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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon emma l.Clayton UK Dementia Research Institute at King’s Col.ege london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Trace elements and stable sulfur isotopes in plants of acid mine drainage area:Implications for revegetation of degraded land

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Journal of environmental Sciences 2020年第8期32卷 128-136页

作者： Agnieszka gałuszka Zdzisław MMigaszewski Andrzej Pelc Andrzej Trembaczowski Sabina Doł˛egowska Artur Michalik Geochemistry and the environment Division Institute of ChemistryJan Kochanowski University7 Uniwersytecka St.25-406 KielcePoland Mass Spectrometry laboratory Institute of PhysicsMaria Curie-Skłodowska University1 Maria Curie-Skłodowska Sq.20-031 LublinPoland

The abundances of trace elements,a low pH of water and soil in areas impacted by the acid mine drainage(AMD)may cause an excessive uptake of potentially toxic elements and nutritional imbalances in ***-tolerant,native plants are used for revegetation of degraded mining *** established levels of selected trace elements and stable sulfur isotopes in the above-ground plant biomass col.ected in a mining area in south-central *** 2016,20 samples of the most common species were col.ected from sites with a different infl.ence of acid mine drainage and analyzed for trace elements by the inductively coupled plasma mass spectrometry *** the basis of the results obtained in 2016,the most contaminated site was selected for a more detailed study,in which sulfur contents and stable sulfur isotope ratios were determined together with trace elements in 17 *** results confirmed that the plants native to the AMD area efficiently accumulated trace elements,especially As and rare earth *** showed the highest content of trace elements,but exhibited the lowest concentrations of sulfur accompanied by the highestδ34S *** has been shown for the first time that stable sulfur isotope composition of AMD plants in south-central Poland is significantly depleted in the 34S isotope showing an averageδ34 S val.e of–10.5‰in comparison with positiveδ34S val.es in local vegetation growing outside the AMD area and in local precipitation.

关键词： Trace elements Stable sulfur isotopes Pyrite oxidation Rare earth elements Plants

Adaptive Bayesian Inference for Discontinuous Inverse Problems,Application to Hyperbolic Conservation laws

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Communications in Computational Physics 2014年第6期16卷 1-34页

作者： Alexandre Birol.eau gaël Poëtte Didier lucor CeA DAMDIFF-91297 ArpajonFrance. UPMC Univ Paris 06 UMR 7190Institut Jean Le Rond d’AlembertF-75005 ParisFrance. CNRS UMR 7190Institut Jean Le Rond d’AlembertF-75005 ParisFrance.

Various works from the literature aimed at accelerating Bayesian inference in inverse *** spectral methods have been recently proposed as surrogate approximations of the forward uncertainty propagation model over the support of the prior *** representations are efficient because they allow affordable simulation of a large number of samples from the posterior ***,they do not perform well when the forward model.exhibits strong nonlinear behavior with respect to its *** this work,we first relate the fast(exponential)l2-convergence of the forward approximation to the fast(exponential)convergence(in terms of Kullback-leibler divergence)of the approximate *** particular,we prove that in case the prior distribution is uniform,the posterior is at least twice as fast as the convergence rate of the forward model in those *** Bayesian inference strategy is developed in the framework of a stochastic spectral projection *** predicted convergence rates are then demonstrated for simple nonlinear inverse problems of varying *** then propose an efficient numerical approach for the Bayesian solution of inverse problems presenting strongly nonlinear or discontinuous system *** comes with the improvement of the forward model that is adaptively approximated by an iterative generalized Polynomial Chaos-based *** numerical approximations and predicted convergence rates of the former approach are compared to the new iterative numerical method for nonlinear time-dependent test cases of varying dimension and complexity,which are relevant regarding our hydrodynamics motivations and therefore regarding hyperbolic conservation laws and the apparition of discontinuities in finite time.

关键词： Stochastic inverse problems Bayesian inference iterative generalized Polynomial Chaos compressible gas dynamics.

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.l.e Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfil.ed by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell.eC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular eCs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Does Cold Plasma Affect Breaking Dormancy and Seed Germination? A Study on Seeds of lamb's Quarters(Chenopodium album agg.)

