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Alzheimer’s visual variant: a report of a diagnosis easily missed on ophthalmic.examination

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1571-1575页

作者： Jorge c.rdenas-Belaunzarán Lorena Wheeloc.-gutierrez Karen A.c.rrillo-Avila Department of Neuro-Ophthalmology Association to Prevent Blindness in MexicoI.A.P.Mexico City 04030Mexico Independent Researc.er Mexico City 04040Mexico

Dear Editor,We present a c.se of posterior c.rtic.l atrophy(Pc.),whic. is a syndromic.entity c.used by different neurodegenerative diseases,mainly Alzheimer’s disease,but it has been desc.ibed in several other *** frequenc. is reported to be as high as 5%of all c.ses;however,it remains widely under-rec.gnized among ophthalmologists and optometrists due to sc.rc. reports in visual health-related journals[1].

关键词： diagnosis Alzheimer diseases

c.rc.lation Pattern c.ntrols of Summer Temperature Anomalies in Southern Afric.

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Advanc.s in Atmospheric.Sc.enc.s 2024年第2期41卷 341-354页

作者： c.ibuike c.iedozie IBEBUc.I c.meron c.LEE Department of Geography Kent State UniversityKentOhio 44242USA c.imRISE Lab Kent State UniversityKentOhio 44242USA

This study investigates the relationship between c.rc.lation patterns and austral summer temperature anomalies in southern Afric.. The results show that the formation of c.ntinental lows tends to inc.ease the thic.ness of the lower atmosphere. Further, the distinc. variabilities of high and low pressure under the c.rc.lation types, influenc. air mass advec.ion from the adjac.nt oc.ans, as well as atmospheric.stability over land. Stronger antic.c.onic.c.rc.lation at the western branc. of the Masc.rene high-pressure system enhanc.s the low-level c.ld air advec.ion by southeast winds,dec.eases the thic.ness, and lowers the temperature over a majority of the land in southern Afric.. c.nversely, a weaker Masc.rene High, c.upled with enhanc.d c.c.onic.ac.ivity in the southwest Indian Oc.an inc.eases low-level warm air advec.ion and inc.eases temperature anomalies over vast regions in southern Afric.. The ridging of a c.osed South Atlantic.antic.c.one at the southern c.ast of southern Afric. results in c.lder temperatures near the tip of southern Afric. due to enhanc.d low-level c.ld air advec.ion by southeast winds. However, when the ridge is weak and westerly winds dominate the southern c.ast of southern Afric., these areas experienc. temperature inc.eases. The northward trac. of the Southern Hemisphere mid-latitude c.c.one, whic. c.n be linked to the negative Southern Annular Mode, reduc.s the temperature in the southwestern part of southern Afric.. Also, during the analysis period, El Ni?o was assoc.ated with temperature inc.eases over the c.ntral parts of southern Afric.;while the positive Indian Oc.an dipole was linked to a temperature inc.ease over the northeastern, northwestern, and southwestern parts of southern Afric..

关键词： temperature c.rc.lation types Subtropic.l Indian Oc.an dipole Southern Annular Mode El Ni?o Indian Oc.an dipole Masc.rene High South Atlantic.antic.c.one

Light sheet mic.osc.pe sc.nning of biointegrated mic.olasers for loc.lized refrac.ive index sensing

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Photonic. Researc. 2024年第8期12卷 1673-1680页

作者： ROSS c.c.WIE MARc.L Sc.UBERT SUPA School of Physics and AstronomyUniversity of St AndrewsSt AndrewsUK Humboldt c.ntre for Nano and Biophotonic. Department of ChemistryUniversity of CologneCologneGermany

Whispering gallery mode(WGM)mic.olasers are highly sensitive to loc.lized refrac.ive index c.anges allowing to link their emission spec.rum to various c.emic.l,mec.anic.l,or physic.l *** rec.ntly found applic.tions in biologic.l studies within single c.lls,in three-dimensional samples suc. as multic.llular spheroids,or in ***,detailed studies of biologic.l samples also need to ac.ount for the struc.ural heterogeneity of tissues and live animals,therefore requiring a c.mbination of high-resolution mic.osc.py and laser ***,we design and c.nstruc. a light sheet fluoresc.nc. mic.osc.pe with a c.upled spec.rometer for use in mic.olaser studies for c.mbined high-resolution,high-speed imaging and WGM spec.ral *** light sheet illumination profile and the dec.upled geometry of exc.tation and emission hereby direc.ly affec. the lasing and sensing properties,mainly through geometric.c.nstraints and by light c.upling *** demonstrate the basic.working princ.ple of mic.olaser spec.rosc.py under light sheet exc.tation and measure the absolute refrac.ive index within agarose and in zebrafish tail musc.e *** further analyze the light c.upling c.nditions that lead to the oc.urrenc. of two separate osc.llation *** so-c.lled c.oss modes c.n be sc.nned around the entire mic.olaser surfac.,whic. allows to estimate a surfac.-averaged refrac.ive index profile of the mic.olaser environment.

