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Management of skin toxicities during panitumumab treatment in metastatic colorectal cancer

World Journal of gastroenterology 2019年第29期25卷 4007-4018页

作者： Olivier Bouche Meher Ben Abdelghani Jean-Luc Labourey Simon Triby René-Jean Bensadoun Thomas Jouary gaétan des guetz Department of gastroenterology and Digestive Oncology Hopital Robert Debre CHU ReimsReims 51000France Oncology Department Centre Paul StraussStrasbourg 67000France Oncology Department Centre HospitalierCarcassonne 11000France Medical Department AMGEN FranceBoulogne-Billancourt 92100France Radiation Oncology Centre de Haute EnergieNice 06000France Dermatology Department Hopital Saint-Andre CHU de BordeauxBordeaux 33000France Oncology Department Avicenne HospitalBobigny 93000France

BACKGROUND Anti-epidermal growth factor receptor therapy is associated with skin adverse events not previously reported with conventional chemotherapy. Prophylactic actions are recommended, but routine clinical management of these toxicities and their impact on quality of life remain unknown. AIM To assess the dermatological toxicities reported after panitumumab initiation, their impact on the quality of life and the clinical practices for their management. METHODS Patients included in this prospective multicenter observational study were over 18 years of age and began treatment with panitumumab for wild-type KRAS metastatic colorectal cancer. The incidence of dermatological toxicities, clinical practices for their management and impact on quality of life were recorded during a 6-mo follow-up. RESULTS Overall, 229 patients (males, 57.6%;mean age, 66.2 years) were included. At day 15, 59.3% of patients had dermatological toxicity;the rate peaked at month 2 (74.7%) and decreased at month 6 (46.5%). The most frequent dermatological toxicities were rash/acneiform rash, xerosis and skin cracks. At least one preventive treatment was administered to 65.9% of patients (oral antibiotics, 84.1%;emollients, 75.5%;both, 62.9%). The rates of patients who received at least one curative treatment peaked at month 2 (63.4%) and decreased at month 6 (44.8%). The impact of the dermatological toxicities on quality of life was limited as assessed with Dermatology Life Quality Index scores and inconvenience visual analogic scale score. The rates of topical corticosteroids administration and visits to specialists were low. CONCLUSION The rates of the different skin toxicities peaked at various times and were improved at the end of follow-up. Nevertheless, their clinical management could be optimized with a better adherence to current recommendations. The impact of skin toxicities on patient’s quality of life appeared to be limited.

关键词： Metastatic colorectal cancer Epidermal growth factor receptor inhibitors Panitumumab Skin toxicity Quality of life

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Hovering rotor aerodynamics in extreme ground effect

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Chinese Journal of Aeronautics 2024年第7期37卷 204-219页

作者： Zhenlong WU Tianyu ZHANG Huijun tan Haoyu ZHOU Wei CHEN Maixiang XIE College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China China Aviation Power Machinery Research Institute Zhuzhou 412002China

This paper presents an experimental and numerical study of the aerodynamics of a moderate-scale rotor hovering in the Extreme Ground Effect(EGE)where rotor height-offground is below half the rotor *** tip vortex field was visualized by using the PIV *** aerodynamic performance,tip vortex trajectory,wall jet characteristics,surface pressure and velocity fields were measured and *** explore more deeply the flow mechanisms of the extreme ground effect,Detached Eddy Simulation(des)was conducted on completely structured *** results showed significant deviations of the rotor performance in EGE from that in Regular Ground Effect(RGE)with the rotor heights of more than half the rotor ***,the flow structures of the rotor in EGE are considerably complex,such as the wall jet and groundwash flow *** rotor wake flow and tip vortices impact the ground more frequently,resulting in distinctive characteristics of the surface pressure and velocity fields in EGE.

关键词： Rotor Ground effect Tip vortex Detached Eddy Simulation(des) Groundwash

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Constant charge method or constant potential method:Which is better for molecular modeling of electrical double layers?

