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Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin liu Yue huang Guang-Cheng Xiao Qing-Cui Bu Jin-Lu Qu Shu Zhang Shuang-Nan Zhang Shu-Mei Jia Fang-Jun Lu xiang Ma lian Tao Wei Zhang li Chen li-Ming Song Ti-Pei li Yu-Peng xu xue-Lei Cao Yong Chen Cong-Zhan liu Ce Cai Zhi chang Gang Chen Tian-xiang Chen Yi-Bao Chen Yu-Peng Chen Wei Cui Wei-Wei Cui Jing-Kang Deng Yong-Wei dong Yuan-Yuan Du Min-xue Fu Guan-hua Gao He Gao Min Gao Ming-Yu Ge Yu-dong Gu Ju Guan Cheng-Cheng guo Da-Wei Han Jia Huo Lu-hua jiang Wei-Chun jiang Jing Jin Yong-Jie Jin ling-Da Kong Bing li Cheng-Kui li Gang li Mao-Shun li Wei li Xian li Xiao-Bo li xu-Fang li Yang-guo li Zheng-Wei li Xiao-hua liang Jing-Yuan liao Bai-sheng liu guo-Qing liu Hong-Wei liu Xiao-Jing liu Yi-Nong liu Bo Lu xue-feng Lu Qi Luo Tao Luo Bin Meng Yi Nang jian-Yin Nie Ge Ou Na Sai Ren-Cheng Shang Xin-Ying Song liang Sun Ying Tan You-li Tuo Chen wang guo-feng wang Juan wang ling-Jun wang Weng-Shuai wang Yu-Sa wang xiang-Yang Wen Bai-Yang Wu Bo-Bing Wu Mei Wu Shuo Xiao Shao-lin Xiong He xu Jia-Wei Yang sheng Yang Yan-Ji Yang Yi-Jung Yang Qi-Bin Yi Qian-Qing Yin Yuan You Ai-Mei Zhang Cheng-Mo Zhang Fan Zhang Hong-Mei Zhang Juan Zhang Tong Zhang Wan-chang Zhang Wen-Zhao Zhang Yi Zhang Yi-Fei Zhang Yong-Jie Zhang Yuan-Hang Zhang Yue Zhang Zhao Zhang Zhi Zhang Zi-liang Zhang Hai-sheng Zhao Xiao-Fan Zhao Shi-Jie Zheng Yao-Guang Zheng Deng-Ke Zhou jian-feng Zhou Yu-xuan Zhu Ren-lin Zhuang Yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

锂离子电池正极材料li_2MnO_3的显微组织与电化学性能

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中国有色金属学报 2015年第3期25卷 705-713页

作者：邵威刘昌位郭玉忠吴佳王剑华昆明理工大学材料科学与工程学院昆明650093 昆明理工大学分析测试中心昆明650093

以MnO2和liOH·H2O为原料,采用固相法分别在750和900℃温度下焙烧得到li2MnO3正极材料,并研究li2MnO3正极材料晶体缺陷结构和相变对电化学容量的影响。通过X射线衍射(XRD)和电子衍射(SAED)进行晶体结构分析,采用扫描电镜(SEM)和透射电镜... 详细信息

以MnO2和liOH·H2O为原料,采用固相法分别在750和900℃温度下焙烧得到li2MnO3正极材料,并研究li2MnO3正极材料晶体缺陷结构和相变对电化学容量的影响。通过X射线衍射(XRD)和电子衍射(SAED)进行晶体结构分析,采用扫描电镜(SEM)和透射电镜(TEM)观察了材料形貌,并对材料进行充放电测试和微分容量分析。结果表明:在750℃下合成的li2MnO3具有类球形结构,晶体中出现大量的层错;电化学活化后获得的139.3m A·h/g放电容量和纳米片状特征与晶体结构中存在较高的层错密度有关;在900℃下合成的li2MnO3晶体结构完整,但电化学过程中难于活化,即使100次循环后,li2MnO3的超晶格结构依然保持完整;在电化学循环过程中,li2MnO3会由层状结构逐渐向尖晶石结构转变;随着循环次数增加,电池容量主要来自尖晶石的电化学容量,其余部分来自li2MnO3的逐渐活化。

