检索结果-南通市图书馆

MiR-32-5p aggravates intestinal epithelial cell injury in pediatric enteritis induced by Helicobacter pylori

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第41期25卷 6222-6237页

作者： Jing Feng jian guo Jun-Ping Wang bao-Feng Chai Institute of Loess Plateau Shanxi UniversityTaiyuan 030006Shanxi ProvinceChina Department of Gastroenterology Shanxi Provincial People's HospitalThe Affiliated People's Hospital of Shanxi Medical UniversityTaiyuan 030012Shanxi ProvinceChina Department of General Surgery Shanxi Provincial People's HospitalThe Affiliated People's Hospital of Shanxi Medical UniversityTaiyuan 030012Shanxi ProvinceChina

BACKGROUND Pediatric enteritis is one of the infectious diseases in the digestive system that causes a variety of digestive problems,including diarrhea,vomiting,and bellyache in ***,Helicobacter pylori(***)infection is one of the common factors to cause pediatric *** has been demonstrated that aberrant expression of microRNAs(miRNAs)is found in gastrointestinal diseases caused by ***,and we discovered a significant increase of miR-32-5p in ***-related pediatric ***,the exact role of miR-32-5p in it is still *** To investigate the role of aberrant miR-32-5p in pediatric enteritis induced by *** MiR-32-5p expression was detected by quantitative real time-polymerase chain *** biological role of miR-32-5p in ***-treated intestinal epithelial cells was evaluated by Cell Counting Kit-8 assay and flow *** potential target of miR-32-5p was predicted with TargetScanHuman and verified by luciferase *** downstream mechanism of miR-32-5p was explored by using molecular biology *** We found that miR-32-5p was overexpressed in serum of ***-induced pediatric *** investigation revealed that *** infection promoted the death of intestinal epithelial cells,and increased miR-32-5p ***,miR-32-5p mimic further facilitated apoptosis and inflammatory cytokine secretion of intestinal epithelial *** exploration revealed that SMAD family member 6(SMAD6)was the direct target of miR-32-5p,and SMAD6 overexpression partially rescued cell damage induced by *** following experiments showed that miR-32-5p/SMAD6 participated in the apoptosis of intestinal epithelial cells induced by transforming growth factor-β-activated kinase 1(TAK1)-p38 activation under *** *** Our work uncovered the crucial role of aberrant expression of miR-32-5p in ***–related pediatric enteritis,and suggested that the TAK1-p38

关键词： MiR-32-5p SMAD family member 6 Transforming growth factor-β-activated kinase 1 Apoptosis Enteritis Helicobacter pylori

A 200-Year Record of Polycyclic Aromatic Hydrocarbons Contamination in an Ombrotrophic Peatland in Great Hinggan Mountain, Northeast China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2014年第5期11卷 1085-1096页

作者： bao Kun-shan SHEN Ji ZHANG Yan WANG jian WANG guo-ping State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and Limnology Chinese Academy of Sciences Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and Agroecology Chinese Academy of Sciences

Peat bogs are regarded as one of the faithful archives of atmospheric polycyclic aromatic hydrocarbons(PAHs) deposition, and a large number of studies on PAHs accumulation in peatlands have been reported in Europe and North America. Comparatively little information is available on peat chronological records of atmospheric PAHs flux in China. We investigated the concentrations and historical accumulation rates of PAHs(AR PAHs) through geochemical analysis of three 210Pb-dated ombrotrophic peat cores from Great Hinggan Mountain, northeast China. Eight USEPA priority PAHs were detected and they are naphthalene(Nap), acenaphthylene(Acl), acenaphthene(Ace), fluorence(Flu), phenanthrene(Phe), anthracene(Ant), fluoranthene(Fla) and pyrene(Pyr), respectively. The average total eight PAHs(tPAHs) concentrations are 135.98- 262.43 μg kg-1 and the average AR tPAHs over the last two centuries are 96.45- 135.98 μg m-2 yr-1. The Ace, Acl and Phe account for 30.93- 54.04%, 25.29- 35.81%, and 9.14- 19.84% of the tPAHs, respectively, and have significant positive correlations with the tPAH. As a result, they are regarded as the iconic compounds of PAHs pollution in this area. A ca.200-yr atmospheric PAHs contamination history was reconstructed from the temporal sequences of bothconcentration and AR tPAHs, suggesting the variation of local environmental pollution. The main sources of the PAHs are identified by two isomer ratios as petrogenic origin including oil extraction and refining process as well as their combustions for industrial development. In addition, the contribution of coal combustion for industrial activities and resident heating could not be ignored. But prior to 1860, the undeveloped industry and most of agricultural activities might mainly account for the low level of PAHs, although it could infer a long-range input of atmospheric PAHs from other industrial areas. Therefore, there is a global implication to study longterm PAHs pollution records and all the results wil

关键词： Ombrotrophic peatland polycyclic aromatic hydrocarbons(PAHs) Lead-210 Environmental pollution

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第01期 522-532页

作者： Jin-Peng Wang guo-Cui Mao Hui-Lin jiang bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词：

