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脑血管功能积分和改良弗明汉卒中风险积分预测效能对比研究

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中国慢性病预防与控制 2024年第5期32卷 349-352页

作者：刘广西王艳郭吉平顾桢茂李学松黄久仪上海市脑血管病防治研究所社区预防室上海200063

目的对比脑血管功能积分(CVFS)和改良弗明汉卒中风险积分量表(MFSP)评估10年首发卒中风险的效能,为首发卒中风险评估工具的选择提供参考。方法2003年4月,以整群抽样的方法在上海市奉贤区某社区建立了40岁及以上人群卒中危险因素研究队列... 详细信息

目的对比脑血管功能积分(CVFS)和改良弗明汉卒中风险积分量表(MFSP)评估10年首发卒中风险的效能,为首发卒中风险评估工具的选择提供参考。方法2003年4月,以整群抽样的方法在上海市奉贤区某社区建立了40岁及以上人群卒中危险因素研究队列,共计7489人纳入研究。以统一的调查表对卒中常见危险因素进行基线调查,同时进行脑血管功能指标检测和心电图检测。逐年随访卒中的发病情况,首发卒中作为观察终点,随访时间截至2014年12月31日。评估和比较CVFS和MFSP预测10年首发卒中风险的效能。采用SPSS 17.0软件进行趋势χ^(2)检验。结果7489名调查对象平均随访(10.6±1.5)年,随访期间共发生首发卒中225例。随着CVFS的降低和MFSP积分的升高,男女性首发卒中风险均呈上升趋势(P<0.01)。MFSP预测男性首发卒中的概率明显高于实际卒中发病率,预测的敏感度、特异度、受试者工作特征(ROC)曲线下面积(AUC)分别为97.0%、17.6%和0.757。女性MFSP积分值<15分者预测首发卒中的概率与实际发病率接近,但积分值≥15分者卒中的预测概率明显高于实际发病率,预测的敏感度、特异度、AUC分别为58.1%、78.3%和0.769。除男性31~40和0~10分段,CVFS预测男、女性首发卒中的概率与实际发病率比较接近。预测男性首发卒中的敏感度、特异度、AUC分别为56.4%、76.4%和0.682,女性分别为60.5%、70.9%和0.709。CVFS与MFSP预测男性卒中高危人群的符合率为39.5%,Kappa值为0.09,预测女性卒中高危人群的符合率为74.1%,Kappa值为0.34。结论CVFS预测男、女首发卒中风险与实际发病率接近,MFSP明显高估男性和高分值段女性国人首发卒中风险。

关键词：卒中风险评估脑血管功能积分弗明汉卒中风险积分量表

分布式配电网中短路越级跳闸故障定位及自愈方法

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自动化与仪器仪表 2024年第8期 311-315,320页

作者：汝石李双超孙杰国际平国网齐齐哈尔供电公司黑龙江齐齐哈尔161005 国网黑龙江省电力有限公司哈尔滨150001 北京国力电气科技有限公司北京100070

分布式电源(Distributed Generation,DG)的大量接入,导致分布式配电网中的电流分布和流动模式发生变化,原有的配电保护装置反应变慢,使得短路越级跳闸问题的检测难度增加。因此,提出分布式配电网短路越级跳闸故障检测及自愈方法。分析... 详细信息

分布式电源(Distributed Generation,DG)的大量接入,导致分布式配电网中的电流分布和流动模式发生变化,原有的配电保护装置反应变慢,使得短路越级跳闸问题的检测难度增加。因此,提出分布式配电网短路越级跳闸故障检测及自愈方法。分析不同类型和容量的DG、不同的接入点以及DG对配电网自动装置的影响;明确短路故障导致的越级跳闸问题的检测特征。基于电流差动原则和故障电流幅值比较原则,及时定位故障区域。采用短路速断闭锁技术快速响应故障,对短路故障区段进行粗定位,并将其闭锁;并对粗定位故障区段进行精准定位和隔离控制,使非故障区段的断路器合闸,恢复电力供应,以实现配电网的自愈。实验结果表明,所提方法能够防止配电网短路越级跳闸,且故障自愈的耗时短。