关键词： li2MnO3 堆垛层错超晶格电化学性能

Efficacy and safety of Shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial

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Journal of Integrative Medicine 2021年第2期19卷 111-119页

作者： Jie Wu Shu-wei Duan Hong-tao Yang Yue-yi Deng Wei li Ya-ni He Zhao-hui Ni Yong-li Zhan Shan lin Zhi-yong guo Jun Zhu Jing-ai Fang xu-sheng liu li-hua wang Rong wang Nian-song wang Xiao-hong Cheng li-qun He Ping Luo Shi-ren Sun Ji-feng Sun Ai-ping Yin Geng-ru jiang Hong-yu Chen Wen-hu liu Hong-li lin Meng liang Lu Ma Ming Chen li-qun Song jian Chen Qing Zhu chang-ying Xing Yun li Ji-ning Gao Rong-shan li Ying li Hao Zhang Ying Lu Qiao-ling Zhou Jun-zhou Fu Qiang He Guang-yan Cai xiang-mei Chen Department of Nephrology Chinese People’s Liberation Army General HospitalChinese People’s Liberation Army Institute of NephrologyState Key Laboratory of Kidney Diseases(2011DAV00088)National Clinical Research Center for Kidney DiseasesBeijing 100853China Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300192China Department of Nephrology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Nephrology Shandong University of Traditional Chinese Medicine Affiliated HospitalJinan 250011.Shandong ProvinceChina Department of Nephrology Daping HospitalArmy Medical UniversityChongqing 400042China Department of Nephrology Renji HospitalShanghai Jiao Tong UniversityShanghai 200127China Department of Nephrology Guang’anmen HospitalChina Academy of Traditional Chinese Medical SciencesBeijing 100053China Department of Nephrology Tianjin Medical University General HospitalTianjin 300052China Department of Nephrology Changhai Hospital of ShanghaiNaval Medical UniversityShanghai 200433China Department of Nephrology West China HospitalChengdu 610083Sichuan ProvinceChina Department of Nephrology First Affiliated Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Nephrology Shanxi Medical University Second Affiliated HospitalTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Shandong Provincial HospitalJinan 250021Shandong ProvinceChina Department of Nephrology and Rheumatology Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai 200233China Department of Nephrology Shaanxi Traditional Chinese Medicine HospitalXi'an 710003Shaanxi ProvinceChina Department of Nephrology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200021China Department of Nephrology Jilin University Se

Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney ***:This trial compared the efficacy and safety of SYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan ***,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical *** glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in China and were randomly divided into five groups:SYKFT,losartan potassium 50 mg or 100 mg,SYKFT plus losartan potassium 50 mg or 100 *** outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of ***:A total of 735 participants were *** percent decline of urine protein quantification in the SYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg *** with the losartan potassium 50 mg group,the SYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(Pline did not change statistically *** average change in TCM syndrome score between the patients who took SYKFT(-3.00[-6.00,-2.00])and who did not take SYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any ***:SYKFT decreased the proteinur

关键词： Herbal medicine,Chinese Shenyankangfu Tablet Primary glomerulonephritis Randomized controlled trial Double blind Double dummy

Effect of bax,bcl-2 and bcl-xL on regulating apoptosis in tissues of normal liver and hepatocellular carcinoma

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World Journal of Gastroenterology 2002年第6期8卷 1059-1062页

作者： Xiao-zhong guo Xiao-dong Shao Min-Pei liu jian-hua xu li-Nan Ren Jia-Jun Zhao Hong-Yu li Di wang,Department of Gastroenterology,General Hospital of Shenyang Military Region,Shenyang 110016,liaoning Province,China Department of Gastroenterology General Hospital of Shenyang Military Region Liaoning Province China.

