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教育教学论坛 2018年第21期 58-59页

作者：郭晓暹曹闻闻中国地质大学(北京)外国语学院北京100083

随着中外交流的不断加深加强,不同文化之间的对比研究日渐深入。本文从跨文化角度,探讨了中德两国文化中高等教育阶段,两国在教师、学生、课堂及学校管理模式上的差异,用跨文化的理论和研究方法,观察和研究学习者在真实学习环境中的文... 详细信息

随着中外交流的不断加深加强,不同文化之间的对比研究日渐深入。本文从跨文化角度,探讨了中德两国文化中高等教育阶段,两国在教师、学生、课堂及学校管理模式上的差异,用跨文化的理论和研究方法,观察和研究学习者在真实学习环境中的文化适应现象。

关键词：跨文化交流中德高等教育文化对比

图像动态识别在光电瞄准仿真系统中的应用研究

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系统仿真学报 2001年第4期13卷 498-500页

作者：郭晓松黄先祥孔祥玉杨必武第二炮兵工程学院西安710025

介绍了光电瞄准图像动态识别系统的构成与原理，并重点分析了基于连通域处理方式的模板匹配新算法和读数图像的细分算法。这些算法精练，运算速度快，识别率和识别精度高，在光电瞄准仿真系统方位角读数自动识别中取得了良好的效果。

关键词：光电瞄准仿真系统图像动态识别射击训练模板匹配法

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口服佐匹克隆片6个月骤停致癫痫发作1例

中国药物应用与监测 2010年第1期7卷 65-66页

作者：郭晓贤于生元解放军总医院神经内科北京100853 陕西省延安市人民医院神经内科陕西延安716000

1例25岁男性患者因失眠连续6个月口服佐匹克隆片15～37.5mg不等,最大量达180mg,突然停药2d后出现癫痫发作,考虑为佐匹克隆戒断症状。给予口服卡马西平片0.1g,每天2次,未再出现肢体抽搐发作。停用佐匹克隆片,出院后3个月回访未再有肢体... 详细信息

1例25岁男性患者因失眠连续6个月口服佐匹克隆片15～37.5mg不等,最大量达180mg,突然停药2d后出现癫痫发作,考虑为佐匹克隆戒断症状。给予口服卡马西平片0.1g,每天2次,未再出现肢体抽搐发作。停用佐匹克隆片,出院后3个月回访未再有肢体抽搐发生。建议应用佐匹克隆片治疗失眠时宜小剂量、短期、间断使用。

关键词：佐匹克隆癫痫不良反应骤停

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丹参多酚酸治疗急性脑梗死的临床研究

现代药物与临床 2016年第9期31卷 1354-1359页

作者：贺亚龙高焱郭晓贤延安市人民医院神经内科陕西延安716000

目的探讨丹参多酚酸治疗急性脑梗死的临床疗效。方法选取2013年4月—2015年4月延安市人民医院收治的脑梗死患者67例,随机分为对照组(32例)和治疗组(35例)。对照组给予常规吸氧、抗血小板聚集、神经营养药物治疗,根据病情需要给予降糖、... 详细信息

目的探讨丹参多酚酸治疗急性脑梗死的临床疗效。方法选取2013年4月—2015年4月延安市人民医院收治的脑梗死患者67例,随机分为对照组(32例)和治疗组(35例)。对照组给予常规吸氧、抗血小板聚集、神经营养药物治疗,根据病情需要给予降糖、调整血压、抗感染等对症处理。治疗组在对照组基础上静脉滴注注射用丹参多酚酸盐,200 mg加入氯化钠溶液250 m L中,1次/d。两组患者持续用药14 d。观察两组的临床疗效,比较两组氧化应激、凝血指标、脑血流动力学、脑血流灌注指标、脑梗死体积、神经功能缺损(NIHSS)评分及日常生活活动量表(Barthel指数)的情况。结果治疗后,对照组和治疗组的总有效率分别为59.38%、82.86%,两组比较差异有统计学意义(P<0.05)。治疗后,两组检测丙二醛(MDA)均明显下降,超氧化物歧化酶(SOD)明显上升,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组纤维蛋白原(FIB)、D-二聚体(D-D)均明显下降,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的下降程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组脑前动脉(ACA)、大脑中动脉(MCA)、大脑后动脉(PCA)均明显上升,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的升高程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组脑血流量相对值(r CBF)、脑血流容积相对值(r CBV)明显上升,脑血流平均通过时间相对值(r MTT)、对比剂峰值时间相对值(r TTP)、梗死体积明显下降,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组NIHSS评分明显下降,Barthel指数明显上升,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论丹参多酚酸治疗急性脑梗死具有较好的临床疗效,可降低血液黏度,减轻机体氧化应激反应,改善脑血流动力学,减少脑梗死体积,具有一定的临床推广应用价值。

