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Artificial intelligence-assisted repair of peripheral nerve injury: a new research hotspot and associated challenges

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Neural Regeneration Research 2024年第3期19卷 663-670页

作者： Yang guo liying Sun Wenyao Zhong Nan Zhang Zongxuan Zhao Wen Tian Department of Hand Surgery Beijing Jishuitan HospitalBeijingChina

Artificial intelligence can be indirectly applied to the repair of peripheral nerve injury.Specifically,it can be used to analyze and process data regarding peripheral nerve injury and repair,while study findings on peripheral nerve injury and repair can provide valuable data to enrich artificial intelligence algorithms.To investigate advances in the use of artificial intelligence in the diagnosis,rehabilitation,and scientific examination of peripheral nerve injury,we used CiteSpace and VOSviewer software to analyze the relevant literature included in the Web of Science from 1994–2023.We identified the following research hotspots in peripheral nerve injury and repair:(1)diagnosis,classification,and prognostic assessment of peripheral nerve injury using neuroimaging and artificial intelligence techniques,such as corneal confocal microscopy and coherent anti-Stokes Raman spectroscopy;(2)motion control and rehabilitation following peripheral nerve injury using artificial neural networks and machine learning algorithms,such as wearable devices and assisted wheelchair systems;(3)improving the accuracy and effectiveness of peripheral nerve electrical stimulation therapy using artificial intelligence techniques combined with deep learning,such as implantable peripheral nerve interfaces;(4)the application of artificial intelligence technology to brain-machine interfaces for disabled patients and those with reduced mobility,enabling them to control devices such as networked hand prostheses;(5)artificial intelligence robots that can replace doctors in certain procedures during surgery or rehabilitation,thereby reducing surgical risk and complications,and facilitating postoperative recovery.Although artificial intelligence has shown many benefits and potential applications in peripheral nerve injury and repair,there are some limitations to this technology,such as the consequences of missing or imbalanced data,low data accuracy and reproducibility,and ethical issues(e.g.,privacy,data security,research transparency).Future re

关键词： artificial intelligence artificial prosthesis medical-industrial integration brain-machine interface deep learning machine learning networked hand prosthesis neural interface neural network neural regeneration peripheral nerve

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Phlorizin alleviates deltamethrin-induced oxidative stress in brine shrimp Artemia

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Journal of Oceanology and Limnology 2024年第1期42卷 163-173页

作者： Dandan MA Qingli ZHOU liying SUI Qingbin guo Huanhuan LIU Honghe LIANG Zhenjing LI Zhongna SANG School of Food Science and Engineering Tianjin University of Science and TechnologyTianjin 300457China Asian Regional Artemia Reference Center Key Laboratory of Marine Resource Chemistry and Food Technology(TUST)Ministry of EducationTianjin University of Science and TechnologyTianjin 300457China Subtropical Crops Research Institute of Guangxi Zhuang Autonomous Region Nanning 530001China Department of Nutrition and Food Hygiene School of Public HealthTianjin Medical UniversityTianjin 300070China

Deltamethrin(DEL),a commonly used pyrethroid pesticide,results in higher reactive oxygen species(ROS)levels in aquatic animals,which consequently unbalance the redox state.Phlorizin(PHL)is a flavonoid and a natural product promising to prevent or reduce pesticide-induced oxidative stress.Artemia is a micro-crustacean widely used in marine hatcheries and an experimental aquatic organism for environmental toxicology research.This research aimed to evaluate the toxicity of DEL on Artemia and the antioxidative effect of PHL against the toxicity.Results show that 0.08-mg/mL PHL exerted its antioxidative effects on hatching percentage of the cysts in 24-h incubation and on body length and survival rate of Artemia in 12-d culture.After 12-d culture,12-,24-,and 36-h DEL exposure showed significant drops in SOD,CAT,and GSH-Px enzyme activities,and significant increases in ROS and malondialdehyde(MDA)levels in Artemia(P<0.05).On the contrary,0.08-mg/mL PHL application improved the enzyme activities and decreased the ROS and MDA levels(P<0.05).Moreover,0.08-mg/mL PHL significantly increased mRNA expression levels of Cu/Zn SOD,CAT,GST,HO-1,NQO1,and Nrf2,and decreased mRNA expression level of Keap1 in the DEL-exposed Artemia(P<0.05).Therefore,DEL is toxic to Artemia,while PHL alleviates DEL-induced oxidative damage by possibly regulating the Nrf2signaling pathway.This study provided a theoretical basis for PHL to reduce pesticide-induced toxicity in aquatic animals.