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Journal of Energy Chemistry 2024年第7期94卷 54-60页

作者： Liang Zeng Xi tan Xiangyu Ji Shiqi Li Jinkai Zhang Jiaxing Peng Sheng Bi Guang Feng State Key Laboratory of Coal Combustion Schoolof Energy and PowerEngineeringHuazhong Universityof Science and Technology(HUST)Wuhan 430074HubeiChina Sorbonne Universite CNRSPhysico-chimie des Electrolytes et Nanosystemes InterfaciauxPHENIXF-75005 ParisFrance

In molecular modeling of electrical double layers(EDLs),the constant charge method(CCM)is prized for its computational efficiency but cannot maintain electrode equipotentiality like the more resourceintensive constant potential method(CPM),potentially leading to *** certain scenarios,CCM can yield results identical to ***,there are no clear guidelines to determine when CCM is sufficient and when CPM is ***,we conduct a series of molecular simulations across various electrodes and electrolytes to present a comprehensive comparison between CCM and CPM under different charging *** reveal that CCM approximates CPM effectively in capturing equilibrium EDL and current-driven dynamics in open electrode systems featuring ionic liquids or regular concentration aqueous electrolytes,while CPM is indispensable in scenarios involving organic and highly concentrated aqueous electrolytes,nanoconfinement effects,and voltage-driven *** work helps to select appropriate methods for modeling EDL systems,prioritizing accuracy while considering computationalefficiency.

关键词： Electrochemical interface Molecular dynamics Electrode polarization modeling Nanoconfinement effect

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Multivariate Approach to Characterizing Soil Quality of gabonese’s Ferralitic Soils

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Open Journal of Soil Science 2024年第4期14卷 237-268页

作者： Neil-Yohan Musadji Rolf gaël Mabicka Obame Michel Mbina Mounguengui Jean Aubin Ondo Lydie-Stella Koutika Eric Ravire Claude Geffroy Laboratoire De Chimie Des Milieux et Des Mat&#233riaux Inorganiques Laboratoire D&#8217Analyse Des Sols et Environnement D&#233partement Des Sciences Fondamentales De L&#8217Ing&#233nieur Institut National D&#8217Agronomie et De Biotechnologies Universit&#233 Des Sciences et Techniques De Masuku Franceville Gabon Institut De Chimie des Milieux et Maté riaux De Poitiers (IC2MP) Universit&#233 De Poitiers Poitiers France Laboratoire De Chimie Des Milieux et Des Mat&#233riaux Inorganiques Laboratoire D&#8217Analyse Des Sols et Environnement D&#233partement De Phytotechnologie Institut National D&#8217Agronomie et De Biotechnologies Universit&#233 Des Sciences et Techniques De Masuku Franceville Gabon Dé partement De G&#233ologie Facult&#233 Des Sciences Universit&#233 Des Sciences et Techniques De Masuku Franceville Gabon Laboratoire Pluridisciplinaire des Sciences Ecole Normale Sup&#233rieure Libreville Gabon Centre De Recherche Sur La Productivité et La Durabilit&#233 Des Plantations Industrielles Pointe Noire Republic of Congo Sucaf gabon Somdiaa Franceville Gabon

Assessing soil quality is essential for crop management and soil temporal changes. The present study aims to evaluate soil quality in the Ferralitic soils context countrywide. This assessment was done using multivariate soil quality indice (SQI) models, such as additive quality index (AQI), weighted quality indexes (WQIadd and WQIcom) and Nemoro quality index (NQI), applied to two approaches of indicator selection: total data set (TDS) and minimum data set (MDS). Physical and chemical soil indicators were extracted from the ORSTOM’s reports resulting from a sampling campaign in different provinces of gabon. The TDS approach shows soil quality status according to eleven soil indicators extracted from the analysis of 1,059 samples from arable soil layer (0 - 30 cm depth). The results indicated that 87% of all provinces presented a very low soil quality (Q5) whatever the model. Among soil indicators, exchangeable K+ and Mg2+, bulk density and C/N ratio were retained in MDS, using principal component analysis (PCA). In the MDS approach, 50 to 63% of provinces had low soil quality grades with AQI, WQIadd and NQI, whereas the total was observed with WQIcom. Only 25% of provinces had medium soil quality grades with AQI and NQI models, while 12.5% (NQI) and 25% (AQI) presented high quality grades. Robust statistical analyses confirmed the accuracy and validation (0.80 r P ≤ 0.016) of AQI, WQIadd and NQI into the TDS and MDS approaches. The same sensitivity index value (1.53) was obtained with AQI and WQIadd. However, WQIadd was chosen as the best SQI model, according to its high linear regression value (R2 = 0.82) between TDS and MDS. This study has important implications in decision-making on monitoring, evaluation and sustainable management of gabonese soils in a pedoclimatic context unfavorable to plant growth.

