检索结果-南通市图书馆

The detection, extraction and parameter estimation of extreme-mass-ratio inspirals with deep learning

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 86-96页

作者： Qianyun Yun Wen-Biao Han yi-Yang guo He Wang Minghui Du Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Shanghai Jiao Tong University School of Astronomy and Space Science University of Chinese Academy of Sciences Taiji Laboratory for Gravitational Wave Universe (Beijing/Hangzhou) University of Chinese Academy of Sciences Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Province Key Laboratory of Quantum Theory and Applications of MoE Lanzhou University Institute of Theoretical Physics & Research Center of Gravitation Lanzhou University International Centre for Theoretical Physics Asia-Pacific (ICTP-AP) University of Chinese Academy of Sciences (UCAS) Center for Gravitational Wave Experiment National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences

One of the primary goals of space-borne gravitational wave detectors is to detect and analyze extreme-mass-ratio inspirals(EMRIs). This task is particularly challenging because EMRI signals are complex, lengthy, and faint. In this work, we introduce a2-layer convolutional neural network(CNN) approach to detect EMRI signals for space-borne detectors, achieving a true positive rate(TPR) of 96.9% at a 1% false positive rate(FPR) for signal-to-noise ratio(SNR) from 50 to 100. Especially, the key intrinsic parameters of EMRIs such as the mass, spin of the supermassive black hole(SMBH) and the initial eccentricity of the orbit can also be inferred directly by employing a neural network. The mass and spin of the SMBH can be determined at 99% and 92% respectively. This will greatly reduce the parameter spaces and computing cost for the following Bayesian parameter *** model also has a low dependency on the accuracy of the waveform model. This study underscores the potential of deep learning methods in EMRI data analysis, enabling the rapid detection of EMRI signals and efficient parameter estimation.

关键词： gravitational wave EMRIs deep-learing

Evaluation of an extracellular matrix-derived acellular biphasic scaffold/cell construct in the repair of a large articular high-load-bearing osteochondral defect in a canine model

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2011年第23期124卷 3930-3938页

作者： YANG Qiang PENG Jiang LU Shi-bi guo quan-yi ZHAO Bin ZHANG Li WANG Ai-yuan XU Weng-jing XIA Qun MA Xin-long HU Yong-cheng XU Bao-shan Institute of Orthopedics Chinese People＇s Liberation Army General Hospital Beijing 100853 China

Osteochondral lesion repair is a challenging area of orthopedic surgery. Here we aimed to develop an extracellular matrix-derived, integrated, biphasic scaffold and to investigate the regeneration potential of the scaffold loaded with chondrogenically-induced bone marrow-derived mesenchymal stem cells （BMSCs） in the repair of a large, high-load-bearing, osteochondral defect in a canine model. Methods The biphasic scaffolds were fabricated by combining a decellularization procedure with a freeze-drying technique and characterized by scanning electron microscopy （SEM） and micro-computed tomography （micro-CT）. Osteochondral constructs were fabricated in vitro using chondrogenically-induced BMSCs and a biphasic scaffold, then assessed by SEM for cell attachment. Osteochondral defects （4.2 mm （diameter） ×6 mm （depth）） were created in canine femoral condyles and treated with a construct of the biphasic scaffold/chondrogenically-induced BMSCs or with a cell-free scaffold （control group）. The repaired defects were evaluated for gross morphology and by histological, biochemical, biomechanical and micro-CT analyses at 3 and 6 months post-implantation. Results The osteochondral defects of the experimental group showed better repair than those of the control group. Statistical analysis demonstrated that the macroscopic and histologic grading scores of the experimental group were always higher than those of the control group, and that the scores for the experimental group at 6 months were significantly higher than those at 3 months. The cartilage stiffness in the experimental group （6 months） was （6.95±0.79） N/mm, 70.77% of normal cartilage; osteochondral bone stiffness in the experimental group was （158.16±24.30） N/mm, 74.95% of normal tissue; glycosaminoglycan content of tissue-engineered neocartilage was （218±21.6） tJg/mg （dry weight）, 84.82% of native cartilage. Micro-CT analysis of the subchondral bone showed mature trabecular bone regularly formed at 3 and 6 months, with n

关键词： osteochondral tissue engineering extracellular matrix bone marrow-derived mesenchymal stem cell biphasic scaffold micro-computed tomography

Exosomes:the next-generation therapeutic platform for ischemic stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing yin Hongyin Ma Yang Qu Jiaxin Ren yingying Sun Zhen-Ni guo yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： yi Wang Yuning Li Yakun Gu Wei Ma Yuying Guan Mengyuan guo Qianqian Shao Xunming Ji Jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