关键词： Artemia deltamethrin phlorizin oxidative stress

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Entangled relationship:Chinese parents’involvement in young learners’English tests

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语言测试与评价 2024年第1期 1-20,112页

作者： guo JIA CHENG liying Queen’s University City University of Macao

Young learners’English(YLE)tests have become increasingly prevalent among and important to Chinese English learners and their parents.In China,parents are actively involved in their children’s education and test-taking decisions,and their participation has given rise to a series of social impacts.Although parent involvement has received increasing public and academic attention in newspaper and scholarly articles,there exists no thorough analysis of current research on parents’roles in young learners’test-taking.To address this gap,we systemically analyzed Chinese newspaper articles and academic articles between 2011 and 2021 to elicit Chinese parents’roles in YLE test-taking.Our thematic analysis of the literature identifies the ways in which parents influence their children’s test-taking experiences,and how the tests affect this influence.Specifically,our results elicit 1)parents’engagement in YLE testing;2)parents’understanding of the intended uses of YLE tests;3)parents’perception and consequences of their involvement in YLE testing;and 4)parents’backgrounds.This analysis reveals the popularity of YLE tests among young learners and their parents in China and public concern over test-related issues.It also broadens our understanding of YLE testing impact and suggests future potential research directions.

关键词： young learners’English(YLE)tests in China parents’roles test impact

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Preparation of Ionic Liquids Immobilized on FMIL-101 Catalysts for Conversion of CO_(2)to Propylene Carbonate

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China Petroleum Processing & Petrochemical Technology 2023年第1期25卷 54-65页

作者： Sun Wenjie Ran Weiting guo liying Song Xiaohui LüDonghao School of Petrochemical Engineering Shenyang University of TechnologyLiaoyang 111003China

Metal-organic frameworks(MOFs)have attracted considerable research attention as a new type of porous material for catalytic applications.Herein,2,5-dihydroxyterephthalic acid was proposed to replace conventional terephthalic acid and reacted with chromic nitrate nonahydrate to synthesize a functional metal–organic framework(FMIL-101).This was then used to immobilize various compound ionic liquids to prepare three ionic liquids immobilized on FMIL-101 catalysts,namely,FMIL-101-[HeMIM]Cl/(ZnBr_(2))_(2),FMIL-101-[CeMIM]Cl/(ZnBr_(2))_(2),and FMIL-101-[AeMIM]Br/(ZnBr_(2))_(2).After characterization by Fourier-transform infrared spectroscopy,X-ray diffraction,ultraviolet spectroscopy,thermogravimetry,specific surface area analysis,and scanning electron microscopy,the catalysts were used to mediate cycloaddition reactions between carbon dioxide(CO_(2))and propylene oxide.The effects of reaction temperature,reaction pressure,reaction time,and catalyst dosage on the catalytic performance were investigated.The results revealed that the FMIL-101-supported CIL catalysts afforded the target product propylene carbonate with good catalytic performance and thermal stability.The optimal catalyst,FMIL-101-[CeMIM]Cl/(ZnBr_(2))_(2),displayed a propylene oxide conversion of 98.64%and a propylene carbonate selectivity of 96.63%at a reaction temperature of 110℃,a reaction pressure of 2.0 MPa,a catalyst dosage of 2.0%relative to propylene oxide,and a reaction time of 2.5 h.In addition,the conversion and selectivity of the catalyst decreased slightly after four cycles.Additionally,the catalyst decreased slightly in catalytic performance after being recycled four times.

