检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

雷公藤甲素治疗胰腺癌的研究进展

现代药物与临床 2024年第6期39卷 1631-1636页

作者：赵文文郭晓琦朱缓缓曾华辉武香香河南中医药大学药学院河南郑州450046 河南中医药大学医学院河南郑州450046 河南中医药大学中医药科学院河南郑州450046

胰腺癌是一种消化道常见恶性肿瘤之一,预后差,诊断期较晚。雷公藤甲素是雷公藤中有效成分之一,具有显著的药理活性。雷公藤甲素可通过抑制细胞周期和增殖、诱导细胞凋亡、抑制细胞迁移和侵袭、调节肿瘤血管生成、协同其他药物抗耐药、... 详细信息

胰腺癌是一种消化道常见恶性肿瘤之一,预后差,诊断期较晚。雷公藤甲素是雷公藤中有效成分之一,具有显著的药理活性。雷公藤甲素可通过抑制细胞周期和增殖、诱导细胞凋亡、抑制细胞迁移和侵袭、调节肿瘤血管生成、协同其他药物抗耐药、抑制热休克蛋白相关基因、诱导自噬等多种途径治疗胰腺癌。总结了雷公藤甲素治疗胰腺癌的药理作用及其作用机制的研究进展,为雷公藤甲素成为胰腺癌治疗的候选药物提供依据。

关键词：雷公藤甲素胰腺癌细胞凋亡细胞迁移细胞侵袭肿瘤血管生成抗耐药热休克蛋白自噬

口服醋酸泼尼松联合局部注射曲安奈德对食管早癌ESD术后食管狭窄及肺部感染的预防疗效分析

在线全文

学校读者我要写书评

暂无评论

中华肺部疾病杂志（电子版） 2024年第2期17卷 288-291页

作者：郭小琦张璞李小军余明王博陕西省核工业二一五医院胸心外科咸阳712000 陕西中医药大学附属医院胸外科咸阳712000

目的分析口服醋酸泼尼松联合局部注射曲安奈德对食管早癌内镜黏膜下剥离术(endoscopic submucosal dissection procedure,ESD)术后食管狭窄及肺部感染的预防疗效。方法选取2021年8月至2022年8月我院行ESD手术治疗的早期食管癌患者43例,... 详细信息

目的分析口服醋酸泼尼松联合局部注射曲安奈德对食管早癌内镜黏膜下剥离术(endoscopic submucosal dissection procedure,ESD)术后食管狭窄及肺部感染的预防疗效。方法选取2021年8月至2022年8月我院行ESD手术治疗的早期食管癌患者43例,按照术后治疗药物不同分为对照组24例和观察组19例。对照组采用局部注射曲安奈德,观察组采用口服醋酸泼尼松联合局部注射曲安奈德治疗。比较两组术后食管狭窄发生情况(发生率、狭窄程度)、出现食管狭窄后内镜下探条扩张的扩张次数,肺部感染发生情况,术后3个月采用欧洲癌症患者生命质量-食管癌专用量表(EORTC QLQ-OES18)判断生活质量。结果观察组术后发生食管狭窄1例(5.26%)低于对照组7例(29.17%)(P<0.05);观察组扩张次数(3.49±0.71 vs.8.62±1.46)次低于对照组(P<0.05);观察组无肺部感染病例低于对照组6例(25.00%)(P<0.05);生活质量评分:观察组吞咽困难症状维度评分(28.12±4.24 vs.41.03±6.30)分、返流(31.25±5.04 vs.48.27±6.74)分、疼痛(26.24±3.26 vs.33.47±4.32)分、咽口水(20.18±2.95 vs.29.17±3.67)分、梗阻(16.96±2.20 vs.25.74±3.26)分、口干(29.68±2.95 vs.39.47±3.58)分、食欲减退(20.21±3.85 vs.35.21±4.59)分、咳嗽(15.69±1.85 vs.26.75±2.61)分低于对照组;功能维度评分进食(79.65±8.98 vs.70.21±8.47)分、言语(81.26±8.47 vs.69.17±6.38)分高于对照组(P<0.05)。结论口服醋酸泼尼松联合局部注射曲安奈德可预防早期食管癌ESD术后食管狭窄及肺部感染,缩小狭窄程度,减少扩张次数,降低肺部感染,提高术后生活质量具有意义。

