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鄂尔多斯地区气传花粉与过敏性鼻炎特征分析

中国环境科学 2024年第5期44卷 2766-2776页

作者：郝玉珠郭春燕王佳内蒙古自治区气象服务中心内蒙古呼和浩特010051

选取2017~2022年4月1日~9月30日花粉浓度、AR患者就诊量和气象资料进行统计分析,鄂尔多斯市花粉浓度有两次高峰期,分别是4月1日~4月30日和7月20日~9月10日,其中夏秋季花粉影响较重,AR患者集中爆发在8月.2017~2022年花粉年均浓度呈逐年... 详细信息

选取2017~2022年4月1日~9月30日花粉浓度、AR患者就诊量和气象资料进行统计分析,鄂尔多斯市花粉浓度有两次高峰期,分别是4月1日~4月30日和7月20日~9月10日,其中夏秋季花粉影响较重,AR患者集中爆发在8月.2017~2022年花粉年均浓度呈逐年降低趋势,花粉浓度年超标日数由76d降至38d,而AR患者逐年就诊量未见减少.通过花粉、AR患者就诊量与气象因子等影响研究,结果表明:植被覆盖率与花粉浓度呈正相关,植被指数的花粉贡献率为38.3%,相对湿度越大、日照时数越小、风速越小,植被生长越好,花粉浓度也随之增大,气象因子的影响贡献了46.3%的花粉浓度变化,植被和气象条件是导致花粉浓度变化的主要因子.而花粉浓度的爆发与积温、地表积温、日照时数的累积量有关,积温、地表积温、日照时数需分别达到1958℃、2296℃、757h条件.当花粉浓度致敏阈值达到80粒/1000mm^(2),2d后AR患者出现倍增.基于花粉浓度对AR患者的响应关系,构建花粉浓度变化模型预估患者数量,可为当地医疗、环境部分提前预防提供重要依据.

关键词： AR患者就诊量花粉浓度高峰期花粉超标日数相关性研究

基于网络药理学方法探讨白芍治疗癫痫的活性成分和作用机制

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神经药理学报 2024年第2期14卷 26-30,46页

作者：夏蕾尤斯涵殷宏艳郝军荣郭春燕河北北方学院药学院张家口075000 河北省神经药理学重点实验室张家口075000

目的:通过网络药理学的方法探讨白芍治疗癫痫的活性成分及作用机制。方法:通过中医药百科全书数据库获取并筛选白芍的活性成分及作用靶点;在GeneCards、OMIM、DisGeNET数据库收集癫痫相关基因。取白芍活性成分靶点与癫痫疾病靶点的交集... 详细信息

目的:通过网络药理学的方法探讨白芍治疗癫痫的活性成分及作用机制。方法:通过中医药百科全书数据库获取并筛选白芍的活性成分及作用靶点;在GeneCards、OMIM、DisGeNET数据库收集癫痫相关基因。取白芍活性成分靶点与癫痫疾病靶点的交集后用STRING数据库构建蛋白质互作网络,用Cytoscape 3.9.1软件进行可视化分析,通过Centiscape 2.2插件筛选核心靶点,并用David数据库进行基因本体功能(gene ontology,GO)注释和京都基因与基因百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)通路富集分析,最后用Cytoscape 3.9.1软件构建药物-成分-靶点网络图。结果:白芍活性成分靶点158个,癫痫的疾病靶点2398个,白芍与癫痫交集基因38个,GO富集分析得到BP 136个条目,CC 41个条目,MF 49个条目,KEGG分析得到106条通路。结论:白芍可能是通过作用于TNF、Akt1、ALB、HSP90AA1等38个靶点,抑制AGE-RAGE、NF-kappa B等信号通路,从而在抗炎方面治疗癫痫。

关键词：网络药理学白芍癫痫活性成分作用机制

甲型流感病毒血凝素HA蛋白保守抗原表位的鉴定

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药物生物技术 2024年第2期31卷 111-115页

作者：郭春艳靳占奎封青黄晓燕徐翠香陕西省人民医院感染与免疫疾病重点实验室陕西西安710068 陕西省细胞免疫工程技术研究中心陕西西安710068 陕西省人民医院骨科陕西西安710068