关键词： functional metal-organic frameworks(FMIL-101) compound salt ionic liquid immobilization catalysis CO_(2) cyclic carbonate

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Identification and Validation of Vascular-Associated Biomarkers for the Prognosis and Potential Pathogenesis of Hypertension Using Comprehensive Bioinformatics Methods

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World Journal of Cardiovascular Diseases 2024年第3期14卷 115-128页

作者： Xiangguang Chang Lei guo liying Zou Yazhao Ma Jilin Feng Department of Laboratory Yangbi Yi Autonomous County People’s Hospital Dali China Department of Obstetrics and Gynecology Yangbi Yi Autonomous County People’s Hospital Dali China Department of Infectious Diseases Yangbi Yi Autonomous County People’s Hospital Dali China Medical Community Office Yangbi Yi Autonomous County People’s Hospital Dali China

Background: Hypertension, also known as increased blood pressure, is a phenomenon in which blood flows in blood vessels and causes persistently higher-than-normal pressure on the vessel wall. The identification of novel prognostic and pathogenesis biomarkers plays a key role in the management of hypertension. Methods: The GSE7483 and GSE75815 datasets from the gene expression omnibus (GEO) database were used to identify the genes associated with hypertension that were differentially expressed genes (DEGs). The functional role of the DEGs was elucidated by gene body (GO) enrichment analysis. In addition, we performed an immune infiltration assay and GSEA on the DEGs of hypertensive patients and verified the expression of novel DEGs in the blood of hypertensive patients by RT-qPCR. Results: A total of 267 DEGs were identified from the GEO database. GO analysis revealed that these genes were associated mainly with biological processes such as fibroblast proliferation, cell structural organization, extracellular matrix organization, vasculature development regulation, and angiogenesis. We identified five possible biomarkers, Ecm1, Sparc, Sphk1, Thbsl, and Mecp2, which correlate with vascular development and angiogenesis characteristic of hypertension by bioinformatics, and explored the clinical expression levels of these genes by RT-qPCR, and found that Sparc, Sphk1, and Thbs1 showed significant up-regulation, in agreement with the results of the bioinformatics analysis. Conclusion: Our study suggested that Sparc, Sphk1 and Thbs1 may be potential novel biomarkers for the diagnosis, treatment and prognosis of hypertension and that they are involved in the regulation of vascular development and angiogenesis in hypertension.

关键词： Hypertension Biomarkers Differentially Expressed Genes Vascular Development and Angiogenesis Bioinformatics Analysis

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Identification and Validation of Novel Biomarkers Related to the Calcium Metabolism Pathway in Hypertension Patients Based on Comprehensive Bioinformatics Methods

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Health 2024年第3期16卷 173-186页

Background: Hypertension is a universal risk factor for cardiovascular diseases and is thus the leading cause of death worldwide. The identification of novel prognostic and pathogenesis biomarkers plays a key role in disease management. Methods: The GSE145854 and GSE164494 datasets were downloaded from the Gene Expression Omnibus (GEO) database and used for screening and validating hypertension signature genes, respectively. Gene Ontology (GO) enrichment analysis was performed on the differentially expressed genes (DEGs) related to calcium ion metabolism in patients with hypertension. The core genes related to immune infiltration were analyzed and screened, and the activity of the signature genes and related pathways was quantified using gene set enrichment analysis (GSEA). The infiltration of immune cells in the blood samples was analyzed, and the DEGs that were abnormally expressed in the clinical blood samples of patients with hypertension were verified via RT-qPCR. Results: A total of 176 DEGs were screened. GO showed that DEGs was involved in the regulation of calcium ion metabolism in biological processes (BP), actin mediated cell contraction, negative regulation of cell movement, and calcium ion transmembrane transport, and in the regulation of protease activity in molecular functions (MF). KEGG analysis revealed that the DEGs were involved mainly in the cGMP-PKG signaling pathway, ubiquitin-protein transferase, tight junction-associated proteins, and the regulation of myocardial cells. MF analysis revealed the immune infiltration function of the cells. RT-qPCR revealed that the expression of Cacna1d, Serpine1, Slc8a3, and Trpc4 was up regulated in hypertension, the expression of Myoz2 and Slc25a23 was down regulated. Conclusion: Cacna1d, Serpine1, Slc8a3, Trpc4, Myoz2 and Slc25a23 may be involved in the regulation of calcium metabolism pathways and play key roles in hypertension. These differentially expressed calcium metabolism-related genes may serve as prognostic markers of hypertension.

