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基于hnRNPF调控的TLR4/NF-κB信号通路研究肾元颗粒对糖尿病肾脏病炎症的影响

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中医药导报 2024年第5期30卷 36-40,49页

作者：郭昕源王岚湖北中医药大学湖北武汉430065 湖北省中医院湖北武汉430061

目的:基于hnRNPF调控的TLR4/NF-κB信号通路探讨肾元颗粒对db/db糖尿病肾脏病小鼠炎症的影响及其作用机制。方法:将16只SPF级db/db小鼠随机分为模型组和肾元颗粒组,予0.2%腺嘌呤模型饲料;另取8只同背景系野生小鼠作为空白组,予普通饲料... 详细信息

目的:基于hnRNPF调控的TLR4/NF-κB信号通路探讨肾元颗粒对db/db糖尿病肾脏病小鼠炎症的影响及其作用机制。方法:将16只SPF级db/db小鼠随机分为模型组和肾元颗粒组,予0.2%腺嘌呤模型饲料;另取8只同背景系野生小鼠作为空白组,予普通饲料。肾元颗粒组予以肾元颗粒混悬液灌胃给药,模型组和空白组小鼠予等量双蒸水灌胃,连续12周。给药12周后代谢笼收集小鼠24 h尿液,取各组小鼠血清、肾脏组织。生化检测各组小鼠血清肌酐(SCr)、血尿素氮(BUN)、谷丙转氨酶(ALT);ELISA法检测尿液中性粒细胞明胶酶相关脂质运载蛋白(NGAL)水平;PAS染色光镜观察肾组织病理改变;R-T PCR法检测小鼠肾脏组织中TLR4 mRNA、IL-6mRNA、IKKαmRNA、NF-κB P65 mRNA、TNF-αmRNA、hnRNPF mRNA表达水平;Western blotting检测肾脏组织中hnRNPF、TLR4蛋白表达及IKKα、NF-κB P65磷酸化水平。结果:模型组小鼠血清SCr、BUN、ALT显著高于空白组(P<0.05);肾元颗粒组小鼠血清SCr、BUN、ALT显著低于模型组(P<0.05)。模型组小鼠尿液NGAL水平显著高于空白组(P<0.05);肾元颗粒组小鼠尿液NGAL水平明显低于模型组(P<0.05)。与空白组比较,模型组小鼠肾脏组织病变严重;与模型组比较,肾元颗粒组小鼠肾脏病变有所改善。模型组小鼠肾脏组织中TLR4 mRNA、IL-6 mRNA、IKKαmRNA、NF-κB P65 mRNA、TNF-αmRNA相对表达量高于空白组(P<0.05),hnRNPF mRNA相对表达量低于空白组(P<0.05);肾元颗粒组小鼠肾脏组织中TLR4 mRNA、IL-6 mRNA、IKKαmRNA、NF-κB P65mRNA、TNF-αmRNA相对表达量低于模型组(P<0.05),hnRNPFmRNA相对表达量高于模型组(P<0.05)。模型组小鼠肾脏组织中hnRNPF蛋白相对表达量低于空白组(P<0.05),TLR4蛋白相对表达量及IKKα、NF-κB P65磷酸化水平高于空白组(P<0.05);肾元颗粒组小鼠肾脏组织中hnRNPF蛋白相对表达量高于模型组(P<0.05),TLR4蛋白相对表达量及IKKα、NF-κB P65磷酸化水平低于模型组(P<0.05)。结论:肾元颗粒可能通过hnRNPF调控的TLR4/NF-κB信号通路,抑制db/db糖尿病肾脏病小鼠炎症反应,从而改善相关生化指标,减轻肾脏损害。