关键词： gabon Ferralitic Soil Soil Indicators Standard Score Function Soil Quality Indices Sustainable Soil Soil Management

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National Soil Organic Carbon Stocks Inventories under Different Mangrove Forest Types in gabon

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Open Journal of Forestry 2024年第2期14卷 127-140页

作者： Rolf gaël Mabicka Obame Neil-Yohan Musadji Jean Hervé Mve Beh Lydie-Stella Koutika Jean Aubin Ondo Farrel Nzigou Boucka Michel Mbina Mounguengui Claude Geffroy Dé partement de Phytotechnologie Institut National d&#8217Agronomie et de Biotechnologies Universit&#233 des Sciences et Techniques de Masuku Franceville Gabon Dé partement des Sciences Fondamentales de l&#8217Ing&#233nieur Institut National d&#8217Agronomie et de Biotechnologies Universit&#233 des Sciences et Techniques de Masuku Franceville Gabon Institut Agronomiques et Forestiè res Centre National des Recherches Scientifiques et Technologiques Libreville Gabon Research Centre on the Durability and the Productivity of Industrial Plantations (CRDPI) Pointe Noire Republic of Congo Laboratoire Pluridisciplinaire des Sciences &#201cole Normale Sup&#233rieure Libreville Gabon Agence gabonaise d’ &#201tude et d&#8217Observation Spatiale Immeuble les Arcades Libreville Gabon Dé partement de G&#233ologie Faculte des Sciences Universit&#233 des Sciences et Techniques de Masuku Franceville Gabon Institut de Chimie des Milieux et Maté riaux de Poitiers (IC2MP) Universit&#233 de Poitiers Poitiers France

gabonese’s estuary is an important coastal mangrove setting and soil plays a key role in mangrove carbon storage in mangrove forests. However, the spatial variation in soil organic carbon (SOC) storage remain unclear. To address this gap, determining the SOC spatial variation in gabonese’s estuarine is essential for better understanding the global carbon cycle. The present study compared soil organic carbon between northern and southern sites in different mangrove forest, Rhizophora racemosa and Avicennia germinans. The results showed that the mean SOC stocks at 1 m depth were 256.28 ± 127.29 MgC ha−1. Among the different regions, SOC in northern zone was significantly (p p −1) than upper layers (55.42 ± 25.37 MgC ha−1). The study highlights that low deforestation rate have led to less CO2 (705.3 Mg CO2e ha−1 - 922.62 Mg CO2e ha−1) emissions than most sediment carbon-rich mangroves in the world. These results highlight the influence of soil texture and mangrove forest types on the mangrove SOC stocks. The first national comparison of soil organic carbon stocks between mangroves and upland tropical forests indicated SOC stocks were two times more in mangroves soils (51.21 ± 45.00 MgC ha−1) than primary (20.33 ± 12.7 MgC ha−1), savanna and cropland (21.71 ± 15.10 MgC ha−1). We find that mangroves in this study emit lower dioxide-carbon equivalent emissions. This study highlights the importance of national inventories of soil organic carbon and can be used as a baseline on the role of mangroves in carbon sequestration and climate change mitigation but the variation in SOC stocks indicates the need for further national data.