关键词：分布式配电网防短路越级跳闸故障自愈技术短路速断闭锁

基于衍生化3-氨基-2-恶唑烷酮的夹心酶联免疫分析

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食品科学 2024年第6期45卷 271-276页

作者：张世伟吴会玲周迎春王炳志杨星星杜业刚汤璐冯荣虎郭继平深圳市计量质量检测研究院广东深圳518000 深圳市易瑞生物技术股份有限公司广东深圳518000

建立一种3-氨基-2-恶唑烷酮(3-amino-2-oxazolidinone,AOZ)夹心免疫检测方法。通过1,6-己二醇连接2-硝基-4-羧基苯甲醛和生物素合成针对AOZ的新型衍生试剂。在样品前处理时加入衍生试剂可对AOZ进行衍生,衍生产率为89%。在酶标板上包被抗... 详细信息

建立一种3-氨基-2-恶唑烷酮(3-amino-2-oxazolidinone,AOZ)夹心免疫检测方法。通过1,6-己二醇连接2-硝基-4-羧基苯甲醛和生物素合成针对AOZ的新型衍生试剂。在样品前处理时加入衍生试剂可对AOZ进行衍生,衍生产率为89%。在酶标板上包被抗AOZ单克隆抗体并以辣根过氧化物酶标记的亲和素或抗生物素抗体作为第二结合物可实现AOZ的夹心酶联免疫吸附检测(enzyme-linked immunosorbnent assay,ELISA)。从实际应用的角度,得到双抗夹心和抗体-亲和素夹心模式下两个表位的极限距离,分别为12Å和13Å,理想距离分别为16Å和17Å。在双抗夹心和抗体-亲和素夹心模式下的检出限分别达到1.8 pg/mL和0.8 pg/mL(以AOZ质量浓度计),相对于竞争ELISA,其灵敏度最高提高了25倍。平均回收率为73%~85%,平均相对标准偏差为9.0%。

关键词： 3-氨基-2-恶唑烷酮夹心酶联免疫分析表位间隔距离辣根过氧化物酶标记亲和素

基于ADAMS的超长超宽梁架桥机行走系统仿真

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科技和产业 2024年第5期24卷 222-226页

作者：韩洪举王永淇郭吉平吴飞胡嫚贵州交通建设集团有限公司贵阳550001 西南大学工程技术学院重庆400715 重庆大学机械与运载工程学院重庆400044

随着公路桥梁施工需求的不断提升,超长超宽梁公路架桥机越来越多地应用在高速公路桥梁的架设施工过程中。针对一种宽度达10.9 m的超长超宽梁公路架桥机进行行走系统刚柔耦合仿真研究。通过对超长超宽梁公路架桥机的过跨过程进行步骤划分... 详细信息

随着公路桥梁施工需求的不断提升,超长超宽梁公路架桥机越来越多地应用在高速公路桥梁的架设施工过程中。针对一种宽度达10.9 m的超长超宽梁公路架桥机进行行走系统刚柔耦合仿真研究。通过对超长超宽梁公路架桥机的过跨过程进行步骤划分,并运用SolidWorks、ANSYS和ADAMS软件联合建立超长超宽梁公路架桥机行走系统的刚柔耦合虚拟样机模型并对其过跨过程进行仿真分析,得到架桥机行走系统主梁在过跨过程中的最大应力。通过分析主梁的应力情况得到主梁应力最大点发生在1号后支腿第二次前移过程中,应力最大值为162.4 MPa。该超长超宽梁公路架桥机行走系统刚柔耦合仿真可为后续改善施工规程、确定施工监测点、降低施工安全风险提供依据。

关键词：架桥机行走系统刚柔耦合虚拟样机

Sharing Thick and Thin Calling for Unity and Cooperation

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Peace 2020年第3期 32-41页

作者： guo jiping People’s Daily

We humans are battling COVID-19,a virus that has ravaged the world and has kept *** this fight,we have witnessed the efforts of governments,dedication of medical workers,exploration of scientists,and perseverance of the *** of different countries have come *** courage,resolve and compassion which lit the dark hour,we have confronted the disaster head *** virus will be *** will win this battle!

关键词： workers Unity disaster

The Promise of a Better Future for the World

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China Today 2015年第8期64卷 16-18页

作者： guo jiping People's Daily commentator.

TWO paintings,Interactive World and Common Homeland,hang in the China Hall of the UN Headquarters in New *** reflect,in UN Secretary General Ban Ki-moon’s opinion,China’s important role in the world’s peaceful development."In promoting mutually beneficial cooperation,we should raise awareness about human beings sharing a community of common destiny.A country should accom-

关键词：世界联合国秘书长中国

Schematic Road Network Map Progressive Generalization Based on Multiple Constraints

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Geo-Spatial Information Science 2008年第3期11卷 215-220页

作者： DONG Weihua guo Qingsheng LIU jiping Institute of Geography and Remote Sensing Beijing Normal University 19 Xinjiekouwai Street Beijing 100875 China.

