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chemical Research in chinese Universities 1997年第2期13卷 46-53页

作者： guo chun xiao chi keung Chan chi ming che Department of chemistry Jilin UniversityChangchun130023 Department of chemistry The University of Hong KongPokfulam RoadHong Kong

The electronic structure and electronic absorption spectra of binuclear Au(Ⅰ) complexes with bidentate phophines and a bidentate ylid ligand have been studied using quasirelativistic pseudopotential ab initio calculations at the HF and MP2 levels by the LANL2DZ basis sets. The electronic properties of the spectral transition and Au(Ⅰ)—Au(Ⅰ) interaction were also discussed.

关键词： Gold binuclear complexes Electronic structure Electronic absorption spectra LANL2DZ basis sets Au(Ⅰ)—Au(Ⅰ) interaction

An　SCF－MS－Xα　Study　of　the　Electronic　Structures　of　Binuclear　and　Trinuclear　Gold（Ⅰ）　Compounds

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chemical Research in chinese Universities 1996年第4期12卷 378-389页

作者： guo chun-xiao(Department of chemistry,Jilin University,Changchun,130023)CHAN chi-keung and che chi-ming(Department of chemistry,University of Hongkong,Hongkong) JILIN UNIV DEPT CHEMCHANGCHUN 130023PEOPLES R CHINA UNIV HONG KONG DEPT CHEMHONG KONGHONG KONG

The SCF-Xα-SW molecular orbital calculations were carried out on the modelcompounds of binuclear and trinuclear gold(Ⅰ)using starting potential of Au atom and the Watson *** energy level order of the frontier orbital of a binuclear gold model compound is in agreement with the experimental *** calculated ionization potential of the binuclear model compound is consistent well with the photoelectron spectrum of Au (Me)(PMe_3).The metal-metal interactions are *** calculated electronic absorption spectra of binuclear and trinuclear gold(Ⅰ)are basically in agreement with experimental results.

关键词： s:Electronic structure,SCF-Xα-SW Gold(Ⅰ)

滨海盐沼湿地地貌形态和植被格局的生态-地貌耦合模拟研究

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海洋与湖沼 2024年第4期55卷 876-886页

作者：张德琛武国相王柯萌梁丙臣张树岩车纯广中国海洋大学工程学院山东青岛266100 中国海洋大学山东省海洋工程重点实验室山东青岛266100 山东黄河三角洲国家级自然保护区黄河口管理站山东东营257061

滨海盐沼湿地是重要的海岸带生态系统,其地貌形态和植被格局受潮汐动力、泥沙供给等条件影响显著。近年来,盐沼生态-地貌动力学研究成为前沿研究热点。以我国典型潮滩盐沼的动力环境为原型,建立考虑水动力-泥沙-地貌-植被互馈过程的动... 详细信息

滨海盐沼湿地是重要的海岸带生态系统,其地貌形态和植被格局受潮汐动力、泥沙供给等条件影响显著。近年来,盐沼生态-地貌动力学研究成为前沿研究热点。以我国典型潮滩盐沼的动力环境为原型,建立考虑水动力-泥沙-地貌-植被互馈过程的动态耦合模型,研究了不同潮差、海平面上升速率、泥沙供给与泥沙性质等关键变量影响下的盐沼湿地植被-地貌耦合演变过程。研究结果表明,外部泥沙供给是控制潮滩-盐沼高程和植被范围的关键要素,外海悬沙浓度越大,滩面坡度越缓、滩面高程越高、植被的海向延伸越宽;泥沙沉降速度越小,易形成上凸型剖面,且湿地植被分布范围更宽;潮差同时影响盐沼在潮间带的下部边界和上部边界,更大的潮差、更强的潮汐水动力有助于形成更高的潮沟密度和泥沙向盐沼内部的输送效率。研究结果可为滨海湿地保护和修复工程提供理论参考。

