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Loss of SHROOM3 affects neuroepithelial cell shape through regulating cytoskeleton proteins in cynomolgus monkey organoids

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Zoological Research 2024年第2期45卷 233-241页

作者： Peng Li ting Zhang Ruo Wu Jun-Yu Zhang Yan Zhuo Shan-Gang Li Jiao-Jian Wang Wen-ting guo Zheng-Bo Wang Yong-Chang Chen State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunmingYunnan 650500China Yunnan Key Laboratory of Primate Biomedical Research KunmingYunnan 650500China

Neural tube defects(NTDs)are severe congenital neurodevelopmental disorders arising from incomplete neural tube *** folate supplementation has been shown to mitigate the incidence of NTDs,some cases,often attributable to genetic factors,remain *** SHROOM3 gene has been implicated in NTD cases that are unresponsive to folate supplementation;at present,however,the underlying mechanism remains *** tube morphogenesis is a complex process involving the folding of the planar epithelium of the neural *** determine the role of SHROOM3 in early developmental morphogenesis,we established a neuroepithelial organoid culture system derived from cynomolgus monkeys to closely mimic the in vivo neural plate *** of SHROOM3 resulted in shorter neuroepithelial cells and smaller *** morphological changes were attributed to the insufficient recruitment of cytoskeletal proteins,namely fibrous actin(F-actin),myosin II,and phospho-myosin light chain(PMLC),to the apical side of the neuroepithelial ***,these defects were not rescued by folate *** sequencing revealed that differentially expressed genes were enriched in biological processes associated with cellular and organ *** summary,we established an authentic in vitro system to study NTDs and identified a novel mechanism for NTDs that are unresponsive to folate supplementation.

关键词： Neural tube defects SHROOM3 Neuroepithelial Organoids Cynomolgus monkey

高职学前教育专业“项目式”舞蹈教学实践研究

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北京舞蹈学院学报 2022年第1期 124-131页

作者：郭婷婷淄博师范高等专科学校学前教育学院淄博255000

文章紧密结合幼儿园实际需要,从高职学前教育专业学生从业角度出发,分析目前学前教育专业高职舞蹈教学存在的问题。依据园校融合理念,通过全学段贯穿“项目式”舞蹈教学,科学优化学前教育专业舞蹈课程,探索“项目式”舞蹈教学园校融合... 详细信息

文章紧密结合幼儿园实际需要,从高职学前教育专业学生从业角度出发,分析目前学前教育专业高职舞蹈教学存在的问题。依据园校融合理念,通过全学段贯穿“项目式”舞蹈教学,科学优化学前教育专业舞蹈课程,探索“项目式”舞蹈教学园校融合的实施路径,有效推进学前教育专业舞蹈教学与幼儿园教学活动的融合,发挥艺术教育在幼儿教育中的积极作用,提高学生在幼儿园教育实践中的综合应用能力,体现“能力本位、园校融合、工学一体”的指导思想,实现高校教学与幼儿园用人的无缝对接。

关键词：高职学前教育园校融合学前教育专业 “项目式”舞蹈教学

(2+1)维KdV方程的孤子解和新Wronskian行列式解

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中北大学学报（自然科学版） 2015年第2期36卷 118-121,125页

作者：郭婷婷山西大学商务学院山西太原030031

对(2+1)维KdV方程进行研究,基于Wronskian行列式和Hirota双线性方法,应用行列式的性质,给出(2+1)维KdV方程Wronskian表示的孤子解.利用Hirota方法,在(2+1)维KdV方程经典孤子解的基础上,得出方程新的单孤子解.通过观察Wronskian行列式元... 详细信息

对(2+1)维KdV方程进行研究,基于Wronskian行列式和Hirota双线性方法,应用行列式的性质,给出(2+1)维KdV方程Wronskian表示的孤子解.利用Hirota方法,在(2+1)维KdV方程经典孤子解的基础上,得出方程新的单孤子解.通过观察Wronskian行列式元素的特征并分析所满足的色散关系,重新定义行列式元素,利用Hirota方法和Wronskian技巧,构造出新的2 N阶Wronskian行列式解,并应用行列式恒等式说明双线性型的孤子方程有Wronskian解.通过直接计算证明了两种新解的一致性.

