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Design, Synthesis and in vitro Evaluation of Thiazole Derivatives of Ibuprofen as Cyclooxygenase-2 Inhibitors

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Chinese Chemical Letters 2006年第3期17卷 325-328页

作者： Chang Bin guo Zhe feng CAI Zong Ru guo zhi Qiang feng feng Ming CHU Gui-Fang CHENG feng Ming CHU Gui Fang CHENG Institute of Materia Medica Chinese Academy of Medical Science and Peking Union Medical College Beijing 100050

A series of thiazole derivatives of ibuprofen, as cyclooxygenase-2 Inhibitors, were designed, synthesized and in vitro evaluated.

关键词： Cyclooxygenase-2 (COX-2) inhibitor ibuprofen thiazole derivative.

Evaluation of the Health Status of Six Volunteers from the Mars 500 Project Using Pulse Analysis

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Chinese Journal of Integrative Medicine 2017年第8期23卷 574-580页

作者： SHI Hong-zhi FAN Quan-chun GAO Jian-yi LIU Jun-lian BAI Gui-e MI Tao ZHAO Shuang LIU Yu XU Dong guo zhi-feng LI Yong-zhi State Key Laboratory of Space Medicine Fundamentals and Application China Astronaut Research and Training Center Beijing 100094 China

Objective：To comprehensively evaluate the health status of 6 volunteers from the Mars 500Project through analyzing their pulse graphs and determining the changes in cardiovascular function,degree of fatigue and autonomic nervous ***：Six volunteers were recruited;all were male aged 26–38years（average 31.83±4.96 years）.Characteristic parameters reflecting the status of cardiovascular functions were extracted,which included left ventricular contraction,vascular elasticity and peripheral *** degree of fatigue was determined depending on the difference between the calendar age and biological age,which was calculated through the analysis of blood pressure value and characteristic *** on the values of pulse height variation and pulse time variation on a 30-s pulse graph,autonomic nervous function was *** parameters examined were marked on an equilateral polygon to form an irregular polygon of the actual figure,then health status was evaluated based on the coverage area of the actual ***：The results demonstrated：（1）volunteers developed weakened pulse power,increased vascular tension and peripheral resistance,and slight decreased ventricular systolic function;（2）the degree of fatigue was basically mild or moderate;and（3）autonomic nervous function was excited but generally ***：These volunteers were in the state of *** to Chinese medicine theories,such symptoms are mainly caused by the weakening of healthy qi,Gan（Liver）failing in free coursing,and disharmony between Gan and Wei（Stomach）,which manifests as a weak and string-like pulse.

关键词： pulse graph cardiovascular function fatigue autonomic nervous function sub-health

Coniferous Canopy BRF Simulation Based on 3-D Realistic Scene

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光谱学与光谱分析 2011年第9期31卷 2495-2498页

作者： WANG Xin-yun guo zhi-feng QIN Wen-han SUN guo-qing Key Lab for Restoration and Reconstruction of Degraded Ecosystem in North-Western China ofMinistry of Education Ningxia University Yinchuan 750021 China Institute of Remote Sensing Applications Chinese Academy of Sciences Beijing 100101 China SSAI/NASA GSFC Greenbelt MD 20771 USA Department of Geography University of Maryland MD 20742 USA

It is difficulties for the computer simulation method to study radiation regime at *** coniferous model was investigated in the present *** makes the computer simulation methods such as L-systems and radiosity-graphics combined method(RGM) more powerful in remote sensing of heterogeneous coniferous forests over a large-scale region.L-systems is applied to render 3-D coniferous forest scenarios,and RGM model was used to calculate BRF(bidirectional reflectance factor) in visible and near-infrared *** in this study show that in most cases both agreed *** at a tree and forest level,the results are also good.

关键词： BRF RGM model L-systems

LAMDA-SSL:a comprehensive semi-supervised learning toolkit

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Science China(Information Sciences) 2024年第1期67卷 306-307页

作者： Lin-Han JIA Lan-Zhe guo zhi ZHOU Yu-feng LI National Key Laboratory for Novel Software Technology Nanjing University

Machine learning, particularly deep learning, has achieved remarkable success across a wide range of tasks. However,most of these tasks demand a substantial amount of labeled training data, which can be challenging to obtain in many real-world applications due to difficulties, costs, or time constraints associated with labeling. In this context,semi-supervised learning (SSL) has emerged as a promising paradigm to alleviate the dependency on large labeled datasets by harnessing the power of unlabeled data [1–3].

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Relationship between TERT Polymorphism and Telomere Length in Workers Exposed to Omethoate

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Biomedical and Environmental Sciences 2021年第10期34卷 838-841页

作者： CHENG Shuai LIU Bin guo zhi feng DUAN Xiao Ran LIU Su Xiang LI Lei YAO Wu YANG Yong Li WANG Wei Department of Occupational Health and Occupational Diseases College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Department of Zhengzhou Institute of Occupational Health Zhengzhou 450053HenanChina Department of Epidemiology and Biostatistics College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina The Key Laboratory of Nano medicine and Health Inspection of Zhengzhou Zhengzhou 450001HenanChina

Omethoate is a highly toxic organophosphorus pesticide that is widely used in agricultural production because of its high efficiency,broad spectrum,and low *** phorus pesticides,such as omethoate,can inhibit acetylcho... 详细信息

关键词： residue pesticides spectrum

Unveiling the Re,Cr,and I diffusion in saturated compacted bentonite using machine-learning methods

