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Comparison of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein cholesterol for the prediction of thin-cap fibroatheroma determined by intravascular optical coherence tomography

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Journal of Geriatric Cardiology 2020年第11期17卷 666-673页

作者： Yao WANG Si-Si ZHANG Qing-Bo LV Ya LI Jin ZHAO Jia HAN guo-sheng fu Wen-Bin ZHANG Department of Cardiology Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang ProvinceSir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouChina Department of Infection Control Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouChina

Background The correlation among the ratios of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol(LDL-C/HDL-C), total cholesterol/high-density lipoprotein cholesterol(TC/HDL-C) and thin-cap fibroatheroma has not yet been established. Methods It was a single center, retrospective observational study. In total, we recruited 421 patients(82.4% men;mean age 65.73 ± 10.44 years) with one culprit vessel which determined by intravascular optical coherence tomography(OCT). The thinnest-capped fibroatheroma(TCFA) group was defined as lipid contents in > 2 quadrants, with the thinnest fibrous cap measuring less than 65 μm. Univariate and multivariate logistic regression were carried out to explore the relationship between lipoprotein ratios, TCFA and other characteristics of plaque. To compare different ratios, the area under curve(AUC) of receiver-operating characteristic(ROC) curve was assessed. Results OCT was performed in 421 patients(TCFA group(n = 109), non-TCFA group(n = 312)). LDL-C/HDL-C in the TCFA group was significantly higher than in the non-TCFA group(2.95 ± 1.20 vs. 2.43 ± 0.92, P < 0.05), as was TC/LDL in TCFA and non-TCFA group(4.57 ± 1.58 vs. 4.04 ± 1.13, P < 0.05). Both LDL-C/HDL-C(OR: 1.002(1.002-1.003), P < 0.05) and TC/HDL-C(OR: 1.001(1.001-1.004), P < 0.05) were considered independent factors for the prediction of TCFA according to the logistic regression. Based on the AUC comparison, LDL-C/HDL-C and TC/HDL-C had no significant difference statistically(LDL-C/HDL-C AUC: 0.63;TC/HDL-C AUC: 0.61;P = 0.10) for the prediction of TCFA. Conclusions LDL-C/HDL-C and TC/HDL-C could be the independent factors for predicting the presence of TCFA, indicating coronary plaque vulnerability in CAD patients. Moreover, TC/HDL-C also showed a comparative performance for the prediction of TCFA as LDL-C/HDL-C.

关键词： Lipoproteins Optical coherence tomography Total cholesterol

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Shorter- versus Longer-duration Dual Antiplatelet Therapy in Patients with Diabetes Mellitus Undergoing Drug-eluting Stents Implantation： A Meta-analysis of Randomized Controlled Trials

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Chinese Medical Journal 2016年第23期129卷 2861-2867页

作者： He Huang Ya Li Yu Chen guo-sheng fu Department of Cardiology Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310016 China Institute of Translational Medicine Zhejiang University School of Medicine Hangzhou Zhejiang 310016 China

Background： Patients with diabetes mellitus （DM） have a higher risk of thromboembolic events： however, the optimal duration of dual antiplatelet therapy （DAPT） remains unclear. The goal of this study was to assess the efficacy and safety of various DAPT durations in patients with DM undergoing drug-eluting stent implantation. Methods： We conducted a literature search for randomized controlled trials （RCTs）. We searched databases including EMBASE, PubMed, Cochrane Library, and Scopus up to June 2016. Investigators extracted data independently, including outcomes, characteristics, and study quality. A random-effect model was used to pool odds ratios （ORs） with 95% confidence intervals （C/s） of the clinical outcomes. Results： Six RCTs totaling 6040 patients with DM were included in the study. Shorter-duration DAPT resulted in an increased rate of stent thrombosis （ST）（OR, 1.83, 95% CI： 1.03-3.26, P = 0.04）, but did not increase the risk of myocardial inihrction （OR. 1.33, 95% CI： 0.71 2.47, P=0.37）, stroke （OR, 0.96, 95% CI： 0.52-1.77, P 0.90）, target vessel revascularization （OR, 1.19, 95% CI： 0.46-3.07, P = 0.71 ）, all-cause death （OR： 0.72, 95% CI： 0.48-1.09, P = 0.12）, or cardiac death （OR, 0.82, 95% CI： 0.49-1.36, P= 0.44） significantly. Shorter-duration DAPT was associated with a decreased risk of major bleeding （OR. 0.60, 95% CI： 0.38-0.94, P = 0.02）. Conclusion： In patients with DM, longer-duration DAPT had a lower risk of ST, but was associated with an increased bleeding risk.

