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Food Science and Human Wellness 2024年第1期13卷 191-197页

作者： Xueqi Li Wenjun Ma ting Yang Chong Wang Wei Zhang Hui Li ting Zhao Xiaofei guo Institute of Nutrition&Health School of Public HealthQingdao UniversityQingdao 260071China Affiliated Hospital of Qingdao University Qingdao 260071China

The associations of individual amino acid with non-alcoholic fatty liver disease(NAFLD)risk remained *** present study aimed to investigate the associations between the two in the Chinese ***:A community-based health check-up program was conducted in Qingdao,*** was diagnosed by ultrasonography accompanied by epidemiological *** dietary intakes of amino acids were investigated with 3-day,24-h dietary records and calculated by Nutrition Calculator *** cubic spline model was used to evaluate a nonlinear relationship between amino acid intake and NAFLD ***:400 NAFLD subjects were identified,and 400 participants were randomly selected as controls and matched by gender and age(±3 years)Dose-response analysis showed that 1000 mg increment of aromatic amino acids(AAAs)was associated with reduced 16%risk of *** increments of 750 mg/d threonine,950 mg/d valine,or 1700 mg/d lysine were associated with a 20%reduction in the NAFLD risk(all P for linearityting against NAFLD in the elderly.

关键词： Amino acid Non-alcoholic fatty liver disease Senior citizen Dose-response analysis

西那卡塞和依特卡肽心脏器官疾病相关的不良事件信号分析:一项药物警戒研究

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中国新药与临床杂志 2024年第3期43卷 236-240页

作者：温馨郭婷婷韩顺戴映王之舟李禄金朱兆华曾一凡程俊杰吴钰娇张秀华石大伟南方医科大学珠江医院临床研究中心广东广州510280 南方医科大学珠江医院肾内科广东广州510280 中山大学孙逸仙纪念医院骨外科广东广州510280 温州医科大学附属第一医院药学部浙江温州325000 温州医科大学附属第一医院信息科浙江温州325000 温州医科大学附属第一医院临床研究中心/药物临床试验机构办公室浙江温州325000 复旦大学附属金山医院上海201203 上海中医药大学交叉科学研究院定量药理研究中心上海201203 南方医科大学第二临床学院广东广州510280

目的通过挖掘并分析西那卡塞和依特卡肽心脏器官疾病相关的不良事件(CRADE)信号,为临床用药安全提供参考。方法收集2013年第一季度至2023年第一季度美国食品和药物管理局不良事件报告系统数据库中西那卡塞和依特卡肽的药物不良事件(ADE... 详细信息

目的通过挖掘并分析西那卡塞和依特卡肽心脏器官疾病相关的不良事件(CRADE)信号,为临床用药安全提供参考。方法收集2013年第一季度至2023年第一季度美国食品和药物管理局不良事件报告系统数据库中西那卡塞和依特卡肽的药物不良事件(ADE)报告,采用频数法检测两药的CRADE信号,并分析CRADE发生的频次、信号强度,与用药疗程、治疗剂量的关系等。结果共纳入ADE报告13136477份,其中西那卡塞和依特卡肽CRADE报告分别为631份和327份。在两药的CRADE信号挖掘中均发现了心脏停搏和心绞痛2个新信号,主动脉狭窄和冠状动脉狭窄则是依特卡肽的另两个新信号。西那卡塞各项CRADE信号强度普遍低于依特卡肽。在依特卡肽CRADE信号中,主动脉狭窄和不稳定型心绞痛报告比值比分别为259.307和179.621,远高于其他CRADE。西那卡塞在30 mg·d^(-1)的给药剂量下,CRADE的报告频次多;当用药疗程大于8周时,CRADE的报告频次更高。结论有新的西那卡塞和依特卡肽CRADE信号被发现,应用西那卡塞疗程较长,或有心血管疾病的患者应用依特卡肽时,需关注治疗药物的安全性。

关键词：西那卡塞依特卡肽药物不良事件药物警戒信号挖掘

Inetetamab combined with pyrotinib and chemotherapy in the treatment of breast cancer brain metastasis: A case report

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World Journal of Clinical Cases 2024年第3期12卷 575-581页

