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Effects of temperature distribution and level on heat transfer on a rotating free disk

航空动力学报 2011年第6期26卷 1310-1320页

作者： ZHAO Xi XU guo-qiang luo Xiang National Key Laboratory of Science and Technology on Aero-Engine Aero-thermodynamics School of Jet Propulsion Beijing University of Aeronautics and Astronautics Beijing 100191 China

In gas turbine engines,with the existence of the intense forced convection and significant buoyancy effects,temperature distribution and level on turbine or compressor disks affect the heat transfer characteristics *** this paper,numerical simulations were performed to analyze these influences for a free disk,with the laminar and turbulent flow *** influences of temperature distribution on the heat transfer were observed by using incompressible cooling air,and temperature profiles of nth order monomial and polynomial were assumed on the *** analysis revealed that the heat transfer for two flow states on the free disk is determined by the exponent n of the monomial profile when specifying the rotating Reynolds number;for an arbitrary polynomial profile,the local Nusselt number can be deduced from results of monomial *** study the effects of temperature level on heat transfer singly,monomial profiles were used and the local Nusselt number of compressible and incompressible cooling air were *** both for two flow states,the following conclusions could be drawn: the relative difference of local Nusselt number is mainly controlled by nondimensional local temperature difference,and almost independent of the monomial's coefficient C,exponent n and the rotating Reynolds ***,a correction method for heat transfer of the free disk is presented and verified computationally,with which the local Nusselt number,obtained with a uniform and low temperature profile,can be revised by arbitrary distribution and high temperature magnitude.

关键词： thermal boundary condition temperature boundary condition rotating disk free disk heat transfer

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Land Use and Land Cover Change on Slope in Qiandongnan Prefecture of Southwest China

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Journal of Mountain Science 2014年第3期11卷 762-773页

作者： LU Liang guo luo ZHAO Song-ting College of Life and Environmental Science Minzu University of China Geomatics Centre of Zhejiang Beijing Institute of Landscape Architecture

This study uses DEM （Digital Elevation Model） data and remote sensing maps of the study area in 1993, 1999, and 2009 to analyze the slope gradient change of land use patterns in Qiandongnan Prefecture, Guizhou province, China. The land use data were classified into five types, forest, farmland, grassland, water and built-up, the slope gradients were divided into four grades. Indices for analyzing land use features were defined by their proportions, transformation matrixes, land use degree and changes The results showed that all land use types can be found at every gradient. Generally, with the slope degree increased, the area of forest being augmented as well, while the area of the other land use types （farmland, grassland and build-up） declined. Moreover, a mass of farmland were shifted from other land use types from o° to 25°, while a quantity of forest were transformed from the other land use types on 〉 25° from 2993 to 2009. In terms of land use degree and changes, the area of farmland and buildup land use types decreased when slope degree increased. Finally, we calculated the five landscape pattern metrics： Patch Density （PD） value, Largest Patch Index （LPI）, Shannon＇s Diversity Index （SHDI）, Area-Weighted Mean Shape Index （AWMSI） and Contagion Index （CONTAG）. The results of metricsanalysis showed that PD values, SHDI values and CONTA values had a similar variation trend, that is, they decreased when slope degree increased. There was no obvious variation trend on LPI value.

关键词： Land use Land cover change Spatialgradient slope Landscape metrics Qiandongnanprefecture

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Plant-derived nanovesicles as an emerging platform for cancer therapy

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Acta Pharmaceutica Sinica B 2024年第1期14卷 133-154页

作者： Hanzhe Liu guo-Feng luo Zhengjun Shang The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of StomatologyWuhan UniversityWuhan 430079China

Plant-derived nanovesicles(PDNVs)derived from natural green products have emerged as an attractive nanoplatform in biomedical *** are usually characterized by unique structural and biological functions,such as the bioactive lipids/proteins/nucleic acids as therapeutics and targeting groups,immune-modulation,and long-term *** the rapid development of nanotechnology,materials,and synthetic chemistry,PDNVs can be engineered with multiple functions for efficient drug delivery and specific killing of diseased cells,which represent an innovative biomaterial with high biocompatibility for fighting against *** this review,we provide an overview of the state-of-theart studies concerning the development of PDNVs for cancer *** original sources,methods for obtaining PDNVs,composition and structure are introduced *** an emphasis on the featured application,the inherent anticancer properties of PDNVs as well as the strategies in constructing multifunctional PDNVs-based nanomaterials will be discussed in ***,some scientific issues and technical challenges of PDNVs as promising options in improving anticancer therapy will be discussed,which are expected to promote the further development of PDNVs in clinical translation.