AIM: To investigate the expression of bax, bcl-2 and bcl-xL mRNA in the tissues of normal liver and hepatocellular carcinoma (HCC), and analyze the relationship between the expression of bax, bcl-2 and bcl-xL mRNA and clinical parameters of HCC ***: The expression of bax, bcl-2 and bcl-xL mRNA of normal liver and HCC was measured by Northern blot. Statistical analyses were made by t test and correlation ***: A very low mRNA level was indicated at bax,bcl-2 and bcl-xL in the HCC tissues in contrast to the tissues of normal liver by Northern blot analysis. The analyses of mRNA level revealed that HCC tissues exhibited a mean 7.6-fold decrease in bax, 4.2-fold in bcl-2 and 3.5-fold in bcl-xL in comparison with normal control tissues, respectively. Positive correlation was found between bax and bcl-xL (r=0.7061,P＜0.01). There was no significance between the mRNA expression of these three genes and age, gender, tumor differentiation and tumor stage of HCC patients. CONCLUSION: The results are consistent with the fact that apoptosis rarely occurs in normal livers but increases in HCC, indicating that bcl-2 and bcl-xL may play a very important role in regulating the apoptosis of normal liver and HCC.

关键词： bax bcl-2 bcl-xL 凋亡介导因子正常肝组织肝细胞癌组织细胞凋亡调节作用

Percent free prostate-specific antigen is effective to predict prostate biopsy outcome in Chinese men with prostate-specific antigen between 10.1 and 20.0 ng ml^-1

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Asian Journal of Andrology 2015年第6期17卷 1017-1021,I0012页

作者： Rui Chen li-Qun Zhou Xiao-Bing Cai li-Ping Xie Yi-Ran huang Da-lin He xu Gao Chuan-liang xu Qiang Ding Qiang wei chang-Jun Yin Shan-Cheng Ren Fu-Bo wang Ye Tian zhong-Quan Sun Qiang Fu Lu-lin Ma Jun-hua Zheng Zhang-Qun Ye Ding-Wei Ye Dan-feng xu jian-Quan Hou Ke-Xin xu jian-lin Yuan Xin Gao Chun-Xiao liu Tie-Jun Pan Ying-Hao Sun Department of Urology Shanghai Changhai Hospital Second Military Medical University Shanghai 200433 China ~Department of Urology Peking University First Hospital Institute of Urology Peking University National Urological Cancer Center Beijing 100034 China Department of Health Care PLA Headquarters of the General Staff Guard Bureau Beijing 100017 China Department of Urology First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 Zhejiang China Department of Urology Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China Department of Urology First Affiliated Hospital of Medical School Xi'an:liaotong University Xi'an 710061 China Department of Urology Huashan Hospital Fudan University Shanghai 200040 China Department of Urology West China Hospital Sichuan University Chengdu 610041 Sichuan China State Key Laboratory of Reproductive Medicine Department of Urology The First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China Department of Urology Beijing-Friendship Hospital Capital Medical University Beijing 100050China Department of Urology Huadong Hospital Fudan University Shanghai 20040 China Department of Urology Shanghai :Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 China Department of Urology Peking University Third Hospital Beijing 100083 China Department of Urology Tenth People's Hospital Tongji University Shanghai 200072 China Department of Urology Tongji Hospital TongjJ Medical College Huazhong University of Science and TechnologyWuhan 430030 China Fudan University Shanghai Cancer Center Department of Oncology Shanghai 200032 China Department of Urology Shanghai ChangzhengHospital Second Military Medical University Shanghai 200003 China Department of Urology The First Affiliated Hospital of Soochow University Suzhou 215006 China Department of Urology Peking University People's Hospital Beijing 100044 China Department of Urology Xiji