关键词：肺部感染泼尼松曲安奈德食管癌内镜黏膜下剥离术食管狭窄

在线全文

学校读者我要写书评

暂无评论

融合多感受野特征的汉字字体生成算法

大连民族大学学报 2024年第5期26卷 425-431页

作者：郭晓琦王存睿刘宇战国栋大连民族大学信息与通信工程学院辽宁大连116605 大连民族大学计算机科学与工程学院辽宁大连116605 大连民族大学设计学院辽宁大连116605 大连民族大学大连市汉字计算机字库设计技术创新中心辽宁大连116605 马来西亚博特拉大学计算机科学与信息技术学院马来西亚雪兰莪州43400

针对目前字体生成算法对字体细节特征关注不足,导致生成笔画细节粗糙和风格特征模糊等问题,提出一种融合多感受野特征的汉字字体生成算法。针对笔画细节缺失引入多感受野特征金字塔模块(Multi-Receptive Field Feature Pyramid,MRFP)捕... 详细信息

针对目前字体生成算法对字体细节特征关注不足,导致生成笔画细节粗糙和风格特征模糊等问题,提出一种融合多感受野特征的汉字字体生成算法。针对笔画细节缺失引入多感受野特征金字塔模块(Multi-Receptive Field Feature Pyramid,MRFP)捕获不同尺度的特征,重建笔画细节,在生成过程中既能处理整体字形又能保留细节特征,提高生成一致性;针对冗余特征影响生成结果质量,引用通道和空间重建卷积(Spatial and Channel Reconstruction Convolution,SCConv)代替普通卷积,采用分离重构和分离变换融合的方法抑制空间和通道的冗余,提高对整体字形特征的关注度,加强模型泛化能力。将多感受野特征金字塔模块和SCConv融合于字体生成模型。实验采用10类中文字库训练,两种测试集验证,将算法与CycleGAN,Zi2zi,DG-Font进行比较。结果表明:该方法的生成结果在整体风格和笔画细节上优于其他字体生成算法,在PSNR,SSIM,LPIPS评价指标上均有改善。

关键词：字体生成特征金字塔冗余特征生成对抗网络

在线全文

学校读者我要写书评

暂无评论

河南郑州市防洪“五预”系统建设及应用

中国防汛抗旱 2024年第4期34卷 72-76页

作者：李匡郭晓麒柴福鑫朱吉生张震中国水利水电科学研究院北京100038 水利部防洪抗旱减灾工程技术研究中心(水旱灾害防御中心) 北京100038 华北水利水电大学水利学院郑州450046 中国南水北调集团有限公司北京100036

当前大数据、云计算、数字孪生等新兴技术在防洪工作中的应用,极大提高了洪水预报预警能力,为新时代防汛减灾提供了新的思路。为响应河南省政府防洪“五预”(预报、预判、预警、预案、预演)措施建设的号召,落实郑州市委、市政府“7·20... 详细信息

当前大数据、云计算、数字孪生等新兴技术在防洪工作中的应用,极大提高了洪水预报预警能力,为新时代防汛减灾提供了新的思路。为响应河南省政府防洪“五预”(预报、预判、预警、预案、预演)措施建设的号召,落实郑州市委、市政府“7·20”特大暴雨灾害调查报告整改和灾后重建工作专题会上的指示精神,针对郑州市河流众多、水系复杂的特点,开展郑州市防洪“五预”系统建设。基于“五预”理念,从监测感知和支撑平台方面梳理了郑州市防洪“五预”系统的总体架构,介绍了防洪预报、预判、预警、预演、预案“五预”模块的主要功能。该系统的建成对提高郑州市灾害预防和预警能力、增强郑州市对突发性洪水灾害的反应能力、有效降低灾害损失、保障社会经济正常运行和社会安定有重要意义,也为大型城市智慧水利建设提供了参考和借鉴。

关键词：防洪“五预” 数字孪生防汛减灾智慧水利河南郑州市

Evidence of Middle Pleistocene hominin migration in the Qinling Mountains(central China)from the Miaokou Paleolithic site

