensors and their intelligent applications are also discussed in ***,the challenges and future opportunities faced by this emerging field are summarized.

关键词： aqueous phase reduction artificial intelligence hydrothermal growth in situ polymerization tactile sensor

Femoral neck stress fractures after trampoline exercise:A case report

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World Journal of Clinical Cases 2021年第18期9卷 4783-4788页

作者： Dae Cheol nam Sun Chul Hwang eun Chang Lee Myung-Geun Song Jun-Il Yoo Department of Orthopaedic Surgery Gyeongsang National University School of MedicineJinju 52727South Korea Department of Orthopaedic Surgery and Institute of Health Sciences Gyeongsang National University School of Medicine and Gyeongsang National University HospitalJinju 52727South Korea

BACKGROUND Femoral neck stress fractures(FNSFs)are commonly found in long-distance running *** FNSFs,early diagnosis and proper treatment are *** objective of this study was to report FNSFs that occurred after excessive exercise using trampoline in middle-aged *** SUMMARY The patient was a 43-year-old woman who exercised jumping on a trampoline for 6 wk for 1-3 h a day to *** includes repeated flexion-extension of the hip *** patient was admitted to the hospital due to sudden bilateral groin pain that occurred suddenly during a trampoline *** magnetic resonance imaging(MRI)revealed bilateral *** 2 wk of follow-up with conservative treatment,the pain slightly ***,it did not disappear *** was determined that it was difficult to control symptoms only by conservation ***,closed reduction and internal fixation using a cannulated screw were performed for the more painful left hip *** operation,the pain was *** using crutches was *** MRI showed that the right femoral head signal was decreased compared to the left femoral head ***,nonsteroidal anti-inflammatory drug and conservative treatment were *** In middle-aged people,excessive trampoline exercise can repeat hip flexion and extension for a short period of time,leading to FNSFs.

关键词： Trampoline exercise Femoral neck stress fracture Neck Fracture Case report

Human Interaction Recognition in Surveillance Videos Using Hybrid Deep Learning and Machine Learning Models

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Computers, Materials & Continua 2024年第10期81卷 773-787页

作者： Vesal Khean Chomyong Kim Sunjoo Ryu Awais Khan Min Kyung Hong eun Young Kim Joungmin Kim Yunyoung nam Department of ICT Convergence Soonchunhyang UniversityAsan31538Republic of Korea ICT Convergence Research Center Soonchunhyang UniversityAsan31538Republic of Korea Emotional and Intelligent Child Care Convergence Center Soonchunhyang UniversityAsan31538Republic of Korea Department of Occupational Therapy Soonchunhyang UniversityAsan31538Republic of Korea College of Hyangsul Nanum Soonchunhyang UniversityAsan31538Republic of Korea

Human Interaction Recognition(HIR)was one of the challenging issues in computer vision research due to the involvement of multiple individuals and their mutual interactions within video frames generated from their *** requires more sophisticated analysis than Human Action Recognition(HAR)since HAR focuses solely on individual activities like walking or running,while HIR involves the interactions between *** research aims to develop a robust system for recognizing five common human interactions,such as hugging,kicking,pushing,pointing,and no interaction,from video sequences using multiple *** this study,a hybrid Deep Learning(DL)and Machine Learning(ML)model was employed to improve classification accuracy and *** dataset was collected in an indoor environment with four-channel cameras capturing the five types of interactions among 13 *** data was processed using a DL model with a fine-tuned ResNet(Residual Networks)architecture based on 2D Convolutional Neural Network(CNN)layers for feature ***,machine learning models were trained and utilized for interaction classification using six commonly used ML algorithms,including SVM,KNN,RF,DT,NB,and *** results demonstrate a high accuracy of 95.45%in classifying human *** hybrid approach enabled effective learning,resulting in highly accurate performance across different interaction *** work will explore more complex scenarios involving multiple individuals based on the application of this architecture.

