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Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin

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Science China(Life Sciences) 2024年第6期67卷 1226-1241页

作者： Zhengyang guo Jiaqi Huang Xiao Huo Chen Huang Xiaotong Yu Yan Sun Yanfang Li Tianhui He hongyan guo Jianling Yang Lixiang Xue Cancer Center of Peking University Third Hospital Beijing 100191China Center of Basic Medical Research Institute of Medical Innovation and ResearchPeking University Third HospitalBeijing 100191China Peking University Third Hospital Cancer Center Department of Radiation OncologyPeking University Third HospitalBeijing 100191China Department of Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China

Ovarian cancer is the most lethal and aggressive gynecological cancer with a high recurrence rate and is often diagnosed late.In ovarian cancer,multiple metabolic enzymes of lipid metabolism are abnormally expressed,resulting in metabolism disorder.As a characteristic pathway in polyunsaturated fatty acid(PUFA)metabolism,arachidonic acid(AA)metabolism is disturbed in ovarian cancer.Therefore,we established a 10-gene signature model to evaluate the prognostic risk of PUFA-related genes.This 10-gene signature has strong robustness and can play a stable predictive role in datasets of various platforms(TCGA,ICGC,and GSE17260).The high association between the risk subgroups and clinical characteristics indicated a good performance of the model.Our data further indicated that the high expression of LTA4H was positively correlated with poor prognosis in ovarian cancer.Deficiency of LTA4H enhanced sensitivity to Cisplatin and modified the characteristics of immune cell infiltration in ovarian cancer.Additionally,our results indicate that CCL5 was involved in the aberrant metabolism of the AA/LTA4H axis,which contributes to the reduction of tumor-infiltrating CD8+T cells and immune escape in ovarian cancer.These findings provide new insights into the prognosis and potential target of LTA4H/CCL5 in treating ovarian cancer.

关键词： ovarian cancer polyunsaturated fatty acids prognostic risk model LTA4H tumor immunity CCL5

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Electrode particulate materials for advanced rechargeable batteries:A review

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Particuology 2024年第3期86卷 160-181页

作者： Mingyang Ma Miao Du Yan Liu hongyan Lü Jialin Yang Zelin Hao Jinzhi guo Xinglong Wu MOE Key Laboratory for UV Light-Emitting Materials and Technology Northeast Normal UniversityChangchunJilin130024China Department of Chemistry Northeast Normal UniversityChangchunJilin130024China

The demand for large-scale energy storage is increasing due to the decreasing non-renewable resources and deteriorating environmental pollution.Developing rechargeable batteries with high energy density and long cycle performance is an ideal choice to meet the demand of energy storage system.The development of excellent electrode particles is of great significance in the commercialization of nextgeneration batteries.The ideal electrode particles should balance raw material reserves,electrochemical performance,price and environmental protection.Among them,the development of electrode particulate materials with excellent electrochemical properties is the top priority at present.In this review,the typical researches of electrode materials are summarized in terms of crystal structure,morphology,pore structure,surface and interface regulation.Firstly,the structural characteristics and improvement methods of transition metal oxides,polyanionic compounds,Prussian blue and their analogues are introduced.Then,the different effects of particulate morphology,pore,surface and interface structure on the performance of electrode materials are discussed.For designing high-performance electrode materials,preparation route should be set according to the particle properties of the materials and the synergistic effect of various optimization methods should be adopted.At the same time,in addition to the electrode materials,other components of the rechargeable batteries,such as current collector,separator and electrolytes,should be optimized to improve the overall performance of the batteries.This review would provide important guiding principle for designing high-performance electrode particulate materials.

关键词： Particulate properties Electrode materials Rechargeable batteries

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A Comprehensive Overview of CFN From a Commonsense Perspective

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Machine Intelligence Research 2024年第2期21卷 239-256页

作者： Ru Li Yunxiao Zhao Zhiqiang Wang Xuefeng Su Shaoru guo Yong Guan Xiaoqi Han hongyan Zhao Key Laboratory of Computational Intelligence and Chinese Information Processing of Ministry of Education School of Computer and Information TechnologyShanxi UniversityTaiyuan 030006China

Chinese FrameNet(CFN)is a scenario commonsense knowledge base(CKB)that plays an important role in research on Chinese language understanding.It is based on the theory of frame semantics and English FrameNet(FN).The CFN knowledge base contains a wealth of scenario commonsense knowledge,including frames,frame elements,and frame relations,as well as annotated instances with rich scenario-related labels on Chinese sentences and discourses.In this paper,we conduct a comprehensive overview of CFN from a commonsense perspective,covering topics such as scenario commonsense representation,CFN resources,and its applications.We also summarize recent breakthroughs and identify future research directions.First,we introduce the concept of scenario commonsense,including its definitions,examples,and representation methods,with a focus on the relationship between scenario commonsense and the frame concept in CFN.In addition,we provide a comprehensive overview of CFN resources and their applications,highlighting the newly proposed frame-based discourse representation and a human-machine collaboration framework for expanding the CFN corpus.Furthermore,we explore emerging topics such as expanding the CFN resource,improving the interpretability of machine reading comprehension,and using scenario CKBs for text generation.