在线全文

学校读者我要写书评

暂无评论

Journal of Geographical Sciences 2022年第2期32卷 358-374页

作者： LIU Dengke SUN Xuefeng HU Xuzhi YI Liang guo xiaoqi WANG Yichao WANG Shejiang LU Huayu School of Geography and Ocean Science Nanjing UniversityNanjing 210023China School of Earth Sciences and Engineering Nanjing UniversityNanjing 210023China State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyCASBeijing 100044China CAS Center for Excellence in Life and Paleoenvironment Beijing 100044China

The Qinling Mountain Range(QMR)spans a large region in China and is an important area of hominin *** Paleolithic sites are found in Bahe,South Luohe,and Hanjiang river valleys in the northern,eastern,and southern part of the range,*** Danjiang River valley acts as a channel connecting these valleys and stretches from the north to the south of the *** previous dating of the Paleolithic sites in the Danjiang valley mainly relied on geomorphologic comparison,stratigraphic correlation,fossil characteristics,and Paleolithic artifacts,indicating a lack of absolute *** this study,we conducted a detailed geochronological investigation of the entire valley,and selected an ideal site—the Miaokou *** on the identification of the loess-paleosol sequences,optically stimulated luminescence,and magnetostratigraphy,the Paleolithic artifacts of the Miaokou site located within the S5 and S6 layers of the profile belong to~0.6-0.7 *** suggests that the Paleolithic site is an old site in the Danjiang River valley,and this period also witnessed a rapid increase in the number of hominin sites during the Middle *** our results with previous reports across the QMR,we propose that the Danjiang River valley might have been a corridor for hominin migration,and is worthy of further investigation.

关键词： Danjiang River valley Miaokou site loess-paleosol sequence magnetostratigraphy hominin routeway

汉江下游罗汉寺和岳家湾旧石器旷野遗址的年代学研究

在线全文

学校读者我要写书评

暂无评论

地球环境学报 2024年第2期15卷 235-248页

作者：严文轩陆成秋郭小奇秦真渝曹雅堃孙雪峰南京大学地理与海洋科学学院南京210023 湖北省文物考古研究院武汉430077

近年来,秦岭地区发现了大量旧石器遗址,并开展了年代学研究。但是,秦岭南麓汉江下游地区的旧石器遗址研究相对较少。2018年夏天对汉江下游地区的野外考察中,在钟祥盆地和江汉平原发现了罗汉寺和岳家湾两处旧石器旷野遗址。两处遗址的剖... 详细信息

近年来,秦岭地区发现了大量旧石器遗址,并开展了年代学研究。但是,秦岭南麓汉江下游地区的旧石器遗址研究相对较少。2018年夏天对汉江下游地区的野外考察中,在钟祥盆地和江汉平原发现了罗汉寺和岳家湾两处旧石器旷野遗址。两处遗址的剖面出土了较多原地埋藏的石制品,包括石片、石核,以及砍砸器、尖状器、刮削器、手稿、手斧等少量工具。利用石英单片再生剂量法(SAR-OSL)和热转移光释光(TT-OSL)技术,测得罗汉寺两个遗址点对应的文化层年代分别为53—30 ka和187 ka,岳家湾遗址旧石器文化层的年代为172—138 ka。这些年代有效填补了汉江下游地区部分旧石器时代遗址的年代空白。

关键词：汉江旧石器罗汉寺岳家湾单片再生剂量法热转移光释光

A Comprehensive Overview of CFN From a Commonsense Perspective

在线全文

学校读者我要写书评

暂无评论

Machine Intelligence Research 2024年第2期21卷 239-256页

作者： Ru Li Yunxiao Zhao Zhiqiang Wang Xuefeng Su Shaoru guo Yong Guan xiaoqi Han Hongyan Zhao Key Laboratory of Computational Intelligence and Chinese Information Processing of Ministry of Education School of Computer and Information TechnologyShanxi UniversityTaiyuan 030006China

Chinese FrameNet(CFN)is a scenario commonsense knowledge base(CKB)that plays an important role in research on Chinese language *** is based on the theory of frame semantics and English FrameNet(FN).The CFN knowledge base contains a wealth of scenario commonsense knowledge,including frames,frame elements,and frame relations,as well as annotated instances with rich scenario-related labels on Chinese sentences and *** this paper,we conduct a comprehensive overview of CFN from a commonsense perspective,covering topics such as scenario commonsense representation,CFN resources,and its *** also summarize recent breakthroughs and identify future research ***,we introduce the concept of scenario commonsense,including its definitions,examples,and representation methods,with a focus on the relationship between scenario commonsense and the frame concept in *** addition,we provide a comprehensive overview of CFN resources and their applications,highlighting the newly proposed frame-based discourse representation and a human-machine collaboration framework for expanding the CFN ***,we explore emerging topics such as expanding the CFN resource,improving the interpretability of machine reading comprehension,and using scenario CKBs for text generation.

