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Protective Mechanism of Cordyceps sinensis Treatment on Acute Kidney Injury-Induced Acute Lung Injury through AMPK/mTOR Signaling Pathway

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Chinese Journal of Integrative Medicine 2023年第10期29卷 875-884页

作者： WANG Ruo-lin LIU Shu-hua SHEN Si-heng JIAN Lu-yong YUAN Qi guo hua-hui huaNG Jia-sheng CHEN Peng-hui huaNG Ren-fa Nephropathy Department Shenzhen Hospital(Futian)of Guangzhou University of Chinese MedicineShenzhenGuangdong Province518034China The Third Clinical Medical School Guangzhou University of Chinese MedicineGuangzhou510006China

Objective: To investigate protective effect of Cordyceps sinensis(CS) through autophagyassociated adenosine monophosphate-activated protein kinase(AMPK)/mammalian target of rapamycin(mTOR) signaling pathway in acute kidney injury(AKI)-induced acute lung injury(ALI). Methods: Forty-eight male Sprague-Dawley rats were divided into 4 groups according to a random number table, including the normal saline(NS)-treated sham group(sham group), NS-treated ischemia reperfusion injury(IRI) group(IRI group), and low-(5 g/kg·d) and high-dose(10 g/kg·d) CS-treated IRI groups(CS1 and CS2 groups), 12 rats in each group. Nephrectomy of the right kidney was performed on the IRI rat model that was subjected to 60 min of left renal pedicle occlusion followed by 12, 24, 48, and 72 h of reperfusion. The wet-to-dry(W/D) ratio of lung, levels of serum creatinine(Scr), blood urea nitrogen(BUN), inflammatory cytokines such as interleukin-βand tumor necrosis factor-α, and biomarkers of oxidative stress such as superoxide dismutase, malonaldehyde(MDA) and myeloperoxidase(MPO), were assayed. Histological examinations were conducted to determine damage of tissues in the kidney and lung. The protein expressions of light chain 3 Ⅱ/light chain 3 Ⅰ(LC3-Ⅱ/LC3-Ⅰ), uncoordinated-51-like kinase 1(ULK1), P62, AMPK and mTOR were measured by Western blot and immunohistochemistry, respectively. Results: The renal IRI induced pulmonary injury following AKI,resulting in significant increases in W/D ratio of lung, and the levels of Scr, BUN, inflammatory cytokines, MDA and MPO(P<0.01);all of these were reduced in the CS groups(P<0.05 or P<0.01). Compared with the IRI groups, the expression levels of P62 and mTOR were significantly lower(P<0.05 or P<0.01), while those of LC3-Ⅱ/LC3-Ⅰ, ULK1, and AMPK were significantly higher in the CS2 group(P<0.05 or P<0.01). Conclusion:CS had a potential in treating lung injury following renal IRI through activation of the autophagy-related AMPK/mTOR signaling pathway in AKI-i

关键词： autophagy ischemic reperfusion injury acute kidney injury acute lung injury Cordyceps sinensis Chinese medicine

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Characterization and Wettability of ZnO Film Prepared by Chemical Etching Method

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Chemical Research in Chinese Universities 2013年第2期29卷 333-337页

作者： guo hua-xi JIA hui-ying ZENG Jian-bo CONG Qian REN Lu-quan Key Laboratory of Bionic Engineering Ministry of Education Jilin University Changchun 130025 P. R. China

ZnO thin films were prepared by a chemical etching method and their wettability was investigated. The structure and surface composition structure were characterized by means of scanning electron microscopy, X-ray photoelectronic spectrometry（XPS）, X-ray diffraction（XRD） and Raman spectrometry. These analyses reveal that the etched films were large-scale micro-nanohierarchical structures composed of a Zn core and a ZnO coating. Superhy- drophobic surfaces with water contact angles of over 150~ were obtained by n-octadecanethiol（ODT） modification. The XPS and Raman results indicate that ODT molecules were bound to the ZnO surface with the S head group by forming Zn--S bond.

关键词： ZnO Chemical etching Micro-nanostructure Raman spectrometry Wettability

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THE ISOSTATIC DATUM FOR STUDYING OF THE SEA LEVEL CHANGES ALONG THE COAST OF CHINA

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地震地质 1991年第1期 8-14页

作者： huang Li-ren, Yang guo-hua and Hu hui-min(Geodetic Brigade, S. S. B. Tianjin 300180)

Relative sea level change can be derived from tide records. In order to study the general sea level change along the coast of China, it is necessary to make a unified reduction for all the results obtained from various tide stations. A so-called isostatic datum of vertical movement of thecoastal land hasbeen suggested as a basis of the unified reduction in this paper, established by useof precise releveling data completed between 50’s and 80’*** vertical movement velocities relative to the datum at the bench marks of 15 tide stations have been calculated. These velocities provide a base for the reduction.