关键词： Naturally occurring nanovesicles Plant Nanotechnology Drug delivery Cancer therapy

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Numerical simulation on characteristics of COREX shaft furnace with central gas distribution

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Journal of Iron and Steel Research International 2019年第6期26卷 567-577页

作者： Xing-sheng Zhang Zong-shu Zou Zhi-guo luo Department of Ferrous Metallurgy School of Metallurgy Northeastern University Shenyang 110819 Liaoning China Key Laboratory of Ecological Utilization of Multi-metallic Mineral of Education Ministry Northeastern University Shenyang 110819 Liaoning China

A three-dimensional steady-state mathematical model, considering the chemical reactions and transfers of momentum, heat and mass between the gas and solid phases, was developed to investigate the characteristics of the shaft furnace with the central gas distribution (CGD) device. The model was verified by the practical production data of a COREX-3000 shaft furnace, and then, it was used to study the inner characteristics of the shaft furnace with CGD. The results show that, compared with the COREX shaft furnace without CGD, the gas utilization rate (UR) and solid metallization rate (MR) increase from 33.66% to 34.18% and 60.4% to 61.8%, respectively. Especially, the standard deviation of solid MR decreases from 6.9% to 0.8%, which means that the MR of direct reduced iron from the furnace with CGD is more uniform than that without CGD. Additionally, the effects of operational conditions and CGD design on gas UR, solid MR and direct reduced iron uniformity were further discussed and the optimized conditions were suggested.

关键词： COREX shaft furnace Central gas distribution Gas utilization Solid metallization Direct reduced iron uniformity

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Study on the quality of recombinant proteins using matrix-assisted laser desorption ionization time of flight mass spectrometry

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World Journal of Gastroenterology 1999年第3期5卷 235-240页

作者： ZHOU guo-Hua luo guo-An SUN guo-Qing CAO Ya-Cheng and ZHU Ming-Sheng 清华大学北京 100084 中科院南京土壤所江苏南京华东医学生物技术所江苏南京

AIM To study the possibility of matrix-assistedlaser desorption/ionization time of flight massspectrometry (MALDI--TOF MS) for controllingthe quality of recombinant *** By using MALDI--TOF MS, themoleCular weights and purity of recombinantbioactive proteins were *** The molecular weights and puritywere obtained in nine recombinant bioactiveproteins, including interleukin 2, tumor necrosisfactor Q, granulocyte--macrophage colonystimulating factor, interferon aZb, interferon al,erythropoietin, calmodulin and its fragment, andneuronal nitric oxide synthase were ***--TOF MS was also used to assay specificproteins in the mixtures and to characterize theerythropoietin tryptic *** The results showed that MALDITOF MS can be employed for the effective qualitycontrol of recombinant proteins.

关键词： MALDI time

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Mechanism and simulation of droplet coalescence in molten steel

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International Journal of Minerals,Metallurgy and Materials 2017年第11期24卷 1251-1259页

作者： Bing Ni Tao Zhang Hai-qi Ni Zhi-guo luo Department of Metallurgical Technology Central Iron and Steel Research Institute School of Metallurgy Northeastern University

Droplet coalescence in liquid steel was carefully investigated through observations of the distribution pattern of inclusions in solidified steel samples. The process of droplet coalescence was slow, and the critical Weber number(We) was used to evaluate the coalescence or separation of droplets. The relationship between the collision parameter and the critical We indicated whether slow coalescence or bouncing of droplets occurred. The critical We was 5.5, which means that the droplets gradually coalesce when We ≤ 5.5, whereas they bounce when We > 5.5. For the carbonate wire feeding into liquid steel, a mathematical model implementing a combined computational fluid dynamics(CFD)–discrete element method(DEM) approach was developed to simulate the movement and coalescence of variably sized droplets in a bottom-argon-blowing ladle. In the CFD model, the flow field was solved on the premise that the fluid was a continuous medium. Meanwhile, the droplets were dispersed in the DEM model, and the coalescence criterion of the particles was added to simulate the collision-coalescence process of the particles. The numerical simulation results and observations of inclusion coalescence in steel samples are consistent.

关键词： mechanism simulation droplet collision coalescence molten steel

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Development and calibration of heat transfer coefficient sensor for rotational state

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航空动力学报 2011年第12期26卷 2684-2690页

作者： QUAN Yong-kai XU guo-qiang luo Xiang ZHANG Da （School of Jet Propulsion Beijing University of Aeronautics and Astronautics Beijing 100000 China

A novel heat transfer coefficient sensor is introduced and the design,manufacture,and calibration are *** intended application of this instrument was on a high rotational speed test *** the experiments,the heat transfer coefficient sensor was calibrated under static state and rotational state *** calibration under the static state was accomplished in a pipe: the inside diameter(ID) was 0.048m and the total length was 4m,the distance between the sensor and the inlet of the pipe was 3.5m;the standard value was measured using a self-made *** calibration under the rotational state was accomplished using a rotating disc: the diameter and thickness of the stainless disc were 800mm and 25mm,respectively;the sensor was installed at the location of r=250mm;the rotating disc driven by a 30kW direct current motor can supply the maximum rotational speed of 3000r/*** standard value under rotational state was provided by an approximate empirical *** results show that the designed sensor can measure heat transfer coefficient directly under rotational state and static state with good accuracy and stability;the correlation factor of K are constant under static state and rotational state.