流感大流行对人类健康危害严重,流感病毒型别多,易变异,现有疫苗不能诱导机体产生不同亚型间的交叉保护力,造成预防困难,因此,精细定位甲型流感病毒保守抗原表位是研究重点。本研究通过使用单克隆抗体和计算机模拟预测两种技术,采用免... 详细信息

流感大流行对人类健康危害严重,流感病毒型别多,易变异,现有疫苗不能诱导机体产生不同亚型间的交叉保护力,造成预防困难,因此,精细定位甲型流感病毒保守抗原表位是研究重点。本研究通过使用单克隆抗体和计算机模拟预测两种技术,采用免疫学方法和生物信息学方法,获得了4株识别血凝素(HA)保守抗原表位的单克隆抗体,以这4株单抗为研究工具,最终明确HA茎部区域多肽STQNAID(409~415 aa)是甲型流感病毒HA保守区抗原表位,为开发甲型流感通用疫苗提供理论和实验基础。

关键词：甲型流感病毒血凝素HA 单克隆抗体阻断ELISA 计算机预测定位保守抗原表位

Numerical Study on the Effect of Gap Diffraction on the Hydrodynamic Performance of A Floating Breakwater

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China Ocean Engineering 2024年第4期38卷 663-675页

作者： BIAN Xiang-qian JI chun-yan XU Sheng guo Jian-ting HUO Fa-li School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Two-dimensional(2D)flume experiments are useful in investigating the performances of floating breakwaters(FBs),including hydrodynamic performances,motion responses,and mooring *** a reasonable gap between the flume wall and the FBs is a critical step in 2D flume ***,research on the effect of the gap on the accuracy of 2D FB experimental results is *** address this issue,a numerical wave tank is developed using CFD to estimate the wave-FB interaction of a moored dual-cylindrical FB,and the results are compared to experimental data from a previously published *** is good agreement between them,indicating that the numerical model is sufficiently *** numerical model is then applied to explore the effect of gap diffraction on the performance of FBs in2D *** was discovered that the nondimensional gap length L_(Gap)/W_(Pool)should be smaller than 7.5%to ensure that the relative error of the transmission coefficient is smaller than 3%.The influence of the gap is also related to the entering wave properties,such as the wave height and period.

关键词： floating breakwater diffraction effect gap hydrodynamic performance model experiments CFD numerical simulation

Double-confined nanoheterostructure Sb/Sb_(2)S_(3)@Ti_(3)C_(2)T_(x)@C toward ultra-stable Li-/Na-ion batteries

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Rare Metals 2024年第5期43卷 2067-2079页

作者： Dan Wang Qun Ma Huan He Zhi-Yuan Wang Run-guo Zheng Hong-Yu Sun yan-guo Liu chun-Li Liu School of Materials Science and Engineering Northeastern UniversityShenyang110819China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao 066004China Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province Qinhuangdao 066004China Department of Physics and Oxide Research Center Hankuk University of Foreign StudiesYongin 17035Korea

Antimony-based materials with high capacities and moderate potentials are promising anodes for lithium-/-sodium-ion ***,their tremendous volume expansion and inferior conductivity lead to poor structural stability and sluggish reaction ***,a doubleconfined nanoheterostructure Sb/Sb_(2)S_(3)@Ti_(3)C_(2)T_(x)@C has been fabricated through a solvothermal method followed by low-temperature heat *** dual protection of“MXene”and“carbon”can better accommodate the volume expansion of Sb/Sb_(2)S_(3).The strong covalent bond(Ti-S,Ti-O-Sb,C-O-Sb)can firmly integrate Sb-based material with Ti_(3)C_(2)T_(x)and carbon,which significantly improves the structure *** addition,the carbon layer can restrain the oxidation of MXenes,and the nano-Sb/Sb_(2)S_(3)can facilitate electron/ion transport and suppress the restacking of *** heterogeneous interface between Sb and Sb_(2)S_(3)can further promote interfacial charge *** MXene-Sb/Sb_(2)S_(3)@C-1 with the optimal Sb content shows high specific capacities,comparable rate properties and ultra-stable cycling performances(250 m Ah·g^(-1)after 2500 cycles at 1 A·g^(-1)for sodium-ion batteries).Ex situ X-ray diffractometer(XRD)test reveals the storage mechanism including the conversion and alloying process of MXene-Sb/Sb_(2)S_(3)@*** voltammetry(CV)test results demonstrate that the pseudocapacitance behavior is dominant in MXene-Sb/Sb_(2)S_(3)@C-1,especially at large *** design paves the way for exploring high-performance alloy-based/conversion-type anode for energy storage devices.