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Nuclear Science and Techniques 2024年第6期35卷 65-77页

作者： Zheng-Ye feng Jun-Lei Tian Tao Wu guo-Jun Wei zhi-Long Li Xiao-Qiong Shi Yong-Jia Wang Qing-feng Li Department of Engineering Huzhou UniversityHuzhou 313000China Institute of Theoretical Physics Shanxi UniversityTaiyuan 030006China College of Physics Science and Technology Shenyang Normal UniversityShenyang 110034China

The safety assessment of high-level radioactive waste repositories requires a high predictive accuracy for radionuclide diffusion and a comprehensive understanding of the diffusion *** this study,a through-diffusion method and six machine-learning methods were employed to investigate the diffusion of ReO_(4)^(−),HCrO_(4)^(−),and I−in saturated compacted bentonite under different salinities and compacted dry *** machine-learning models were trained using two *** dataset contained six input features and 293 instances obtained from the diffusion database system of the Japan Atomic Energy Agency(JAEA-DDB)and 15 *** other dataset,comprising 15,000 pseudo-instances,was produced using a multi-porosity model and contained eight input *** results indicate that the former dataset yielded a higher predictive accuracy than the *** gradient-boosting exhibited a higher prediction accuracy(R2=0.92)and lower error(MSE=0.01)than the other machine-learning *** addition,Shapley Additive Explanations,Feature Importance,and Partial Dependence Plot analysis results indicate that the rock capacity factor and compacted dry density had the two most significant effects on predicting the effective diffusion coefficient,thereby offering valuable insights.

关键词： Machine learning Effective diffusion coefficient Through-diffusion experiment Multi-porosity model Global analysis

New insights into the deposition of natural gas hydrate on pipeline surfaces:A molecular dynamics simulation study

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Petroleum Science 2024年第1期21卷 694-704页

作者： Jun Zhang Hai-Qiang Fu Mu-zhi guo Zhao Wang Li-Wen Li Qi Yin You-guo Yan Wei Wei Wei-feng Han Jie Zhong School of Materials Science and Engineering China University of Petroleum(East China)Qingdao 266580ShandongChina School of Petroleum Engineering China University of Petroleum(East China)Qingdao 266580ShandongChina Department of Alternative Energy PetroChina Research Institute of Petroleum Exploration&DevelopmentLangfang 065007HebeiChina

Natural gas hydrate(NGH)can cause pipeline blockages during the transportation of oil and gas under high pressures and low *** hydrate adhesion on pipelines is viewed as an efficient way to prevent NGH *** studies suggested the water film can greatly increase hydrate adhesion in gas-dominant ***,by performing the molecular dynamics simulations,we find in water-dominant system,the water film plays different roles in hydrate deposition on Fe and its corrosion ***,due to the strong affinity of water on Fe surface,the deposited hydrate cannot convert the adsorbed water into hydrate,thus,a water film *** water affinities decrease(Fe>Fe_(2)O_(3)>FeO>Fe_(3)O_(4)),adsorbed water would convert to amorphous hydrate on Fe_(2)O_(3)and form the ordered hydrate on FeO and Fe_(3)O_(4)after hydrate *** absorbed water film converts to amorphous or to hydrate,the adhesion strength of hydrate continuously increases(Fe

关键词： Deposition Natural gas hydrate Pipelines Water affinity Adhesion strength

A Local Tb Theorem for Square Functions and Parabolic Layer Potentials

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Acta Mathematica Sinica,English Series 2024年第8期40卷 1941-1966页

作者： zhi Dan WANG guo Ming ZHANG School of Physical and Mathematical Sciences Nanjing Tech UniversityNanjing 211816P.R.China Frontiers Science Center for Nonlinear Expectations Ministry of EductionResearch Center for Mathematics and Interdisciplinary SciencesShandong UniversityQingdao266237P.R.China

In this paper,we give a locally parabolic version of Tb theorem for a class of vector-valued operators with off-diagonal decay in L^(2) and certain quasi-orthogonality on a subspace of L^(2),in which the testing functions themselves are also *** an application,we establish the boundedness of layer potentials related to parabolic operators in divergence form,defined in the upper half-space Rn+2+:={(x,t,λ)∈R^(n+1)×(0,∞)},with uniformly complex elliptic,L^(∞),t,λ-independent coefficients,and satisfying the De Giorgi/Nash estimates.

关键词： Local Tb theorems Calderon-Littlewood-Paley family Parabolic layer potentials Carleson measure estimates

Association between Polymorphisms in Telomere-Associated Protein Genes and the Cholinesterase Activity of Omethoate-Exposed Workers

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Biomedical and Environmental Sciences 2022年第5期35卷 448-452页

作者： FAN Ya Hui LI Xin Ling LIU Xiao Hua guo zhi feng YAN Meng Qing DUAN Xiao Ran MIAO Wen Bin WANG Wei Department of Occupational Health and Occupational Diseases College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Biotherapy Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450052HenanChina Director of Efficacy and Safety Evaluation Laboratory Pony Testing Group Shanghai Co.Ltd.Shanghai 201600China

Organophosphorus pesticides(OPs)are extensively used for their high efficiency,broad spectrum,and low ***,the health hazards caused by long-term,low-dose exposure to OPs are easily *** is a large class of OPs that is widely used in *** inhibition of the cholinesterase(ChE)activity is the main toxicity mechanism of OPs,and such an activity is used as a biomarker of exposure to OPs.

关键词： pesticides China. residue