关键词： rotational state steady method heat transfer coefficient sentor calibration

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Journal of Integrative Plant Biology 2012年第10期54卷 814-827页

作者： guo luo Hongya Gu Jingjing Liu Li-Jia Qu State Key Laboratory for Protein and Plant Gene Research College of Life SciencesPeking-Tsinghua Center of Life SciencesPeking UniversityBeijing 100871China The National Plant Gene Research Center Beijing 100101China

Ubiquitination of proteins is one of the critical regulatory mechanisms in eukaryotes. In higher plants, protein ubiquitination plays an essential role in many biological processes, including hormone signaling, photomorphogenesis, and pathogen defense. However, the roles of protein ubiquitination in the repro- ductive process are not clear. In this study, we identified four plant-specific RING-finger genes designated Aberrant_Pollen Development 1_ （APD1） to APD4, as regulators of pollen mitosis II （PMII） in Arabidopsis thaliana （L.）. The apdl apd2 double mutant showed a significantly increased percentage of bicellular-like pollen at the mature pollen stage. Further downregulation of the APD3 and APD4 transcripts in apdl apd2 by RNA interference （RNAi） resulted in more severe abnormal bicellular-like pollen phenotypes than in apdl apd2, suggesting that cell division was defective in male gametogenesis. All of the four genes were expressed in multiple stages at different levels during male gametophyte development. Confocal analysis using green florescence fusion proteins （GFP） GFP-APD1 and GFP-APD2 showed that APDs are associated with intracellular membranes. Furthermore, APD2 had E2-dependent E3 ligase activity in vitro, and five APD2-interacting proteins were identified. Our results suggest that these four genes may be involved, redundantly, in regulating the PMII process during male gametogenesis.

关键词： Male gametogenesis pollen mitosis II RING-finger E3 ligase Arabidopsis.

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Nanomedicine Disrupts Stromal Barriers to Augment Drug Penetration for Improved Cancer Therapy

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Chinese Journal of Chemistry 2024年第10期42卷 1175-1189页

作者： guo-Feng luo Wei-Hai Chen Xian-Zheng Zhang state Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei KeyLaboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanHubei 430079China Key Laboratoryof Biomedical Polymers of Ministry of Education&Departmentof Chemistry Wuhan UniversityWuhanHubei 430072China

Tumor stroma composing diverse extracellular matrixes(ECM)and stromal cells shapes a condensed physical barrier,which severely hampers the efficient accessibility of nanomedicine to tumor cells,especially these deep-seated in the core of *** barrier significantly compromises the antitumor effects of drug-loaded nanomedicine,revealing the remarkable importance of disrupting stromal barrier for improved tumor therapy with deep penetration *** achieve this goal,various nanoparticle-based strategies have been developed,including direct depleting ECM components via delivering anti-fibrotic agents or targeting stromal cells to suppress ECM expression,dynamic regulation of nanoparticles’physicochemical properties(i.e.,size,surface charge,and morphology),mechanical force-driven deep penetration,natural/biomimetic self-driven nanomedicine,and transcytosis-inducing *** these nanostrategies were systemically summarized in this review,and the design principles for obtaining admirable nanomedicine were *** the rapid development of nanotechnology,elaborate design of multifunctional nanomedicine provides new opportunities for overcoming the critical stromal barriers to maximize the therapeutic index of various therapies,such as chemotherapy,photodynamic therapy,and immunotherapy.

关键词： Nanomedicine Tumor stroma Deep penetration Enhanced drug perfusion Cancer therapy Drug carriers Biomaterials Nanotechnology

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Robust cubature Kalman filter method for the nonlinear alignment of SINS

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Defence Technology（防务技术） 2021年第2期17卷 593-598页

作者： Shi-luo guo Ying-jie Sun Li-min Chang Yang Li Department of Instrument Electric Aviation University Air ForceChangchunPeople’s Republic of China

Nonlinear initial alignment is a significant research topic for strapdown inertial navigation system(SINS).Cubature Kalman filter(CKF)is a popular tool for nonlinear initial *** CKF assumes that the statics of the observation noise are pre-given before the filtering ***,any unpredicted outliers in observation noise will decrease the stability of the *** view of this problem,improved CKF method with robustness is *** fading factors are introduced to rescale the observation noise *** the update stage of the filter can be autonomously tuned,and if there are outliers exist in the observations,the update should be less *** the Gaussian assumption of KF,the Mahalanobis distance of the innovation vector is supposed to be Chi-square *** a judging index based on Chi-square test is designed to detect the noise outliers,determining whether the fading tune are *** proposed method is applied in the nonlinear alignment of SINS,and vehicle experiment proves the effective of the proposed method.

关键词： SINS Nonlinear alignment Cubature Kalman filter Robust Multiple fading factors Hypothesis test

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