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Chinese Annals of Mathematics,Series B 2002年第2期23卷 293-310页

作者： J.l.VZQUeZ e.ZUAZUA Departamento de Matematicas Universidad AutonomaDepartamento de Matematica AplicadaUniversidadComplutense 28049MadridSpain28040 M

The authors study the asymptotic behaviour of solutions of the heat equation and a number of evolution equations using scaling techniques. It is proved that in the framework of bounded data stabilization need not occur and the general asymptotic behaviour is complex. This behaviour reflects for large times, even on compact sets, the complexity of the initial data at infinity.

关键词： Asymptotic behaviour Scaling Omega-limit Heat equation Hyperbolic conservation laws

Rice spouted bed for manufacturing inclusion complexes of endopleura uchi l.extracts in β-cyclodextrin

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Particuology 2019年第1期17卷 208-215页

作者： l.V.D. Freitas A.C.R. Montes e.I.A. Campos e.C. Conceicao l.A. Tacon A.D. lanchote l.A.P.Freitas Faculdade de Ciencias Farmaceuticas de Ribeirao Preto University of Sao PauloVia do Cafe s/n14040-903Ribeirao PretoSPBrazil

Uxi (endopleura uchi) is a plant from the Brazilian Amazon. It has many biological activities that are attributed to its main active component, bergenin (BG), which has low water solubility. The aim of this work was to obtain β-cyclodextrin (β-CD) inclusion complexes of uxi using lyophilized cooked rice as the solid substrate. The process was studied using a Box–Behnken design with the solution feed rate, molar ratio of β-CD to BG, and rice bed load as factors. These factors greatly affected the product bulk density, angle of repose, water content, and BG content, loss, and water solubility. The optimum process conditions determined using a desirability functions methodology were an extract feed rate of 1 ml/min, a ratio of β-CD to BG of 3:1, and a substrate load of 100 g. The predicted val.es under the optimum conditions were close to the experimental results of a water content of 5.8%± 0.2%, BG content of 985.7 ± 15.4 μg/g, BG water solubility of 2230.2 ± 21.1 μg/ml, and BG loss of 1.2%± 0.1%. These results confirm that spouted beds are an important tool for rapid, one-step preparation of pharmaceutical β-CD inclusion complexes in a solid form.

关键词： Bergenin Chromatography Yield Active loss Solubility

Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione:Characteristics of non-enzymatic and glutathione S-transferase-mediated reactions

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Journal of Pharmaceutical Analysis 2021年第6期11卷 791-798页

作者： Agnieszka Potega Michal Kosno Zofia Mazerska Department of Pharmaceutical Technology and Biochemistry Faculty of ChemistryGda nsk University of TechnologyGdansk80-233Poland

Unsymmetrical bisacridines(UAs) are a novel potent class of antitumor-active therapeutics.A significant route of phase II drug metabolism is conjugation with glutathione(GSH),which can be non-enzymatic and/or catalyzed by GSH-dependent *** aim of this work was to investigate the GSHmediated metabolic pathway of a representative UA,***-supplemented incubations of C-2028 with rat,but not with human,liver cytosol led to the formation of a single GSH-related ***,it was also revealed with rat liver *** formation was NADPH-independent and was not inhibited by co-incubation with the cytochrome P450(CYP450) inhibitor ***,the direct conjugation pathway occurred without the prior CYP450-catalyzed bioactivation of the *** turn,incubations of C-2028 and GSH with human recombinant glutathione S-transferase(GST) P1-1 or with heat-/ethacrynic acid-inactivated liver cytosolic enzymes resul.ed in the presence or lack of GSH conjugated form,*** findings proved the necessary participation of GST in the initial activation of the GSH thiol group to enable a nucleophilic attack on the substrate *** C-2028-GSH S-conjugate was also formed during non-enzymatic *** GSH S-conjugates were characterized by combined liquid chromatography/tandem mass *** for their formation were *** ability of C-2028 to GST-mediated and/or direct GSH conjugation is suspected to be clinically *** may affect the patient’s drug clearance due to GST activity,loss of GSH,or the interactions with GSH-conjugated ***,GST-mediated depletion of cellular GSH may increase tumor cell.exposure to reactive products of UA metabolic transformations.