Percent free prostatic-specific antigen （%fPSA） has been introduced as a tool to avoid unnecessary biopsies in patients with a serum PSA level of 4.0-10.0 ng ml^-1, however, it remains controversial whether %fPSA is effective in PSA range of 10.1-20.0 ng ml^-1 in both Chinese and Western population. In this study, the diagnostic performance of %fPSA and serum PSA in predicting prostate cancer （PCa） and high-grade PCa （HGPCa） was analyzed in a multi-center biopsy cohort of 5915 consecutive Chinese patients who underwent prostate biopsy in 22 hospitals across China from January 1, 2010 to December 31, 2013. The indication for biopsy was PSA〉4.0 ng ml^-1 or/and suspicious digital rectal examination. Total and free serum PSA determinations were performed by three types of electrochemiluminescence immunoassays with recalibration to the World Health Organization standards. The diagnostics accuracy of PSA, %fPSA and %fPSA in combination with PSA （%fPSA ＋ PSA） was determined by the area under the receivers operating characteristic curve （AUC）. %fPSA was more effective than PSA in men aged ≥60 years old. The AUC was 0.584 and 0.635 in men aged ≥60 years old with a PSA of 4.0-10.0 ng ml^-1 and 10.1-20.0 ng ml^-1, respectively. The AUC of %fPSA was superior to that of PSA in predicting HGPCa in patients ≥60 years old in these two PSA range. Our results indicated that %fPSA is both statistically effective and clinical applicable to predict prostate biopsy outcome in Chinese patients aged ≥60 years old with a PSA of 4.0-10.0 ng ml^-1 and 10.1-20.0 ng ml^-1.

关键词： Chinese population diagnosis percent free prostate-specific antigen prostate cancer prostate carcinoma tumor antigen prostate-specific antigen

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主客体包结法选择分离白花前胡的化学成分

化学学报 2007年第3期65卷 222-226页

作者：佟健王忠华徐赫男袁雷郭放常键刘成雁郭文生辽宁大学化学科学与工程学院沈阳110036 郑州大学化学系郑州450052 沈阳药科大学制药工程学院沈阳110015 辽宁省分析测试研究院沈阳110015

以1,1,6,6-四苯基-2,4-己二炔-1,6-二醇为主体分子,可简单、迅速地从白花前胡粗提物中选择分离有效成分3'-乙酰氧基-4'-β-羟基丙酰氧基-3',4'-二氢邪蒿内酯,收率为0.17%.IR,1H NMR,13C NMR光谱和单晶衍射证实了包结化合物的形成及其晶... 详细信息

以1,1,6,6-四苯基-2,4-己二炔-1,6-二醇为主体分子,可简单、迅速地从白花前胡粗提物中选择分离有效成分3'-乙酰氧基-4'-β-羟基丙酰氧基-3',4'-二氢邪蒿内酯,收率为0.17%.IR,1H NMR,13C NMR光谱和单晶衍射证实了包结化合物的形成及其晶体结构,并且用气相色谱方法(GC)评价了选择分离效果.

关键词：白花前胡包鲒化合物选择分离 3’-乙酰氧基-4’-β-羟基丙酰氧基-3’ 4'-二氢邪蒿内酯

主客体包结法选择分离青花椒挥发油中的化学成分

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化学学报 2007年第23期65卷 2731-2737页

作者：郭文生王忠华郭放胡志泉张爽徐赫男常键刘成雁辽宁大学化学科学与工程学院沈阳110036 郑州大学化学系辽宁省分析测试研究院沈阳110015

以1,1,6,6-四苯基-2,4-己二炔-1,6-二醇为主体分子,可简单、迅速地从青椒挥发油中选择分离出化学成分烯丙基茴香醚,基于挥发油的用量,收率为3.78%.IR,1HNMR,13CNMR光谱和单晶衍射证实了包结化合物结构,用气相色谱法评价了选择分离效果,... 详细信息

以1,1,6,6-四苯基-2,4-己二炔-1,6-二醇为主体分子,可简单、迅速地从青椒挥发油中选择分离出化学成分烯丙基茴香醚,基于挥发油的用量,收率为3.78%.IR,1HNMR,13CNMR光谱和单晶衍射证实了包结化合物结构,用气相色谱法评价了选择分离效果,分离的烯丙基茴香醚气相色谱纯度为94.5%.同时,主体分子形成的隧道框架对茴香醛具有识别作用,形成2∶1(主/客)物质的量比的特殊结构包结物晶体,它是主客体分子物质的量比为1∶2包结物的超分子异构体.

