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Effects of TAT-SOD at Acupoints on Essential Hypertension by Monitoring Meridians Electrical Potential

Chinese Journal of Integrative Medicine 2020年第9期26卷 694-700页

作者： guo jing-ke XU Jin-sen CHEN Tian-bao XU Ming-ming LIU Shu-tao ZHANG Chao-xin ke Li-jing ZHOU Jian-wu WANG Qiang RAO Ping-fan Shanghai Institutes for Biological Sciences Chinese Academy of Sciences/Zhejiang Gongshang University Joint Centre for Food and Nutrition ResearchZhejiang Gongshang UniversityHangzhou(310035)China Acupuncture College Fujian University of Traditional Chinese MedicineFuzhou(350003)China Natural Drug Discovery Group School of PharmacyQueen's UniversityBelfast(BT97BL)UK College of Oceanology and Food Science Quanzhou Normal UniversityQuanzhouFujian(362000)China College of Biological Science and Technology Fuzhou UniversityFuzhou(350108)China Guangzhou Halcyon Technology Ltd. Guangzhou(510630)China Institute of Food Science and Technology Chinese Academy of Agricultural SciencesBeijing(100193)China

Objectives:To investigate the effect on essential hypertension of the topical application of TAT-Cu,Zn-superoxide dismutase(TAT-SOD)at left acupoint Zusanli(ST 36),and to observe whether the change of electrical potential difference(EPD)can be related to the change of blood ***:Sixteen patients with essential hypertension and 16 healthy subjects were included in the *** between the left acupoints of Yanglingquan(GB 34)and Qiuxu(GB 40)was firstly screened out for the EPD *** intracellular superoxide quenching enzyme,TAT-SOD,was topically applied to the acupoint ST 36 within an area of 1 cm^2 once a day,and the influence on EPD was *** dosage applied to TAT-SOD group(n=8)was 0.2 mL of 3000 U/mL TAT-SOD cream prepared by adding purified TAT-SOD to a vehicle cream,while placebo group(n=8)used the vehicle cream *** left acupoints of Yanglingquan(GB 34)and Qiuxu(GB 40)were selected for EPD measurement after comparing EPD readings between 5 acupoints on each of all 12 ***:EPDs between the left acupoints of GB 34 and GB 40 for 16 patients of essential hypertension and 16 healthy subjects were 44.9±6.4 and 5.6±0.9 mV,*** application of TAT-SOD for 15 days at ST 36 of essential hypertension patients significantly decreased systolic blood pressure(SBP)and diastolic blood pressure(DBP)of 179.6 and 81.5 mm Hg to 153.1 and 74.1 mm Hg,*** to the change in blood pressure,EPD between the left acupoints of GB 34 and GB 40 also declined from 44.4 to 22.8 mV with the same *** change was observed with SBP,DBP and EPD between the left acupoints of GB 34 and GB 40 with the daily application of the placebo ***:Enzymatic scavenging of the intracellular superoxide at ST 36 proved to be effective in decreasing SBP and *** results reconfirm the involvement of superoxide anions and its transportation along the meridians,and demonstrate that EPD between acupoints may be an indi

关键词： TAT-SOD reactive oxygen species electrical potential essential hypertension acupoints

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A Retrospective Study of 1526 Cases of Transcatheter Occlusion of Patent Ductus Arteriosus

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Chinese Medical Journal 2015年第17期128卷 2284-2289页

作者： Mei Jin Yong-Mei Liang Xiao-Fang Wang Bao-jing guo ke Zheng Yan Gu Zhen-Yu Lyu Department of Pediatric Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Background： Patent ductus arteriosus （PDA） is one of the most common congenital heart diseases and began to get treated by transcatheter occlusion since 1997 in China. Since then, several devices have been invented for occluding PDA. This study aimed to evaluate the technical feasibility, safety, and efficacy of transcatheter occlusion of PDA with different devices. Methods： One thousand five hundred and twenty-six patients （537 boys, 989 girls） with PDA from January 1997 to September 2014 underwent descending aortogram and transcatheter occlusion procedure. We retrospectively analyzed data of these patients, including gender, age, weight, size and morphology of PDA, and devices used in transcatheter occlusion, outcomes, and postoperational complications. Results： Median age and median weight were 4.0 years （range： 0.3 5-2.0 years old） and 15.3 kg （range： 4.5-91.0 kg）, respectively. Mean ductal diameter, aortic ductal diameter, ductal length, and pulmonary artery pressure were 3.50 ± 2.15 mm, 10.08 ± 2.46 ram, 7.49 ± 3.02 mm, and 30.21 ± 17.28 mmHg, respectively. Morphology of PDA assessed by descending aortogram was of type A in 1428 patients, type B in 6 patients, type C in 79 patients, type D in 4 patients, and type E in 9 patients according to the classification of Krichenko. Of all the 1526 patients, 1497 patients underwent transcatheter PDA closure, among which 1492 were successful. Devices used were Amplatzer duct occluder I （ADO I, 1280, 85.8%）, Cook detachable coils （116, 7.8%）, ADO II （ADO II, 68, 4.6%）, muscular VSD occluder （12, 0.8%）, and Amplatzer vascular plug （16, 1.0%）. Conclusions： Excellent occlusion rates with low complication rates were achieved with all devices regardless of PDA types. With transcatheter occlusion technique and devices developing, more patients with PDA can be treated with transcatheter closure both safely and efficiently.