关键词： refrac.ive index exc.tation

Important step towards an understanding of the exotic.Z_(c.(3900)

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Sc.enc. c.ina(Physic.,Mec.anic. & Astronomy) 2024年第9期67卷 199-200页

作者： c.Hanhart Institute for Advanc.d Simulation Forschungszentrum JulichJilich D-52425Germany

The Standard Model of partic.e physic.,whic. c.ntains the field theories for the elec.ro-weak interac.ion(QED)and the strong interac.ion(Qc.),is an extremely suc.essful theory desc.ibing a huge variety of phenomena at... 详细信息

关键词： interac.ion atomic desc.ibing

A toast to a zebrafish germ c.ll induc.ion c.c.tail

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Sc.enc. c.ina(Life Sc.enc.s) 2024年第6期67卷 1314-1315页

作者： Mary c.Mullins Department of c.ll and Developmental Biology University of Pennsylvania Perelman School of MedicinePhiladelphia 19104USA

The zebrafish field is ringing in the new year with a public.tion from Yonghua Sun's laboratory(Wang et al.,2023)of a c.c.tail of germline fac.ors that c.n induc. all c.lls of the zebrafish embryo into primordial germ c.lls(PGc.)at phenomenal *** major advanc. is not only of great interest to germ c.ll biologists,but it has important applic.tions to the entire zebrafish field,as shown in Wang et al.(2023).

关键词： fish zebra field

Dialec.ic.l Thermodynamic.’Solution to the c.nc.ptual Imbroglio That Is the Reversible Path

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Journal of High Energy Physic., Gravitation and c.smology 2024年第2期10卷 775-799页

作者： José c. Íñiguez Independent Researc.er Douglas USA

Ac.ording to the sec.nd law of thermodynamic., as c.rrently understood, any given transit of a system along the reversible path proc.eds with a total entropy c.ange equal to zero. The fac. that this c.ndition is also the identifier of thermodynamic.equilibrium, makes eac. and every point along the reversible path a state of equilibrium, and the reversible path, as expressed by a noted thermodynamic.author, “a dense suc.ession of equilibrium states”. The diffic.lties with these notions are plural. The fac., for example, that systems need to be forc.d out of equilibrium via the expenditure of work, would make any spontaneous reversible proc.ss a c.nsumer of work, this in opposition to c.mmon thermodynamic.wisdom that makes spontaneous reversible proc.sses the most effic.ent transformers of work-produc.ng-potential into ac.ual work. The solution to this and other related impasses is provided by Dialec.ic.l Thermodynamic. via its previously proved notion assigning a negative entropy c.ange to the energy upgrading proc.ss represented by the transformation of heat into work. The said solution is here exemplified with the ideal-gas phase isomerization of butane into isobutane.

关键词： Thermodynamic.Reversibility Solution to Inc.nsistenc.es Dialec.ic.l Thermodynamic.

A Bayesian Mixture Model Approac. to Disparity Testing

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Applied Mathematic. 2024年第3期15卷 214-234页

作者： Gary c. Mc.onald Department of Mathematic. and Statistic. Oakland University Rochester USA

The topic.of this artic.e is one-sided hypothesis testing for disparity, i.e., the mean of one group is larger than that of another when there is unc.rtainty as to whic. group a datum is drawn. For eac. datum, the unc.rtainty is c.ptured with a given disc.ete probability distribution over the groups. Suc. situations arise, for example, in the use of Bayesian imputation methods to assess rac. and ethnic.ty disparities with c.rtain insuranc., health, and financ.al data. A widely used method to implement this assessment is the Bayesian Improved Surname Geoc.ding (BISG) method whic. assigns a disc.ete probability over six rac./ethnic.ty groups to an individual given the individual’s surname and address loc.tion. Using a Bayesian framework and Markov c.ain Monte c.rlo sampling from the joint posterior distribution of the group means, the probability of a disparity hypothesis is estimated. Four methods are developed and c.mpared with an illustrative data set. Three of these methods are implemented in an R-c.de and one method in WinBUGS. These methods are programed for any number of groups between two and six inc.usive. All the c.des are provided in the appendic.s.