关键词：青花椒包结化合物选择分离烯丙基茴香醚茴香醛

Lung-protective Ventilation in Patients with Brain Injury： A Multicenter Cross-sectional Study and Questionnaire Survey in China

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Chinese Medical Journal 2016年第14期129卷 1643-1651页

作者： xu-Ying Luo Ying-Hong Hu xiang-Yuan Cao Yan Kang li-Ping liu Shou-Hong wang Rong-guo Yu xiang-You Yu Xia Zhang Bao-Shan li Zeng-xiang Ma Yi-Bing Weng Heng Zhang De-chang Chen Wei Chen Wen-Jin Chen Xiu-Mei Chen Bin Du Mei-li Duan Jin Hu Yun-feng Hoang Gui-Jun Jia li-Hong li Yu-Min liang Bing-Yu Qin Xian-dong wang jian Xiong li-Mei Yan Zheng-Ping Yang Chen-Ming dong dong-Xin wang Qing-Yuan Zhan Shuang-lin FU lin Zhao Qi-Bing huang Ying-Guang Xie Xiao-Bo huang guo-Bin Zhang wang-Bin xu Yuan xu Yaling liu He-ling Zhao Rong-Qing Sun Ming Sun Qing-Hong Cheng Xin Qu Xiao-feng Yang Ming xu zhong-hua Shi Han Chen xuan He Yan-lin Yang Guang-Qiang Chen Xiu-Mei Sun jian-Xin Zhou Department of Critical Care Medicine Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Critical Care Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Department of Critical Care Medicine General Hospital of Ningxia Medical University Yinchuan Ningxia 750004 China Department of Critical Care Medicine West China Hospital Sichuan University Chengdu Sichuan 610041 China Neurological Intensive Care Unit Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Critical Care Medicine Guangdong General Hospital Guangzhou Guangdong 510000 China Surgical Intensive Care Unit Fujian Province Hospital Fuzhou Fujian 350000 China Department of Critical Care Medicine First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China Department of Critical Care Medicine Bethune International Peace Hospital Shijiazhuang Hebei 050000 China Department of Critical Care Medicine Yuncheng Central Hospital Yuncheng Shanxi 044000 China Department of Emergency and Critical Care Medicine Cangzhou People's Hospital Cangzhou Hebei 061000 China Department of Critical Care Medicine Beijing Luhe Hospital Capital Medical University Beijing 101100 China Department of Critical Care Medicine First Hospital of China Medical University Shenyang Liaoning 110000 China Department of Critical Care Medicine Shanghai Changzheng Hospital Shanghai 200000 China Department of Critical Care Medicine Beijing Shijitan Hospital Capital Medical University Beijing 100038 China Department of Critical Care Medicine Xuanwu Hospital Capital Medical University Beijing 100053 China Department of Critical Care Medicine Miyun County Hospital Beijing 100038 China Medical Intensive Care Unit Peking Union Medical College Hospital Beijing 101500 China Department of Critical Care Medicine Beijing Friendship Hospital Capital Medical University Beijing 100050 Chin

Background： Over the years, the mechanical ventilation （MV） strategy has changed worldwide. The aim of the present study was to describe the ventilation practices, particularly lung-protective ventilation （LPV）, among brain-injured patients in China. Methods： This study was a multicenter, 1-day, cross-sectional study in 47 Intensive Care Units （ICUs） across China. Mechanically ventilated patients （18 years and older） with brain injury in a participating ICU during the time of the study, including traumatic brain injury, stroke, postoperation with intracranial tumor, hypoxic-ischemic encephalopathy, intracranial infection, and idiopathic epilepsy, were enrolled. Demographic data, primary diagnoses, indications for MV, MV modes and settings, and prognoses on the 60th day were collected. Multivariable logistic analysis was used to assess factors that might affect the use of LPV. Results： A total of 104 patients were enrolled in the present study, 87 （83.7%） of whom were identified with severe brain injury based on a Glasgow Coma Scale 〈8 points. Synchronized intermittent mandatory ventilation （SIMV） was the most frequent ventilator mode, accounting for 46.2% of the entire cohort. The median tidal volume was set to 8.0 ml/kg （interquartile range [IQR], 7.0-8.9 ml/kg） of the predicted body weight; 50 （48.1%） patients received LPV. The median positive end-expiratory pressure （PEEP） was set to 5 cmH20 （IQR, 5-5 cmH20）. No PEEP values were higher than 10 cmH20. Compared with partially mandatory ventilation, supportive and spontaneous ventilation practices were associated with LPV. There were no significant differences in mortality and MV duration between patients subjected to LPV and those were not. Conclusions： Among brain-injured patients in China, SIMV was the most frequent ventilation mode. Nearly one-half of the brain-injured patients received LPV. Patients under supportive and spontaneous ventilation were more likely to receive LPV.