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Plasma Science and Technology 2009年第6期11卷 750-754页

作者： Bozena era Michal eRY Vitězslav TRANAK Petr PATeNKA Milan TICHY Institute of Systems Biology and ecology Academy of Sciences of the Czech RepublicNa Sadkach 7CZ-370 05 Ceske BudejoviceCzech Republic University of South Bohemia in Ceske Budejovice Faculty of EducationDepartment of PhysicsJeronymova 10CZ-371 15 Ceske BudejoviceCzech Republic Technical University of liberec Department of Material SciencesHalkova 6CZ-461 17 Liberec 1Czech Republic Charles University in Prague Faculty of Mathematics and PhysicsV Holesovickach CZ-180 00 Praha 8Czech Republic

low-pressure discharge is appl.ed for stimulation of germination of two seed lots of lamb＇s Quarters （Chenopodium album agg.） with different starting germinations （17%, 8%） and in different stages of dormancy. Different exposition durations with cold plasma treatment were appl.ed. The variable of the ratio cumulative germination was calculated. The Richards＇ equation was used for curve-fitting and simulation of the growth curves. Population parameters, namely Vi - viability, Me - time, Qu - dispersion, and Sk - skewness, counted from the curves described the germination rate well. Significant differences among Qu confirmed the erratic dormancy and gradual germination of lamb＇s Quarters. No difference in the Me parameter was found between two tested seed lots, and no interspecies characteristics were changed using low-pressure discharge. The results suggested that plasma treatment changed seed germination in lamb＇s Quarters seeds.

关键词： chenopodium album fitting treatment parameter. seed germination low-pressure discharge plasma

Unveiling the lamellar structure of the human cornea over its full thickness using polarization-resol.ed SHG microscopy

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light(Science & Applications) 2023年第9期12卷 1782-1794页

作者： Clothil.e Raoux Anatole Chessel Pierre Mahou gaël latour Marie-Claire Schanne-Klein laboratory for Optics and Biosciences Ecole PolytechniqueCNRSINSERMInstitut Polytechnique de Paris91128 PalaiseauFrance UniversitéParis-Saclay 91190 Gif-sur-YvetteFrance

A key property of the human cornea is to maintain its curvature and consequently its refraction capability despite daily changes in intraocular *** is closely related to the multiscale structure of the corneal stroma,which consists of 1-3µm-thick stacked lamell.e made of thin collagen ***,the distribution,size,and orientation of these lamell.e along the depth of the cornea are poorly characterized up to *** this study,we use second harmonic generation(SHG)microscopy to visualize the collagen distribution over the full depth of 10 intact and unstained human corneas(500-600µm thick).We take advantage of the small coherence length in epi-detection to axially resol.e the lamell.e while maintaining the corneal physiological ***,as raw epi-detected SHG images are spatially homogenous because of the sub-wavelength size of stromal collagen fibrils,we use a polarimetric approach to measure the collagen orientation in every *** a careful validation of this approach,we show that the collagen lamell.e(i)are mostly oriented along the inferior-superior axis in the anterior stroma and along the nasal-temporal axis in the posterior stroma,with a gradual shift in between and(ii)exhibit more disorder in the anterior *** results represent the first quantitative characterization of the lamellar structure of the human cornea continuously along its entire thickness with micrometric *** also shows the unique potential of P-SHG microscopy for imaging of collagen distribution in thick dense tissues.

关键词： structure curvature resol.ed

Production of composites with high relative permittivity using the spouted bed technique

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Particuology 2019年第1期17卷 184-189页

作者： e. eichner P.-K. Fischer S. Heinrich ga Schneider Institute of Solids Process engineering and Particle Technology Denickestr1521073 HamburgGermany Institute of Advanced Ceramics Hamburg University of TechnologyDenickestr1521073 HamburgGermany

This contribution presents a new application of the spouted bed technique. The developed production process invol.es coating fine copper particles with a polymer in a spouted bed plant and then hot pressing the produced granules to form a compact consisting of a copper–polymer composite with a high filling degree. The fabricated composites possess high relative permittivity, which is advantageous for the production of effective capacitors. With increasing filling degree of copper, the relative permittivity of the composites increased, with a maximum relative permittivity of 214 obtained for the composite containing 78.1 vol% copper. Such a high filling degree can be achieved with conductive particles without obtaining a conductive composite by using the spouted bed technology in the production process. The high relative permittivity results from the high filling degree of particles isolated by a polymer coating.

关键词： Spouted bed High relative permittivity Fine particles Coating Metal-polymer composite

A Note on Solutions for Asymptotically linear elliptic Systems

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Acta Mathematicae Applicatae Sinica 2008年第3期24卷 511-522页

作者： lei-ga Zhao Department of Mathematics Beijing University of Chemical Technology 100029 Beijing China Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China Department of Mathematics Yunnan Normal University Kunming 650092 China

In this paper, we are concerned with the elliptic system of{ -△u＋V（x）u=g（x,v）, x∈R^N, -△v＋V（x）v=f（x,u）, x∈R^N, where V（x） is a continuous potential well, f, g are continuous and asymptotically linear as t→∞. The existence of a positive solution and ground state solution are established via variational methods.

关键词： elliptic system ground state solution variational methods concentration-compactness principle