关键词： Hirota 方法 (2+1)维 KdV 方程孤子解 Wronskian 行列式解

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上市公司破产风险时间效应的理论猜想

求是学刊 2017年第2期44卷 74-81页

作者：郭婷婷吉林大学商学院吉林长春130012

国内外已有研究主要关注破产风险的度量方法和预测效果,较少涉及企业上市后破产风险随时间变化的一般性规律问题。基于2003年3月至2015年6月中国沪深A股市场季度、半年度和年度全样本数据,利用横截面固定效应面板模型,实证判别企业破产... 详细信息

国内外已有研究主要关注破产风险的度量方法和预测效果,较少涉及企业上市后破产风险随时间变化的一般性规律问题。基于2003年3月至2015年6月中国沪深A股市场季度、半年度和年度全样本数据,利用横截面固定效应面板模型,实证判别企业破产风险特征随上市时间变化的内生性规律,并通过实证结果给出理论猜想解释上市公司破产风险存在内生性时间效应的经济学原因。实证结果表明:上市公司破产风险的时间效应显著且稳健,随上市时间变化呈现倒U型曲线规律,拐点大约出现在6.5年左右;引入偿债能力、营运能力和盈利能力等可能的影响因素作为控制变量,上市公司破产风险的时变规律仍然显著且稳健。因此,上市公司的破产风险存在时间效应,且时间效应具有内生性特征。理论猜想认为:上市条件的硬性约束、企业管理者的上市亢奋、债务的税盾效应以及企业价值影响效果的权衡导致企业破产风险特征呈现先上升再下降的倒U型内生时变规律。

关键词：上市公司破产风险时间效应内生性

Strategies that regulate LSD1 for novel therapeutics

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1494-1507页

作者： Meng Li Mengge Dai Bing Cheng Shaotong Li Enhui guo Junwei Fu ting Ma Bin Yu School of Pharmaceutical Sciences&Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationZhengzhou UniversityZhengzhou 450001China College of Chemistry Zhengzhou UniversityZhengzhou 450001China Tianjian Laboratory of Advanced Biomedical Sciences Institute of Advanced Biomedical SciencesZhengzhou UniversityZhengzhou 450000China Pingyuan Laboratory State Key Laboratory of Antiviral DrugsHenan Normal UniversityXinxiang 453007China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Histone methylation plays crucial roles in regulating chromatin structure and gene transcrip-tion in epigenetic ***-specific demethylase 1(LSD1),the first identified histone de-methylase,is universally overexpressed in various ***1 dysregulation is closely associated with cancer,viral infections,and neurodegenerative diseases,etc.,making it a promising therapeutic *** LSD1 inhibitors and two small-molecule degraders(UM171 and BEA-17)have entered the clinical ***1 can remove methyl groups from histone 3 at lysine 4 or lysine 9(H3K4 or H3K9),resulting in either transcription repression or *** the roles of LSD1 in transcrip-tional regulation are well-established,studies have revealed that LSDl can also be dynamically regulated by other *** example,the expression or activity of LSD1 can be regulated by many proteins that form transcriptional corepressor complexes with ***,some post-transcriptional modifica-tions and cellular metabolites can also regulate LSD1 expression or its demethylase ***,in this review,we will systematically summarize how proteins involved in the transcriptional corepressor complex,various post-translational modifications,and metabolites act as regulatory factors for LSD1 ac-tivity.

关键词： LSD1 regulation Transcription repression Transcription activation the Corepressor complex Post-transcriptional modifications Metabolites

Translocation of a fish spike from the pharynx to the thyroid gland:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1365-1370页

作者： Deng Li Wan-ting Zeng Jian-guo Jiang Ji-Chuan Chen Department of Otolaryngology Head and Neck Surgery Army Medical Center of PLAChongqing 400042China

