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丛书名：外国文学名著精品

2003年

作者：（法）莫泊桑（guy de Maupassant）唐珍等译

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人生

4号染色体短臂微卫星多态性与鼻咽癌相关性的研究

丛书名：世界文学名著

1993年

作者：（法）莫泊桑（guy de Maupassant）李青崖译

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遗传 2006年第7期28卷 783-790页

作者：郭秀婵 O’BRIEN Stephen J WINKLER Cheryl SCOTT Kevin HUTCHESON Holli DAVID Victor KESSING Bailey 郑裕明廖建刘彦 guy de the 曾毅中国疾病预防控制中心病毒病预防控制所北京100052 美国国家癌症研究所基因组多样性研究室 frederickmd21702 广西梧州市肿瘤防治研究所梧州543002 广西苍梧县鼻咽癌防治所苍梧543100 法国巴士德研究所 parisfrance75724

鼻咽癌（NPC）是一种多因素复杂疾病。其发病过程涉及EB病毒慢性感染、环境致癌因素及宿主基因之间的相互作用。在这一过程中，那些宿主基因在EB病毒感染及鼻咽癌的发生发展中起了关键作用仍不清楚。本研究的目的是发现与鼻咽癌发生发... 详细信息

鼻咽癌（NPC）是一种多因素复杂疾病。其发病过程涉及EB病毒慢性感染、环境致癌因素及宿主基因之间的相互作用。在这一过程中，那些宿主基因在EB病毒感染及鼻咽癌的发生发展中起了关键作用仍不清楚。本研究的目的是发现与鼻咽癌发生发展中两个关键步骤相关的遗传变异，即EB病毒持续性感染鼻咽部上皮细胞和鼻咽癌的形成。我们在广西梧州市及苍梧县鼻咽癌高发区收集汉族鼻咽癌患者350例、EB病毒壳抗原IgA抗体阳性者（IgA／VCA＋）288例和EB病毒壳抗原IgA抗体阴性者（IgA／VCA—）346例。对先前鼻咽癌家系研究显示的鼻咽癌易感区4号染色体短臂（4p15．1～q12）进行了微卫星精细扫描，在18Mb的范围内选择34个微卫星标记，包括319个等位基因，对其进行基因分型。比较分析NPC组和IgA／VCA＋组等位基因频率结果显示，9个等位基因与鼻咽癌呈相关，其中5个为易感等位基因（OR=1．51～5．36，P=0．01～0．03），4个为限制性等位基因（OR值为0．3～0．71，P值为0．02～0．045）。比较分析IgA／VCA＋组和IgA／VCA-组及比较所有IgA／VCA＋者（包括NPC患者）和IgA／VCA-者等位基因频率的结果显示，12个等位基因与EB病毒壳抗原IgA抗体持续存在相关，其中3个在两组比较中均呈显著相关。等位基因D4S3241～136（P=0．004，OR=1．9，95％CI=1．2～3．0）和D4S3347-213（P=0．001，OR=1．6，95％CI=1．2～2．1）可增加EB病毒IgA／VCA抗体形成的危险，为易感基因；而等位基因D4S174．202（P=0．001，OR=0．5，95％CI=0．3～0．7）可限制IgA／VCA抗体的形成。但上述结果经多因素比较校正后，均失去相关性。结果不能确定该区域与非家族性鼻咽癌的形成相关，但本研究却提供了进一步发现鼻咽癌相关基因的研究模式。有关4号染色体短臂与EB病毒慢性持续感染及鼻咽癌的形成仍值得进一步深入研究。

关键词：鼻咽癌 4号染色体微卫星相关研究

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Identification and immune analysis of antimicrobial peptides from the cigarette beetle(Lasioderma serricorne)

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Insect Science 2024年第4期31卷 1121-1134页

作者： Yue Zhang Yi Yan guy Smagghe Hong Yang Ren-huai Dai Wen-jia Yang Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous Region Institute of EntomologyGuizhou UniversityGuiyangChina Guizhou Provincial Key Laboratory for Rare Animal and Economic Insect of the Mountainous Region College of Biology and Environmental EngineeringGuiyang UniversityGuiyangChina