关键词：盐沼湿地潮滩-潮沟系统植被生态地貌学

复合微生物菌剂对葡萄生长、品质及根际土壤环境的影响

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生物技术通报 2024年第8期40卷 264-274页

作者：车建美赖恭梯李思雨郭奥琳陈冰星陈杏刘波赖呈纯福建省农业科学院资源环境与土壤肥料研究所福州350002 福建省农业科学院农产品加工研究所福州350002

【目的】葡萄是我国栽培广泛的五大果树品种之一,长期过量施用化肥,破坏微生物生态,从而影响葡萄产量和品质。探究不同来源菌株的复合微生物菌剂对改善葡萄果实品质的作用。【方法】采用复合微生物菌剂[短短芽胞杆菌(Brevibacillus brev... 详细信息

【目的】葡萄是我国栽培广泛的五大果树品种之一,长期过量施用化肥,破坏微生物生态,从而影响葡萄产量和品质。探究不同来源菌株的复合微生物菌剂对改善葡萄果实品质的作用。【方法】采用复合微生物菌剂[短短芽胞杆菌(Brevibacillus brevis)FJAT-0809-GLX、贝莱斯芽胞杆菌(Bacillus velezensis)FJAT-55034及短短芽胞杆菌(***)FJAT-10623]灌根,分析复合微生物菌剂对葡萄生长和果实品质及根际土壤酶活性、可培养芽胞杆菌多样性等的影响。【结果】复合微生物菌剂能够促进葡萄叶片生长,提高叶片的叶绿素a和类胡萝卜素含量及POD和PPO活性。处理组葡萄幼果的叶绿素b含量、SOD和PPO活性分别比对照组提高了100%、11.77%和66.67%。施用复合微生物菌剂能够促进葡萄提早成熟及果实转色,提升果实品质,其中,单果重比对照高出29.06%,可溶性固形物和可溶性蛋白分别比对照组提高了7.31%和94.74%,且处理组成熟果实的PPO酶活性显著高于对照组。此外,复合微生物菌剂能够显著提高土壤淀粉酶、过氧化氢酶、纤维素酶、蔗糖酶活性及芽胞杆菌的种类和数量。相关性分析表明,辣椒芽胞杆菌(Bacillus zanthoxyli)和假蕈状芽胞杆菌(Bacillus pseudomycoides)可促进葡萄叶片生长及果实品质提升。【结论】复合微生物菌剂具有改良土壤、促进葡萄生长和提升果实品质的作用。

关键词：复合微生物短短芽孢杆菌贝莱斯芽孢杆菌葡萄品质土壤

腓骨固定在胫腓骨关节外骨折中治疗效果的Meta分析

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中国骨伤 2024年第1期37卷 74-80页

作者：丛琳琳蒋品品郭华汪航车先达王春芳李文晋李鹏翠山西医科大学基础医学院生物化学与分子生物学教研室山西太原030001 山西医科大学第二医院骨与软组织损伤修复山西省重点实验室山西太原030001 山西医科大学第二医院骨科山西太原030001 山西医科大学山西太原030001 山西医科大学实验动物中心山西太原030001 山西医科大学第二临床医学院口腔科山西太原030001

目的:通过Meta分析比较腓骨固定在胫腓骨关节外骨折中的作用及重要性。方法:通过对中国知网、维普、万方、The Cochrane Library、Web of science、Pubmed等数据库关于固定腓骨与否对胫腓骨关节外骨折治疗疗效比较的相关文献进行检索,... 详细信息

目的:通过Meta分析比较腓骨固定在胫腓骨关节外骨折中的作用及重要性。方法:通过对中国知网、维普、万方、The Cochrane Library、Web of science、Pubmed等数据库关于固定腓骨与否对胫腓骨关节外骨折治疗疗效比较的相关文献进行检索,检索时间为2012年1月至2022年2月,使用RevMan 5.3软件进行统计分析。对腓骨固定组与不固定组的复位不良率、旋转畸形率、内翻或外翻畸形率、前或后发畸形率、不愈合率、术后感染率、二次手术率及手术时间进行比较。结果:共纳入11篇文献,6篇随机对照研究和5篇病例对照研究,有8篇为高质量文献,共813例患者,其中腓骨固定治疗383例,未固定腓骨430例。Meta分析结果显示,与未固定腓骨相比,治疗胫腓骨关节外骨折时固定腓骨可以降低术后旋转畸形率[RR=0.22,95%CI(0.10,0.45),P0.05)。结论:在治疗胫腓骨关节外骨折时腓骨固定组相较于不固定组在防止旋转畸形和内翻或外翻畸形以及促进愈合方面更具优势。