关键词： Chinese FrameNet(CFN) commonsense scenario commonsense frame knowledge

Generation of double-virus-resistant marker-free transgenic potato plants

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2009年第5期19卷 543-548页

作者： Yunfeng Bai, Zhihua guo, xiaoqi Wang, Dongmei Bai, Weifeng Zhang Institute of Crop Genetics, Shanxi Academy of Agricultural Sciences, Nongke Beilu No. 16, Taiyuan 030031, China Institute of Crop Genetics Shanxi Academy of Agricultural Sciences Nongke Beilu No. 16 Taiyuan 030031 China

Viruses are very widespread in nature, and they cause severe diseases and yield losses in potato production. The transfer of the dsRNA-producing gene could confer a high level virus resistance by specific targeting of cognate viral RNA. In this study, we constructed a marker-free expression vector of a chimeric gene derived from the coat protein sequence of Potato virus X (PVX) and the nuclear inclusion protein sequence of Potato virus Y (PVY) in the form of an intramolecular dsRNA. Then this chimeric gene was introduced into potato cv. Zihuabai, a popular variety in China, via Agrobacterium tumefaciens-mediated transformation. Marker gene-free transgenic plants resistant to both PVX and PVY were obtained and confirmed by RT-PCR and DAS-ELISA detection. Northern blot analysis showed that transgene-derived mRNA was cleaved into short interfering RNAs (siRNAs), and that the virus resistance was mediated by RNA silencing. One important aspect of the study is that the transgenic viral sequence is not translated and the actual RNA transcript is cleaved, which possibly limit the environmental risks, such as transcapsidation and recombination of the transgene with an incoming virus. In addition, the biosafety risk resulting from marker genes can be avoided because of the absence of marker genes in transgenic plants.

关键词： Solanum tuberosum Marker-free RNA silencing Double-virus resistance Transgene

High performance wide bandgap perovskite solar cell with low V_(OC) deficit less than 0.4 V

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第4期91卷 313-322页

作者： Haikuo guo Fuhua Hou Xuli Ning xiaoqi Ren Haoran Yang Rui Liu Tiantian Li Chengjun Zhu Ying Zhao Wei Li Xiaodan Zhang School of Physical Science and Technology Key Laboratory of Semiconductor Photovoltaic Technology and Energy Materials at Universities of Inner Mongolia Autonomous RegionInner Mongolia UniversityHohhot 010021Inner MongoliaChina Institute of Photoelectronic Thin Film Devices and Technology of Nankai University Key Laboratory of Photoelectronic Thin Film Devices and Technology of TianjinSolar Energy Research Center of Nankai UniversityTianjin 300350China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430000HubeiChina

Wide bandgap perovskite solar cells(PSCs)have attracted significant attention because they can be applied to the top cells of tandem solar ***,high open-circuit voltage(V_(OC))deficit(>0.4 V)result from poor crystallization and high non-radiative recombination losses become a serious limitation in the pursuit of high ***,the relevance between different Pbl_(2)proportions and performance parameters are revealed through analysis of surface morphology,residual stress,and *** increase of Pbl_(2)proportion promotes crystal growth and reduces the work function of the perovskite film surface and promotes the energy level alignment with the carrier transport layer,which decreased the V_(OC)***,residual PbI_(2)exacerbated the stress level of perovskite film,and the resulting lattice disorder deteriorated the photostability of the ***,after the synergistic passivation of residual PbI_(2)and PEAI,the V_(OC)achieves 1.266 V and V_(OC)deficit is less than 0.4 V,the record value in wide bandgap PSCs.

关键词： Pb management Perovskite solar cell Strain Wide bandgap Stability