关键词： Antitumor agent Unsymmetrical bisacridine Metabolic detoxification Glutathione S-Conjugate Glutathione S-transferase Non-enzymatic conjugation

The functional role of miRNAs in colorectal cancer: insights from a large population-based study

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Cancer Biology & Medicine 2019年第2期16卷 211-219页

作者： lila e.Mullany Martha l.Slattery Department of Internal Medicine University of Utah

Identification of causal microRNAs(miRNAs) in colorectal cancer(CRC) is elusive, due to our lack of understanding of how specific miRNAs affect biological pathways and outcomes. An miRNA can regulate many mRNAs and an mRNA can be associated with many miRNAs;appreciation of these complex networks in which miRNAs operate is necessary to transition from identifying dysregulated miRNAs to identifying individual miRNAs or groups of miRNAs that are suitable for therapeutic purposes. The aim of the paper is to compile results from a population-based study(n = 1,954 cases with matched carcinoma/normal tissue) of miRNAs in CRC. The information gained allows for cohesive and comprehensive insight into miRNAs and CRC in terms of function and impact. Comparison of miRNA expression with mRNA expression from nine signaling pathways in carcinogenic processes allowed us to identify miRNA targets within a biological context. MiRNAs that directly infl.ence mRNA expression may be effective biomarkers or therapeutic targets.

关键词： mRNA miRNA pathways colorectal cancer

How can the neutrino interact with the electromagnetic field？

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Chinese Physics C 2018年第1期42卷 23-31页

作者： M.Novello C.e.l.Ducap Centro Brasileiro de Pesquisas Fisicas (CeAC/CBPF) Rua Dr. Xavier Sigaud 150 CEP 22290-180 Rio de Janeiro Brazil

Maxwell.electrodynamics in the fixed Minkowski space-time background can be described in an equivalent way in a curved Riemannian geometry that depends on the electromagnetic field and that we call the electromagnetic metric（e-metric for short）. After showing such geometric equivalence we investigate the possibility that new processes dependent on the e-metric are allowed. In particular, for very high val.es of the field, a direct coupling of uncharged particles to the electromagnetic field may appear.

关键词： neutrino electromagnetic field effective metric

Analysis and design of axially loaded piles in rock

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Journal of Rock Mechanics and Geotechnical.engineering 2019年第3期11卷 535-548页

作者： C.M.Haberfield A.l.e.lochaden Gol.er Associates Pty.ltd. MelbourneAustralia

Despite significant advancements in in situ test techniques,construction practices,understanding of rock joint and rock mass behaviours,and numerical analysis methods,the design of bored concrete cast-insitu piles in rock is still largely based on the assessment of bearing ***,for many of the rock conditions encountered,the bearing capacity of piles is a nebulous concept and a figment of the designer’s *** if it can be reasonably quantified,it has little,if any,significance to the performance of a pile in *** load carrying capacity of even low strength rock(in most situations)is far in excess of the strength of the structure(for example,a building column)transmitting the *** performance of a pile in rock is usually a displacement issue and is a function of rock mass stiffness rather than rock mass *** addition,poor pile performance is much more likely to result from poor construction practices than excessive displacement of the rock *** occur for footings that are undermined,or where unfavourable structure in the rock allows movement towards a free surface to ***,codes of practices,reference books and other sources of design information should focus foundation design in rock on displacement rather than strength *** investigations should measure rock mass stiffness and defect properties,as well as intact rock *** paper summarises the fundamental concepts relating to performance of piles in rock and provides a basis for displacement focused design of piles in *** also presents comments relating to how piles are model.ed in widely used commercial finite element software for soil-structure interaction analysis,within the context of the back-analysis of a pile load test,and proposes recommendations for pile analysis and design.

关键词： Pile design Pile analysis Pile load test Finite element analysis

Infl.ence of flooding and vegetation on carbon,nitrogen,and phosphorus dynamics in the pore water of a Spartina al.erniflora salt marsh

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Journal of environmental Sciences 2011年第2期23卷 212-221页

作者： Vanesa l.Negrin Carla V.Spetter Raúl O.Asteasuain Gerardo M.e.Perillo Jorge e.Marcovecchio Argentine Institute of Oceanography (IADO CONICETCCT-Bahía Blanca)Camino La Carrindanga km 75Building E-1 CC 804Bahía Blanca 8000Argentina Department of Chemistry Southern National Institute of Chemistry (INQUISUR)Southern National University (UNS)Av Alem 1253Bahía Blanca 8000Argentina Department of Geology Southern National University (UNS)San Juan 670Bahía Blanca 8000Argentina National Technological University Regional Faculty of Bahía Blanca (UTN-FRBB)11 de Abril 461Bahía Blanca 8000Argentina University of the Fraternity of Associations Santo Toms de Aquino (FASTA) Gascón 3145Mar del Plata 7600Argentina