关键词： Convolutional neural network deep learning human interaction recognition ResNet skeleton joint key points human pose estimation hybrid deep learning and machine learning

Longitudinal evolution of cortical thickness signature reflecting Lewy body dementia in isolated REM sleep behavior disorder:a prospective cohort study

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Translational Neurodegeneration 2023年第1期12卷 514-528页

作者： Jung Hwan Shin Heejung Kim Yu Kyeong Kim eun Jin Yoon Hyunwoo nam Beomseok Jeon Jee-Young Lee Department of Neurology Seoul Metropolitan Government-Seoul National University Boramae Medical Center and Seoul National University College of MedicineSeoulSouth Korea Department of Nuclear Medicine Seoul Metropolitan Government-Seoul National University Boramae Medical Center and Seoul National University College of MedicineSeoulSouth Korea Institute of Radiation Medicine Medical Research CenterSeoul National UniversitySeoulSouth Korea Department of Neurology Seoul National University Hospital and Seoul National University College of MedicineSeoulSouth Korea

Background The isolated rapid-eye-movement sleep behavior disorder(iRBD)is a prodromal condition of Lewy body disease including Parkinson’s disease and dementia with Lewy bodies(DLB).We aim to investigate the longitudinal evolution of DLB-related cortical thickness signature in a prospective iRBD cohort and evaluate the possible predictive value of the cortical signature index in predicting dementia-first phenoconversion in individuals with *** We enrolled 22 DLB patients,44 healthy controls,and 50 video polysomnography-proven iRBD *** underwent 3-T magnetic resonance imaging(MRI)and clinical/neuropsychological *** characterized DLB-related whole-brain cortical thickness spatial covariance pattern(DLB-pattern)using scaled subprofile model of principal components analysis that best differentiated DLB patients from age-matched *** analyzed clinical and neuropsychological correlates of the DLB-pattern expression scores and the mean values of the whole-brain cortical thickness in DLB and iRBD *** repeated MRI data during the follow-up in our prospective iRBD cohort,we investigated the longitudinal evolution of the cortical thickness signature toward Lewy body ***,we analyzed the potential predictive value of cortical thickness signature as a biomarker of phenoconversion in iRBD *** The DLB-pattern was characterized by thinning of the temporal,orbitofrontal,and insular cortices and relative preservation of the precentral and inferior parietal *** DLB-pattern expression scores correlated with attentional and frontal executive dysfunction(Trail Making Test-A and B:R=−0.55,P=0.024 and R=−0.56,P=0.036,respectively)as well as visuospatial impairment(Rey-figure copy test:R=−0.54,P=0.0047).The longitudinal trajectory of DLB-pattern revealed an increasing pattern above the cut-off in the dementia-first phenoconverters(Pearson’s correlation,R=0.74,P=6.8×10−4)but no significant change in parki

关键词： Rapid eye movement sleep behavior disorder Dementia with Lewy bodies Lewy body disease Cortical thickness Spatial covariance pattern Magnetic resonance imaging

Anti-senescence and anti-wrinkle activities of 3-bromo-4,5-dihydroxybenzaldehyde from Polysiphonia morrowii Harvey in human dermal fibroblasts

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Asian Pacific Journal of Tropical Biomedicine 2021年第2期11卷 74-80页

作者： Su-Hyeon Cho eun-Yi Ko Soo-Jin Heo Seo-Young Kim Juhee Ahn Kil-nam Kim Chuncheon Center Korea Basic Science InstituteChuncheon 24341Republic of Korea Bio research Center DermaproJeju 63309Republic of Korea Jeju Marine Research Center Korea Institute of Ocean Science&TechnologyJeju 63349Republic of Korea Department of Medical Biomaterials Engineering College of Biomedical SciencesKangwon National UniversityChuncheon 24341Republic of Korea

Objective:To investigate the anti-senescence effect of 3-bromo-4,5-dihydroxybenzaldehyde(BDB)from Polysiphonia morrowii Harvey in human dermal fibroblasts(HDF).Methods:HDF were subjected to treatment of BDB and then treated with hydrogen peroxide(H2O2)to induce premature ***-associatedβ-galactosidase(SA-β-gal)activity in HDF was determined using the SA-β-gal staining *** reactive oxygen species(ROS)production was measured using the 2’,7’-dichlorodihydrofluorescein diacetate *** blotting assay was performed to assess the level of antioxidant enzyme glutathione peroxidase 1(GPX1).In addition,intracellular collagen and collagenase contents were analyzed using the respective ELISA *** activity in HDF supernatants was measured from p-nitroaniline release and normalized using total protein ***:Treatment of HDF with H2O2 increased the activity of SA-β-gal,but BDB pre-treatment resulted in the reduction of SA-β-gal ***,BDB significantly reduced H2O2-induced intracellular ROS *** also markedly increased the level of GPX1,which was inhibited by 400μM of ***,in in vitro study,BDB significantly increased intracellular collagen content and decreased matrix metalloproteinase-1 and elastase activities in ***:Our results demonstrate that BDB shows antisenescence and anti-wrinkle activities in vitro.