关键词： Chinese FrameNet(CFN) commonsense scenario commonsense frame knowledge

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Protein crystallization with DNA templates

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Particuology 2024年第3期86卷 262-268页

作者： Bo Zhang Jia Yu Zhe Pu Wenhui guo Ruoqi Yang Yu Wen Zhijiang Rong Hui Wang Xiaoli Wu Bo Wang hongyan Sun School of Environment and Resources Taiyuan University of Science and TechnologyTaiyuan030024China School of Chemical Engineering and Technology Taiyuan University of Science and TechnologyTaiyuan030024China

Protein crystallization plays a significant role in three-dimensional structural analysis and protein pu-rification.It is important to increase the crystallization efficiency,which is possible by adding hetero-geneous templates in crystallization systems.DNA is biologically compatible and artificially designable polymer,which is easy to extract.In this study,single-and double-stranded DNA of precise sequences were designed and used as templates to promote protein crystallization of lysozyme and catalase.In-fluence of DNA,single-stranded DNA with 10,20,40 bases and double-stranded DNA with 10,20,40 base pairs,were investigated.The success rate of obtaining crystals of lysozyme and catalase in equal period was significantly improved with the addition of DNA comparing without templates added.Double-stranded DNA led to higher nucleation rate than that with single-stranded DNA.The promotion of nucleation was more obvious at low concentration of protein solution and with longer chain DNA templates.Crystal number and crystallization rate was enhanced with addition of long double-stranded DNA templates.All the results confirm that DNA is an effective polymer additive to enhance protein crystallization,especially for the application of the scarce protein crystallization.

关键词： DNA Polymer Additive Protein Crystallization

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A Bifunctional-Blocker-Aided Hybridization Chain Reaction Lighting-Up Self-calibrating Nanocluster Fluorescence for Reliable Nucleic Acid Detection

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Journal of Analysis and Testing 2024年第2期8卷 160-169页

作者： Dan Zhang guobao Zhou hongyan Yang Yi Wang Lijun Shen Yuxuan Qiu Lei Li Longhua guo College of Chemistry and Materials Science Zhejiang Normal UniversityJinhua321004China Jiaxing Key Laboratory of Molecular Recognition and Sensing College of BiologicalChemical Sciences and EngineeringJiaxing UniversityJiaxing314001China College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou314000China

In this work,we proposed a ratiometric silver nanoclusters(AgNCs)fluorescent assay by designing a bifunctional-blockeraided hybridization chain reaction(HCR).Hairpin probe 1(HP1)containing two special DNA fragments(5′-CAC CGC T-3′and 5′-ATT TGC CTT TTG GGG ACG GATA-3′)at two terminals creates a red-emitting AgNC nucleation sequence(rNS,5′-CAC CGC TAT TTG CCT TTT GGG GAC GGATA-3′).We found that the presence of a toehold fragment(5′-TGCCC-3′)in HP1 could silence the rNS.Upon the addition of a target nucleic acid,HCR of HP1 and hairpin probe 2(HP2)could be initiated,resulting in the formation of long chain of DNA duplexes with multibranched rNS.As the toehold fragment in HP1participated in generating duplexes,a strong emission of rNS-templated AgNCs was observed at 670 nm.More significantly,a bifunctional blocker was introduced not only to reduce the background red-emitting fluorescence but also to play as an internal green-emitting AgNCs nucleation sequence.On the one hand,the blocker could increase the signal-to-noise-ratio of the constructed biosensor,and on the other hand,the blocker also helped to prepare ratiometric HCR-AgNCs assay with self-calibrating ability to strengthen its reproducibility.Compared with the traditional HCR-AgNCs sensors,the developed ratiometric assay based on the bifunctional-blocker-aided HCR has higher reliability,which is important for the fabrication of biosensors in various fields for practical biosensing applications.