Four sites were selected in a salt marsh in the Bahia Blanca estuary （Argentina）：（1） low marsh （flooded by the tide twice daily） vegetated by S. al.erniflora; （2） non-vegetated low marsh; （3） high marsh （flooded only in spring tides） vegetated by S. al.erniflora; （4） non-vegetated high marsh. The pH and eh were measured in sediments, while dissol.ed nutrients （ammonium, nitrate, nitrite and phosphate） and particulate organic matter （POM） were determined in pore water, pH （6.2-8.7） was only affected by vegetation in low areas. eh （from -300 to 250 mV） was lower at low sites than at high ones; in the latter, the val.es were higher in the non-vegetated sediments. The POM concentration was greater in the high marsh than in the low marsh, with no effect of vegetation. Ammonium was the most abundant nitrogen nutrient species in pore water, except in the non-vegetated high marsh where nitrate concentration was higher. All nitrogen nutrients were affected by both flooding and vegetation. Phosphate was always present in pore water at all sites throughout the year and its concentration varied within narrow limits, with no effect of flooding and greater val.es always at non-vegetated sites. Our results showed that the variability of the pore water composition within the marsh is greater than the temporal variation, meaning that both tidal flooding and vegetation are important in the dynamics of nutrients and organic matter in the sediment pore water.

关键词： organic matter nutrients flooding Spartina al.erniflora

Utilization of Crop Stubble as Al.ernate Source of electricity Generation

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Journal of Atmospheric Science Research 2019年第4期2卷 5-11页

作者： Sourabh Singh Chandel.era Upadhyay Amity University Rajasthan JaipurIndia

The Indian states including Punjab,Haryana,Bihar,Uttar Pradesh,Madhya Pradesh,and Himachal Pradesh follow combine harvesting method followed by burning of crop stubble to prepare the fields for next *** stubble burning is the reason of annual increment in pollution concentrations which lead to massive winter pollution in the ***,the state governments have taken several initiatives for proper management of crop stubble through various departments and institutions but still air pollution level is *** of burning the crop residue,it can be used in other ways,which are beneficial to *** the direction of rising issues due to burning of the crop stubble,efforts have been carried out to explore the options to utilize the crop stubble rather than burning of *** experimental study is an attempt to outline al.ernative use of crop stubble like utilization of rice straw for electricity generation through microbial fuel *** 10 days experimental set up,the MFC produced the maximum voltage of 0.002 V corresponding to the maximum current of 2.5 mA which results in power output of 0.05 *** experiments'results of the study accentuate the significance of biomass by utilizing the rice paddy straw for generating the electricity by means of microbial fuel *** electricity generated through crop stubble can be used as a sustainable source of energy in the remote *** is also focused on suggesting policies to the government so that air pollution can be minimized in affected areas.

关键词： Crop stubble burning electricity Microbial fuel cell

Disturbance cue communication is shaped by emitter diet and receiver background risk in Trinidadian guppies

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Current Zoology 2022年第4期68卷 433-440页

作者： Jack A Goldman Adam l Crane laurence e A Feyten emily Collins Grant e Brown Department of Biology Concordia University7141 Sherbrooke Street WestMontrealQCCanada H4B 1R6

In animal communication systems,individuals that detect a cue(i.e.,“receivers”)are often infl.enced by characteristics of the cue *** instance,in many species,receivers avoid chemical cues that are released by emitters experiencing *** chemical“disturbance cues”appear to benefit receivers by warning them about nearby danger,such as a predator’s *** the active ingredients in disturbance cues have been largely unexplored,by-products of metabolized protein are thought to play a role for some *** so,the content(quality)and volume(quantity)of the emitter’s diet should affect their disturbance cues,thus al.ering how receivers perceive the cues and *** Poecilia reticulata are a species known to discriminate among disturbance cues from different types of donors,but dietary variation has yet to be *** this study,we found evidence that diet quality and quantity can affect disturbance cues released by guppy emitters(i.e.,experimental“donors”).Receivers discriminated between donor cue treatments,responding more strongly to cues from donors fed a protein-rich bloodworm diet(experiment 1),as well as an overall larger diet(experiment 2).We also found that receivers exposed to higher background risk were more sensitive to disturbance cue variation,with the strongest avoidance responses displayed by high-risk receivers toward disturbance cues from donors fed the high-quality ***,diet,and perhaps protein specifically,affects either the concentration or composition of disturbance cues released by *** variation may be important in information signaling in social species like the guppy.

关键词： alarm cues chemical cues diet quality diet quantity protein