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Chemical Research in Chinese Universities 2006年第6期22卷 803-807页

作者： SONG li-ming ZHU Tao WANG Qiu-sheng ZHANG Xiao li guo-wen Key Lab for Supramolecular Structure and Materials of Ministry of Education Jilin University Changchun 130012 P. R. China

A functional amphiphile, N^6 -myristoyl-9-[ 8-（ 1-trimethylamino） octyl ] adenine bromide （MTOAB）, was used to form coliposomes of phosphatidyleholine（PC）, PC/thymine, and PC/TOTB using sonication . The morphologies of the coliposomes were characterized using TEM （transmission electron microscopy）. The UV-Vis spectroscopic behavior of PC/MTOAB/thymine （molar ratio = 5： 1： 1 ） and PC/MTOAB/TOTB （molar ratio = 5： 1： 1 ） of coliposomal solutions showed that as a result of base pairing, absorption intensity showed a decrease at 263 nm with increase of time. The decrease of absorption intensity is ascribed to the hypochromic effect, which is because of the formation of hydrogen bonds between adenine and thymine in the coliposomes. The same effect was also observed for the mixture of aqueous PC/MTOAB liposomes and PC/TOTB liposomes after fusion, whereas the nocomplementary coliposomcs formed from PC/MTOAB and PC/TOTB did not show these spectroscopic changes. The molecular recognition through hydrogen interactions between adenine and thymine is very slow because of the possible occurrence of molecular lateral diffusion and exchange of amphiphile before recognition progresses in coliposomes. These results provide useful information for the design of supramolecular devices such as vesicles and liposomes,which can be used to mimic primitive recognition processes observed in biological systems.

关键词： Coliposomes Nueleobase Molecular recognition Amphiphile

Effect of temperature and stress on molecular structure and carbon monoxide generation of lignite from Kailuan mining area

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International Journal of Mining Science and Technology 2016年第3期26卷 437-441页

作者： Xiao Cangyan Wei Chongtao guo li wen Shen Jian Key Laboratory of Coalbed Methane Resources & Reservoir Formation Processes Ministry of Education School of Resources and Earth Science China University of Mining and Technology North China Institute of Aerospace Engineering

In order to analyze the origin of carbon monoxide(CO) in coal seams, stress–strain experiments under temperature of 50, 150 and 250 °C were conducted using lignite from Kailuan mining area. Fourier transform infrared spectroscopy and elemental analysis were carried out before and after deformation of the samples. The results indicated that CO generated at 150 and 250 °C; the gas component was mostly oxygen(O_2), with small amount of carbon dioxide(CO_2), methane(CH_4) and hydrogen(H_2). At 50 °C, O_2 and a little CO_2 were observed and no CO was found. The carbon content of the coal samples increased slightly after deformation, and the oxygen content, H/C ratio, and O/C ratio decreased. The molecular structure of coal displayed different evolution characteristics at various temperatures. At 50 and 150 °C, the falling off of side chains, broken of ether bond and directional realignment of the aliphatic chains resulting in the formation of long chains were the main performance of coal molecular structure evolution. While at 250 °C, the side chains fell off and short chains formed. Furthermore, at both 150 and 250 °C, condensed degree of aromatic ring increased. Under the action of temperature and pressure, CO forms in two *** first is that ether bond breaks, oxygen and carbon atoms combine together and forms CO, or O_2 forming in the broken of ether–oxygen bond leads to the oxidation of free radicals and resulting in the formation of CO. And the second is that CO derives from falling off of C=O group.

关键词： lignite Molecular structure Carbon monoxide generation Deformation Temperature

Effect of the Haoqinqingdan decoction on damp-heat syndrome in rats with influenza viral pneumonia

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Asian Pacific Journal of Tropical Medicine 2013年第8期6卷 653-657页

作者： Shi-Jin Zhang Zhuo Chen guo-wen li Bo-liang Wang Department of Traditional Chinese Medicine People's Hospital of Zhengzhou Pharmacy Department Cancer Hospital Affiliated to Zhengzhou University Department of Radiotherapy Tangdu Hospital The First Affiliated Hospital of Zhengzhou University Out-patient Department Tangdu Hospital The Second Affiliated Hospital of the Fourth Military Medical University