关键词：糖尿病肾脏病肾元颗粒 hnRNPF TLR4/NF-κB信号通路炎症反应

韩国第22届国会议员选举:特点、影响及走向

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当代韩国 2024年第2期 66-80页

作者：郭欣源崔明旭山东大学东北亚学院山东大学韩国研究中心

2024年4月10日,韩国举行第22届国会议员选举。本次选举中执政党国民力量党惨败,继续面临“朝小野大”局面,泛在野党阵营继续占据压倒性优势。“审判论”背景下韩国选民投票热情高涨,呈现出政治“极化”特点。尹锡悦则被认为是执政党失... 详细信息

2024年4月10日,韩国举行第22届国会议员选举。本次选举中执政党国民力量党惨败,继续面临“朝小野大”局面,泛在野党阵营继续占据压倒性优势。“审判论”背景下韩国选民投票热情高涨,呈现出政治“极化”特点。尹锡悦则被认为是执政党失利的“罪魁祸首”,选举结果导致国民力量党面临党内势力重组的局面,并牵动在野党派系格局走向。尹锡悦政府不得不重新思考与在野党之间的关系,尹锡悦可能成为“跛脚鸭”总统,而本次选举结果再次加剧了韩国政党政治的不稳定性,导致第21届总统选举充满不确定性。

关键词：韩国第22届国会议员选举韩国政党政治朝小野大尹锡悦政府

城市群集聚发展的区域性中心城市人力资源体系研究

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湖南理工学院学报（自然科学版） 2024年第1期37卷 66-73页

作者：刘钢郭新媛潘一帆李武湖南理工学院湖南岳阳414006 湖南民族职业学院湖南岳阳414000

人力资源在经济社会发展中具有基础性、决定性地位和作用.在城市群集聚发展趋势下,为着力发挥区域性中心城市在推动区域经济发展和一体化进程中的引导作用,对区域性中心城市的人力资源体系进行研究是当务之急.以岳阳市为例,对岳阳人力... 详细信息

人力资源在经济社会发展中具有基础性、决定性地位和作用.在城市群集聚发展趋势下,为着力发挥区域性中心城市在推动区域经济发展和一体化进程中的引导作用,对区域性中心城市的人力资源体系进行研究是当务之急.以岳阳市为例,对岳阳人力资源体系进行了横纵向对比分析,并从具化人力资源体系、优化人力资源配置、强化人才资源集聚、孕化人与自然和谐四方面提出了具体的解决方案,以期为加大人才队伍建设、优化资源配置提供具体策略,为区域性中心城市人力资源体系提供人才支撑和智力支持.

关键词：人力资源体系区域性中心城市城市群集聚发展

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Yushu earthquake synergic analysis using multimodal SAR datasets

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Chinese Science Bulletin 2010年第31期55卷 3499-3503页

作者： guo HuaDong WANG xinyuan LI XinWu LIU Guang ZHANG Lu YAN ShiYong Key Laboratory of Digital Earth Center for Earth Observation and Digital Earth Chinese Academy of Sciences Beijing 100190 China

The large earthquake measuring 7.1 on the Richter scale that occurred in Yushu County,Qinghai Province,China,on April 14,2010,caused a huge loss of life and major damage to people's *** three modal synthetic-aperture radar(SAR) datasets,wide-swath SAR,interferometric SAR and polarimetric SAR,the following studies were conducted:(1) From Radarsat-2 wide swath SAR data,the regional geological structures and lithologic distribution characteristics of the Yushu earthquake were analyzed.(2) Using advanced land observing satellite/phased array L-band interferometric SAR data,the coseismic deformation field of the Yushu earthquake was obtained,and the size and spatial distribution of deformation were studied combining with the result of regional geological background analysis.(3) From Radarsat-2 polarimetric SAR data,the H-α-ρ method was used to extract the spatial distribution of building collapse caused by the earthquake in the Yushu urban area,and the reasons for the severe earthquake damage to buildings are also discussed and *** study results demonstrate the effectiveness and important potential of using multimodal SAR data for synergic analysis and assessment of earthquake disasters.