CAE碰撞安全前后处理自动化平台研究与应用

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

环境技术 2023年第8期41卷 142-146,155页

作者：王辉汤小生吴泽勋闫高峰包国建郝庆全重庆睿蓝汽车研究院有限公司重庆400707

目前汽车行业竞争激烈,研发周期不断被压缩,CAE碰撞安全分析作为研发重要手段急需进一步改善工作效能以快速响应市场推出新产品。CAE碰撞安全分析可有效缩短研发周期和减少试验次数。本文基于传统CAE碰撞安全分析前后处理工作存在效能... 详细信息

目前汽车行业竞争激烈,研发周期不断被压缩,CAE碰撞安全分析作为研发重要手段急需进一步改善工作效能以快速响应市场推出新产品。CAE碰撞安全分析可有效缩短研发周期和减少试验次数。本文基于传统CAE碰撞安全分析前后处理工作存在效能低的相关问题,对模型和工作流程进行了梳理整合,针对痛点问题进行程序平台模块规划,对自动化程序平台架构的搭建进行了各维度设计逻辑研究。最后,本文基于Ansa&Meta商业软件,通过Python开源编程语言,所开发的CAE碰撞安全前后处理自动化平台实现了工作的流程化、标准化及高效能,同时保障了结果准确性,提高了汽车碰撞试验的可靠性,最大程度减少碰撞试验车报废数量,利于环境保护。

关键词： CAE碰撞安全前后处理自动化平台 Ansa&Meta Python

Mn evaporation and denitrification behaviors of molten Mn steel in the vacuum refining with slag process

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2021年第8期28卷 1288-1297页

作者： jian-hua Chu Yan-ping bao State Key Lab of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

Considering the precise composition control on the vacuum refining of high-Mn steel, the behaviors of both Mn evaporation and nitrogen removal from molten Mn steel were investigated via vacuum slag refining in a vacuum induction furnace. It was found that the reaction interfaces of denitrification and Mn evaporation tend to migrate from the surface of slag layer to the surface of molten steel with the gradual exposure of molten steel during the vacuum slag refining process. Significantly, compared with the experimental group without slag addition, the addition of slag into steel can result in a lower Mn evaporation rate constant of 0.0192 cm·min~(-1) at 370 Pa, while the denitrification rate is almost not affected. Besides, the slag has a stronger inhibitory effect on Mn evaporation than the reduced vacuum pressure. Moreover, the inhibitory effect of the slag layer on Mn evaporation can be weakened with the increase of the initial Mn content in molten steel. The slag layer can work as an inhibitory layer to reduce the Mn evaporation from molten steel, the evaporation reaction of Mn mainly proceeds on the surface of the molten steel. This may be attributed to the Mn mass transfer coefficient for one of reaction at steel/slag interface, mass transfer in molten slag, and evaporation reaction at slag/gas interface is lower than that of evaporation reaction at steel/gas interface. The introduction of slag is proposed for both denitrification and manganese control during the vacuum refining process of Mn steels.

关键词： manganese evaporation denitrification vacuum slag evaporation rate

On Group Phase Quantization and Its Physical Characteristics

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2011年第5期28卷 64-67页

作者： DU bao-Qiang ZHOU Wei YU jian-guo DONG Shao-Feng Department of Measurement and Instrument Xidian UniversityXi’an 710071 Department of Information Engineering Henan Vocational and Technical CollegeZhengzhou 450046

The physical characteristics of phase quantum are further revealed,based on the proposition of concepts of the greatest common factor frequency,the least common multiple period,quantized phase shift resolution and equivalent phase comparison *** the problem of phase comparison between different frequency signals is certified in *** the basic principle of phase comparison between different frequencies and the variation law of group phase difference,a point of view on group phase quantization is *** phase quantum is not only an indivisible individual of group phase,but also a basic unit composing group phase *** is equal to the equivalent phase comparison period of phase comparison between different frequencies in *** results show not only a high measurement resolution of 10^(-12)/s in frequency measurement based on group phase quantum,but also a super-high locked phase precision of 10^(-13)/s in active H atomic clock.

关键词： phase quantum comparison

CXC CHEMOKINE RECEPTOR 3 MODULATES BLEOMYCIN-INDUCED PULMONARY INJURY VIA INVOLVING INFLAMMATORY PROCESS

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Sciences Journal 2006年第3期21卷 152-156页

作者： Jin-ming Gao bao Lu Zi-jian guo Department of Respiratory Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 Ina Sue Perlmutter Laboratory Division of Pulmonary Children＇s Hospital Department of Medicine Harvard Medical School Boston MA 02115