关键词： Congenital Heart Disease Devices Patent Ductus Arteriosus Transcatheter Occlusion

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4-氧乙酸苯乙酸构筑的双核Zn(Ⅱ)和Co(Ⅱ)配合物的合成,晶体结构及荧光性能(英文)

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无机化学学报 2011年第5期27卷 996-1000页

作者：傅君丹郭静轲温一航浙江师范大学物理化学研究所浙江省固体表面反应化学重点实验室金华321004

用水热法合成得到2个新配合物,[M2L2(phen)2(H2O)2](L=4-氧乙酸苯乙酸,phen=1,10-邻菲咯啉,M=Zn,1;Co,2),并测定了它们的晶体结构。配合物1和2为异质同晶,单斜晶系,P21/c空间群。中心金属M为六配位,相邻的M(Ⅱ)通过2个桥连的配体形成双... 详细信息

用水热法合成得到2个新配合物,[M2L2(phen)2(H2O)2](L=4-氧乙酸苯乙酸,phen=1,10-邻菲咯啉,M=Zn,1;Co,2),并测定了它们的晶体结构。配合物1和2为异质同晶,单斜晶系,P21/c空间群。中心金属M为六配位,相邻的M(Ⅱ)通过2个桥连的配体形成双核笼状次级结构单元,通过氢键和π-π堆积弱作用链接形成二维层结构。通过对配合物1的固态荧光测试,结果表明其在紫光区显示发光效应。

关键词： 4-氧乙酸苯乙酸双核配合物氢键荧光

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煤岩混合型粉尘云最低着火温度试验研究

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安全与环境学报 2017年第4期17卷 1331-1333页

作者：郭柯惊刘剑辽宁工程技术大学安全科学与工程学院辽宁葫芦岛125105 矿山热动力灾害与防治教育部重点实验室辽宁葫芦岛125105

为研究半煤岩巷道中岩粉质量分数和煤的挥发分与煤岩混合型粉尘云最低着火温度的关系,选取挥发分差异较大的5种煤样以相同比例配制煤岩混合型粉尘,利用粉尘云最小点火温度测定仪进行煤岩混合型粉尘试验。结果表明,当煤岩混合型粉尘中岩... 详细信息

为研究半煤岩巷道中岩粉质量分数和煤的挥发分与煤岩混合型粉尘云最低着火温度的关系,选取挥发分差异较大的5种煤样以相同比例配制煤岩混合型粉尘,利用粉尘云最小点火温度测定仪进行煤岩混合型粉尘试验。结果表明,当煤岩混合型粉尘中岩粉质量分数低于40%时,岩粉的混合会导致混合型粉尘云最低着火温度发生小幅度波动;当岩粉质量分数高于40%时,煤岩混合型粉尘最低着火温度会随岩粉质量分数的增加而大幅度升高;挥发分质量分数越小的煤粉,其混合型粉尘云最低着火温度越容易受岩粉质量分数的影响。

关键词：安全工程爆炸特征参数粉尘云煤岩混合型粉尘最低着火温度挥发分

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Realization of Single-station Location by Electro-optical System Combining with Radar Ranging System

Realization of Single-station Location by Electro-optical Sy...

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第三届国际仪器科学技术学术研讨会

作者： guo jing-ke XIU Da-peng WU Zheng Institute of Ultra-Precision Optoelectronic Instrument Engineering Harbin Institute of Technology Harbin 150001 China

In the measurement of exterior ballistic, intersect measure is restricted by the condition of partial navigational field. The large distance of single laser measurement needs cooperative targets. In o

关键词： radar ranging infrared single-station location precision analysis

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浅谈建筑空间设计——空间的几何与时间

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淮海工学院学报（人文社会科学版） 2012年第16期10卷 82-84页

作者：郭克景郑州华信学院艺术学院河南郑州451150

阐述了建筑空间的特性,空间并非客观实体,其观念来自于知觉体验。现代建筑活动对几何空间的发展产生了很大的影响,使得空间也越来越依赖几何学。分析了空间存在的虚实两面性以及物质与精神两重性,从建筑空间的物质属性和空间的时间性论... 详细信息

阐述了建筑空间的特性,空间并非客观实体,其观念来自于知觉体验。现代建筑活动对几何空间的发展产生了很大的影响,使得空间也越来越依赖几何学。分析了空间存在的虚实两面性以及物质与精神两重性,从建筑空间的物质属性和空间的时间性论述了时间化的空间。

关键词：空间几何空间建筑空间空间虚实物质属性时间化空间

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闽产土牛膝抑菌活性的研究

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福州大学学报（自然科学版） 2005年第2期33卷 269-272页

作者：郭静科张雯陈娟倪莉福州大学生物工程研究所福建福州350002

用传统煎煮中药的方法制备土牛膝药液,对其中能抑制诱发慢性扁桃体炎的需氧致病菌的有效成分进行分析.结果表明,能抑制诱发慢性扁桃体炎的需氧致病菌的有效成分主要为水溶性物质,并且其相对分子量大于10 0 0 0 .

