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Delivery strategies for macromolecular drugs in cancer therapy

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Acta Pharmaceutica Sinica B 2020年第6期10卷 979-986页

作者： qin guo Chen Jiang Key Laboratory of Smart Drug Delivery Ministry of EducationState Key Laboratory of Medical NeurobiologyDepartment of PharmaceuticsSchool of PharmacyFudan UniversityShanghai 201203China

With the development of biotherapy,biomacromolecular drugs have gained tremendous attention recently,especially in drug development field due to the sophisticated functions in *** the past few years,a motley variety of drug delivery strategies have been developed for biomacromolecular drugs to overcome the difficulties in the druggability,e.g.,the instability and easily restricted by physiologic *** application of novel delivery systems to deliver biomacromolecular drugs can usually prolong the half-life,increase the bioavailability,or improve patient compliance,which greatly improves the efficacy and potentiality for clinical use of biomacromolecular *** this review,recent studies regarding the drug delivery strategies for macromolecular drugs in cancer therapy are summarized,mainly drawing on the development over the last five years.

关键词： Macromolecular drugs Delivery strategies Cancer therapy Membrane-camouflage systems Exosomes

Quantum Hadamard Operators and Their Decomposition Derived by Virtue of IWOP Technique

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Communications in Theoretical Physics 2008年第4期49卷 859-862页

作者： FAN Hong-Yi guo qin Department of Physics Shanghai Jiao Tong University Shanghai 200030 China Department of Physics Jiangxi Normal University Nanchang 330022 China

We introduce the quantum Hadamard operator in continuum state vector space and find that it can be decomposed into a single-mode squeezing operator and a position-momentum mutual transform operator. The two-mode Hadamard operator in bipartite entangled state representation is also introduced, which involves the two-mode squeezing operator and [η〉 ←→｜ξ〉 mutual transformation operator, where [η〉 and ｜ξ〉 are mutual conjugate entangled states. All the discussions are proceeded by virtue of the IWOP technique.

关键词： quantum Hadamard operator squeezing operator position-momentum transformation operator IWOP technique

Weyl-Ordered Operator Product Formula Derived by Technique of Integration Within Weyl-Ordered Product of Operators

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Communications in Theoretical Physics 2007年第5X期48卷 823-826页

作者： FAN Hong-Yi guo qin Department of Physics Shanghai Jiao Tong University Shanghai 200030 China Department of.Material Science and Engineering University of Science and Technology of China Hefei 230026 China

Based on the explicit Weyl-ordered form of Wigner operator and the technique of integration within Weylordered product of operators we derive the Weyl-ordered operator product formula. The formula is then generalized ... 详细信息

关键词： Weyl-ordering IWOP technique entangled state Weyl product

Revised Virial Theorem for Hamiltonians with Coordinates-Momentum Coupling Terms

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Communications in Theoretical Physics 2008年第7期50卷 117-119页

作者： guo qin FAN Hong-Yi Department of Physics Jiangxi Normal University Nanchang 330022 China Department of Physics Shanghai Jiao Tong University Shanghai 200030 China Department of Material Science and Engineering University of Science and Technology of China Hefei 230026 China

Usually the Virial theorem,which can be derived from the Feynman-Hellmann theorem,applies to Hamil-tonians without coordinates-momentum *** this paper we discuss when there are such kind of couplings inHamiltonians then how the Virial theorem should be *** also discuss the energy contribution arising from thecoordinates-momentum coupling for a definite energy level.

关键词： revised Virial theorem Feynnlan Hellmann theorem coordinates-momentum coupling

Antibonding orbital tailor and stress relief engineering for FeS_(2)complex toward superior sodium storage

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Rare Metals 2024年第10期43卷 5048-5059页

作者： You-Bin Zhang Zhen-guo Qi Fu-Sheng Liu guo-Hui qin State Key Laboratory Base for Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao 266042China Shandong Synergetic Innovation Center of Ecological and Chemical Engineering Qingdao 266042China

The sluggish kinetics behaviors and vast volume variations of Na^(+)hosts to FeS_(2)anode involved intercalation,and conversion reactions plague its applicability of sodium-ion batteries(SIBs).Here,a significantly expedited kinetics via cation intercalation and considerably relieved stress accumulation by constructing the concave scaffold protector are approached for FeS_(2)*** Mn^(2+)intercalation into FeS_(2),a new stable Mn-FeS_(2)was generated with distorted coordination;elevated antibonding orbital occupancy and lowed d band center to the release of more free Na^(+)were achieved,which was further encapsulated by hollow bowl-like carbon spheres(BC)This cation intercalation and concave morphology strategies confer Mn-FeS_(2)@BC significantly enhanced electron ion transport kinetics via reversed electron transfer to FeS_(2)fast desolvation kinetics,and evidently depressed structural deformation during Na^(+)insertion and ***,Mn-FeS_(2)@BC delivers the longevity and stable Na^(+)storage capacity in both half and full cell ***,Mn-FeS_(2)@BC also displays excellen adaptability in a wider temperature *** work proposes new views into the deep regulation of electrochemical performance of transition metal anodes via intercalation chemistry and concave engineering.