作者： Qing-Qing Dou ting-ting Sun guo-Qiang Wang Wei-Bing Tong Graduate Student Institute Inner Mongolia Medical UniversityHohhot 010000Inner Mongolia Autonomous RegionChina Central Breast Area B Beijing University Cancer Hospital Inner Mongolia HospitalHohhot 010000Inner Mongolia Autonomous RegionChina

BACKGROUND Breast cancer brain metastasis(BCBM)is an advanced breast disease that is difficult to treat and is associated with a high risk of *** prognosis is usually poor,with reduced quality of *** this context,we report the case of a patient with HER-2-positive BCBM treated with a macromolecular mAb(ine-tetamab)combined with a small molecule tyrosine kinase inhibitor(TKI).CASE SUMMARY The patient was a 58-year-old woman with a 12-year history of type 2 *** was compliant with regular insulin treatment and had good blood glucose *** patient was diagnosed with invasive carcinoma of the right breast(T3N1M0 stage IIIa,HER2-positive type)through aspiration biopsy of the ipsilateral breast due to the discovery of a breast tumor in February *** showed ER(-),PR(-),HER-2(3+),and Ki-67(55-60%+).Preoperative neoadjuvant chemotherapy,i.e.,the AC-TH regimen(epirubicin,cyclophosphamide,docetaxel-paclitaxel,and trastuzumab),was administered for 8 *** underwent modified radical mastectomy of the right breast in November 2019 and received tocilizumab targeted therapy for 1 *** metastasis was found 9 mo after *** underwent brain metastasectomy in August *** showed ER(-)and PR.(-),HER-2(3+),and Ki-67(10-20%+).In November 2020,the patient experienced headache *** an examination,tumor recurrence in the original surgical region of the brain was observed,and the patient was treated with inetetamab,pyrotinib,and ***-brain radiotherapy was *** patient and her family refused radiotherapy for personal *** September 2021,a routine examination revealed that the brain tumor was considerably *** original systemic treatment was continued and combined with intensity-modulated radiation therapy for brain metastases,followed by regular hospitalization and routine *** patient’s condition is generally stable,and she has a relatively high qua

关键词： Breast cancer brain metastasis Resistance to trastuzumab Macromolecule inetetamab Small molecule tyrosine kinase inhibitor Radiation therapy HER2-positive Case report

N-doping offering higher photodegradation performance of dissolved black carbon for organic pollutants: experimental and theoretical studies

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第4期25卷 340-356页

作者： Yong guo Mengxia CHEN ting CHEN Ying guo Zixuan XU guowei XU Soukthakhane SINSONESACK Keophoungeun KANMANY Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes Ministry of EducationCollege of EnvironmentHohai UniversityNanjing 210093China Key Laboratory of Environmental Engineering of Jiangsu Province Jiangsu Provincial Academy of Environmental ScienceNanjing 210036China State Key Laboratory of Pollution Control and Resource Reuse Nanjing UniversityNanjing 210023China Central Environmental Laboratory Natural Resources and Environment Research InstituteMinistry of Natural Resources and EnvironmentVientiane 999012Laos

We investigated the influence mechanism of N-doping for dissolved black carbon(DBC)photodegradation of organic *** degradation performance of N-doped dissolved black carbon(NDBC)for tetracycline(TC)(71%)is better than that for methylene blue(MB)(28%)under *** levels are both better than DBC degradation performances for TC(68%)and MB(18%)under *** species quenching experiments suggest that h and-O,are the main reactive species for NDBC photodegraded TC,while-OH and h*are the main reactive species for NDBC photodegraded MB.-OH is not observed during DBC photodegradation of *** is likely because N-doping increases valence-band(VB)energy from 1.55 eV in DBC to 2.04 eV in NDBC;the latter is strong enough to oxidize water to ***,N-doping increases the DBC band gap of 2.29 to 2.62 eV in NDBC,resulting in a higher separation efficiency of photo-generated electrons-holes in NDBC than in *** these factors give NDBC stronger photodegradation performance for TC and MB than ***-performance liquid chromatography-mass spectrometry(HPLC-MS)characterization and toxicity evaluation with the quantitative structure-activity relationship(QSAR)method suggest that TC photodegradation intermediates produced by NDBC have less aromatic structure and are less toxic than those produced by *** adopted a theoretical approach to clarify the relationship between the surface groups of NDBC and the photoactive species *** results add to the understanding of the photochemical behavior of NDBC.