关键词：地震台网协同分析玉树县数据集多式联运特区合成孔径雷达区域地质构造

2型糖尿病患者非酒精性脂肪肝及肝纤维化与骨骼肌质量关系的研究

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中华内分泌代谢杂志 2024年第8期40卷 660-668页

作者：郭馨远韩梅马邓荣昝晓晖赵阳婷吕小羽李凯陈重阳王亚雯刘靖芳兰州大学第一临床医学院兰州兰州大学第一医院内分泌科兰州

目的探讨2型糖尿病患者(type 2 diabetes mellitus, T2DM)非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)及肝纤维化与骨骼肌质量之间的关系。方法 2022年4月至2023年5月兰州大学第一医院内分泌科确诊的685例T2DM患者... 详细信息

目的探讨2型糖尿病患者(type 2 diabetes mellitus, T2DM)非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)及肝纤维化与骨骼肌质量之间的关系。方法 2022年4月至2023年5月兰州大学第一医院内分泌科确诊的685例T2DM患者根据是否伴有NAFLD分为NAFLD组和Non-NAFLD组, NAFLD人群根据天冬氨酸转氨酶(aspartate aminotransferase, AST)/丙氨酸转氨酶(alanine aminotransferase, ALT)水平分为肝纤维化和无肝纤维化组, 比较各组之间四肢骨骼肌质量(appendicular skeletal muscle mass, ASM)、四肢骨骼肌质量指数(appendicular skeletal muscle mass index, ASMI)水平及肌肉质量减少患病率的差异。二元logistic回归分析T2DM患者ASMI与NAFLD、肝纤维化的独立相关性。结果男性T2DM患者NAFLD组ASMI水平低于Non-NAFLD组, 肌肉质量减少患病率高于Non-NAFLD组;女性NAFLD组ASM、ASMI水平均低于Non-NAFLD组, 肌肉质量减少患病率高于Non-NAFLD组。男性、女性T2DM患者ASMI水平与NAFLD患病风险独立负相关(OR=-0.696, 95%CI 0.579～0.837;OR=-0.757, 95%CI 0.629～0.911)。NAFLD患者肝纤维化组ASM、ASMI水平低于无肝纤维化组;肌肉质量减少患病率差异无统计学意义。男性NAFLD患者肝纤维化组ASM水平、ASMI水平低于无肝纤维化组, 女性患者ASM及ASMI水平组间差异无统计学意义。男性NAFLD患者ASMI水平与肝纤维化患病风险独立负相关(OR=-0.726, 95%CI 0.537～0.983), 女性患者ASMI水平与肝纤维化患病风险无相关性。结论男性或女性T2DM患者肌肉质量减少与T2DM患者NAFLD患病风险独立相关。男性T2DM患者肌肉质量减少与其肝脏纤维化患病风险独立相关。

关键词：糖尿病, 2型四肢骨骼肌质量非酒精性脂肪肝肝纤维化

EGFR-targeted and gemcitabine-incorporated chemogene for combinatorial pancreatic cancer treatment

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Nano Research 2024年第2期17卷 848-857页

作者： Miao Xie Qiushuang Zhang Yuanyuan guo Lijuan Zhu xinyuan Zhu Chuan Zhang School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesInstitute of Molecular MedicineSixth people’s HospitalSchool of MedicineShanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai 200240China Department of Radiology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200233China Institute of Molecular Medicine Shanghai Jiao Tong University Affiliated Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China