BACKGROUND A fish spike stuck in the throat is a common ear,nose,and throat(ENT)***,it is very rare for a fish spike to reach the thyroid tissue through the throat,which is very dangerous and can lead to pharyngeal fistula,cervical abscess,mediastinal abscess,and thyroid *** and timely management can help reduce complications,especially in elderly *** SUMMARY In the case presented here,the causative factor was dentures,but improper management aggravated the *** the case presented here,an elderly woman with a history of accidentally swallowing fish bones for 20 d had a sensation of foreign bodies in her ***,computed tomography(CT)of the neck showed that the left side of the thyroid gland had a dense shadow in the form of a *** If a fishbone foreign body is not visible during endoscopic examination but the patient has significant symptoms,the surgeon should be aware that the fishbone may be lodged in the *** avoid a misdiagnosis,ultrasound,CT,and other tests can be used to clarify the diagnosis.T The first step in treating a fish bone in the thyroid gland is to determine the position of the foreign body and the extent of the infection,and to develop a personalized surgical plan for its *** the same time,scientific information should be made available to the general public so that people know that if a fish bone is accidentally lodged,they should not force it to be swallowed or be spit out by inducing vomiting,which are incorrect methods and may aggravate the condition or even cause it to migrate outside the cavity,leading to serious complications,as in this reported case.

关键词： Fish spike Thyroid Pharynx Foreign body migration Case report

Bilateral macular edema secondary to nab-paclitaxel therapy for breast cancer

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1963-1966页

作者： Zi-Yi Zhou Ya-ting Ye Jing-ting Zhu Dong-Jie Sun Yu-Sheng Wang guo-Rui Dou Department of Ophthalmology Eye Institute of Chinese PLAXijing HospitalFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina College of Life Sciences Northwestern UniversityXi’an 710032Shaanxi ProvinceChina

Dear Editor,Nanoparticle albumin bound(nab)–paclitaxel is a member of the taxane agents that has been proven efficient and widely applied in breast cancer as well as other kind of *** taxane-induced macular edema has been recognized as an uncommon side effect which might regress after the drug *** we presented our case as a rarely observed macular edema secondary to nab–paclitaxel therapy as *** consent from the patient was achieved and the research was approved by the Ethics Committee of Xijing Hospital(KY20202009-C-1).

关键词： edema breast macular

Effect of post rolling stress on phase transformation behavior of microalloyed dual phase steel

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Journal of Iron and Steel Research International 2024年第3期31卷 688-699页

作者： Wen-quan Sun Sheng-yi Yong Tie-heng Yuan ting-song Yang An-rui He Chao Liu Rui-chun guo National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing 100083China

The slow phase transformation of microalloyed dual phase steel makes the nonuniform stress and temperature fields during the post rolling cooling process have a significant impact on the phase transformation *** the relatively slow phase transformation of DP780 steel within the microalloyed dual phase steel series,the influence of stress on the phase transformation behavior of DP780 steel was *** quantify the nonuniform thermal and stress conditions in the steel coil,a thermo-mechanical coupled finite element model of the hot-rolled strip cooling process was *** on the simulation data,DP780 steel was chosen as the research material,and Gleeble 3500 thermal simulation equipment was used for experimental *** thermal expansion curves were analyzed through regression to establish the dynamic model of DP780 steel phase transformation under ***,metallographic analysis was conducted to determine phase transformation type and grain size of DP780 *** results confirmed that the stress promotes the occurrence of semi-diffusion-type bainite ***,an appropriate level of stress facilitates the growth of bainitic grains,while the increased stress inhibits the growth of ferritic grains.

关键词： Microalloyed dual phase steel Stress Bainitic transformation Grain Finite element method

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一个(3+1)维非线性演化方程的周期波解

中北大学学报（自然科学版） 2018年第1期39卷 25-31页

作者：郭婷婷山西大学商务学院山西太原030031

基于一般的多维黎曼theta函数,直接推广双线性方法来构造(3+1)维非线性演化方程的黎曼theta函数周期波解.在多周期波解中,1-周期波的水平形态是一维的,2-周期波在独立的两个水平方向上有两个独立周期,因而它是1-周期波解的直接推广,并... 详细信息

基于一般的多维黎曼theta函数,直接推广双线性方法来构造(3+1)维非线性演化方程的黎曼theta函数周期波解.在多周期波解中,1-周期波的水平形态是一维的,2-周期波在独立的两个水平方向上有两个独立周期,因而它是1-周期波解的直接推广,并且其水平形态是二维的.在非线性方程双线性表示的基础上,运用双线性方法,构造出该(3+1)维非线性偏微分方程的1-孤子解和2-孤子解.这两种解之间的关系可以用极限的方法来描述,并相应地分析了多周期波解的渐近性态,得出在小振幅限制的极限情况下,周期波解将趋近于孤子解.

关键词： (3+1)维非线性演化方程周期波解孤子解渐近性态黎曼theta函数