关键词： sea level change Isostatic datum Leveling

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Effects of partial portal vein arterialization on the hilar bile duct in a rat model

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Hepatobiliary & Pancreatic Diseases International 2011年第5期10卷 533-538页

作者： Shao-hua guo, Chong-hui Li,Yong-Liang Chen, Jian-Ning Song,Ai-Qun Zhang and Cheng Zhou Department of Hepatobiliary Surgery (guo SH, Li CH, Chen YL, Song JN, Zhang AQ and Zhou C) and Department of Surgical Oncology (guo SH), General Hospital of PLA, Beijing 100853, China [a] Department of Hepatobiliary Surgery General Hospital of PLA Beijing 100853 China [b] Department of Surgical Oncology General Hospital of PLA Beijing 100853 China

BACKGROUND: Liver revascularization is frequently required during the enlarged radical operation for hilar cholangio carcinoma involving the hepatic artery. Researchers have carried out a number of experiments applying partial porta vein arterialization (PVA) in clinical practice. In this study we aimed to establish a theoretical basis for clinical application o partial PVA and to investigate the effects of partial PVA on ra hilar bile duct and hepatic functions. METHODS: Thirty rats were randomly and equally assigned into 3 groups: control (group A), hepatic artery ligation+bile duct recanalization (group B), and partial PVA+bile duc recanalization (group C). Proliferation and apoptosis o rat hilar bile duct epithelial cells, arteriolar counts of the peribiliary plexus (PBP) of the bile duct wall, changes in serum biochemistry, and pathologic changes in the bile duc were assessed 1 month after operation. RESULTS: The proliferation of hilar bile duct epithelial cells in group B was greater than in groups A and C (P0.05), but the coun was lower in group B than in group A (P<0.01). No statistically significant differences in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and albumin were found in the 3 groups. The gamma-glutamyltransferase value was higher in group B than in groups A and C (P<0.01) The hepatic tissues of groups A and C showed no significan abnormality. Chronic inflammatory changes in the hilar bile duct walls were observed only in group B. CONCLUSION: Partial PVA can restore the arterial blood supply of the hilar bile duct and significantly extenuate the injury to hilar bile duct epithelial cells resulting from hepatic artery ligation.

关键词： portal vein arterialization biliary epithelial cells peribiliary plexus

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预应力锚索基本试验的案例研究

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人民黄河 2012年第9期34卷 124-126页

作者：华国辉三峡大学三峡库区地质灾害教育部重点实验室湖北宜昌443002

高边坡预应力锚索防护工程设计的可靠性直接影响到高边坡的安全和稳定。以湖北省巴乐县某高切坡防护工程为例,使用与实例的实际情况相同的钢绞线制成锚索,安装后进行基本试验,最大试验荷载为钢绞线抗拉强度标准值的80%,检测预应力锚索... 详细信息

高边坡预应力锚索防护工程设计的可靠性直接影响到高边坡的安全和稳定。以湖北省巴乐县某高切坡防护工程为例,使用与实例的实际情况相同的钢绞线制成锚索,安装后进行基本试验,最大试验荷载为钢绞线抗拉强度标准值的80%,检测预应力锚索设计的合理性。试验结果表明,在各级荷载作用下各试验锚索的锚头总弹性位移均满足要求,当施加拉力达到最大试验荷载1 034 kN时,预应力锚索均没有发生破坏,从而验证了该实例600 kN级预应力锚索设计的正确性。

关键词：预应力锚索基本试验伸长量弹性位移承载能力案例研究

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陕甘川豫区试小麦品种对小麦条锈菌流行小种抗性的聚类分析

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麦类作物学报 2008年第2期28卷 349-353页

作者：李海英华国辉陕西省畜牧兽医总站陕西西安 710014 陕西省宝鸡市农业于部学校陕西宝鸡 721006

为弄清中国小麦条锈病主要流行区后备小麦品种的抗锈性,选用6个条锈菌流行小种,对陕、甘、川、豫四省近年来培育的后备小麦品种进行苗期鉴定,并进行了聚类分析。供试品种对中国条锈菌优势种群的抗性总体表现为:四川省后备品种总体抗锈... 详细信息

为弄清中国小麦条锈病主要流行区后备小麦品种的抗锈性,选用6个条锈菌流行小种,对陕、甘、川、豫四省近年来培育的后备小麦品种进行苗期鉴定,并进行了聚类分析。供试品种对中国条锈菌优势种群的抗性总体表现为:四川省后备品种总体抗锈性最强,对供试菌系全免疫的品种占80.82%;陕西省和甘肃省次之,对供试菌系全免疫的品种分别为52.73%和50.00%;从抗性类型和分布来看,陕西省后备品种抗性分化明显,中间类型少,说明陕西省后备品种所含有的抗锈基因比较单一,而甘肃省品种的抗性类型分布比较均匀,表明甘肃省后备品种中所含的抗病基因类型复杂,这可能与甘肃省近年来重视抗源多样化育种有关。