关键词： FeS_(2) Intercalation chemistry Concave engineering Sodium capture

Regulation of solvation structure and the cooperation environment of potassium bonds for wider-temperature adaptive potassium storage

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Rare Metals 2024年第4期43卷 1610-1621页

作者： Bing-Bing Liu Yi-Hui Liu You-Bin Zhang Zhen-guo Qi guo-Hui qin State Key Laboratory Base for Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao266042China Shandong Synergetic Innovation Center of Ecological and Chemical Engineering Qingdao266042China

Antimony selenide(Sb_(2)Se_(3))is one of the perspective candidates for potassium-ion batteries due to its advanced virtues stem including featured high capacity,fertile reserves and the relative narrow band *** the unique advantages,it is still plagued by the unstable interface compatibility and poor wider-temperature *** optimization of microstructure and the construction of inorganic-organic hybrids with a low desolvation barrier and rapid kinetics behaviors are efficient to address these *** Sb_(2)Se_(3)nanorods enclosed by the S-doped carbon layer(SC),further crosslinked by the poly(N-isopropylacrylamide)(PM)film(PM@Sb_(2)Se_(3)@SC),were artificially fabricated,and it displays the enrichment ion aggregated model as well as contacted ion pair state,the well-tailored cooperation environment of potassium bonds,assuring a homogeneous potassium deposition and an excellent widertemperature *** complicated experimental studies and theoretical calculations authenticate the synergistic effects of geometric conformation and compositional design for the tremendously enhanced potassium ***,the full device over PM@Sb_(2)Se_(3)@SC anode and the potassium Prussian blue cathode manifests impressively durable cycling life and wider-temperature adaptability,verifying the glorious contribution from the finely manipulation in solvation structure and potassium bonds to enhancing the potassium storage behaviors.

关键词： Anode Sb_(2)Se_(3) rods Interface compatibility Inorganic-organic electrode Potassium ion battery

New Cutting Force Modeling Approach for Flat End Mill

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Chinese Journal of Aeronautics 2007年第3期20卷 282-288页

作者： WAN Min ZHANG Wei-hong TAN Gang qin guo-hua Sino-French Laboratory of Concurrent Engineering The Key Laboratory of Contemporary Design ＆ Integrated Manufacturing Technology Northwestern Polytechnical University Xi＇an 710072 China

A new mechanistic cutting force model for flat end milling using the instantaneous cutting force coefficients is proposed. An in-depth analysis shows that the total cutting forces can be separated into two terms: a nominal component independent of the runout and a perturbation component induced by the runout. The instantaneous value of the nominal component is used to calibrate the cutting force coefficients. With the help of the perturbation component and the cutting force coefficients obtained above, the cutter runout is identified. Based on simulation and experimental results, the validity of the identification approach is demonstrated. The advantage of the proposed method lies in that the calibration performed with data of one cutting test under a specific regime can be applied for a great range of cutting conditions.

关键词： runout cutting force flat end mill calibration cutting force coefficient

Innovative Design and Performance Evaluation of a High-speed Bionic Mechanical Leg

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Journal of Bionic Engineering 2015年第3期12卷 352-360页

作者： Hua Nie Ronglei Sun Chaoke guo guohua qin Huiyang Yu State Key Lab of Digital Manufacturing Equipment and Technology Huazhong University of Science and Technology Wuhan 430070 China

For most legged robots the drive-motors are mounted on the joints of legs, which increase leg＇s mass and rotary inertia. When mounted on legs, the drive-motor has to rotate clockwise and anticlockwise periodically to swing a leg back and forth. Larger inertia of the leg, as well as the ever-changing status of frequent acceleration and deceleration of the motors, limits the moving speed of the legged robots. This article proposes an improved mechanical design to overcome such problems. All the drive-motors are installed on the robot body to reduce the rotary inertia of the legs. Then a crank-rocker mechanism is used to transform continuous rotation of motors to back and forth motion of the leg. With this scheme, the motor may reach higher rotation speed since it drives a lighter leg with no change of the rotation direction. In addition, an elastic tendon is attached to the ankle to reduce the pulse stress on the leg. Kinematics and dynamics analysis demonstrates that the new design enlarges end-workspace, reduces driving torque and increases ground reaction force, which means the new robot has lager stride and higher swing frequency of leg to achieve faster moving.

关键词： high-speed mechanical design bionic leg dynamics

Zonal disintegration phenomenon in rock mass surrounding deep tunnels

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Journal of China University of Mining and Technology 2008年第2期18卷 187-193页

作者： WU Hao FANG qin guo Zhi-kun Engineering Institute of Engineering Corps PLA University of Science and Technology Nanjing Jiangsu 210007 China

Zonal disintegration is a typical static phenomenon of deep rock masses. It has been defined as alternating regions of fractured and relatively intact rock mass that appear around or in front of the working stope during excavation of a deep tunnel. Zonal disintegration phenomenon was successfully demonstrated in the laboratory with 3D tests on analogous gypsum models, two circular cracked zones were observed in the test. The linear Mohr-Coulomb yield criterion was used with a constitutive model that showed linear softening and ideal residual plastic to analyze the elasto-plastic field of the enclosing rock mass around a deep tunnel. The results show that tunneling causes a maximum stress zone to appear between an elastic and plastic zone in the surrounding rock. The zonal disintegration phenomenon is analyzed by considering the stress-strain state of the rock mass in the vicinity of the maximum stress zone. Creep instability failure of the rock due to the development of the plastic zone, and transfer of the maximum stress zone into the rock mass, are the cause of zonal disintegration. An analytical criterion for the critical depth at which zonal disintegration can occur is derived. This depth depends mainly on the character and stress concentration coefficient of the rock mass.

关键词： block-hierarchical structure zonal disintegration phenomenon enclosing rock mass around deep tunnel equivalent material stress concentration coefficient