关键词： Mangroves Forest Soil Organic Carbon Stocks Rizophora Racemose Avicenia germinans gabon

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des-Fe3O4 composite for rapid extraction of residual plant growth regulators in edible vegetable oil

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Chinese Chemical Letters 2019年第6期30卷 1182-1185页

作者： Ting tan Xiaomei Xu Yiqun Wan State Key Laboratory of Food Science and Technology Nanchang University Nanchang 330047 China Center of Analysis and Testing Nanchang University Nanchang 330031 China School of Chemistry Nanchang University Nanchang 330031 China

A rapid des-Fe3O4 microextraction coupled with liquid chromatography method was ingeniously developed for simultaneous control of five typical plant growth regulators in a planting cycle including indole-3-acetic acid, abscisic acid, thidiazuron, 1-naphthylacetic acid and forchlorfenuron. The experiments were carried out with one type of carboxylic acid-assisted deep eutectic solvent (nChCl:nacetic acid=1:3) as extractant, coupled with ultrasonic wave extraction for 30 min at bath temperature at 50 ℃. Under the optimum conditions, good extraction performances of linearities for five plant growth regulators were achieved separately in the range of 0.10–50 mg/L of indole-3-acetic acid, 0.06–50 mg/L of abscisic acid, 0.20–50 mg/L of thidiazuron, 0.50–50 mg/L of 1-naphthylacetic acid and 0.06–50 mg/L of forchlorfenuron and recoveries were ranged from 70.4%to 102.2%. Meanwhile, Fe3O4 was preferentially combined with des in the oil matrix, the advantage of which was pointed to rapid and efficient separation of targeted plant growth regulators from complicated oil matrix. The proposed approach achieved satisfied results and met the monitoring requirements of plant growth regulators control in edible vegetable oil samples.

关键词： des-Fe3O4 composite Deep eutectic solvent Rapid separation Plant growth regulators Edible vegetable oil

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Sphincter preservation for distal rectal cancer - a goal worth achieving at all costs?

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World Journal of gastroenterology 2011年第7期17卷 855-861页

作者： Jürgen Mulsow des C Winter Institute for Clinical Outcomes Research and Education St. Vincent’s University Hospital

To assess the merits of currently available treatment options in the management of patients with low rectal cancer, a review of the medical literature pertaining to the operative and non-operative management of low rectal cancer was performed, with particular emphasis on sphincter preservation, oncological outcome, functional outcome, morbidity, quality of life, and patient preference. Low anterior resection (AR) is technically feasible in an increasing proportion of patients with low rectal cancer. The cost of sphincter preservation is the risk of morbidity and poor functional outcome in a significant proportion of patients. Transanal and endoscopic surgery are attractive options in selected patients that can provide satisfactory oncological outcomes while avoiding the morbidity and functional sequelae of open total mesorectal excision. In complete responders to neo-adjuvant chemoradiotherapy, a non-operative approach may prove to be an option. Abdominoperineal excision (APE) imposes a permanent stoma and is associated with significant incidence of perineal morbidity but avoids the risk of poor functional outcome following AR. Quality of life following AR and APE is comparable. Given the choice, most patients will choose AR over APE, however patients following APE positively appraise this option. In striving toward sphincter preservation the challenge is not only to achieve the best possible oncological outcome, but also to ensure that patients with low rectal cancer have realistic and accurate expectations of their treatment choice so that the best possible overall outcome can be obtained by each individual.

关键词： Rectal cancer Survival Local recurrence Morbidity Anorectal function Quality of life Patient preference

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Establishment and development of the World Association for Sedimentation and Erosion Research

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International Journal of Sediment Research 2023年第6期38卷 901-909页

作者： Cheng Liu Zhaoyin Wang des E.Walling International Research and Training Center on Erosion and Sedimentation Department of Hydraulic Engineering Tsinghua University Geography Faculty of EnvironmentScience and EconomyUniversity of Exeter