关键词： Diabetes Mellitus Dual Antiplatelet Therapy Meta-analysis Stent Thrombosis

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Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： guo-fu Xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

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miR-22 eluting cardiovascular stent based on a self-healable spongy coating inhibits in-stent restenosis

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Bioactive Materials 2021年第12期6卷 4686-4696页

作者： Jing Wang Hong-Lin Qian sheng-Yu Chen Wei-Pin Huang Dan-Ni Huang Hong-Ye Hao Ke-Feng Ren Yun-Bing Wang guo-sheng fu Jian Ji MOE Key Laboratory of Macromolecular Synthesis and functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalZhejiang UniversityHangzhou310016China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu610064China

The in-stent restenosis(IRS)after the percutaneous coronary intervention contributes to the major treatment failure of stent *** have been revealed as powerful gene medicine to regulate endothelial cells(EC)and smooth muscle cells(SMC)in response to vascular injury,providing a promising therapeutic candidate to inhibit ***,the controllable loading and eluting of hydrophilic bioactive microRNAs pose a challenge to current lipophilic stent ***,we developed a microRNA eluting cardiovascular stent via the self-healing encapsulation process based on an amphipathic poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone)(PCL-PEG-PCL,PCEC)triblock copolymer spongy *** miR-22 was used as a model microRNA to regulate *** dynamic porous coating realized the uniform and controllable loading of miR-22,reaching the highest dosage of 133 pmol cm^(-2).We demonstrated that the sustained release of miR-22 dramatically enhanced the contractile phenotype of SMC without interfering with the proliferation of EC,thus leading to the EC dominating growth at an EC/SMC ratio of *** importantly,the PCEC@miR-22 coated stents showed reduced inflammation,low switching of SMC phenotype,and low secretion of extracellular matrix,which significantly inhibited *** work provides a simple and robust coating platform for the delivery of microRNAs on cardiovascular stent,which may extend to other combination medical devices,and facilitate practical application of bioactive agents in clinics.

关键词： microRNA Spongy coating Biodegradable stent Contractile phenotype Restenosis

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Substrate stiffness differentially impacts autophagy of endothelial cells and smooth muscle cells

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Bioactive Materials 2021年第5期6卷 1413-1422页

作者： Mi Hu Fan Jia Wei-Pin Huang Xu Li Deng-Feng Hu Jing Wang Ke-Feng Ren guo-sheng fu Yun-Bing Wang Jian Ji MOE Key Laboratory of Macromolecular Synthesis and functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalZhejiang UniversityHangzhou310016China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu610064China

Stiffening of blood vessels is one of the most important characteristics in the process of many cardiovascular pathologies such as atherosclerosis,angiosteosis,and vascular *** stiffness of the vascular extracellular matrix drives artery pathology and alters phenotypes of vascular *** how substrate stiffness impacts vascular cell behaviors is of great importance to the biomaterial design in tissue engineering,regenerative medicine,and medical *** we report that changing substrate stiffness has a significant impact on the autophagy of vascular endothelial cells(VECs)and smooth muscle cells(VSMCs).Interestingly,our findings demonstrate that,with the increase of substrate stiffness,the autophagy level of VECs and VSMCs showed differential changes:endothelial autophagy levels reduced,leading to the reductions in a range of gene expression associated with endothelial function;while,autophagy levels of VSMCs increased,showing a transition from contractile to the synthetic *** further demonstrate that,by inhibiting cell autophagy,the expressions of endothelial functional gene were further reduced and the expression of VSMC calponin increased,suggesting an important role of autophagy in response of the cells to the challenge of microenvironment stiffness *** the underlying mechanism requires further study,this work highlights the relationship of substrate stiffness,autophagy,and vascular cell behaviors,and enlightening the design principles of surface stiffness of biomaterials in cardiovascular practical applications.

关键词： Substrate stiffness Autophagy Endothelial cells Smooth muscle cells Polyelectrolyte film

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Comparison of the safety and efficacy of two types of drug-eluting balloons （RESTORE DEB and SeQuent Please） in the treatment of coronary in-stent restenosis： study protocol for a randomized controlled trial （RESTORE ISR China）

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Journal of Geriatric Cardiology 2018年第2期15卷 117-122页

作者： Lei GAO Qin QIN Shao-Liang CHEN Hui CHEN Le-Feng WANG Ze-Ning JIN Hui LI Jun ZHANG Jian-An WANG Yang ZHENG guo-sheng fu Yun-Dai CHEN Department of Cardiology Chinese PLA General Hospital Beijing China Department of Cardiology Tianjin Chest Hospital Tianjin China Department of Cardiology Nanjing First Hospital Nanjing China Department of Cardiology Beijing Friendship Hospital Capital Medical University Beijing China Department of Cardiology Beijing Chao-yang Hospital Capital Medical University Beijing China Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing China Department of Cardiology Daqing Oilfield General Hospital Daqing China Department of Cardiology Cangzhou Central Hospital Cangzhou China Department of Cardiology the Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China Department of Cardiology the First Hospital of Jilin University Changchun China Department of Cardiology Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China

1 Introduction In-stent restenosis （ISR）, characterized by neointimal proliferation and/or neoatherosclerosis in the vessel of the stent, can cause a reduction in lumen diameter after stent implantation, which can directly induce the recurrence of angina symptoms or an acute coronary syndrome in patients and is usually life-threatening.