关键词：胫骨腓骨骨折固定 Meta分析

Penicacids E-G, three new mycophenolic acid derivatives from the marine-derived fungus Penicillium parvum HDN17-478

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chinese Journal of Natural Medicines 2020年第11期18卷 850-854页

作者： cheN Xiao-Hui ZHOU guo-Liang SUN chun-Xiao ZHANG Xiao-min ZHANG guo-Jian ZHU Tian-Jiao LI Jing che Qian LI De-Hai Key Laboratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Laboratory.for Marine Drugs and Bioproducts of Qingdao Pilot National Laboratory for Marine Science and Technology Qing-dao266237China

Three new mycophenolic acid derivatives, penicacids E-G(1-3), together with three known analogues, mycophenolic acid(4), 4′-hydroxy-mycophenolic acid(5) and mycophenolic methyl ester(6), were isolated from a marine-derived fungus Penicillium parvum HDN17-478 from a South china Sea marine sediment sample. The structures of compounds 1-3 were elucidated by HRMS, NMR, and Mosher’s method. Among them, compounds 1 and 2 were the first examples of mycophenolic acid analogs with a double bond at C-3′/C-4′ position. The cytotoxicity of 1-6 was evaluated against the HCT-116, BEL-7402, MGC-803, SH-SY5 Y, HO-8910 and HL-60 cell lines, and compounds 4 and 6 showed potent cytotoxicity with IC50 values ranging from 1.69 to 12.98 μmol·L–1.

关键词： Mycophenolic acid derivatives Marine-derived fungus Penicillium parvum Cytotoxicity

Interactions of the HSV-1 UL25 Capsid Protein with Cellular Microtubule-associated Protein

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Virologica Sinica 2008年第3期23卷 211-217页

作者： Lei guo Ying ZHANG Yan-chun che Wen-juan WU Wei-zhong LI Li-chun WANG Yun LIAO Long-ding LIU Qi-han LI Institute of Medical Biology Chinese Academy of Medical Sciences Peking Union Medical College Kunming 650118 China

An interaction between the HSV-1 UL25 capsid protein and cellular microtubule-associated protein was found using a yeast two-hybrid screen and β-D-galactosidase activity assays. Immunofluorescence microscopy of the UL25 protein demonstrated its co-localization with cellular microtubule-associated protein in the plasma membrane. Further investigations with deletion mutants suggest that UL25 is likely to have a function in the nucleus.

关键词： HSV-1 Capsid UL25 Microtubule-associated protein

Synthesis and antitumor activity of novel 10-amino acids ester homocamptothecin analogues

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chinese chemical Letters 2008年第7期19卷 811-813页

作者： Liang You Wan Nian Zhang Zhen Yuan Miao Wei guo Xiao Ying che Wen Ya Wang chun Quan Sheng Jiang Zhong Yao Ting Zhou School of Pharmacy Second Military Medical University Shanghai 200433 China

Nine racemic homocamptothecin derivatives were synthesized and in vitro antitumor activities were evaluated by standard MTT method. The results showed that some of the compound had higher antitumor activity than irite... 详细信息

关键词： Homocamptothecin Amino acids ester Antitumor activity Synthesis

Mobilization of Peripheral Blood Stem Cells Using Regimen Combining Docetaxel with Granulocyte Colony-stimulating Factor in Breast Cancer Patients

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chinese Journal of Cancer Research 2011年第1期23卷 49-53页