关键词： Dissolved black carbon(DBC) N-doping Organic pollutants Band gap Photodegradation

Metal-Free Synthesis of 2-Aminobenzothiazoles via I2-Catalyzed Tandem Cyclization Reaction of Amines and Carbon Disulfide

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Chinese Journal of Chemistry 2024年第8期42卷 846-852页

作者： ting Chen Wei Feng Ruitong Yang Shanping Chen guo-Jun Deng Key Laboratory for Green Organic Synthesis and Application of Hunan Province Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of EducationCollege of ChemistryXiangtan UniversityXiangtanHunan411105 China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiangHunan453007 China

Comprehensive Summary,A convenient approach for the construction of 2-aminobenzothiazoles via I2-catalyzed tandem cyclization reaction of amines and carbon disulfide has been *** present approach starts from simple and readily available starting materials,affording a series of 2-aminobenzothiazoles in up to 89%yields under metal-free *** this work,C—H/N—H functionalization was achieved and multiple C-hetero bonds were successfully constructed in one pot.

关键词： Sulfur heterocycles C-H functionalization Cyclization Tandem reaction Transition-metal-free Amines lodine N-Heterocycles

Numerical Study on the Effect of Gap Diffraction on the Hydrodynamic Performance of A Floating Breakwater

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China Ocean Engineering 2024年第4期38卷 663-675页

作者： BIAN Xiang-qian JI Chun-yan XU Sheng guo Jian-ting HUO Fa-li School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Two-dimensional(2D)flume experiments are useful in investigating the performances of floating breakwaters(FBs),including hydrodynamic performances,motion responses,and mooring *** a reasonable gap between the flume wall and the FBs is a critical step in 2D flume ***,research on the effect of the gap on the accuracy of 2D FB experimental results is *** address this issue,a numerical wave tank is developed using CFD to estimate the wave-FB interaction of a moored dual-cylindrical FB,and the results are compared to experimental data from a previously published *** is good agreement between them,indicating that the numerical model is sufficiently *** numerical model is then applied to explore the effect of gap diffraction on the performance of FBs in2D *** was discovered that the nondimensional gap length L_(Gap)/W_(Pool)should be smaller than 7.5%to ensure that the relative error of the transmission coefficient is smaller than 3%.The influence of the gap is also related to the entering wave properties,such as the wave height and period.

关键词： floating breakwater diffraction effect gap hydrodynamic performance model experiments CFD numerical simulation

An improved deep dilated convolutional neural network for seismic facies interpretation

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Petroleum Science 2024年第3期21卷 1569-1583页

作者： Na-Xia Yang guo-Fa Li ting-Hui Li Dong-Feng Zhao Wei-Wei Gu State Key Laboratory of Petroleum Resources and Engineering CNPC Key Lab of Geophysical ExplorationChina University of Petroleum(Beijing)Beijing 102249China Dagang Branch Research InstituteBGPTianjin300280China

With the successful application and breakthrough of deep learning technology in image segmentation,there has been continuous development in the field of seismic facies interpretation using convolutional neural *** intelligent and automated methods significantly reduce manual labor,particularly in the laborious task of manually labeling seismic ***,the extensive demand for training data imposes limitations on their wider *** overcome this challenge,we adopt the UNet architecture as the foundational network structure for seismic facies classification,which has demonstrated effective segmentation results even with small-sample training ***,we integrate spatial pyramid pooling and dilated convolution modules into the network architecture to enhance the perception of spatial information across a broader *** seismic facies classification test on the public data from the F3 block verifies the superior performance of our proposed improved network structure in delineating seismic facies *** analysis against the traditional UNet model reveals that our method achieves more accurate predictive classification results,as evidenced by various evaluation metrics for image ***,the classification accuracy reaches an impressive 96%.Furthermore,the results of seismic facies classification in the seismic slice dimension provide further confirmation of the superior performance of our proposed method,which accurately defines the range of different seismic *** approach holds significant potential for analyzing geological patterns and extracting valuable depositional information.