关键词： Drug-eluting balloons In-stent restenosis Percutaneous coronary interventions

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Experience in treating a case of the cardiac rupture during transcatheter aortic valve implantation procedure

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Chinese Medical Journal 2020年第20期133卷 2518-2520页

作者： Wei-Min Zhang Jian-Mao Hong Fan He guo-sheng fu Fei-Cheng Yu Department of Cardiovascular Surgery Sir Run Run Shaw HospitalZhejiang UniversityHangzhouZhejiang 310016China Department of Cardiology Sir Run Run Shaw HospitalZhejiang UniversityHangzhouZhejiang 310016China

To the Editor:A 70-year-old male patient underwent transcatheter aortic valve implantation(TAVI)for severe aortic *** showed that the peak velocity in aortic valve was 4.33 m/s,with a peak pressure gradient of 75 mmHg and a mean pressure gradient of 38 *** end-systolic dimension and end-diastolic dimension of left ventricle was 31.7 and 50.0 mm,respectively.

关键词： aortic rupture transcatheter

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非恒定水流计算的最优控制问题及其变分求解

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水科学进展 2008年第4期19卷 537-545页

作者：赖锡军傅国圣孙波中国科学院南京地理与湖泊研究所湖泊与环境国家重点实验室江苏南京210008 扬泰水文水资源勘测局江苏扬州225000 山东省安丘市水利局山东潍坊262100

为综合利用各类可用的信息源(如水流运动规律,观测资料和统计信息),在反问题的框架下构建了非恒定水流计算的变分模型。针对模型预测的可能误差来源,给出了初始条件、边界条件、物理参数三类独立参量及综合控制问题的定义。在此基础上,... 详细信息

为综合利用各类可用的信息源(如水流运动规律,观测资料和统计信息),在反问题的框架下构建了非恒定水流计算的变分模型。针对模型预测的可能误差来源,给出了初始条件、边界条件、物理参数三类独立参量及综合控制问题的定义。在此基础上,阐述了变分法求解这类偏微分方程最优化控制问题的基本原理及模型求解步骤。同时,为便于应用参考,选取初始条件、边界条件和物理参数作为控制向量,以实际常用的水流运动微分方程为基础,导出了一、二维非恒定水流计算的通用伴随方程。并以珠江黄浦至大虎段二维潮流计算为例,展示了变分模型的应用。

关键词：非恒定流反问题变分法最优控制数据同化数学模型

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Knockout of the tumor necrosis factor a receptor 1 gene can up-regulate erythropoietin receptor during myocardial ischemia-reperfusion injury in mice

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Chinese Medical Journal 2009年第5期122卷 566-570页

作者： LI Chang-ling JIANG Jun FAN You-qi fu guo-sheng WANG Jian-an FAN Wei-ming Sir Run Run Shaw Institution of Clinical Medicine of Zhejiang University Department of Cardiology Sir Run Run Shaw Hospital Affiliated to Medical College of Zhejiang University Hangzhou Zhejiang 310016 China Department of Cardiology Second Hospital Affiliated to Medical College of Zhejiang University Hangzhou Zhejiang 310004 China Department of Pathological and Medicine Medical University of South Carolina Charleston SC 29403 USA