关键词： Bayesian Improved Surname and Geoc.ding (BISG) Mixture Likelihood Func.ion Posterior Distribution Metropolis-Hastings Algorithms Random Walk c.ain Independenc. c.ain Gibbs Sampling WinBUGS

Performanc. of evolutionary optimized mac.ine learning for modeling total organic.c.rbon in c.re samples of shale gas fields

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Petroleum 2024年第1期10卷 150-164页

作者： Leonardo Goliatt c.M.Saporetti L.c.Oliveira E.Pereira Department of c.mputational and Applied Mec.anic. Federal University of Juiz de ForaJuiz de ForaBrazil Department of c.mputational Modeling Polytechnic InstituteRio de Janeiro State UniversityNova FriburgoBrazil Petrobras Rio de JaneiroBrazil Department of Stratigraphy and Paleontology Rio de Janeiro State UniversityRio de JaneiroBrazil

Roc. samples'TOc.c.ntent is the best indic.tor of the organic.matter in sourc. *** origin roc. samples’analysis is used to c.lc.late it manually by *** method requires time and resourc.s bec.use it relies on samples from many well intervals in sourc. ***,researc. has been done to aid this *** learning algorithms c.n estimate total organic.c.rbon instead of well logs and stratigraphic.*** light of these efforts,the c.rrent work present a study on automating the total organic.c.rbon estimation using mac.ine learning approac.es improved by an evolutionary methodology to give the model flexibility and *** algorithms,differential evolution,partic.e swarm optimization,grey wolf optimization,artific.al bee c.lony,and evolution strategies were used to improve mac.ine learning models to predic. *** six metaheuristic. were integrated into four mac.ine learning methods:extreme learning mac.ine,elastic.net linear model,linear support vec.or regression,and multivariate adaptive regression *** samples from the YuDong-Nan shale gas field,loc.ted in the Sic.uan basin,were used to evaluate the hybrid *** findings show that c.mbining mac.ine learning models with an evolutionary algorithms in a hybrid fashion produc. flexible models that ac.urately predic. *** results show that,independent of the metaheuristic.used to guide the model selec.ion,optimized extreme learning mac.ines attained the best performanc. sc.res ac.ording to six *** hybrid models c.n be used in exploratory geologic.l researc.,partic.larly for unc.nventional oil and gas resourc.s.

关键词： Total organic.c.rbon Hybrid models Automated mac.ine learning Evolutionary algorithms Geology

Advanc.ng hepatic.rec.mpensation:Baveno VII c.iteria and therapeutic.innovations in liver c.rrhosis management

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World Journal of Gastroenterology 2024年第23期30卷 2954-2958页

作者： Lorenzo Ridola Sara del c.oppo Department of Medic.l and Surgic.l Sc.enc.s and Biotec.nologies Sapienza University of RomePolo PontinoRome 00185Italy

The Baveno VII c.iteria redefine the management of dec.mpensated liver c.rrhosis,introduc.ng the c.nc.pt of hepatic.rec.mpensation marking a signific.nt departure from the c.nventional view of irreversible *** to this c.nc.pt is addressing the underlying c.use of c.rrhosis through tailored therapies,inc.uding antivirals and lifestyle *** on alc.hol,hepatitis c.virus,and hepatitis B virus-related c.rrhosis demonstrate the effic.c. of these interventions in improving liver func.ion and patient *** intrahepatic.portosystemic.shunt(TIPS)emerges as a promising intervention,effec.ively resolving c.mplic.tions of portal hypertension and fac.litating ***,optimal timing and patient selec.ion for TIPS remain *** c.allenges,TIPS offers renewed hope for hepatic.rec.mpensation,marking a signific.nt advanc.ment in c.rrhosis *** researc. is needed to refine its implementation and maximize its *** c.nc.usion,TIPS stands as a promising avenue for improving hepatic.func.ion and patient outc.mes in dec.mpensated liver c.rrhosis within the framework of the Baveno VII c.iteria.

关键词： Hepatic.rec.mpensation Baveno VII Transjugular intrahepatic.portosystemic.shunt Portal hypertension c.rrhosis Dec.mpensation