关键词： Hypertension Biomarkers Differentially Expressed Genes Ca2+ Metabo-lism Bioinformatics Analysis

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A Network Pharmacology Study on Active Components and Targets of Citri Reticulatae Pericarpium for Treating Keloids

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Medicinal Plant 2024年第1期15卷 18-23,31页

作者： Chang REN Ru CHEN Lei SONG Kun guo liying QIU College of Pharmacy Southwest Minzu UniversityChengdu 610041China

[Objectives]To investigate the mechanisms and pharmacologic effects of Citri Reticulatae Pericarpium against keloids by network pharmacology systematically.[Methods]TCMSP,Uniprot and BATMAN-TCM databases were used to obtain the active constituents and targets of Citri Reticulatae Pericarpium."Keloid"was used as key word to search for related therapeutic targets from Drug Bank,OMIM,TTD,and GEO databases.The Chinese medicine compound-target network was constructed by Cytoscape software.Besides,gene ontology(GO)and Kyoto Encyclopedia of genes and genome enrichment analysis were also performed.Afterward,Discovery Studio software was used to assess the interaction of key components and genes.[Results]Five active components of Citri Reticulatae Pericarpium,773 compound targets and 676 keloid treatment targets were obtained in the databases.After the intersection,there are 47 targets of Citri Reticulatae Pericarpium for treating keloids.Hub genes were identified such as MMP9,IL6,TNF,TP53,and VEGFA,which were enriched in tumor necrosis factor-α,nuclear factor kappa-B,and other signaling pathways.The molecular docking stimulation confirmed the interaction between the MMP9 and three components of Citri Reticulatae Pericarpium.[Conclusions]Citri Reticulatae Pericarpium may play an important role in treating keloids through modulating genes and signaling pathways.The present study sheds light on the mechanisms of active compounds of Citri Reticulatae Pericarpium for the treatment of keloids.

关键词： Network pharmacology Keloids Citri Reticulatae Pericarpium

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A study on the spatial difference of farmland nitrogen nutrient budget in the Bohai Rim region, China

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Journal of Geographical Sciences 2012年第4期22卷 761-768页

作者： guo liying YANG Ren WANG Daolong Institute of Natural Resources and Regional Planning Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China Institute of Geographic Sciences and Natural Resources Research CASBeijing 100101China

The Bohai Rim region is one the most important bases for commodity grain production in China. With the rapid pace of agricultural industrialization, nitrogenous fertilizer has been used at an ever increasing rate, which resulted in the trace of accumulative nitrogen in the soil and caused serious environmental problems. In this study we made use of the farmland nitrogen balance model to assess the spatial difference of farmland nitrogen nutrient budget in the Bohai Rim region in 2008 with the assistance of GIS. Our results indicated that： 1） Farmland in this region has a nitrogen surplus totaling 5.0822 million tons, or an average of 288.54 kg/ha. 2） In the Bohai Rim region, farmland nitrogen input and farmland nitrogen budget both show a spatial differentiation. Major grain-producing areas have a higher nitrogen input than that of the grazing-farming areas. The main sources of nitrogen input include chemical fertilizer, organic fertilizer, deposition from atmospheric drying and wetting, and biological fixation, which account for 79.47%, 9.53%, 4.62%, and 3.58% of the total input, respectively. Therefore, chemical fertilizer is the predominant source of nitrogen input to farmland. 3） A total of 3.3398 million tons of nitrogen were output from the farmland via harvested crops and it accounts for 52.36% of the total nitrogen output from farmland in this region. On average, the amount of nitrogen output from unit farmland is equal to 176.65kg/ha. This study has shed light on farmland nitrogen budget and its spatial variation in the study area, may provide scientific evidences for rationalizing the use of chemical fertilizer and managing agricultural operation on the regional scale and is also valuable for improving the economic and ecological efficiency of fertilizer use at the regional scale.