关键词：注射用丹参多酚酸盐急性脑梗死氧化应激脑血流动力学脑血流灌注 NIHSS评分

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一种新的用于编制露天矿生产计划开采模型

中南大学学报（自然科学版） 2011年第9期42卷 2819-2824页

作者：黄俊歆郭小先王李管谭正华毕林李德陈建宏中南大学资源与安全工程学院湖南长沙410083 湖南工学院安全与环境工程系湖南衡阳421001 西部矿业股份有限公司青海西宁810001 玉溪矿业有限公司云南玉溪653100

用混合整数规划法求解露天矿生产计划编制问题(OMPSP),其算法的时间复杂度为指数阶。提出一种基于成本流的露天矿开采锥模型(CFCM)。采用图论的方法将矿床块段模型抽象为节点的集合,用有向边表示成本流,将所有正价值节点与其开采锥内负... 详细信息

用混合整数规划法求解露天矿生产计划编制问题(OMPSP),其算法的时间复杂度为指数阶。提出一种基于成本流的露天矿开采锥模型(CFCM)。采用图论的方法将矿床块段模型抽象为节点的集合,用有向边表示成本流,将所有正价值节点与其开采锥内负价值节点相连形成初始CFCM。研究采用线性规划的方法对成本流进行合理分配而形成最终CFCM的方法,并应用于实际露天矿山的计划编制工程中。研究结果表明:CFCM能极大地减少用混合整数规划法求解OMPSP时的整数变量个数,适应于复杂的实际OMPSP,其计算结果与工程实际结果较吻合,为解决实际OMPSP提供了一种新的有效方法。

关键词：露天矿块段模型生产计划编制线性规划混合整数规划

Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia

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World Journal of Psychiatry 2025年第1期15卷 37-53页

作者： Yan-Ning Song Shuang Xia Zhi Sun Yong-Chao Chen Lu Jiao Wen-Hua Wan Hong-Wei Zhang xiao guo Hua guo Shou-Feng Jia xiao-Xin Li Shi-xian Cao Li-Bin Fu Meng-Meng Liu Tian Zhou Lv-Feng Zhang Qing-Quan Jia Department of Pharmacy The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pharmacy Zhumadian First People's HospitalZhumadian 463000Henan ProvinceChina Scientific Education Section The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Psychiatry The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Clinical Laboratory The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Publicity Division The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina

BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment *** To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent *** Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were *** pharmacology was used to establish protein-protein interaction networks of the core targets of *** Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently *** Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis *** treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with *** effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis *** core targets of olanzapine were involved in several key *** The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.

关键词： Schizophrenia Violent aggression Olanzapine Metabolomics Network pharmacology

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting guo Yiran Zhang Tingting Xing Peng Yin Shihua Li xiao-Jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

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高温悬浮态的煤焦燃烧反应动力学研究

水泥工程 2010年第4期 14-17页

作者：赵俊肖国先李秀秀苏州大学材料与化学化工学部江苏苏州215123 中国中材国际工程股份有限公司江苏南京211100

在高温气固悬浮态试验台上,对无烟煤、烟煤的煤焦燃烧模型进行了研究。在恒温条件下,分别获得A煤(无烟煤)煤焦与B煤(烟煤)煤焦的燃烧曲线,通过传递函数进行修正后的燃尽率与时间的关系曲线与已知的机理函数进行拟合,采用相关性系数选取... 详细信息

在高温气固悬浮态试验台上,对无烟煤、烟煤的煤焦燃烧模型进行了研究。在恒温条件下,分别获得A煤(无烟煤)煤焦与B煤(烟煤)煤焦的燃烧曲线,通过传递函数进行修正后的燃尽率与时间的关系曲线与已知的机理函数进行拟合,采用相关性系数选取最佳反应模型。对A煤煤焦与B煤煤焦的模型的动力学参数进行求解并拟合理论燃烧曲线,结果与实验的测定值吻合良好,表明动力学分析结果的可靠性。

关键词：煤焦悬浮态燃烧动力学模型

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo guo Di Wang Zhao-xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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基于辅助线的等高线生成三维地形算法研究

系统仿真学报 2011年第6期23卷 1191-1194页

作者：郭晓刚黄先祥仲启媛张志利第二炮兵工程学院兵器发射理论与技术实验室西安710025

针对从等高线地图读取地形数据和地形数据高程自动赋值两个问题,提出了基于辅助线的等高线地图提取三维数据的算法,同时实现等高线自动采样和高程自动赋值。利用山顶高程、等高距和等高线地图上任意计曲线的高程三个参数实现了等高线高... 详细信息

针对从等高线地图读取地形数据和地形数据高程自动赋值两个问题,提出了基于辅助线的等高线地图提取三维数据的算法,同时实现等高线自动采样和高程自动赋值。利用山顶高程、等高距和等高线地图上任意计曲线的高程三个参数实现了等高线高程的自动计算和赋值。根据像素的孤立、连续特性,遍历等高线像素点,并按照一定的规则对等高线进行数据采样。总结了算法的特点,并用仿真实验验证了该算法的正确性和有效性。

关键词：等高线地图三维地形数据采样高程赋值不规则三角网