Objective: To investigate the effect of Chinese medicine prescription-Haoqinqingdan decoction on damp-heat syndrome in rats with influenza viral pneumonia and its influence on the immune function. Methods: A total of 48 Wistar rats were randomly divided into the normal control group, the damp-heat syndrome model group, the Haoqinqingdan decoction group (high, medium and low dose group) and the ribavirin group. The body temperature and weight of rats in each group were recorded after modeling. After treatment for 6 d, the concentration of T lymphocyte subgroup (CD3+ CD4+ , CD3+ CD8+ ) was determined by flow cytometry. The OD value of IFN毭/IL-4 was detected by double-antibody sandwich EliSA method, and its concentration was acquired through conversion. Results: After modeling, the temperature and weight of rats in each modeling group showed the increasing trend ( Pling group ( Plined significantly ( Plined CD4+ /CD8+ ratios can be observed in the low dose group and ribavirin group ( P<0.05). Moreover, the CD3+ CD4+ percentage of ribavirin group was lower than in the control group ( P<0.05). After treatment, the IFN-毭 and IFN-毭/ IL-4 levels in the peripheral blood of rats in the dampheat syndrome group were obviously higher than in the control group ( P<0.05). Conclusions: Compared with ribavirin, the high dose Haoqinqingdan decoction can improve the ratio of T lymphocyte subgroup and Th1/Th2 cell balance more effectively.

关键词： Haoqinqngdan decoction Ribavirin Damp-heat syndrome Influenza virus Wistar rat

Clinical Evaluation of Oral Fructus Bruceae Oil Combined with Radiotherapy for the Treatment of Esophageal Cancer＊

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Chinese Journal of Integrative Medicine 2011年第12期17卷 933-936页

作者： SHAN guo-yong ZHANG Song li guo-wen CHEN Yong-shun liU Xing-an WANG Jian-kun Department of Radiation Oncology Zhengzhou People＇s Hospital Zhengzhou （450053） China Department of Radiation Oncology Affiliated Hospital of Zhengzhou University Zhengzhou （450052） China

T Objective： To evaluate the therapeutic efficacy and side effects of oral Fructus bruceae oil combined with radiotherapy in the treatment of esophageal cancer. Methods： A total of 80 patients with esophageal cancer were equally and randomly divided into two groups. The patients in Group A were treated with radiotherapy （60-65 Gy, 6-7 weeks） and oral Fructus bruceae oil （20 mL, 3 times per day for 12 weeks）, while the patients in Group B were treated with radiotherapy alone. The short-term effect was evaluated by Response Evaluation Criteria in Solid Tumors （RECIST） and quality of life （QOL） was evaluated by the Kamofsky scoring （KFS）. The outcome measures included complete remission （CR） rate, partial remission （PR） rate, effective rate as CR＋PR, patients＇ QOL and adverse effects. Results： After 12-week treatment, the CR and CR＋PR were significantly higher in Group A than those in Group B （P〈0.05）. There was an improvement in esophageal obstruction of 67.5% and 60.0%, respectively, and in KFS of 84.6% and 43.9%, respectively, in Groups A and B. Conclusion： Oral medication with oral Fructus bruceae oil could effectively improve the efficacy of radiotherapy in esophageal cancer, including a reduction in esophageal obstruction, and also reduce the side effects of radiotherapy; thus it would be very promising for clinical application.

关键词： Fructus bruceae esophageal cancer radiotherapy Chinese medicine

Research on the influence of content of vitrinoid group and content of inert group to CO adsorption-proliferation quantity

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Journal of Coal Science & Engineering(China) 2009年第1期15卷 94-97页

作者： XIAO Cang-yan guo li-wen ZHENG Ning College of light Industry Hebei Polytechnic University Tangshan 063020 China College of Resource and Environment Hebei Polytechnic University Tangshan 063009 China

Dispersed coal was analyzed and rock experiment was conducted on four coalsof medium-low rank in the aspect of coal and rock configuration, which resulted in eightcoal samples mostly of the vitrinoid group or inert group. Then, an adsorption experimentof CO under different temperatures and pressures as well as a diffusion experiment undernormal temperature and pressure were conducted. The research results indicate that formedium-low rank coal, because the pore structure in the inert group is bigger than that inthe vitrinoid group, the influence on CO adsorption-proliferation of the inert group is biggerthan that in the vitrinoid group, and the adsorption quantity of the inert group is more susceptive. The difference of adsorption quantity between the two groups diminish along withthe improvement of coalification degree. The difference of adsorption quantity between thetwo groups shows no obvious change along with the change of temperature.

关键词： CO adsorption proliferation microstructure

Relation Between Cellular Senescence and liver Diseases

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Chinese Medical Sciences Journal 2016年第2期31卷 121-126页

作者： guo-wen li Xue-feng Yang Nian Fu Yan Ou-yang Kai Qing Department of Gastroenterology the Affiliated Nanhua Hospital of University of South China

Cellular senescence refers to a process that cellular proliferation and differentiation modulated by the multiple stimulating factors gradually decline. Aging cells present the irreversible stop of proliferation and differentiation and change in secretory function because the cell cycle of aging cells is steadily blocked at some point. It has have been shown that cellular senescence plays an important role in the occurrence and development of liver diseases. In this paper, we review the advances in relations between cellular senescence and liver diseases.