Problems of soil erosion and sedimentation are issues of global *** the intensification of global change and the impacts of human activities,many countries are facing severe challenges from wideranging sediment-related *** prevention and control of sediment disasters and the rational use of soil and sediment resources are important requirements for the sustainable development strategies of all *** sediment problems are closely related to social,economic,and other human activities,the effective solution of sediment problems requires the concerted efforts of experts in different fields and thus an interdisciplinary approach is *** view of the increasing recognition of sediment as a topic of global significance and the need to promote interdisciplinary research in this field,the World Association for Sedimentation and Erosion Research(WASER) was inaugurated in *** this paper the history of the establishment of WASER is reviewed and its main activities are briefly *** series of International Symposia on River Sedimentation(ISRS) has served as the official symposium of WASER since *** triennial technical events have been held in China,Russia,Japan,South Africa,and Germany with about 2,000 *** addition to sponsoring the ISRS,WASER has to date also sponsored/organized or co-sponsored/co-organized over 30 other international conferences,workshops,training courses,and study tours besides sponsoring the *** adoption of the International Journal of Sediment Research(IJSR) as the official journal of WASER in 2004has also played an important role in increasing the exposure of the *** activities have served to raise WASER’s profile as well as promoting collaboration with agencies and other organizations working in the field of erosion and *** types of prizes and honors are awarded by *** include the International Qian Ning Prize for Erosion and Sedimentation Technolog

关键词： Erosion and sedimentation Association Symposia Journal

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舰载直升机主动甲板着舰气动载荷特性

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北京航空航天大学学报 2024年第7期50卷 2206-2217页

作者：谭剑锋邢肖兵崔钊武杰张卫国南京工业大学机械与动力工程学院南京211816 中国飞行试验研究院技术中心飞机所西安710089 中国空气动力研究与发展中心旋翼空气动力学重点实验室绵阳621000

被动与主动流动控制可减小舰艇艉流强度,但直升机着舰甲板处仍存在明显回流现象,由此导致直升机气动载荷变化显著。提出了自动升降的舰艇主动甲板,建立基于格子玻尔兹曼方法 (LBM)的舰艇主动甲板流场分析方法,并结合单向耦合模型,嵌入... 详细信息

被动与主动流动控制可减小舰艇艉流强度,但直升机着舰甲板处仍存在明显回流现象,由此导致直升机气动载荷变化显著。提出了自动升降的舰艇主动甲板,建立基于格子玻尔兹曼方法 (LBM)的舰艇主动甲板流场分析方法,并结合单向耦合模型,嵌入旋翼黏性涡粒子法,研究直升机主动甲板着舰气动载荷特性。通过与SFS2舰艇流场试验、分离涡模拟(des)方法、大涡模拟(LES)方法比较,验证了所建方法的准确性。随后研究主动甲板对舰艇流场和直升机着舰气动载荷的影响特性。结果表明:相比于标准SFS2舰艇,主动甲板有效抑制了直升机着舰甲板处回流,以及直升机旋翼拉力损失、滚转和俯仰力矩,最大降幅分别为21.6%、55.1%、74.6%。

关键词：主动甲板直升机旋翼舰艇艉流格子玻尔兹曼方法黏性涡粒子

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Synthesis of a Novel Perfluorinated Vinyl Ether Containing Sulfonimide and Phosphonic Acid Functionalities

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Chinese Journal of Chemistry 2002年第11期20卷 1268-1273,1128页

作者：朱士正金桂芳 des Marteau D.D Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China Department of Chemistry H. L. Hunter Chemistry Laboratory Clemson University Clemson SC 29634–1905 U.S.A.

The novel perfluorinated vinyl ether containing sulfonimide and phosphonic acid functionalities, CF2 = CFOCF2CF(CF3)-OCF2CF2SO2NHSO2(CF2)2P(O)(OH)2, has been synthesized by multiple reaction steps. It is a very strong bi-functional acid and exhibits a high degree of stability in aqueous solution at an elevated temperature. These properties make it an attractive monomer for the preparation of the co-polymer with TFE to obtain the high quality ionomer membrane and proton conductor.

关键词： perfluorinated vinyl ether sulfonimide phosphonic acid

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