关键词： Brain Injury Epidemiology Lung-protective Ventilation Mechanical Ventilation

Laboratory Safety of Dupilumab,and Its Effect on Inflammatory Biomarkers,in Chinese Adults With Moderate-to-Severe Atopic Dermatitis:An Analysis of a Randomized,Double-Blind Phase III Study

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International Journal of Dermatology and Venereology 2022年第4期5卷 218-225页

作者： Yan Zhao li-Ming Wu Qian-Jin Lu Xing-hua Gao Xiao-Hong Zhu xu Yao lin-feng li Wei li Yang-feng Ding Zhi-Qiang Song ling-ling liu Ning-Ning Dang Chun-Lei Zhang Xiao-Ming liu Jun Gu Jin-Yan wang Song-Mei Geng Quan-zhong liu Yi-feng guo li dong Shelley li Christine xu John T.O’Malley Elizabeth Laws Nikhil Amin Ashish Bansal Min wang jian-zhong Zhang Department of Dermatology Peking University People’s HospitalBeijing 100044China Hangzhou First People’s Hospital HangzhouZhejiang 310006China The Second xiangya Hospital of Central South University ChangshaHunan 410011China The First Hospital of China Medical University ShenyangLiaoning 110001China Wuxi Second People’s Hospital WuxiJiangsu 214002China Hospital for Skin Diseases Institute of DermatologyChinese Academy of Medical SciencesNanjingJiangsu 210042China Beijing Friendship Hospital Capital Medical UniversityBeijing 100050China huashan Hospital Fudan UniversityShanghai 200040China Shanghai Skin Disease Hospital Shanghai 200040China The Southwest Hospital of AMU Chongqing 400038China Peking University First Hospital Beijing 100034China Jinan Central Hospital JinanShandong 250013China Peking University Third Hospital Beijing 100191China University of Hong Kong-Shenzhen Hospital ShenzhenGuangdong 518040China changhai Hospital of Shanghai Shanghai 200433China Ningbo No.2 Hospital NingboZhejiang 315099China The Second Affiliated Hospital of Xi’an Jiaotong University Xi’anShaanxi 710004China Tianjin Medical University General Hospital Tianjin 300052China Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai 200092China Research&Development SanofiBridgewaterNJ 08807USA Research&Development RegeneronTarrytownNY 10591USA Medical Sanofi ChinaShanghai 200040China.

Objective:limited information is available on the use of dupilumab for the treatment of atopic dermatitis(AD)in the Chinese ***:We analyzed laboratory data from a previously published randomized,double-blind phase III trial(NCT03912259)to provide further insight into the safety of dupilumab in Chinese adults with moderate to severe *** trial participants received either 300 mg of dupilumab or placebo every 2 weeks for 16 ***,blood chemistry,serum thymus and activation-regulated chemokine(TARC),and total immunoglobulin E(IgE)were ***:In total,82 participants received dupilumab and 83 received *** the exception of eosinophil counts of>0.8×109/L,which were found less frequently with dupilumab(9.8%)than with placebo(18.7%),the hematology and blood chemistry values were generally stable in both treatment *** were no clinically significant differences between the dupilumab and placebo groups,and no participants developed treatment-emergent abnormalities of potential clinical ***,compared with placebo,greater decreases in serum lactate dehydrogenase(mean change,−97.4 vs.−33.5 IU/L),TARC(median percent change,−78.6%vs.−30.8%),and total IgE(median percent change,−53.4%vs.−0.2%)were observed with dupilumab than placebo at week ***:Dupilumab demonstrated a favorable laboratory safety profile in Chinese adults with moderate to severe AD.

关键词： atopic dermatitis dupilumab laboratory safety Chinese