Pancreatic cancer stands out as a recognized intractable tumor due to its high malignancy and mortality rates,which are largely attributed to the insensitivity of current clinical chemotherapies or *** chemo and gene therapy that integrates different therapeutic targets,may increase the chemosensitivity of pancreatic cancer and synergistically enhance the antitumor ***,conventional co-delivery of gene and chemo drugs is intensively dependent on complex nanoparticle delivery systems,thus would be limited by unstable drug packaging,nonspecific biodistribution,and biosafety ***,we rationally designed an epidermal growth factor-receptor(EGFR)-targeted and gemcitabine-incorporated oligonucleotide(termed as chemogene)with anti-Bcl-2 sequence,which achieves simple and precise integration of gemcitabine into a gene regulative agent,as well as the EGFR-targeted delivery for pancreatic cancer *** solid-phase synthesis,gemcitabine,as the first-line chemodrug for pancreatic cancer,is introduced to the antisense oligonucleotide to replace all cytosine nucleosides to obtain the gemcitabine-integrated chemogene(Ge-ASO^(Bcl-2)).Thereafter,Ge-ASO^(Bcl-2)is covalently coupled with EGFR nanobody to construct the final targeted chemogene without any exogenous ***,this nanobody-conjugated chemogene exhibits remarkable tumor targeting capability and antitumor effects both in vitro and in vivo,which initiates a first step toward the application of combinatorial chemo and gene therapy for future pancreatic cancer treatment.

关键词： antisense oligonucleotide chemogene nanobody drug delivery system pancreatic cancer

Aesthetic art development and protection of Tujia waving dance in Hunan Province

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International Journal of Technology Management 2013年第6期 124-126页

作者： xinyuan guo Changsha University ChangshaHunanChina

Tujia dance is an advanced, special form of human aesthetic activities. The so-called aesthetic, simply put, is to feel, and understand the objective things or phenomena presented by the United States itself： specifically, it refers to the people in their social practice and objective process of historical things or phenomena occur and construct a special performance relationship. There are basically three kinds of relationships of man and objective things or phenomena： firstly, cognitive relation of science; Secondly, ethical norms relations; thirdly, aesthetic performance relationship. Focus on the relationship between the performances of the aesthetic object vivid sense of the expressive form of regularity is the unity and purpose, with freedom. The essence of aesthetic is liberty. Art aesthetic and general aesthetic are different, mainly because of its aesthetic objects, which is based on works of art as an aesthetic object. General aesthetic contemplation of beauty of reality, the reality of objective things or phenomena, not as people practice the original object mad the object of knowledge exists. In social practice, they first form a rational understanding of relationships and will practice relationship. On this basis, when the society develops to the degree of no direct utilitarian attitude, practical attitude towards the object of an object only when there has been more mature, purely aesthetic relationship. The beauty of art is different from the reality beauty, which is produced and existed as an aesthetic object.

关键词： Aesthetic art Tujia dance Protection.

The aesthetic arts and heritage conservation study of Hunan Tujia Waving Dance

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International Journal of Technology Management 2013年第5期 49-51页

作者： xinyuan guo Changsha University ChangshaHunanChina

Tujia Waving Dance, as an important part of culture, has drawn the attention of many scholars in sociology and ethnology and researched by them in recent years, with the results one after another. But from the perspective of sports and culture to observe and understand the Waving Dance, there are still not many learners and their analysis is limited to the discussions of the value of fitness and the recreational sports, but being ambiguous on the classification of the Waving Dance and its genes discussions, with some problems having big controversy. We can start from the basic shape of the Waving Dance to identify its dance category, to determine its basic factor, and to analyze the diversity value of the Waving Dance.

关键词： heritage conservation Tujia Waving Dance aesthetic arts.

Department of the Ministry of Higher non-art large-scale theatrical show themes and pre-planning studies

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International Journal of Technology Management 2013年第7期 40-42页

作者： xinyuan guo Changsha University ChangshaHunanChina

Gala is the creation of a complex system of project, planning is one of the important aspect of its creation. Party theme is clear, determination of content, the party structure, artistic, rendering of the program, the cast, in planning sessions are established. In the process of planning, we need use star advantage of media expansion strategy, and rely on government agencies, planning strategies such as beauty handsome effect to complete; system restructuring, backward thinking, and innovative methods such as the application of new technologies to accomplish the party＇s breakthrough innovation. But no matter what strategy is used, how, in the planning of cultural show, Planner is always the first factor, if there is no ＂planer＂ to participate in; party planning will be a problem. It is the use of planning methods and people are taking advantage of the above strategies, using the right kind of htunan way at the same time that complete party planning.

关键词： Literary Planning Design.