In vitro cartilage production using an extracellular matrix-derived scaffold and bone marrow-derived mesenchymal stem cells

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第16期126卷 3130-3137页

作者： ZHAO Yan-hong YANG Qiang XIA Qun PENG Jiang LU Shi-bi guo quan-yi MA Xin-long XU Bao-shan HU Yong-cheng ZHAO Bin ZHANG Li WANG Ai-yuan XU Weng-jing MIAO Jun LIU Yue Institute of Orthopedics Chinese People's Liberation Army GeneralHospital Beijing 100853 China Stomatological Hospital of Tianjin Medical University Tianjin300070 China Department of Spine Surgery Tianjin Hospital Tianjin 300211 China Tianjin Medical University Tianjin 300211 China

Background Cartilage repair is a challenging research area because of the limited healing capacity of adult articular *** had previously developed a natural,human cartilage extracellular matrix （ECM）-derived scaffold for in vivo cartilage tissue engineering in nude ***,before these scaffolds can be used in clinical applications in vivo,the in vitro effects should be further *** We produced cartilage in vitro using a natural cartilage ECM-derived *** scaffolds were fabricated by combining a decellularization procedure with a freeze-drying technique and were characterized by scanning electron microscopy （SEM）,micro-computed tomography （micro-CT）,histological staining,cytotoxicity assay,biochemical and biomechanical *** being chondrogenically induced,the induction results of BMSCs were analyzed by histology and *** attachment and viability assessment of the cells on scaffolds were analyzed using SEM and LIVE/DEAD ***-scaffold constructs cultured in vitro for 1 week and 3 weeks were analyzed using histological and immunohistochemical *** SEM and micro-CT revealed a 3-D interconnected porous *** majority of the cartilage ECM was found in the scaffold following the removal of cellular debris,and stained positive for safranin O and collagen Ⅱ.Viability staining indicated no cytotoxic effects of the *** analysis showed that collagen content was （708.2±44.7）μg/mg,with GAG （254.7±25.9） μg/*** testing showed the compression moduli （E） were （1.226±0.288） and （0.052±0.007） MPa in dry and wet conditions,*** canine bone marrow-derived stem cells （BMSCs） were induced down a chondrogenic pathway,labeled with PKH26,and seeded onto the *** staining of the cell-scaffold constructs indicated that chondrocyte-like cells were derived from seeded BMSCs and excreted *** cell-scaffold constructs contained pink,smooth

关键词： bone marrow-derived mesenchymal stem cells cartilage tissue engineering extracellular matrix in vitro scaffold

MoS2 synaptic transistor with one-step manufacture

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2025年第1期68卷 357-365页

作者： yihao guo Yang WANG Wenjie DENG yi WU Jingtao LI Kexin LI Yuehui ZHAO Songlin YU Xiaoting WANG Yongzhe ZHANG Hui YAN Key Laboratory of Optoelectronics Technology of Education Ministry of China Faculty of Information TechnologyBeijing University of Technology Key Laboratory of Advanced Functional Materials Ministry of Education Faculty of Materials and ManufacturingBeijing University of Technology The 11th Research Institute of Electronics Technology Group Corporation

The synaptic transistor,which is a neuromorphic device with brain-like functions,has garnered significant attention due to characteristics such as low energy consumption,high integration,multiple functions,and high computational ***,the current synaptic transistor possesses a complicated structure and involves complex manufacturing steps,which is not conducive to low-cost,large-scale bionic ***,we introduce a simple MoS2synaptic transistor exhibiting robust synaptic *** transistor utilizes magnetron sputtering manufacture to combine the process of device metal electrode deposition and the introduction of defect states,which helps streamline the manufacturing process into a single *** long-term potentiation and long-term depression in photoelectric coordination are initially ***,biological functions,such as double pulse facilitation and the transformation behavior of short-term memory to long-term memory,are thoroughly evaluated,along with learning-forgetting-relearning ***,the device exhibits robust synaptic plasticity until incident light angles down to 30° to imitate the multi-to-one axon-cellular ***,a classical simulation of Pavlov's dog conditioned reflex is demonstrated along with the multiview extraction *** experimental results demonstrate a promising synaptic transistor with a simple structure,manufacturing technique,and excellent *** further indicates the potential for large-scale integration of bionic neuromorphic systems.