关键词： Sb/Sb_(2)S_(3) MXene Carbon Anode Lithium-ion batteries Sodium-ion batteries

Three-dimensional Modeling of Ore-forming Elements and Mineralization Prognosis for the Yechangping Mo Deposit,Henan Province,China

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 736-752页

作者： DING Gaoming JI Genyuan yan guolong XU Yongzhong WANG Kunming XIAO chun WANG Quanle guo Dongbao China National Administration of Coal Geology Beijing 100038China MNR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesCAGSBeijing 100037China China Gold Group Geological Co. Ltd.Beijing 100011China China Gold Group ZhongYuan Mining Co. Ltd.SanmenxiaHenan 472000China Lanzhou Mineral Exploration Institute of Gansu Nonferrous Metal Geological Exploration Bureau Lanzhou 730046China

Three-dimensional geochemical modeling of ore-forming elements is crucial for predicting deep *** approach provides key information for the quantitative prediction of deep mineral localization,three-dimensional fine interpolation,analysis of spatial distribution patterns,and extraction of quantitative mineral-seeking *** Yechangping molybdenum(Mo)deposit is a significant and extensive porphyry-skarn deposit in the East Qinling-Dabie Mo polymetallic metallogenic belt at the southern margin of the North China *** borehole data on oreforming elements underpin deep geochemical *** methodology includes the following steps:(1)Threedimensional geological modeling of the deposit was established.(2)Correlation,cluster,and factor analyses post delineation of mineralization stages and determination of mineral generation sequence to identify(Cu,Pb,Zn,Ag)and(Mo,W,mfe)assemblages.(3)A three-dimensional geochemical block model was constructed for Mo,W,mfe,Cu,Zn,Pb,and Ag using the ordinary kriging method,and the variational function was developed.(4)Spatial distribution and enrichment characteristics analysis of ore-forming elements are performed to extract geological information,employing the variogram and w(Cu+Pb+Zn+Ag)/w(Mo+W)as predictive indicators.(5)Identifying the western,northwestern,and southwestern areas of the mine with limited mineralization potential,contrasted by the northeastern and southeastern areas favorable for mineral exploration.

关键词： 3D geochemical model ore-forming elements geostatistics deep mineralization prediction Yechangping Mo deposit

SEMI-IMPLICIT SPECTRAL DEFERRED CORRECTION METHODS BASED ON SECOND-ORDER TIME INTEGRATION SCHEMES FOR NONLINEAR PDES

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Journal of Computational Mathematics 2024年第1期42卷 111-133页

作者： Ruihan guo yan Xu School of Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026China

In[20],a semi-implicit spectral deferred correction(SDC)method was proposed,which is efficient for highly nonlinear partial differential equations(PDEs).The semi-implicit SDC method in[20]is based on first-order time integration methods,which are corrected iteratively,with the order of accuracy increased by one for each additional *** this paper,we will develop a class of semi-implicit SDC methods,which are based on second-order time integration methods and the order of accuracy are increased by two for each additional *** spatial discretization,we employ the local discontinuous Galerkin(LDG)method to arrive at fully-discrete schemes,which are high-order accurate in both space and *** experiments are presented to demonstrate the accuracy,efficiency and robustness of the proposed semi-implicit SDC methods for solving complex nonlinear PDEs.