Multiple constraints for schematic road network map cartographic design are analyzed and summarized. Based on this, a set of quantitative criteria are set up and a new road network generalization method including progressive selection and displacement is proposed. Furthermore, topological checking methods for road networks are researched. Based on these constraints, the points in a road network are classified, and a satisfactory and effective schematic map is designed in a con- crete experiment while maintaining topological consistency of the road network between the original and the schematic map

关键词： schematic map spatial cognition progressive cartographic generalization graphic simplification

Evaluation of the relative risk of stroke in patients with hypertension using cerebrovascular hemodynamic accumulative score

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Frontiers of Medicine 2007年第3期1卷 274-278页

作者： HUANG Jiuyi WANG Guiqing guo jiping CAO Yifeng WANG Yan YANG Yongju YU Xuehai Shanghai Institute of Cerebrovascular Disease Control Shanghai 201318China

The relative risk(RR)of stroke in patients with hypertension was evaluated by using synthetic index of cerebrovascular hemodynamics.A total of 7,371 patients with hypertension with ages i40 years were selected from a population-based cohort study of the risk factors for *** data on the baseline investigation of risk factors,the determination of cerebrovascular hemodynamic parameters(CVHP),and stroke follow-up were *** RR of stroke in patients with hypertension was evaluated by CVHP *** analysis indicated that hypertension,complicated by other risk factors,had significant statistical association with the onset of *** for stroke when hypertension complicated with decrease of hemodynamic scores,heart disease,cigarette smoking and alcohol consumption were 4.93(95%CI,3.26–7.45),1.90(95%CI,1.36–2.66),1.99(95%CI,1.42–2.79)and 1.73(95%CI,1.19–2.53)*** multivariate analysis,hemodynamic score,age,sex,cigarette smoking,family history of stroke and systolic blood pressure were selected by the Cox regression for inclusion in the final *** them,the RR of hemodynamic score was *** analysis of doseresponse relationships indicated that when the hemodynamic scores in patients with hypertension were lower than 75 points,the RR of stroke at 75,60,45,30 and 15 points were 2.85,4.43,4.54,5.40 and 9.88,*** risk of stroke in patients with hypertension is closely asso ciated with hemodynamic impairment and the hemodynamic score may be used for quantitative evaluation of relative risks of stroke.

关键词： hypertension stroke hemodynamic processes cohort studies

Identification, pathogenicity, and fungicide sensitivity of Eutiarosporella dactylidis associated with leaf blight on maize in China

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Journal of Integrative Agriculture 2024年第3期23卷 888-900页

作者： Cheng guo Xiaojie Zhang Baobao Wang Zhihuan Yang jiping Li Shengjun Xu Chunming Wang Zhijie guo Tianwang Zhou Liu Hong Xiaoming Wang Canxing Duan Institute of Plant Protection Gansu Academy of Agricultural SciencesLanzhou 730070China Pratacultural College Gansu Agricultural UniversityLanzhou 730070China Shijiazhuang Academy of Agriculture and Forestry Sciences Shijiazhuang 050050China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBejing 100081China

Maize(Zea mays L.) is an economically vital grain crop that is cultivated worldwide. In 2011, a maize foliar disease was detected in Lingtai and Lintao counties in Gansu Province, China. The characteristic signs and symptoms of this disease include irregular chlorotic lesions on the tips and edges of infected leaves and black punctate fruiting bodies in dead leaf tissues. Given favourable environmental conditions, this disease spread to areas surrounding Gansu. In this study, infected leaves were collected from Gansu and Ningxia Hui Autonomous Region between 2018and 2020 to identify the disease-causing pathogen. Based on morphological features, pathogenicity tests, and multilocus phylogenetic analysis involving internal transcribed spacer(ITS), 18S small subunit rDNA(SSU), 28S large subunit rDNA(LSU), translation elongation factor 1-alpha(TEF), and β-tubulin(TUB) sequences, Eutiarosporella dactylidis was identified as the causative pathogen of this newly discovered leaf blight. Furthermore, an in vitro bioassay was conducted on representative strains using six fungicides, and both fludioxonil and carbendazim were found to significantly inhibit the mycelial growth of E. dactylidis. The results of this study provide a reference for the detection and management of Eutiarosporella leaf blight.

关键词： maize leaf blight morphology molecular phylogeny Eutiarosporella dactylidis fungicide sensitivity