关键词：小麦条锈菌抗条锈性聚类分析

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CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang guo-Cui Mao hui-Lin Jiang Bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

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Spaceflight alters the gene expression profile of cervical cancer cells

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Chinese Journal of Cancer 2011年第12期30卷 842-852页

作者： Zhi-Jie Zhang Yong-Qing Tong Jia-Jia Wang Cheng Yang guo-hua Zhou Yue-hui Li Ping-Li Xie Jin-Yue Hu Guan-Cheng Li Cancer Research Inst tute Xiangya Schoo of Med c neCentral South University Changsha Hunan 410078 P. R. China

Our previous study revealed that spaceflight induced biological changes in human cervical carcinoma Caski cells. Here, we report that 48A9 cells, which were subcloned from Caski cells, experienced significant growth suppression and exhibited low tumorigenic ability after spaceflight. To further understand the potential mechanism at the transcriptional level, we compared gene expression between 48A9 cells and ground control Caski cells with suppression subtractive hybridization (SSH) and reverse Northern blotting methods, and analyzed the relative gene network and molecular functions with the Ingenuity Pathways Analysis (IPA) program. We found 5 genes, SUB1, SGEF, MALAT-1, MYL6, and MT-CO2, to be up-regulated and identified 3 new cDNAs, termed B4, B5, and C4, in 48A9 cells. In addition, we also identified the two most significant gene networks to indicate the function of these genes using the IPA program. To our knowledge, our results show for the first time that spaceflight can reduce the growth of tumor cells, and we also provide a new model for oncogenesis study.

关键词：基因表达谱航天飞行癌细胞宫颈癌 Northern 抑制性消减杂交生长抑制基因网络

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几种金属基板上冷喷涂铜涂层的试验与模拟

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材料热处理学报 2009年第6期30卷 158-163页

作者：郭辉华周香林巫湘坤崔华刘敬春张济山北京科技大学新金属材料国家重点实验室北京100083 北京科技大学材料科学与工程学院北京100083

采用自主研制的冷喷涂设备在三种典型基板上进行喷涂试验,相同的工艺参数下,在铜和铝基板上得到良好的铜涂层,而在钢基板上则没有沉积。实验结果表明:涂层与基板界面、涂层内部颗粒界面结合良好,铜涂层组织致密,显微硬度高达150HV0.1;... 详细信息

采用自主研制的冷喷涂设备在三种典型基板上进行喷涂试验,相同的工艺参数下,在铜和铝基板上得到良好的铜涂层,而在钢基板上则没有沉积。实验结果表明:涂层与基板界面、涂层内部颗粒界面结合良好,铜涂层组织致密,显微硬度高达150HV0.1;从涂层表面形貌扫描电镜(SEM)照片中可以观察到射流状的金属,说明颗粒发生了巨大变形,经计算知颗粒在碰撞中压缩率达69%;粉末和涂层的X射线衍射(XRD)结果表明铜粉末在冷喷涂过程中没有发生氧化。同时,数值模拟了铜颗粒与三种基板的碰撞过程,讨论了形成有效结合的判断准则,根据该准则,计算出铜颗粒在铜、铝、钢基板上的临界沉积速度分别为600m/s,500m/s,800m/s,从而解释了铜颗粒在三种基板上不同的沉积行为。

关键词：冷喷涂铜涂层显微结构碰撞模拟

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ImSpiRE: image feature-aided spatial resolution enhancement method

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Science China Life Sciences 2025年第1期 272-283页

作者： Yuwei hua Yizhi Zhang Zhenming guo Shan Bian Yong Zhang State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center Institute for Regenerative MedicineDepartment of NeurosurgeryShanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji University

The resolution of most spatially resolved transcriptomic technologies usually cannot attain the single-cell level, limiting their applications in biological discoveries. Here, we introduce ImSpiRE, an image feature-aided spatial resolution enhancement method for in situ capturing spatial transcriptome. Taking the information stored in histological images, ImSpiRE solves an optimal transport problem to redistribute the expression profiles of spots to construct new transcriptional profiles with enhanced resolution, together with extending the gene expression profiles into unmeasured regions. Applications to multiple datasets confirm that ImSpiRE can enhance spatial resolution to the subspot level while contributing to the discovery of tissue domains, signaling communication patterns, and spatiotemporal characterization.

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