作者： Jing Yu Jun Ren Li-jun Di guo-hong Song Yu-lin Zhu Jie Zhang Xu Liang Li che Han-fang Jiang Jun Jia chun-rong Zhang Key laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Breast OncologyBeijing 100142China Key laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Transfusion Peking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing 100142 China

Objective：To evaluate the effectiveness and safety of the mobilization of peripheral blood hematopoietic stem cells by combining docetaxel with granulocyte colony-stimulating factor（G-CSF） in breast cancer ***：A total of 57 breast cancer patients were treated with docetaxel 120 mg/*** the white blood cell（WBC） count decreased to 1.0×109/L,patients were given G-CSF 5-g/kg daily by subcutaneous injection until the end of *** blood mononuclear cells（MNC） were isolated by Cobe Spectra Apheresis *** percentage of CD34＋ cell was assayed by flow ***：At a median 6 of days（range 3-8） after the administration of docetaxel,the median WBC count decreased to 1.08×109/L（range 0.20-2.31）.The median duration of G-CSF mobilization was 3 days（range 2-7）.The MNC collection was conducted 8-12 days（median 10 days） after docetaxel *** median MNC was 5.35×108/kg（range 0.59-14.07）,the median CD34＋ cell count was 2.43×106/kg（range 0.16-16.69）.The CD34＋ cell count was higher than 1.00×106/kg in 47 of 57 cases（82.46%） and higher than 2.00×106/kg in 36 cases（63.16%）.The CD34＋ cell count was higher than 2.00×106/kg in 27 collections（23.68%）.The MNC count and the CD34＋ cell count were correlated with the bottom of WBC after docetaxel chemotherapy（r=0.364,0.502,P=0.005,0.000）.The CD34＋ cell count was correlated with the MNC count（r=0.597,P=0.000）.The mobilization and apheresis were well tolerated in all *** perioral numbness and numbness of hand or feet were observed in 3 *** serious adverse events were ***：Mobilization of peripheral blood hematopoietic stem cell by combining docetaxel with G-CSF was effective and safety in breast cancer patients.

关键词： Docetaxel Granulocyte colony-stimulating factor(G-CSF) Mobilization Stem cell

Analysis of textbook outcomes for ampullary carcinoma patients following pancreaticoduodenectomy

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World Journal of Gastrointestinal Surgery 2023年第10期15卷 2259-2271页

作者： Xiao-Jie Zhang He Fei chun-Guang guo Chong-Yuan Sun Ze-Feng Li Zheng Li Ying-Tai chen Xu che Dong-Bing Zhao Department of Pancreatic and Gastric Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Hepatobiliary and Pancreatic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen518116China

BACKGROUND Textbook outcomes(TOs)have been used to assess the quality of surgical treatment for many digestive tumours but not ampullary carcinoma(AC).AIM To discuss the factors associated with achieving a TO and further explore the prognostic value of a TO for AC patients undergoing curative pancreaticoduodenectomy(PD).METHODS Patients who underwent PD at the china National Cancer Center between 1998 and 2020 were identified.A TO was defined by R0 resection,examination of≥12 Lymph nodes,no prolonged hospitalization,no intensive care unit treatment,no postoperative complications,and no 30-day readmission or *** regression analysis was used to identify the prognostic value of a TO for overall survival(OS)and recurrence-free survival(RFS).Logistic regression was used to identify predictors of a *** rate of a TO and of each indicator were compared in patients who underwent surgery before and after *** Ultimately,only 24.3%of 272 AC patients achieved a TO.A TO was independently associated with improved OS[hazard ratio(HR):0.443,95%confidence interval(95%CI):0.276-0.711,P=0.001]and RFS(HR:0.379,95%CI:0.228-0.629,Pchieved a TO following PD.A TO was independently related to favourable oncological outcomes in AC and should be considered as an outcome measure for the quality of *** multicentre research is warranted to better elucidate its impact.

关键词： Ampullary carcinoma Textbook outcomes Pancreaticoduodenectomy Prognosis