关键词： Spectral deferred correction method Nonlinear PDEs Local discontinuous Galerkin method Second-order scheme

Artificial neural network-based method for discriminating Compton scattering events in high-purity germaniumγ-ray spectrometer

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Nuclear Science and Techniques 2024年第2期35卷 64-84页

作者： chun-Di Fan guo-Qiang Zeng Hao-Wen Deng Lei yan Jian yang Chuan-Hao Hu Song Qing yang Hou College of Nuclear Technology and Automation Engineering Chengdu University of TechnologyChengdu 610059China

To detect radioactive substances with low activity levels,an anticoincidence detector and a high-purity germanium(HPGe)detector are typically used simultaneously to suppress Compton scattering background,thereby resulting in an extremely low detection limit and improving the measurement ***,the complex and expensive hardware required does not facilitate the application or promotion of this ***,a method is proposed in this study to discriminate the digital waveform of pulse signals output using an HPGe detector,whereby Compton scattering background is suppressed and a low minimum detectable activity(MDA)is achieved without using an expensive and complex anticoincidence detector and *** electric-field-strength and energy-deposition distributions of the detector are simulated to determine the relationship between pulse shape and energy-deposition location,as well as the characteristics of energy-deposition distributions for fulland partial-energy deposition *** relationship is used to develop a pulse-shape-discrimination algorithm based on an artificial neural network for pulse-feature *** accurately determine the relationship between the deposited energy of gamma(γ)rays in the detector and the deposition location,we extract four shape parameters from the pulse signals output by the *** learning is used to input the four shape parameters into the ***,the pulse signals are identified and classified to discriminate between partial-and full-energy deposition *** partial-energy deposition events are removed to suppress Compton *** proposed method effectively decreases the MDA of an HPGeγ-energy dispersive *** results show that the Compton suppression factors for energy spectra obtained from measurements on ^(152)Eu,^(137)Cs,and ^(60)Co radioactive sources are 1.13(344 keV),1.11(662 keV),and 1.08(1332 keV),respectively,and that the corresponding MDAs are 1.4%,5.

关键词： High-purity germaniumγ-ray spectrometer Pulse-shape discrimination Compton scattering Artificial neural network Minimum detectable activity

Corrosion behavior of Gd_(2)Zr_(2)O_(7)thermal barrier coatings under Fe-containing environmental sediment attack

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Journal of Advanced Ceramics 2024年第4期13卷 447-462页

作者： Lei guo yanyan Li Kai yan School of Materials Science and Engineering Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Advanced Joining Technology Key Lab of Advanced Ceramics and Machining Technology of Ministry of EducationTianjin 300072China Key Laboratory of Special Equipment Safety and Energy-saving for State Market Regulation China Special Equipment Inspection&Research InstituteBeijing 100029China

Environmental sediments mainly consisting of CaO–MgO–Al_(2)O_(3)–SiO_(2)(CMAS)corrosion are a serious threat to thermal barrier coatings(TBCs),in which Fe element is usually ***_(2)Zr_(2)O_(7)TBCs are famous for their excellent CMAS *** this study,the characteristics of Fe-containing environmental sediments(CMAS-Fe)and their corrosiveness to Gd_(2)Zr_(2)O_(7)coatings were *** types of CMAS-Fe glass with different Fe contents were *** melting points were measured to be 1322–1344℃,and the high-temperature viscosity showed a decreasing trend with increasing Fe *** corrosion behavior of four types of CMAS-Fe to Gd_(2)Zr_(2)O_(7)coatings at 1350℃was *** the initial corrosion stage(0.1 h),anorthite was precipitated in CMAS-Fe with a high Ca:Si ratio,while Fe-garnet was formed in the melt with the highest Fe *** the corrosion time resulted in the formation of a reaction layer,which exhibited an interpenetrating network composed of Gd-oxyapatite,ZrO_(2),and residual *** spinel was precipitated within the reaction *** 1 h or even longer time,the reaction layers tended to be stable and compact,which had comparable hardness and fracture toughness to those of Gd_(2)Zr_(2)O_(7)*** the cyclic CMAS-Fe attack,the residual CMAS-Fe in the interpenetrating network provided a pathway for the redeposited CMAS-Fe infiltration,resulting in the continuous growth of the reaction *** a result,the Gd_(2)Zr_(2)O_(7)coatings had a large consumption in the thickness,degrading the coating ***,the Gd_(2)Zr_(2)O_(7)coatings exhibit unsatisfactory corrosion resistance to CMAS-Fe attack.

关键词： thermal barrier coatings(TBCs) Gd_(2)Zr_(2)O_(7) Fe-containing CaO-MgO-Al2O3-SiO_(2)(CMAS) corrosion resistance reaction layer