Antimicrobial peptides(AMPs)in insects are endogenous peptides that are effector components of the innate defense system of the *** may serve as antimicrobial agents because of their small molecular weight and broad-spectrum antimicrobial *** this study,we performed transcriptome analysis of cigarette beetle(Lasioderma serricorne)larvae,parasitized by the ectoparasitic wasp,Anisopteromalus *** AMP genes were significantly upregulated following *** parasitism,postulating the hypothesis that the parasitization enhanced the host's resistance against pathogenic microorganisms through the regulation of host AMP ***,3 AMP genes(Lsdef1,Lsdef2,and LsCole)were significantly upregulated and we studied their immune function in *** challenge and functional analysis showed that LsCole was responsible for the immune response against Gram-negative and Gram-positive bacteria,while Lsdef1 and Lsdef2 were involved in insect defense against Gram-positive *** recombinant LsCole exhibited antimicrobial activities against the Gram-negative bacterium Escherichia coli and the Gram-positive bacterium Staphylococcus ***2 showed an antibacterial effect against *** and Lsdef2 exhibited antibiofilm activity against *** 2 AMPs disrupted cell membranes and caused leakage of *** cell *** results indicated that the 3 AMPs in *** are involved in the innate immunity of this pest *** AMPs may have potential as antimicrobial agents for bacterial infection ***,data are discussed in relation to new control strategies with greater biosafety against pest insects with use of microbial biocontrol agents in combination with RNA interference against the insect's defensive AMP genes.

关键词： antimicrobial activity antimicrobial peptides innate immune response Lasioderma serricorne RNA interference

GEOLOGY　AND　GEOCHEMISTRY　OF　THE　QIANLISHAN　GRANITE　STOCK　AND　ITS　RELATIONSHIP　TOPOLYMETALLIC　TUNGSTEN　MINERALIZATION

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Scientia Geologica Sinica 1994年第4期 437-456页

作者： Mao Jingwen and Li Hongyan (Institute of Mineral depothe, Chinese Academy of Geological Sciences)L. Raimbault (Centre de Geologie Gmle et Minters, Ecole des Mines de Paris)B. guy(departenzent de Geologie, Ecole des Mines de Saint-Etienne)

ＧＥＯＬＯＧＹＡＮＤＧＥＯＣＨＥＭＩＳＴＲＹＯＦＴＨＥＱＩＡＮＬＩＳＨＡＮＧＲＡＮＩＴＥＳＴＯＣＫＡＮＤＩＴＳＲＥＬＡＴＩＯＮＳＨＩＰＴＯＰＯＬＹＭＥＴＡＬＬＩＣＴＵＮＧＳＴＥＮＭＩＮＥＲＡＬＩＺＡＴＩＯＮＭａｏＪｉ... 详细信息

ＧＥＯＬＯＧＹＡＮＤＧＥＯＣＨＥＭＩＳＴＲＹＯＦＴＨＥＱＩＡＮＬＩＳＨＡＮＧＲＡＮＩＴＥＳＴＯＣＫＡＮＤＩＴＳＲＥＬＡＴＩＯＮＳＨＩＰＴＯＰＯＬＹＭＥＴＡＬＬＩＣＴＵＮＧＳＴＥＮＭＩＮＥＲＡＬＩＺＡＴＩＯＮＭａｏＪｉｎｇｗｅｎａｎｄＬｉＨｏｎｇｙａｎ...

关键词： ITS RELATIONSHIP GEOCHEMISTRY AND

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她的一生 1版

Air traffic monitoring using optimized ADS-B CubeSat constellation

丛书名：世界女性题材经典名著

1993年

作者：（法）莫泊桑（Maupassant guy de）李玉民李玉满译

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Astrodynamics 2024年第1期8卷 189-208页

作者： Ghulam Jaffer Rameez AMalik Elias Aboutanios Nazish Rubab Ronnie Nader Hans U.Eichelberger guy A.E.Vandenbosch Interdisciplinary Centre for Security Reliability and Trust(SnT)University of LuxembourgLuxembourg1855Luxembourg

The primary technique used for air traffic surveillance is ***,nowadays,its role in surveillance is gradually being replaced by the recently adopted Automatic dependent Surveillance-Broadcast(ADS-B).ADS-B offers a higher accuracy,lower power consumption,and longer range than radar,thus providing more safety to *** coverage of terrestrial radar and ADS-B is confined to continental parts of the globe,leaving oceans and poles uncovered by real-time surveillance *** study presents an optimized Low-Earth Orbit(LEO)-based ADS-B constellation for global air traffic surveillance over intercontinental trans-oceanic flight *** optimization algorithm is based on performance evaluation parameters,i.e.,coverage time,satellite availability,and orbit stability(precession and perigee rotation),and communication *** results indicate that the constellation provides ample coverage in the simulated global oceanic *** constellation is a feasible and cost-effective solution for global air supervision,which can supplement terrestrial ADS-B and radar systems.

关键词： constellation automatic dependent surveillance-broadcast (ADS-B) air traffic surveillance precession perigee rotation.