关键词： farmland nitrogen nutrient nitrogen budget spatial difference agricultural production the BohaiRim region

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The causes of land landscape changes in semi-arid area of Northwest China: a case study of Yulin city

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Journal of Geographical Sciences 2006年第2期16卷 192-198页

作者： guo liying REN Zhiyuan LIU Yansui College of Tourism and Environmental Sciences Shaanxi Normal University Xi＇an 710062 China Institute of Geographic Sciences and Natural Resources Research CAS Beijing 100101 China

Rapid land landscape change has taken place in many arid and semi-arid regions such as the vulnerable ecological area over the last decade. In this paper, we quantified land landscape change of Yulin in this area between 1985 and 2000 using remote sensing and GIS. It was found that fallow landscape decreased by 125,148 hm^2 while grassland and woodland increased by 107,975 hm^2 and 17,157 hm^2, respectively. The major factors responsible for these changes are identified as the change in the government policy on preserving the environment, continued growth in mining, and urbanization. The efforts in restoring the deteriorated ecosystem have reaped certain benefits in reducing the spatial extent of sandy land through replacement by non-irrigated farmland, woodland and grassland. On the other hand, continued expansion of mining industry and urbanization has exerted adverse impacts on the land landscape. At present regional economic development conflicts directly with the protection of the natural environment. Such a conflict has caused the destruction to the land resources and fragmentation of the landscape accompanied by land desertification, the case is even serious in some localities.

关键词： land landscape patterns driving forces semi-arid areas Yulin city

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纤维织物增强高延性混凝土加固RC短柱抗剪性能试验研究

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湖南大学学报（自然科学版） 2024年第1期51卷 79-89页

作者：邓明科雷恒张雨顺郭莉英张伟西安建筑科技大学土木工程学院陕西西安710055 上海建科工程咨询有限公司上海200032

为研究纤维织物增强高延性混凝土(TR-HDC)加固钢筋混凝土短柱的抗剪性能,设计了6根钢筋混凝土柱,包括2个对比柱和4个TR-HDC加固柱.通过低周反复荷载试验,对比分析剪跨比、纤维织物层数对试件破坏形态、变形、承载力和耗能能力的影响.结... 详细信息

为研究纤维织物增强高延性混凝土(TR-HDC)加固钢筋混凝土短柱的抗剪性能,设计了6根钢筋混凝土柱,包括2个对比柱和4个TR-HDC加固柱.通过低周反复荷载试验,对比分析剪跨比、纤维织物层数对试件破坏形态、变形、承载力和耗能能力的影响.结果表明:采用TR-HDC加固钢筋混凝土短柱,可显著提高其抗剪承载力;TR-HDC与原混凝土柱协同工作性能良好,加固后的混凝土柱的变形、承载力和耗能能力明显提高;增加纤维织物的层数对钢筋混凝土短柱的抗剪承载力提高幅度较小,但可大幅增强柱的耗能和变形能力;剪跨比较大时,更有利于发挥TR-HDC加固材料的力学性能.基于桁架-拱模型,提出TR-HDC加固钢筋混凝土短柱的抗剪承载力计算方法,计算结果较准确.

关键词：低周反复荷载纤维织物增强高延性混凝土加固 RC短柱抗剪承载力

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