Background Tumor necrosis factor a receptor 1 （TNFaR1） plays an important role in the signal pathway of apoptosis. The objective of this study was to investigate the effects of TNFaR1 knockout on the up-regulation of erythropoietin receptor （Epo-R） and the coordinated anti-apoptosis functions during myocardial ischemia-reperfusion injury in mice. Methods The ischemia-reperfusion injury model for cardiomyocytes was performed by ligating the left circumflex branch artery of TNFaR1 knockout （P55/） C17 B6 mice, as well as wild-type （P55^＋/^＋） C17 B6 mice. Triphenyltetrazolium chloride （TTC） staining was performed to observe the damaged area of the heart. TUNEL staining and DNA fragmentation were used to identify apoptosis. Mitochondrial Bcl-2 and Bax as well as expression of Epo-R and its downstream genes （Jak-2, stat-5, Akt, lkB-a, HIF-1a） were measured by Western blotting. The gene knockout mice were assigned into those undergoing the apoptosis surgical model group （KO group）, and those subjected to sham operation （KOs group）. Similarly, wild-type mice were either exposed to the surgical model （WT group） or subject to a sham operation （WTs group）. Results The myocardial damage ratio of the wild-type group after the operation was significantly higher than that of the knockout group, （50.5±6.4）% vs （36.9±6.9）%, P 〈0.01. Similarly, TUNEL positive ratio of the wild-type group was significantly higher than that of the knockout group, （63.1±5.6）% vs （42.1±4.7）%, P〈0.01. The gray value ratios of Epo-R, Jak-2, stat-5, Akt, IkB-a, HIF-1 and mitochondrial Bcl-2 in the KO group were significantly higher than those of the WT group, P 〈0.05; however, mitochondrial Bax was significantly lower than that of the WT group significantly （P 〈0.05）. Conclusions Using the ischemia-reperfusion injury model in mice, cardiomyocytes of TNFaR1 knockouts exhibited anti-apoptotic characteristics. This information could be used to coordinate the prevention of myocardial apoptosis by up-regulating

关键词： tumor necrosis factor receptor erythropoietin receptor cardiomyocytes ischemia-reperfusion injury apoptosis

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Evaluation of metoprolol standard dosing pathway in Chinese patients with acute coronary syndrome:a prospective multicenter single-arm interventional study

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Journal of Geriatric Cardiology 2023年第4期20卷 256-267页

作者： Xiao-Yun YIN Yun-Mei ZHANG Ai-Dong SHEN Jing-Ping WANG Zhe-Xun LIAN Yi-Bing SHAO Wen-Qi ZHANG Shu-Ying ZHANG Yang ZHENG Kang CHENG Biao XU Cheng-Xing SHEN Rong-Chong HUANG Jin-Cheng guo guo-sheng fu Dong-Kai SHAN Dan-Dan LI Yun-Dai CHEN Senior Department of Cardiology the Sixth Medical CentreChinese PLA General HospitalBeijingChina Medical School of Chinese PLA BeijingChina Department of Cardiology Yunnan First People’s HospitalKunmingChina Department of Heart Center Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Cardiology Shanxi Cardiovascular HospitalTaiyuanChina Department of Cardiology the Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Cardiology Qingdao Municipal HospitalQingdaoChina Department of Cardiology China-Japan Union Hospital of Jilin UniversityChangchunChina Department of Cardiology the Affiliated Zhongshan Hospital of Dalian UniversityZhongshanChina Cardiovascular Center the First Hospital of Jilin UniversityChangchunChina Department of Cardiology the Affiliated Hospital of Northwest University&Xi’an No.3 HospitalXi’anChina Department of Cardiology Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjingChina Department of Cardiology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghaiChina Department of Cardiology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Cardiology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Cardiology School of MedicineSir Run Run Shaw HospitalZhejiang UniversityHangzhouChina

OBJECTIVE To evaluate the feasibility and tolerability of metoprolol standard dosing pathway(MSDP)in Chinese patients with acute coronary syndrome(ACS).METHODS In this multicenter,prospective,open label,single-arm and interventional study that was conducted from February 2018 to April 2019 in fifteen Chinese hospitals.A total of 998 hospitalized patients aged≥18 years and diagnosed with ACS were *** MSDP was applied to all eligible ACS patients based on the standard treatment recommended by international *** primary endpoint was the percentage of patients achieving the target dose at discharge(V2).The secondary endpoints included the heart rate and blood pressure at V2 and four weeks after discharge(V4),and percentage of patients experiencing bradycardia(heart ratefunction at V2 and *** Of the 998 patients,29.46%of patients achieved the target dose(≥95 mg/d)at *** total population was divided into two groups:target group(patients achieving the target dose at V2)and non-target group(patients not achieving the target dose at V2).There was significant difference in the reduction of heart rate from baseline to discharge in the two groups(-4.97±11.90beats/min vs.-2.70±9.47 beats/min,P=0.034).There was no significant difference in the proportion of bradycardia that occurred in the two groups at V2(0 vs.0,P=1.000)and V4(0.81%vs.0.33%,P=0.715).There was no significant difference in the proportion of hypotension between the two groups at V2(0.004%vs.0.004%,P=1.000)and V4(0 vs.0.005%,P=0.560).No transient cardiac dysfunction occurred in two groups during the study.A total of five adverse events(1.70%)and one serious adverse event(0.34%)were related to the pathway in target *** In Chinese ACS patients,the feasibility and tolerability of the MSDP have been proved to be acceptable.

关键词： patients prospective coronary

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