关键词： Ratiometric fluorescence Hybridization chain reaction Silver nanocluster Biosensor Bifunctional blocker

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The application and perspective of NMR and MS based strategies for functional compounds mining in medicinal and dietary plants

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Food Science and Human Wellness 2024年

作者： Bodou Zhang Sheng Li Zhenzhen Liang Yinling Wei Jing Dong hongyan Wen Lingli guo Xiaojiang Hao Yu Zhang University of Chinese Academy of Sciences State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences

Medicinal and dietary plants provide numerous nutritional and functional compounds and also have various potential health benefits to humanity. The specific and efficient techniques for accurate identification of nutritional compounds and functional metabolites is crucial for the development of functional foods from medicinal and dietary plants. Nuclear magnetic resonance (NMR) and mass spectrometry (MS) are indispensable and essential technologies that provide an unsurpassed wealth of untargeted identification， quantitative and qualitative analysis， and structural information in the study of food and plant products. In the past decade， the rapid development of modern analytical technology has led to the emergence of new approaches and strategies for natural products discovery. Especially the application of novel NMR- and MS-based identification and dereplication strategies aided by artificial intelligence and machine learning algorithms have brought about a significant shift in the natural products discovery process. These developments and changes in the natural products filed have given us insights into how to accurately target and mining nutritional， functional， and bioactive compounds. Thus， we have summarized recent research on novel NMR and MS based strategies and methods focusing on functional compounds， accurate identification and efficient discovery mainly in medicinal and dietary plants. This review could provide a comprehensive perspective for a better understanding of novel strategies and methods based on NMR and MS technologies， which could provide valuable insights and ideas for functional compounds mining.

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Elevated Atmospheric CO_(2)Reduced Antibiotics Accumulation in Rice Grains and Soil ARGs Abundance in Multiple Antibiotics-contaminated Paddy Fields

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Chemical Research in Chinese Universities 2023年第3期39卷 455-464页

作者： WANG Yabo XU Meiling WANG Xiaojie AI Fuxun DU Wenchao YIN Ying JI Rong guo hongyan State Key Laboratory of Pollution Control and Resource Reuse School of EnvironmentNanjing UniversityNanjing210023China Joint International Research Centre for Critical Zone Science-University of Leeds and Nanjing University Nanjing UniversityNanjing210023China School of Environment Nanjing Normal UniversityNanjing210036China College of Environmental Science and Engineering Yangzhou UniversityYangzhou225127China

Antibiotic resistance genes(ARGs)as new pollutants have become a global environmental pollution problem in recent years.Elevated atmospheric CO_(2) is one of the major factors affecting global climate change.But,the impacts of elevated CO_(2) on soil ARGs in multiple antibiotics-contaminated paddy soils are largely unknown.In this study,six antibiotics including sulfadiazine(SDZ),sulfamethoxazole(SMZ),tetracycline(TC),oxytetracycline(OTC),enrofloxacin(ENR),and ciprofloxacin(CIP)were selected to investigate their combined effects on rice biomass,antibiotics accumulation,soil bacterial community and ARGs under elevated CO_(2) levels.Results showed that elevated CO_(2) significantly reduced the accumulation of SMZ,OTC,ENR,and CIP in rice grains by 18.98%,20.07%,41.73%,and 44.25%,respectively.Elevated CO_(2) could affect soil microbialβ-diversity,and tend to reduce the microbial functions of human diseases,organismal systems,and genetic information processing.In addition,elevated CO_(2) significantly decreased the abundance of sulfonamide ARGs,tetracycline ARGs,and quinolone ARGs by 19.59%,18.58%,and 28.96%,respectively,while increased that of multidrug ARGs by 11.54%.Overall,this study emphasized that elevated CO_(2) may mitigate the threat of antibiotics contamination to rice food security but aggravate the environmental risk of multidrug ARGs in soil,contributing to a better understanding of the consequences of elevated CO_(2) levels on food security and soil ecological health in multiple antibiotics-contaminated paddy fields.

关键词： Antibiotics Antibiotic resistance gene(ARG) Bacterial community Elevated CO_(2) Rice

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lncRNA MAFG-AS1靶向miR-3180-3p调控口腔鳞癌HSC4细胞增殖和凋亡

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中国免疫学杂志 2024年第4期40卷 761-766页

作者：吴福焱郭红燕聊城市第四人民医院口腔科聊城252000

目的:探讨长链非编码RNA(lncRNA)MAFG反义RNA1(MAFG-AS1)靶向miR-3180-3p对口腔鳞癌细胞增殖和凋亡的影响。方法:实时定量PCR检测口腔鳞癌组织和对应正常黏膜中MAFG-AS1和miR-3180-3p表达。以口腔鳞癌细胞HSC4为研究对象,分别构建干扰MA... 详细信息