关键词： cellular senescence mechanism liver diseases liver fibrosis liver cancer

Organic light-Emitting Diodes Based on New Oxadiazole and Pyrazoline Derivatives

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Chinese Physics Letters 2000年第6期17卷 454-456页

作者： ZHANG Zhi-Ming ZHANG Rui-Feng WU Fang MA Yu-Guang li guo-wen TIAN wen-Jing SHEN Jia-Cong Key Laboratory for Supramolecular Structure and Spectra Jilin UniversityChangchun 130023

The bilayer heterojunction devices were fabricated successfully by using a novel oxadiazole derivative:2,2-(2,5-thiophenediyl)bis(5-(4-methyl)phenyl-1,3,4-oxadiazole)(T-OXD)as the electron-transporting layer(ETL)and a pyrazoline derivative:1-phenyl-3-(dimethylamino)styryl-5-(p-(dimethylamino)phenyl)pyrazoline(PDP)as the light-emitting layer and the hole-transporting *** emission at 500nm was derived from PDP *** comparison with the bilayer device of tris(8-hydroxyquinoline)aluminum(Alq)as the ETL,the luminous efficiency of the PDP/T-OXD heterojunction device was enhanced by 104 times.

关键词： layer derivative luminous

FLUORESCENCE　STUDIES　ON　SELF－ASSEMBliNG　BEHAVIOR　OF　AMPHIPHILES　WITH　NAPHALENE－1，5－DIOXY　GROUP

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Chinese Chemical Letters 1996年第8期7卷 735-736页

作者： guo wen li Ying Qiu liANG2(Institute of Theoretical Chemistry, Jilin University, Changchun, 130023)(Department of Chemistry, Nanjing University, Nanjing 210093) Institute of Theoretical Chemistry Jilin University Changchun 130023 Department of Chemistry Nanjing University Nanjing 210093

Fluorescene Spectra in dilute aqueous solution of a series of single chain amphiphileswith an interposed naphthalene-1,5-dioxy group were studied to elucidate the characteristic selfassembling behavior. which indicates the abrupt change in fluorescence intensity associated withphase transiton of gel to liquid crystal.

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Basic Features of Climate Change in North China during 1961-2010

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Advances in Climate Change Research 2013年第2期4卷 73-83页

作者： guo wen-li SHI Hong-Bo MA Jing-Jin ZHANG Ying-Juan WANG Ji SHU wen-Jun ZHANG Zi-Yin Beijing Regional Climate Center Beijing Meteorological Service

The spatial and temporal variations of some important near-surface climate parameters and extreme climate events in North China during 1961-2010 are analyzed by using 94 meteorological stations＇ data in the study area. Results show that the annual mean surface air temperature in North China increased at the rate of 0.36℃ per decade, higher than the national average in the same period. Increasing was particularly significant since the mid-1980s, with maximum increase in the middle and northeastern parts of Inner Mongolia. Increasing rate of the annual mean minimum temperature is much higher than that of the maximum temperature, which results in the decrease of the annual mean diurnal temperature range. Noticeable decrease is also observed in the frequency of cold wave. Annual precipitation shows a slight decreasing trend, with more pronounced decrease in southern Shanxi and eastern Hebei provinces, which is mainly represented as decreasing in contribution rates of rainstorm and heavy storm in flood-season （May to September）. During 1961 -2010, North China is characterized by a noticeable reduction in annual extreme precipitation, and an increase in high-temperature days over most parts, as well as more frequent droughts. There are remarkable reductions in annual sunshine duration and mean wind speed, associated with the most significant reduction of mean wind speed in midwestern and eastern parts of Inner Mongolia. Meanwhile, North China has experienced a noticeable decrease/increase in annual mean sanddust/haze days during the study period. However, there is no significant trend in fog days, except a pronounced decrease since the 1990s.

关键词： North China temperature precipitation extreme climate events

Fatigue life prediction of workpiece with 3D rough surface topography based on surface reconstruction technology

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Journal of Central South University 2018年第9期25卷 2069-2075页

作者： li guo-wen TANG Jin-yuan ZHOU Wei li lin State Key Laboratory of High Performance Complex Manufacturing Central South University Hunan Provincial Key Laboratory of High Efficiency and Precision Machining of Difficult-to-cut Materials Hunan University of Science and Technology

The fatigue performance of a workpiece depends on its surface *** traditional fatigue life prediction,the effect of surface quality is commonly accounted for by using empirical correction factors,which is imprecise when safety is of great *** surface quality,the surface topography is an important parameter,which introduces stress concentration that reduces the fatigue *** is not feasible to test the stress concentration of different surface *** the one hand,it is time-consuming and high-cost,and on the other hand,it cannot reflect the general statistical *** the help of surface reconstruction technology and interpolation method,a more efficient and economic approach is proposed,where FE simulation of workpiece with the reconstructed surface topography is used as a foundation for fatigue life *** relationship between surface roughness(Sa)and fatigue life of the workpiece is studied with the proposed approach.

关键词： fatigue life stress concentration surface reconstruction technology surface topography