关键词： process optimization artificial synaptic device one-stepmanufacture synaptic plasticity bionic simulation

同方期刊数据库

在线全文

学校读者我要写书评

暂无评论

骨科英语教学现状分析与探索

中国医学创新 2017年第11期14卷 128-131页

作者：郭全义李旭解放军总医院骨科研究所北京100853

随着骨科学不断发展,国际之间学术交流日益增多,提高骨科医生英语水平势在必行。骨科医生工作强度大,骨科医生英语学习时间较短。骨科亚学科分科细,与其他学科具有交叉,需要掌握的知识量大。骨科专业英语词汇来源广泛,背景复杂增加了专... 详细信息

随着骨科学不断发展,国际之间学术交流日益增多,提高骨科医生英语水平势在必行。骨科医生工作强度大,骨科医生英语学习时间较短。骨科亚学科分科细,与其他学科具有交叉,需要掌握的知识量大。骨科专业英语词汇来源广泛,背景复杂增加了专业英语学习难度。因此,临床骨科教学有一定的特殊性。目前,骨科医生英语能力仍不足,英语教学师资队伍有待提高,考核机制需要完善。面对临床骨科教学存在的问题,优化教育模式有利于骨科医生医学专业水平与英语水平的提高。因此,以"骨科英语教学现状分析与探索"为题展开论述。

关键词：英语教学骨科学教学改革

Formation and evolution of supercritical geofluid

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2025年第1期68卷 39-51页

作者： Huaiwei NI yilin XIAO Xiaolin XIONG Xiandong LIU Chunxiao GAO yi-Xiang CHEN Yunguo LI Wan-Cai LI Xuan guo Yang-Yang WANG Dong-Bo TAN Li ZHANG State Key Laboratory of Lithospheric and Environmental Coevolution University of Science and Technology of China Deep Space Exploration Laboratory/School of Earth and Space Sciences University of Science and Technology of China Guangzhou Institute of Geochemistry Chinese Academy of Sciences School of Earth Sciences and Engineering Nanjing University State Key Lab of Superhard Materials Jilin University

In this work, we provide a comprehensive review on the formation, evolution, properties, and effects of supercritical geofluid. In Earth's interior, enhanced miscibility between H2O and silicate by the addition of special components or by the increase of pressure and temperature gives rise to supercritical geofluid with a significant amount of both H2O and silicate *** formation of supercritical geofluid in magmatic-hydrothermal systems, typified by pegmatite system, is governed by meltfluid critical curve. The formation of supercritical geofluid in metamorphic systems, typified by subducted slab, is governed by the second critical end point. Experimental results suggest that the presence of boron and fluorine in pegmatite system makes it possible to form supercritical geofluid at crustal depths, but the release of supercritical geofluid from subducted slab is withheld until almost 100 km depth. A major presence of both H2O and depolymerized structural units（monomers, dimers, etc.） endows supercritical geofluid with unique physical properties including low density, low elastic moduli, low viscosity, high diffusivity,and high electrical conductivity. Supercritical geofluid can effectively mobilize a variety of elements even including high field strength elements and heavy rare earth elements. The chemical signatures of supercritical geofluid can be inherited by metasomatized mantle and mantle-derived melts, and this could give an explanation of the oxidation of arc magmas. Phase separation of supercritical geofluid through the mechanism of spinodal decomposition leads to formation of a melt network. Multiphase fluid inclusions recovered from subduction zone rocks and pegmatites are possible relics of supercritical geofluid. Supercritical geofluid can cause electrical anomaly and low seismic velocity near the top of subducted slab, and can be linked with intermediate-focus earthquakes. Supercritical geofluid may have played a crucial role in the formation of pe

关键词： Supercritical geofluid Miscibility Subduction zone Pegmatite

同方期刊数据库

在线全文

学校读者我要写书评

暂无评论

持续被动关节活动仪在软骨修复中的应用

中华关节外科杂志（电子版） 2007年第2期1卷 67-68页

作者：卢世璧郭全义中国人民解放军总医院骨科研究所北京100853

人体软骨组织和其他组织的区别在于：软骨组织没有血管、淋巴管和神经纤维；软骨细胞稀疏分散于由水和大分子物质组成的基质中，而且软骨细胞所占的体积不足总体积的5％。软骨细胞被包裹在大量的基质中，因此曾被认为是休眠的细胞，但Ma... 详细信息

人体软骨组织和其他组织的区别在于：软骨组织没有血管、淋巴管和神经纤维；软骨细胞稀疏分散于由水和大分子物质组成的基质中，而且软骨细胞所占的体积不足总体积的5％。软骨细胞被包裹在大量的基质中，因此曾被认为是休眠的细胞，但Mankin研究发现：软骨细胞是活跃的细胞，特别是儿童时期的软骨细胞，如与生长密切相关的骺软骨细胞就特别活跃。另外，软骨细胞的活跃性还表现在，当软骨受损伤时，软骨细胞的代谢明显增强。

关键词：软骨修复被动关节活动骺软骨细胞软骨组织神经纤维物质组成儿童时期淋巴管