目的:探讨长链非编码RNA(lncRNA)MAFG反义RNA1(MAFG-AS1)靶向miR-3180-3p对口腔鳞癌细胞增殖和凋亡的影响。方法:实时定量PCR检测口腔鳞癌组织和对应正常黏膜中MAFG-AS1和miR-3180-3p表达。以口腔鳞癌细胞HSC4为研究对象,分别构建干扰MAFG-AS1、过表达miR-3180-3p或抑制miR-3180-3p表达的口腔鳞癌细胞株,CCK-8、平板克隆实验、流式细胞术、蛋白印迹法检测细胞活力、克隆形成数、凋亡率及cleaved-caspase 3、cleaved-caspase 9表达。荧光素酶报告实验验证MAFG-AS1和miR-3180-3p的靶向关系。结果:与正常黏膜比较,口腔鳞癌组织MAFG-AS1表达显著升高(P<0.05),miR-3180-3p表达显著降低(P<0.05)。干扰MAFG-AS1或过表达miR-3180-3p均可降低HSC4细胞活力和克隆形成数(P<0.05),促进细胞凋亡(P<0.05),上调cleaved-caspase 3和cleaved-caspase 9蛋白表达(P<0.05)。miR-3180-3p是MAFG-AS1的直接靶点,MAFG-AS1负调控miR-3180-3p表达。抑制miR-3180-3p可增加HSC4细胞活力和克隆形成数(P<0.05),抑制细胞凋亡(P<0.05),下调cleaved-caspase 3和cleaved-caspase 9蛋白表达(P<0.05),进而削弱干扰MAFG-AS1对HSC4细胞的增殖抑制和凋亡促进作用(P<0.05)。结论:干扰MAFG-AS1通过上调miR-3180-3p表达抑制口腔鳞癌HSC4细胞增殖,促进细胞凋亡。

关键词： MAFG-AS1 口腔鳞癌 miR-3180-3p HSC4细胞细胞增殖凋亡

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基于自适应局部邻域条件下的点云匹配

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光学精密工程 2024年第10期32卷 1606-1621页

作者：李晋儒王晋郭松涛索红燕山西省煤炭地质物探测绘院有限公司山西晋中030600 山东科技大学测绘空间信息学院山东青岛266590 中国人民解放军战略支援部队信息工程大学地理空间信息学院河南郑州450001

为了应对传统迭代最近点(ICP)算法在处理复杂点云空间特征时,面临噪声干扰和数据缺失等问题导致收敛速度缓慢、配准精度不高以及鲁棒性较差等问题,本文提出了一种基于自适应局部邻域条件下的点云匹配算法。首先,采用体素网格滤波对数据... 详细信息

为了应对传统迭代最近点(ICP)算法在处理复杂点云空间特征时,面临噪声干扰和数据缺失等问题导致收敛速度缓慢、配准精度不高以及鲁棒性较差等问题,本文提出了一种基于自适应局部邻域条件下的点云匹配算法。首先,采用体素网格滤波对数据进行预处理,根据不同半径邻域内邻近点的分布情况,定义邻域表面的弯曲程度,在此基础上,充分考虑到法向量分布和邻域曲率特征,从而得到更精确的特征点提取;其次,通过运用最小二乘曲面拟合方法,进一步提取出邻域曲率变化最为显著的特征点,采用快速点特征直方图(FPFH)对特征点进行描述,并通过设定距离阈值的采样一致性算法来匹配相似的特征点对,计算出关键的坐标转换参数,完成初始配准。最后,利用线性最小二乘优化点到面的ICP算法,以实现更精确的配准结果。通过一系列实验对比发现相较于现有的几种配准算法(ICP,SAC-IA+ICP,K4PCS+ICP),在存在噪声干扰和数据缺失的情况下,所提方法的配准准确度平均提高45%,配准速度平均提高38%,充分验证了该方法在应对大数据量、低重叠率点云配准方面具备出色的稳健性能。

关键词：点云匹配邻域法向量快速点特征直方图迭代最近点

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耐低温菌固定化涂层电极处理印染废水的研究

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水处理技术 2024年第3期50卷 103-107页

作者：郭洪丹马红艳天津科技大学化工与材料学院天津滨海新区300457

通过制备固定化涂层电极,将固定化技术和电化学技术结合,双重强化了耐低温菌处理印染废水的能力。对固定化涂层电极的性能进行了研究,对比了不同处理方式处理模拟印染废水的能力。结果表明:固定化涂层材料具有较好的机械强度,压缩应变达... 详细信息

通过制备固定化涂层电极,将固定化技术和电化学技术结合,双重强化了耐低温菌处理印染废水的能力。对固定化涂层电极的性能进行了研究,对比了不同处理方式处理模拟印染废水的能力。结果表明:固定化涂层材料具有较好的机械强度,压缩应变达95%以上,孔隙率为81.86%,溶胀率为302.76%;固定化涂层电极具有较好的电催化活性和较低的能耗,电极寿命是无涂层电极的2.17倍;固定化涂层电极电化学技术处理印染废水降解能力高于其他处理方式,脱色率为95.76%,化学需氧量(COD)去除率为84.16%,增强了菌株的降解能力,是一种有效的处理模拟印染废水的技术。

关键词：涂层电极电化学印染废水

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