Objeelive To investigate the role of CXC chemokine receptor 3 （ CXCR3 ） in bleomycin-induced lung injury by using CXCR3 gene deficient mice. Methods Sex-, age-, and weight-matched C57BL/6 CXCR3 gene knockout mice and C57BL/6 wide type mice were challenged by injection of bleomycin via trachea. Lung tissue was stained with HE method. Airway resistance was measured. Bronchoalveolar lavage （BAL） was performed using phosphate buffered saline twice, cell number and differentials were counted by Diff-Quick staining. Interleukin （IL）-4, IL-5, IL-12p40, and interfon-~ in BAL fluid and lung homogenate were measured by enzyme-linked immunosorbent assay. Unpaired t test was explored to compare the difference between two groups. Results On day 7 after bleomycin injection via trachea, CXCR3 knockout mice were protected from bleomycininduced lung injury as evidenced by fewer accumulation of inflammatory cells in the airway and lung interstitium compared with their wild type littermates （ P 〈 0. 05 ）. Airway resistance was also lower in CXCR3 knockout mice compared with wild type mice （P 〈 0. 01 ）. Significantly lower level of inflammatory cytokines release, including the altered production of IL-4 and IL-5 both in BAL fluid and lung tissue was seen in CXCR3 knockout mice than in wild type mice （both P 〈0. 05）. Conclusion CXCR3 signaling promotes inflammatory cells recruiting and initiates inflammatory cytokines cascade following endotracheal bleomycin administration, indicating that CXCR3 might be a therapeutic target for pulmonary injury.

关键词： chemokine receptor bleomycin lung injury inflammation

Enhanced Mechanical Properties of Poly(arylene sulfide sulfone)Membrane by Co-electrospinning with Poly(m-xylene adipamide)

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2020年第1期38卷 63-71,I0007页

作者： Lu Chen Xin-Lin Tuo Xi-Chuan Fan Chun-Jie Xie bao-Hua guo jian Yu Ping Hu Zhao-Xia guo Key Laboratory of Advanced Materials (Ministry of Education) Department of Chemical Engineering Tsinghua University

The mechanical properties of poly(arylene sulfide sulfone)(PASS) electrospun membrane were significantly enhanced by coelectrospinning with semi-aromatic nylon poly(m-xylene adipamide)(MXD6), another engineering plastic with high thermal stability and good mechanical properties. The tensile strength of PASS membrane increased with increased incorporation of MXD6, and was tripled when 20%MXD6 was incorporated. The mechanism of the mechanical property improvement is the existence of hydrogen bonding interaction between PASS and MXD6 and between adjacent fibers at the intersections. Thermal properties of the PASS/MXD6 membranes were evaluated by differential scanning calorimetry(DSC) and thermogravimetric analysis(TGA), which showed that the membranes could be stably utilized up to180 °C without any change in appearance and without decomposition. Contact angle measurements of all the membranes showed hydrophobic character. To demonstrate the potential applications of PASS/MXD6 blend membranes, their oil absorption capacities were evaluated with three oils of different viscosities, which proved that the PASS/MXD6 membranes are better absorbents than commercial non-woven polypropylene fibers. Therefore, PASS/MXD6 fibrous membranes produced by electrospinning have a great potential in practical applications.

关键词： Electrospinning Mechanical properties PASS MXD6 Oil absorption

GSK3β inhibitor promotes myelination and mitigates muscle atrophy after peripheral nerve injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第2期13卷 324-330页

作者： jian Weng Yan-hua Wang Ming Li Dian-ying Zhang bao-guo jiang Department of Orthopedics and Trauma Peking University People's Hospital

Delay of axon regeneration after peripheral nerve injury usually leads to progressive muscle atrophy and poor functional recovery. The Wnt/β-catenin signaling pathway is considered to be one of the main molecular mechanisms that lead to skeletal muscle atrophy in the elderly. We hold the hypothesis that the innervation of target muscle can be promoted by accelerating axon regeneration and decelerating muscle cell degeneration so as to improve functional recovery of skeletal muscle following peripheral nerve injury. This process may be associated with the Wnt/β-catenin signaling pathway. Our study designed in vitro cell models to simulate myelin regeneration and muscle atrophy. We investigated the effects of SB216763, a glycogen synthase kinase 3 beta inhibitor, on the two major murine cell lines RSC96 and C2C12 derived from Schwann cells and muscle satellite cells. The results showed that SB216763 stimulated the Schwann cell migra- tion and myotube contraction. Quantitative polymerase chain reaction results demonstrated that myelin related genes, myelin associated glycoprotein and cyclin-D1, muscle related gene myogenin and endplate-associated gene nicotinic acetylcholine receptors levels were stimulated by SB216763. Immunocytochemical staining revealed that the expressions of ^-catenin in the RSC96 and C2C12 cytosolic and nuclear compartments were increased in the SB216763-treated cells. These findings confirm that the glycogen synthase kinase 3 beta in- hibitor, SB216763, promoted the myelination and myotube differentiation through the Wnt/β-catenin signaling pathway and contributed to nerve remyelination and reduced denervated muscle atrophy after peripheral nerve injury.

关键词： nerve regeneration glycogen synthase kinase 3 beta inhibitor SB216763 myelination myotube differentiation denervated muscle atrophy Wnt/^-catenin Schwann cell muscle cells peripheral nerve injury neural regeneration