Heatwave exacerbates air pollution in China through intertwined climate-energy-environment interactions

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Science Bulletin 2024年第17期69卷 2765-2775页

作者： Tianshu Chen Tao Wang Likun Xue guy Brasseur department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China Environment Research Institute Shandong UniversityQingdao 266237China Big Data Research Center for Ecology and Environment Shandong UniversityQingdao 266237China Environmental Modelling Group Max Planck Institute for MeteorologyHamburg 20146Germany National Center for Atmospheric Research BoulderCO 80307USA

Climate change is increasing the frequency and intensity of heatwaves, raising concerns about their detrimental effects on air quality. However, a role for heatwave-human-environment interactions in air pollution exacerbation has not been established. In the summer of 2022, record-breaking heatwaves struck China and Europe. In this study, we use integrated observational data and machine learning to elucidate the formation mechanism underlying one of the most severe ozone pollution seasons on record in central eastern China, an area that encompasses approximately half of China's total population and sown *** findings reveal that the worsened ozone and nitrogen dioxide pollution resulted from a mismatch between energy demand and supply, which was driven by both heatwaves and energy policy-related factors. The observed adverse heatwave-energy-environment feedback loop highlights the need for the diversification of clean energy sources, more resilient energy structures and power policies, and further emission control to confront the escalating climate challenge in the future.

关键词： Heatwaves Air pollution Ozone Energy Machine learning

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Epstein-Barr病毒相关疾病的IgG/Z抗体检测

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病毒学报 1992年第3期8卷 218-222页

作者：曾毅 Jean-claude Nicolas guy Schwaab guy de the Bernard Clausse Thomas Tursz Irene Joab 中国预防医学科学院病毒学研究所法国Rothschild医院法国Gustave Roussy肿瘤研究所法国巴斯德研究所

血清中Epstein-Barr病毒(EBV)的IgG/Z抗体对鼻咽癌和传染性单核细胞增多症是较特异的,其阳性率分别为85.7％和84％。50％的伯基特淋巴瘤病人亦有IgG/Z抗体。正常人则没有,但有IgG/VCA等抗体,表明IgG/Z抗体在初次感染后是容易消失的。Z... 详细信息

血清中Epstein-Barr病毒(EBV)的IgG/Z抗体对鼻咽癌和传染性单核细胞增多症是较特异的,其阳性率分别为85.7％和84％。50％的伯基特淋巴瘤病人亦有IgG/Z抗体。正常人则没有,但有IgG/VCA等抗体,表明IgG/Z抗体在初次感染后是容易消失的。Z抗原与EBV复制相关,故IgG/Z抗体对鼻咽癌不仅有诊断意义,还可能有预后的意义。

关键词：鼻咽肿瘤 EB病毒抗体 IgG/Z

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Genomics,transcriptomics,and peptidomics of the greater wax moth Galleria mellonella neuropeptides and their expression in response to lead stress

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Insect Science 2024年第3期31卷 773-791页

作者： Li-Lin Luo Yang Lin Jun-Hong Linghu Wei Gong Yuan-Hong Luo Man Liu Dao-Chao Jin guy Smagghe Tong-Xian Liu Shun-Hua Gui Tian-Ci Yi Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous Region Institute of EntomologyGuizhou UniversityGuiyangGuizhouChina Guizhou Institute of Biology Guizhou Academy of SciencesGuiyangChina Institute of Plant Health and Medicine Guizhou UniversityGuiyangChina

Neuropeptides are crucial in regulation of a rich variety of developmental,physiological,and behavioral functions throughout the life cycle of *** an integrated approach of multiomics,we identified neuropeptide precursors in the greater wax moth Galleria mellonella,which is a harmful pest of honeybee hives with a worldwide ***,a total of 63 and 67 neuropeptide precursors were predicted and annotated in the *** genome and transcriptome,in which 40 neuropeptide precursors were confirmed in the *** ***,we identified 12 neuropeptide precursor genes present in *** but absent in honeybees,which may be potential novel pesticide target *** hives were contaminated with heavy metals such as lead,enabling its bioaccumulation in *** bodies through the food chain,we performed transcriptome sequencing to analyze the effects of Pb stress on the mRNA expression level of *** neuropeptide *** treatment by Pb,the expression of neuropeptide F1 was found to be significantly downregulated,implying that this neuropeptide might be associated with responding to the heavy metal stress in *** study comprehensively identified neuropeptide precursors in ***,and discussed the effects of heavy metals on insect neuropeptides,with the example of *** results are valuable for future elucidation of how neuropeptides regulate physiological functions in *** and contribute to our understanding of the insect's environmental plasticity and identify potential new biomarkers to assess heavy metal toxicity in insects.

关键词： Galleria mellonella genomics heavy metal stress neuropeptide peptidomics transcriptomics