关键词： Seismic facies interpretation Dilated convolution Spatial pyramid pooling Internal feature maps Compound loss function

An experimental study on effects of temperature gradient on microstructure of a 308L stainless steel manufactured by directed energy deposition

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Journal of Iron and Steel Research International 2024年第8期31卷 2031-2040页

作者： ting Dai De-yu Gu Yu-wen Qiu Wei guo Hui Ding Yi-wei Sun School of Materials Science and Engineering Jiangsu Key Laboratory of Advanced Metallic MaterialsSoutheast UniversityNanjing 211189JiangsuChina

The effect of spatial temperature gradient on the microstructural evolution of a 308L stainless steel during the directed energy deposition(DED)process was experimentally investigated.A novel cooling system was designed and incorporated to a DED system in order to control the temperature gradient along the deposition direction during *** deposition,the workpiece was placed on a lifting platform,and as the deposition process proceeded,the platform and workpiece were gradually lowered into cooling water so that the temperature gradient along the deposition direction could be controlled and maintained stable during the deposition *** microstructure characterization results indicated that a deposition strategy with higher G and G/R values(where G is temperature gradient and R is solidification rate)produced finer cellular grains that were better aligned with the deposition direction,while a deposition strategy with lower G and G/R values produced columnar grains with larger primary arm spacing and less aligned with the deposition direction.

关键词： Additive manufacturing Directed energy deposition Stainless steel Microstructure Temperature gradient

A multifunctional shear apparatus for rocks subjected to true triaxial stress and high temperature in real-time

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3524-3543页

作者： Jun Zhao Xia-ting Feng Jia-Rong Wang Liang Hu Yue guo Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang110819China Key Laboratory of Liaoning Province on Deep Engineering and Intelligent Technology Northeastern UniversityShenyang110819China

Deep engineering disasters,such as rockbursts and collapses,are more related to the shear slip of rock joints.A novel multifunctional device was developed to study the shear failure mechanism in *** this device,the complete shearedeformation process and long-term shear creep tests could be performed on rocks under constant normal stiffness(CNS)or constant normal loading(CNL)conditions in real-time at high temperature and true-triaxial *** the research and development process,five key technologies were successfully broken through:(1)the ability to perform true-triaxial compressioneshear loading tests on rock samples with high stiffness;(2)a shear box with ultra-low friction throughout the entire stress space of the rock sample during loading;(3)a control system capable of maintaining high stress for a long time and responding rapidly to the brittle fracture of a rock sample as well;(4)a refined ability to measure the volumetric deformation of rock samples subjected to true triaxial shearing;and(5)a heating system capable of maintaining uniform heating of the rock sample over a long *** developing these technologies,loading under high true triaxial stress conditions was *** apparatus has a maximum normal stiffness of 1000 GPa/m and a maximum operating temperature of 300*** differences in the surface temperature of the sample are constant to within5*** types of true triaxial shear tests were conducted on homogeneous sandstone to verify that the apparatus has good performance and *** results show that temperature,lateral stress,normal stress and time influence the shear deformation,failure mode and strength of the *** novel apparatus can be reliably used to conduct true-triaxial shear tests on rocks subjected to high temperatures and stress.

关键词： True-triaxial shear apparatus Rocks Complete shear stressedeformation process Creep Real-time high-temperature

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异常链路分析在电力网络恢复中的应用

电子科技大学学报 2016年第5期45卷 854-859页

作者：郭婷婷赵承业中国计量大学理学院杭州310018

在大规模瘫痪状态下的电力系统的恢复过程中,网络中的一些特殊连边起到了关键作用,这是该文提出的基于异常链路分析的网络重构策略的主要思想。通过链路预测算法对网络中真实存在的连边进行异常度排名,以优先恢复异常度高的电源节点为目... 详细信息

在大规模瘫痪状态下的电力系统的恢复过程中,网络中的一些特殊连边起到了关键作用,这是该文提出的基于异常链路分析的网络重构策略的主要思想。通过链路预测算法对网络中真实存在的连边进行异常度排名,以优先恢复异常度高的电源节点为目标,建立骨架网络恢复策略,然后根据链路的重要性进行骨架网络之外的线路的修复。这样不仅可以快速连通电源发电机,也能及时恢复重要线路,具有实际意义。

关键词：异常度异常链路链路预测网络重构恢复策略骨架网络