关键词： Polysiphonia morrowii Harvey 3-bromo-4,5-dihydroxybenzaldehyde Oxidative stress Human dermal fibroblast Anti-senescence activity Anti-wrinkle activity

Interface characterization of Al/Cu 2-ply composites under various loading conditions

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Transactions of Nonferrous Metals Society of China 2014年第S1期24卷 36-41页

作者： Kwang Seok LEE Su eun LEE Yong-nam KWON Materials Deformation Department Light Metal DivisionKorea Institute of Materials Science

The effects of reduction ratio during roll bonding on the microstructural evolution at interface and subsequent mechanical properties of roll-bonded Al/Cu 2-ply sheets were investigated. The interface microstructures for several Al/Cu 2-ply sheets fabricated under different reduction ratios between 30% and 65% were verified by transmission electron microscopy(TEM). Taking the difference of interface microstructure into consideration, 3-point bending and peel tests were performed for obtaining flexural and bonding strengths for Al/Cu 2-ply sheets. The effect of the quantified areas of metallurgical bonding at interfaces on the bonding strength was also discussed. The results show that both the bonding and flexural strengths for Al/Cu 2-ply sheets are reduced by decreasing the reduction ratio during the roll bonding process, which is strongly correlated with the interface microstructure. This was especially verified by observing the interface delamination from the 3-point bent samples.

关键词： Al/Cu 2-ply composite flexural strength roll bonding reduction ratio interface

Negative impact of bone-marrow-derived mesenchymal stem cells on dextran sulfate sodium-induced colitis

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World Journal of gastroenterology 2015年第7期21卷 2030-2039页

作者： Young-Sun nam Nayoun Kim Keon-Il Im Jung-Yeon Lim eun-Sol Lee Seok-Goo Cho Institute for Translational Research and Molecular Imaging Laboratory of Immune Regulation Convergent Research Consortium for Immunologic Disease Seoul St. Mary's Hospital the Catholic University of Korea College of Medicine Department of Hematology Catholic Blood and Marrow Transplantation Center Seoul St. Mary’s Hospital Institute for Translational Research and Molecular Imaging Laboratory of Immune Regulation Convergent Research Consortium for Immunologic Disease the Catholic University of Korea College of Medicine

AIM:To investigate the effects of mesenchymal stem cells(MSCs)on dextran sulfate sodium-induced inflammatory bowel disease(IBD).METHODS:C57BL/6 mice were fed 3.5%(g/L)dextran sulfate *** day seven,the mice received intraperitoneal injections of 1×106 *** survival rate,disease activity index values,and body weight,were monitored *** day ten,colon lengths and histopathologic changes were *** addition,immunoregulatory changes following MSC administration were evaluated by determining the levels of effector T cell responses in the spleen and mesenteric lymph nodes,and the expression levels of inflammatory cytokines in homogenized ***:Intraperitoneal administration of MSCs did not prevent development of colitis and did not reduce the clinicopathologic severity of *** significant difference was evident in either survival rate or disease activity index score between the control and MSCtreated *** ten-sacrificed mice exhibited no significant difference in either colon length or histopathologic ***,the MSC-treated group exhibited elevated levels of interleukin(IL)-6 and transforming growth factor-β,and a reduced level of IL-10,in spleens,mesenteric lymph nodes,and homogenized *** IL-17 level was lower in the mesenteric lymph nodes of the MSC-treated group(P=0.0126).In homogenized colons,the IL-17 and tumor necrosis factor-α(P=0.0092)expression levels were also lower in the treated ***:MSC infusion provided no significanthistopathologic or clinical improvement,thus representing a limited therapeutic approach for *** enhancement of MSCs is needed in further study.

关键词： Crohn’s disease Dextran sulfate sodium Inflammator

Osthol attenuates hepatic steatosis via decreased triglyceride synthesis not by insulin resistance

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World Journal of gastroenterology 2014年第33期20卷 11753-11761页

作者： Ho Hyun nam Dae Won Jun Hye Joon Jeon Jai Sun Lee Waqar Khalid Saeed eun Kyung Kim Department of Translational Medicine Hanyang University Graduate School of Biomedical Science and Engineering Seoul 133-791 South Korea Department of Internal Medicine Hanyang University School of Medicine Seoul 133-791 South Korea Department of Pathology Eulji University College of Medicine Seoul 139-872 South Korea

AIM: To evaluate the effects of osthol on intrahepatic fat synthesis, β-oxidation, inflammation, and insulin resistance by multifaceted analysis.

关键词： Osthol Non-alcoholic fatty liver disease Ste-rol regulatory element binding protein