关键词：土牛膝扁桃体炎抑菌活性福建

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Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin Zhang Guangyu Yang Lei Xiao Zhiyong Kan jing guo Qiang Li Wanqi Jie State key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

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Mito-cpYFP cDNA转基因小鼠的建立及其自由基分布规律的初步探讨

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中国病理生理杂志 2018年第9期34卷 1648-1652页

作者：戴优郭静科陈琦刘树滔周建武柯李晶饶平凡浙江工商大学中国科学院上海生命科学研究院-浙江工商大学食品营养科学联合研究中心浙江杭州310012 福州大学生物科学与工程学院福建福州350108

目的:利用可实时动态测量超氧阴离子自由基的环状排列黄色荧光蛋白(circularly permuted yellow fluorescent protein,cpYFP)构建可实时动态监测活体动物体内自由基的转基因动物模型。方法:应用转基因技术将载有可定位于线粒体内的cpYFP... 详细信息

目的:利用可实时动态测量超氧阴离子自由基的环状排列黄色荧光蛋白(circularly permuted yellow fluorescent protein,cpYFP)构建可实时动态监测活体动物体内自由基的转基因动物模型。方法:应用转基因技术将载有可定位于线粒体内的cpYFP(mitochondria-targeted cpYFP,mito-cpYFP)的载体pRP(Exp)-CAGG>mitocpYFP注射到C57BL/6小鼠的受精卵中,采用PCR及RT-PCR的方法鉴定阳性小鼠,通过荧光观察自由基的分布并辅助鉴定阳性小鼠。结果:PCR、RT-PCR及荧光观察结果表明mito-cpYFP cDNA转基因小鼠构建成功。通过与野生型C57BL/6小鼠交配,得到F1、F2和F3代的新生幼鼠共计494只,其中,阳性幼鼠为255只,阳性率为51.6%。转基因阳性鼠体内出现了绿色荧光,其解剖伤口、肠道、脑部及口腔黏膜等荧光明显,而肾脏、肝脏及胸腺等荧光则较弱,耻骨联合部和膀胱出现绿色荧光,但约0.5 h后消失。结论:我们成功制备了可稳定表达并遗传mito-cpYFP的转基因小鼠品系。在活体动物体内,自由基在黏膜层含量较多。此模型可研究自由基在生物体内的含量及分布规律,为后续生物自由基作为信号分子在机体内传导途径的研究提供有效的工具。

关键词：转基因小鼠环状排列黄色荧光蛋白自由基

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Extramedullary plasmacytoma with the uvula as first affected site:A case report

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World Journal of Clinical Oncology 2025年第1期16卷 53-58页

作者： jing Yang Hui Peng Sheng-ke Tu Min Li Kui Song Department of Hematology The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina

BACKGROUND Extramedullary plasmacytoma(EMP)represents one of the rarer forms of plasma cell malignancies,capable of impacting a variety of tissues and organs throughout the *** majority of EMP cases are predominantly found in the head and neck region,especially within the laryngopharynx,as well as in the gastrointestinal *** there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature,it is important to note that EMP specifically affecting the uvula is exceedingly ***,it is noteworthy that over 60% of epithelial carcinomas in the upper respiratory tract and oropharynx tend to metastasize to the cervical lymph nodes,indicating a propensity for regional spread in these types of *** this context,we present a rare case of extramedullary plasmacytoma where the uvula served as the initially affected *** case emphasizes the need for heightened awareness among clinicians regarding such unusual comorbidities,as early recognition and diagnosis can significantly influence patient management and treatment *** addition,a review of the relevant literature is included to further educate and inform healthcare professionals about this rare presentation,ultimately aiming to enhance clinical understanding and improve patient care in similar *** SUMMARY A 51-year-old man was admitted to our hospital because of a slowly enlarging neck mass.A physical examination revealed a palpable left lymph node,and magnetic resonance imaging(MRI)of the oropharynx and the neck showed a soft tissue mass in the oropharynx and enlargement of multiple lymph nodes in the *** soft tissue mass was diagnosed as plasmacytoma by immunohistochemical *** immunoglobulins and bone marrow biopsy showed normal ***,we diagnosed that as EMP of the *** four cycles of adjuvant chemotherapy dominated by bortezomib,MRI reexamination showed a significant reduction of the mass

关键词： Extramedullary plasmacytoma Plasmacytoma Uvula Multiple myeloma Case report

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